Polypyrimidine Tract Binding Protein: A Universal Player in Cancer
Development

Elizabeth      Gonzalez; Terrie   G   Flatt; Midhat      Farooqi; Lisa      Johnson; Atif   A.   Ahmed

doi:10.2174/0115665240251370231017053236

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Abstract

Objectives: Polypyrimidine tract binding protein is a 57-Kda protein located in the perinucleolar compartment where it binds RNA and regulates several biological functions through the regulation of RNA splicing. Numerous research articles have been published that address the cellular network and functions of PTB and its isoforms in various disease states.

Methodology: Through an extensive PubMed search, we attempt to summarize the relevant research into this biomolecule.

Results: Besides its roles in embryonic development, neuronal cell growth, RNA metabolism, apoptosis, and hematopoiesis, PTB can affect cancer growth via several metabolic, proliferative, and structural mechanisms. PTB overexpression has been documented in several cancers where it plays a role as a novel prognostic factor.

Conclusion: The diverse carcinogenic effect opens an argument into its potential role in inhibitory targeted therapy.

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DOI https://dx.doi.org/10.2174/0115665240251370231017053236	Print ISSN 1566-5240
Publisher Name Bentham Science Publisher	Online ISSN 1875-5666

Current Molecular Medicine

Polypyrimidine Tract Binding Protein: A Universal Player in Cancer Development

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