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Current Green Chemistry

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ISSN (Print): 2213-3461
ISSN (Online): 2213-347X

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Research Article

Ultrasound-Assisted Catalyst-Free Knoevenagel Condensation of Carbonyl Compounds with C – H Acids in Water

Author(s): Goutam Brahmachari*, Indrajit Karmakar, Mullicka Mandal and Bhagirath Mandal

Volume 11, Issue 2, 2024

Published on: 11 October, 2023

Page: [210 - 220] Pages: 11

DOI: 10.2174/0122133461268098231004072803

Price: $65

Abstract

An ultrasound-assisted catalyst-free green protocol has been developed for the synthesis of a series of diversely substituted Knoevenagel condensation products from the reaction between functionalized aromatic aldehydes/isatin derivatives and substituted malononitriles as the C-H acids in water at ambient conditions. The method is simple, straightforward, and highly efficient. The major advantages of this newly developed protocol are expedient catalyst-free synthesis, good to excellent yields, energy efficiency, use of water as reaction medium, easy isolation of products, no need for column chromatographic purification, eco-friendliness, and operational simplicity.

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