Biological Potential of a Bibenzyl Compound ‘Gigantol’ for the Treatment
of Human Disorders: Pharmacological Activities and Analytical Aspects of
an Active Phytochemical Isolated from Orchid

Kanika      Patel; Gireesh   Kumar   Singh; Gulam Mohammed      Husain; Satyendra K.      Prasad; Dinesh Kumar      Patel

doi:10.2174/0115748855254948231024112016

Abstract

Background: Dendrobium chrysotoxum Lindl. is an important medicinal plant of the genus Dendrobium from the Orchidaceae family. Gigantol is one of the key bioactive phytochemicals found in Dendrobium plants. Gigantol is reported to have diverse pharmacological activities.

Aims: This narrative review explores the analytical aspects along with pharmacological activities of gigantol as reported in different scientific publications.

Methods: To find appropriate information related to Dendrobium plants and gigantol, extensive data extraction was done using ScienceDirect, Google, PubMed, and Scopus databases, and diverse facts were collected, arranged and analyzed to know the therapeutic potential of gigantol. Analytical aspects of gigantol were also discussed in the present work.

Results: Gigantol has a wide distribution in the Dendrobium officinale, Dendrobium chrysanthum, Dendrobium crystallinum, Dendrobium aphyllum, and Dendrobium devonianum. Available data indicates diverse pharmacological activities of gigantol. Preclinical studies have shown its effectiveness in the treatment of cataractogenesis, liver injury, leishmaniasis, nephrotoxicity, spasm, and skin disorders. Gigantol has been found to control hepatocellular cancer, lung cancer, breast cancer, bladder cancer, and cervical cancer. The neuroprotective, antinociceptive, anti-inflammatory, antioxidant, vasorelaxant, immune modulatory effect, antimalarial, and anti-herpetic properties of gigantol have also been observed. Applications of different analytical techniques for the isolation and characterization of gigantol were also discussed in detail.

Conclusion: Gigantol has significant and diverse pharmacological activities that must be explored in clinical setup to develop therapeutic leads for different diseases and health conditions.

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Graphical Abstract

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DOI https://dx.doi.org/10.2174/0115748855254948231024112016	Print ISSN 1574-8855
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Current Drug Therapy

Biological Potential of a Bibenzyl Compound ‘Gigantol’ for the Treatment of Human Disorders: Pharmacological Activities and Analytical Aspects of an Active Phytochemical Isolated from Orchid

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