The Functions and Mechanisms of Long Non-coding RNA SNHGs in Gastric Cancer

Title:The Functions and Mechanisms of Long Non-coding RNA SNHGs in Gastric Cancer

Volume: 27 Issue: 18

Author(s): Songhua Liu, Yao Rong, Mingzheng Tang, Qiqi Zhao, Chunyan Li, Wenbin Gao and Xiaojun Yang*

Affiliation:

• The First Clinical Medical School of Lanzhou University, Lanzhou 730000, China
• Department of General Surgery, Gansu Provincial Hospital, Lanzhou 730000, China
• Gansu key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology, Gansu Provincial Hospital, Lanzhou 730000, China
• Gansu Research Center of Prevention and Control Project for Digestive Oncology, Gansu Provincial Hospital, Lanzhou, 730000, China
• Key Laboratory of Gastrointestinal Tumor Diagnosis and Treatment of National Health and Health Commission, Lanzhou, 730000, China

Abstract: Gastric cancer (GC) is one of the most common malignancies worldwide. Despite significant advancements in surgical and adjuvant treatments, patient prognosis remains unsatisfactory. Long non-coding RNAs (lncRNAs) are a class of RNA molecules that lack protein-coding capacity but can engage in the malignant biological behaviors of tumors through various mechanisms. Among them, small nucleolar host genes (SNHGs) represent a subgroup of lncRNAs. Studies have revealed their involvement not only in gastric cancer cell proliferation, invasion, migration, epithelial- mesenchymal transition (EMT), and apoptosis but also in chemotherapy resistance and tumor stemness. This review comprehensively summarizes the biological functions, molecular mechanisms, and clinical significance of SNHGs in gastric cancer. It provides novel insights into potential biomarkers and therapeutic targets for the exploration of gastric cancer.

Cite this article as:

Liu Songhua, Rong Yao, Tang Mingzheng, Zhao Qiqi, Li Chunyan, Gao Wenbin and Yang Xiaojun*, The Functions and Mechanisms of Long Non-coding RNA SNHGs in Gastric Cancer, Combinatorial Chemistry & High Throughput Screening 2024; 27 (18) . https://dx.doi.org/10.2174/0113862073268591230928100922

DOI https://dx.doi.org/10.2174/0113862073268591230928100922	Print ISSN 1386-2073
Publisher Name Bentham Science Publisher	Online ISSN 1875-5402