Abstract
Diabetic nephropathy (DN) has gradually become one of the main causes of end-stage renal disease (ESRD). However, there is still a lack of effective preventive measures to delay its progression. As the energy factory in the cell, mitochondria play an irreplaceable role in maintaining cell homeostasis. Interestingly, recent studies have shown that in addition to maintaining homeostasis in cells in which mitochondria reside, when mitochondrial perturbations occur in one tissue, distal tissues can also sense and act through mitochondrial stress response pathways through a group of proteins or peptides called “mitokines”. Here, we reviewed the mitokines that have been found thus far and summarized their research progress in DN. Finally, we explored the possibility of mitokines as potential therapeutic targets for DN.
Current Medicinal Chemistry
Title:The Role of Mitokines in Diabetic Nephropathy
Volume: 31
Author(s): Ming Yang, Wei Chen, Liyu He, Xi Wang, Di Liu, Li Xiao and Lin Sun*
Affiliation:
- Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China
Abstract: Diabetic nephropathy (DN) has gradually become one of the main causes of end-stage renal disease (ESRD). However, there is still a lack of effective preventive measures to delay its progression. As the energy factory in the cell, mitochondria play an irreplaceable role in maintaining cell homeostasis. Interestingly, recent studies have shown that in addition to maintaining homeostasis in cells in which mitochondria reside, when mitochondrial perturbations occur in one tissue, distal tissues can also sense and act through mitochondrial stress response pathways through a group of proteins or peptides called “mitokines”. Here, we reviewed the mitokines that have been found thus far and summarized their research progress in DN. Finally, we explored the possibility of mitokines as potential therapeutic targets for DN.
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Cite this article as:
Yang Ming, Chen Wei, He Liyu, Wang Xi, Liu Di, Xiao Li and Sun Lin*, The Role of Mitokines in Diabetic Nephropathy, Current Medicinal Chemistry 2024; 31 () . https://dx.doi.org/10.2174/0109298673255403230919061828
DOI https://dx.doi.org/10.2174/0109298673255403230919061828 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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