[1]
Gaur, S.; Agnihotri, R. Alzheimer’s disease and chronic periodontitis: Is there an association? Geriatr. Gerontol. Int., 2015, 15(4), 391-404.
[http://dx.doi.org/10.1111/ggi.12425] [PMID: 25511390]
[http://dx.doi.org/10.1111/ggi.12425] [PMID: 25511390]
[2]
Li, X.; Kiprowska, M.; Kansara, T.; Kansara, P.; Li, P. Neuroinflammation: A distal consequence of periodontitis. J. Dent. Res., 2022, 101(12), 1441-1449.
[http://dx.doi.org/10.1177/00220345221102084] [PMID: 35708472]
[http://dx.doi.org/10.1177/00220345221102084] [PMID: 35708472]
[3]
Pritchard, A.B.; Crean, S.; Olsen, I.; Singhrao, S.K. Periodontitis, microbiomes and their role in Alzheimer’s disease. Front. Aging Neurosci., 2017, 9, 336.
[http://dx.doi.org/10.3389/fnagi.2017.00336] [PMID: 29114218]
[http://dx.doi.org/10.3389/fnagi.2017.00336] [PMID: 29114218]
[4]
Tuganbaev, T.; Yoshida, K.; Honda, K. The effects of oral microbiota on health. Science, 2022, 376(6596), 934-936.
[http://dx.doi.org/10.1126/science.abn1890] [PMID: 35617380]
[http://dx.doi.org/10.1126/science.abn1890] [PMID: 35617380]
[5]
Dominy, S.S.; Lynch, C.; Ermini, F.; Benedyk, M.; Marczyk, A.; Konradi, A.; Nguyen, M.; Haditsch, U.; Raha, D.; Griffin, C.; Holsinger, L.J.; Arastu-Kapur, S.; Kaba, S.; Lee, A.; Ryder, M.I.; Potempa, B.; Mydel, P.; Hellvard, A.; Adamowicz, K.; Hasturk, H.; Walker, G.D.; Reynolds, E.C.; Faull, R.L.M.; Curtis, M.A.; Dragunow, M.; Potempa, J. Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Sci. Adv., 2019, 5(1), eaau3333.
[http://dx.doi.org/10.1126/sciadv.aau3333] [PMID: 30746447]
[http://dx.doi.org/10.1126/sciadv.aau3333] [PMID: 30746447]
[6]
Han, E.C.; Choi, S.Y.; Lee, Y.; Park, J.W.; Hong, S.H.; Lee, H.J. Extracellular RNAs in periodontopathogenic outer membrane vesicles promote TNF‐α production in human macrophages and cross the blood‐brain barrier in mice. FASEB J., 2019, 33(12), 13412-13422.
[http://dx.doi.org/10.1096/fj.201901575R] [PMID: 31545910]
[http://dx.doi.org/10.1096/fj.201901575R] [PMID: 31545910]
[7]
Ha, J.Y.; Choi, S.Y.; Lee, J.H.; Hong, S.H.; Lee, H.J. Delivery of periodontopathogenic extracellular vesicles to brain monocytes and microglial IL-6 promotion by RNA cargo. Front. Mol. Biosci., 2020, 7, 596366.
[http://dx.doi.org/10.3389/fmolb.2020.596366] [PMID: 33330627]
[http://dx.doi.org/10.3389/fmolb.2020.596366] [PMID: 33330627]
[8]
Pulgar, V.M. Transcytosis to cross the blood brain barrier, new advancements and challenges. Front. Neurosci., 2019, 12, 1019.
[http://dx.doi.org/10.3389/fnins.2018.01019] [PMID: 30686985]
[http://dx.doi.org/10.3389/fnins.2018.01019] [PMID: 30686985]
[9]
Matsumoto, J.; Stewart, T.; Sheng, L.; Li, N.; Bullock, K.; Song, N.; Shi, M.; Banks, W.A.; Zhang, J. Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: Another mechanism for initiation and progression of Parkinson’s disease? Acta Neuropathol. Commun., 2017, 5(1), 71.
[http://dx.doi.org/10.1186/s40478-017-0470-4] [PMID: 28903781]
[http://dx.doi.org/10.1186/s40478-017-0470-4] [PMID: 28903781]
[10]
Bonnington, K.E.; Kuehn, M.J. Protein selection and export via outer membrane vesicles. Biochim. Biophys. Acta Mol. Cell Res., 2014, 1843(8), 1612-1619.
[http://dx.doi.org/10.1016/j.bbamcr.2013.12.011] [PMID: 24370777]
[http://dx.doi.org/10.1016/j.bbamcr.2013.12.011] [PMID: 24370777]
[11]
Lee, H.J. Microbe-host communication by small RNAs in extracellular vesicles: Vehicles for transkingdom RNA transportation. Int. J. Mol. Sci., 2019, 20(6), 1487.
[http://dx.doi.org/10.3390/ijms20061487] [PMID: 30934547]
[http://dx.doi.org/10.3390/ijms20061487] [PMID: 30934547]
[12]
Théry, C.; Witwer, K.W.; Aikawa, E.; Alcaraz, M.J.; Anderson, J.D.; Andriantsitohaina, R.; Antoniou, A.; Arab, T.; Archer, F.; Atkin-Smith, G.K.; Ayre, D.C.; Bach, J-M.; Bachurski, D.; Baharvand, H.; Balaj, L.; Baldacchino, S.; Bauer, N.N.; Baxter, A.A.; Bebawy, M.; Beckham, C.; Bedina Zavec, A.; Benmoussa, A.; Berardi, A.C.; Bergese, P.; Bielska, E.; Blenkiron, C.; Bobis-Wozowicz, S.; Boilard, E.; Boireau, W.; Bongiovanni, A.; Borràs, F.E.; Bosch, S.; Boulanger, C.M.; Breakefield, X.; Breglio, A.M.; Brennan, M.Á.; Brigstock, D.R.; Brisson, A.; Broekman, M.L.; Bromberg, J.F.; Bryl-Górecka, P.; Buch, S.; Buck, A.H.; Burger, D.; Busatto, S.; Buschmann, D.; Bussolati, B.; Buzás, E.I.; Byrd, J.B.; Camussi, G.; Carter, D.R.; Caruso, S.; Chamley, L.W.; Chang, Y-T.; Chen, C.; Chen, S.; Cheng, L.; Chin, A.R.; Clayton, A.; Clerici, S.P.; Cocks, A.; Cocucci, E.; Coffey, R.J.; Cordeiro-da-Silva, A.; Couch, Y.; Coumans, F.A.; Coyle, B.; Crescitelli, R.; Criado, M.F.; D’Souza-Schorey, C.; Das, S.; Datta Chaudhuri, A.; de Candia, P.; De Santana, E.F.; De Wever, O.; Del Portillo, H.A.; Demaret, T.; Deville, S.; Devitt, A.; Dhondt, B.; Di Vizio, D.; Dieterich, L.C.; Dolo, V.; Dominguez Rubio, A.P.; Dominici, M.; Dourado, M.R.; Driedonks, T.A.; Duarte, F.V.; Duncan, H.M.; Eichenberger, R.M.; Ekström, K.; El Andaloussi, S.; Elie-Caille, C.; Erdbrügger, U.; Falcón-Pérez, J.M.; Fatima, F.; Fish, J.E.; Flores-Bellver, M.; Försönits, A.; Frelet-Barrand, A.; Fricke, F.; Fuhrmann, G.; Gabrielsson, S.; Gámez-Valero, A.; Gardiner, C.; Gärtner, K.; Gaudin, R.; Gho, Y.S.; Giebel, B.; Gilbert, C.; Gimona, M.; Giusti, I.; Goberdhan, D.C.; Görgens, A.; Gorski, S.M.; Greening, D.W.; Gross, J.C.; Gualerzi, A.; Gupta, G.N.; Gustafson, D.; Handberg, A.; Haraszti, R.A.; Harrison, P.; Hegyesi, H.; Hendrix, A.; Hill, A.F.; Hochberg, F.H.; Hoffmann, K.F.; Holder, B.; Holthofer, H.; Hosseinkhani, B.; Hu, G.; Huang, Y.; Huber, V.; Hunt, S.; Ibrahim, A.G-E.; Ikezu, T.; Inal, J.M.; Isin, M.; Ivanova, A.; Jackson, H.K.; Jacobsen, S.; Jay, S.M.; Jayachandran, M.; Jenster, G.; Jiang, L.; Johnson, S.M.; Jones, J.C.; Jong, A.; Jovanovic-Talisman, T.; Jung, S.; Kalluri, R.; Kano, S-I.; Kaur, S.; Kawamura, Y.; Keller, E.T.; Khamari, D.; Khomyakova, E.; Khvorova, A.; Kierulf, P.; Kim, K.P.; Kislinger, T.; Klingeborn, M.; Klinke, D.J.; Kornek, M.; Kosanović, M.M.; Kovács, Á.F.; Krämer-Albers, E-M.; Krasemann, S.; Krause, M.; Kurochkin, I.V.; Kusuma, G.D.; Kuypers, S.; Laitinen, S.; Langevin, S.M.; Languino, L.R.; Lannigan, J.; Lässer, C.; Laurent, L.C.; Lavieu, G.; Lázaro-Ibáñez, E.; Le Lay, S.; Lee, M-S.; Lee, Y.X.F.; Lemos, D.S.; Lenassi, M.; Leszczynska, A.; Li, I.T.; Liao, K.; Libregts, S.F.; Ligeti, E.; Lim, R.; Lim, S.K.; Linē, A.; Linnemannstöns, K.; Llorente, A.; Lombard, C.A.; Lorenowicz, M.J.; Lörincz, Á.M.; Lötvall, J.; Lovett, J.; Lowry, M.C.; Loyer, X.; Lu, Q.; Lukomska, B.; Lunavat, T.R.; Maas, S.L.; Malhi, H.; Marcilla, A.; Mariani, J.; Mariscal, J.; Martens-Uzunova, E.S.; Martin-Jaular, L.; Martinez, M.C.; Martins, V.R.; Mathieu, M.; Mathivanan, S.; Maugeri, M.; McGinnis, L.K.; McVey, M.J.; Meckes, D.G.; Meehan, K.L.; Mertens, I.; Minciacchi, V.R.; Möller, A.; Møller Jørgensen, M.; Morales-Kastresana, A.; Morhayim, J.; Mullier, F.; Muraca, M.; Musante, L.; Mussack, V.; Muth, D.C.; Myburgh, K.H.; Najrana, T.; Nawaz, M.; Nazarenko, I.; Nejsum, P.; Neri, C.; Neri, T.; Nieuwland, R.; Nimrichter, L.; Nolan, J.P.; Nolte-’t Hoen, E.N.; Noren Hooten, N.; O’Driscoll, L.; O’Grady, T.; O’Loghlen, A.; Ochiya, T.; Olivier, M.; Ortiz, A.; Ortiz, L.A.; Osteikoetxea, X.; Østergaard, O.; Ostrowski, M.; Park, J.; Pegtel, D.M.; Peinado, H.; Perut, F. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): A position statement of the international society for extracellular vesicles and update of the MISEV2014 guidelines. J. Extracell. Vesicles, 2018, 7(1), 1535750.
[http://dx.doi.org/10.1080/20013078.2018.1535750] [PMID: 30637094]
[http://dx.doi.org/10.1080/20013078.2018.1535750] [PMID: 30637094]
[13]
Xie, J.; Cools, L.; Van Imschoot, G.; Van Wonterghem, E.; Pauwels, M.J.; Vlaeminck, I.; De Witte, C.; EL Andaloussi, S.; Wierda, K.; De Groef, L.; Haesebrouck, F.; Van Hoecke, L.; Vandenbroucke, R.E. Helicobacter pylori‐derived outer membrane vesicles contribute to Alzheimer’s disease pathogenesis via C3‐C3aR signalling. J. Extracell. Vesicles, 2023, 12(2), 12306.
[http://dx.doi.org/10.1002/jev2.12306] [PMID: 36792546]
[http://dx.doi.org/10.1002/jev2.12306] [PMID: 36792546]
[14]
Lee, H.J. Microbial extracellular RNAs and their roles in human diseases. Exp. Biol. Med ., 2020, 245(10), 845-850.
[http://dx.doi.org/10.1177/1535370220923585] [PMID: 32370631]
[http://dx.doi.org/10.1177/1535370220923585] [PMID: 32370631]
[15]
Bao, J.; Li, L.; Zhang, Y.; Wang, M.; Chen, F.; Ge, S.; Chen, B.; Yan, F. Periodontitis may induce gut microbiota dysbiosis via salivary microbiota. Int. J. Oral Sci., 2022, 14(1), 32.
[http://dx.doi.org/10.1038/s41368-022-00183-3] [PMID: 35732628]
[http://dx.doi.org/10.1038/s41368-022-00183-3] [PMID: 35732628]
[16]
Kitamoto, S.; Nagao-Kitamoto, H.; Hein, R.; Schmidt, T.M.; Kamada, N. The Bacterial connection between the oral avity and the gut diseases. J. Dent. Res., 2020, 99(9), 1021-1029.
[http://dx.doi.org/10.1177/0022034520924633] [PMID: 32464078]
[http://dx.doi.org/10.1177/0022034520924633] [PMID: 32464078]
[17]
Qian, J.; Lu, J.; Huang, Y.; Wang, M.; Chen, B.; Bao, J.; Wang, L.; Cui, D.; Luo, B.; Yan, F. Periodontitis salivary microbiota worsens colitis. J. Dent. Res., 2022, 101(5), 559-568.
[http://dx.doi.org/10.1177/00220345211049781] [PMID: 34796773]
[http://dx.doi.org/10.1177/00220345211049781] [PMID: 34796773]
[18]
Li, L.; Bao, J.; Chang, Y.; Wang, M.; Chen, B.; Yan, F. Gut Microbiota may mediate the influence of periodontitis on prediabetes. J. Dent. Res., 2021, 100(12), 1387-1396.
[http://dx.doi.org/10.1177/00220345211009449] [PMID: 33899584]
[http://dx.doi.org/10.1177/00220345211009449] [PMID: 33899584]
[19]
Hendrix, A.; De Wever, O. Systemically circulating bacterial extracellular vesicles: Origin, fate, and function. Trends Microbiol., 2022, 30(3), 213-216.
[http://dx.doi.org/10.1016/j.tim.2021.12.012] [PMID: 35033427]
[http://dx.doi.org/10.1016/j.tim.2021.12.012] [PMID: 35033427]
[20]
Brown, G.J.; Cañete, P.F.; Wang, H.; Medhavy, A.; Bones, J.; Roco, J.A.; He, Y.; Qin, Y.; Cappello, J.; Ellyard, J.I.; Bassett, K.; Shen, Q.; Burgio, G.; Zhang, Y.; Turnbull, C.; Meng, X.; Wu, P.; Cho, E.; Miosge, L.A.; Andrews, T.D.; Field, M.A.; Tvorogov, D.; Lopez, A.F.; Babon, J.J.; López, C.A.; Gónzalez-Murillo, Á.; Garulo, D.C.; Pascual, V.; Levy, T.; Mallack, E.J.; Calame, D.G.; Lotze, T.; Lupski, J.R.; Ding, H.; Ullah, T.R.; Walters, G.D.; Koina, M.E.; Cook, M.C.; Shen, N.; de Lucas Collantes, C.; Corry, B.; Gantier, M.P.; Athanasopoulos, V.; Vinuesa, C.G. TLR7 gain-of-function genetic variation causes human lupus. Nature, 2022, 605(7909), 349-356.
[http://dx.doi.org/10.1038/s41586-022-04642-z] [PMID: 35477763]
[http://dx.doi.org/10.1038/s41586-022-04642-z] [PMID: 35477763]
[21]
Allen, R.M.; Michell, D.L.; Cavnar, A.B.; Zhu, W.; Makhijani, N.; Contreras, D.M.; Raby, C.A.; Semler, E.M.; DeJulius, C.; Castleberry, M.; Zhang, Y.; Ramirez-Solano, M.; Zhao, S.; Duvall, C.; Doran, A.C.; Sheng, Q.; Linton, M.F.; Vickers, K.C. LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8. Nat. Cell Biol., 2022, 24(12), 1701-1713.
[http://dx.doi.org/10.1038/s41556-022-01030-7] [PMID: 36474072]
[http://dx.doi.org/10.1038/s41556-022-01030-7] [PMID: 36474072]
[22]
Kinane, D.F.; Demuth, D.R.; Gorr, S.U.; Hajishengallis, G.N.; Martin, M.H. Human variability in innate immunity. Periodontol. 2000, 2007, 45(1), 14-34.
[http://dx.doi.org/10.1111/j.1600-0757.2007.00220.x] [PMID: 17850446]
[http://dx.doi.org/10.1111/j.1600-0757.2007.00220.x] [PMID: 17850446]
[23]
Strong, M.J.; Xu, G.; Morici, L.; Splinter Bon-Durant, S.; Baddoo, M.; Lin, Z.; Fewell, C.; Taylor, C.M.; Flemington, E.K. Microbial contamination in next generation sequencing: Implications for sequence-based analysis of clinical samples. PLoS Pathog., 2014, 10(11), e1004437.
[http://dx.doi.org/10.1371/journal.ppat.1004437] [PMID: 25412476]
[http://dx.doi.org/10.1371/journal.ppat.1004437] [PMID: 25412476]
[24]
Li, D.; Huang, Q.; Huang, L.; Wen, J.; Luo, J.; Li, Q.; Peng, Y.; Zhang, Y. Baiting out a full length sequence from unmapped RNA-seq data. BMC Genomics, 2021, 22(1), 857.
[http://dx.doi.org/10.1186/s12864-021-08146-4] [PMID: 34837950]
[http://dx.doi.org/10.1186/s12864-021-08146-4] [PMID: 34837950]