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Current Drug Targets

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ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

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Targeting Lysyl Oxidase as a Potential Therapeutic Approach to Reducing Fibrotic Scars Post-operatively: Its Biological Role in Post-Surgical Scar Development

Author(s): Mahin Ghorban Sabbagh, Mohsen Aliakbarian, Rozita Khodashahi, Gordon-A Ferns, Hoda Rahimi, Kiarash Ashrafzadeh, Mahmoud Tavakkoli and Mohammad-Hassan Arjmand*

Volume 24, Issue 14, 2023

Published on: 27 October, 2023

Page: [1099 - 1105] Pages: 7

DOI: 10.2174/0113894501249450231023112949

Price: $65

Abstract

Abdominal and pelvic surgery, or any surgical injury of the peritoneum, often leads to chronic abdominal adhesions that may lead to bowel obstruction, infertility, and pain. Current therapeutic strategies are usually ineffective, and the pathological mechanisms of the disease are unclear. Excess collagen cross-linking is a key mediator for extra-cellular matrix deposition and fibrogenesis. Lysyl oxidase is a key enzyme that catalyzes the formation of stabilizing cross-links in collagen. Dysregulation of Lysyl oxidase (Lox) expressing upregulates collagen cross-linking, leading ECM deposition. Tissue hypoxia during surgery induces molecular mechanisms and active transcription factors to promote the expression of several genes related to inflammation, oxidative stress, and fibrosis, such as transforming growth factor beta, and Lox. Studies have shown that targeting Lox improves clinical outcomes and fibrotic parameters in liver, lung, and myocardial fibrosis, therefore, Lox may be a potential drug target in the prevention of postsurgical adhesion.

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Graphical Abstract

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