Abstract
Evasion of apoptosis, the cells intrinsic death program, is a hallmark of human cancers including neuroblastoma. Also, failure to undergo apoptosis may cause treatment resistance, since the cytotoxic activity of anticancer therapies commonly used in the clinic, e.g. chemotherapy, γ-irradiation or immunotherapy, is predominantly mediated by triggering apoptosis in tumor cells. Therefore, a better understanding of the signaling pathways and molecules that govern apoptosis in neuroblastoma cells is expected to open new avenues for the design of molecular targeted therapies for neuroblastoma.
Keywords: Apoptosis, neuroblastoma, TRAIL, caspase-8, Bcl-2, IAPs
Current Pharmaceutical Design
Title: Apoptosis Pathways and Neuroblastoma Therapy
Volume: 15 Issue: 4
Author(s): S. Fulda
Affiliation:
Keywords: Apoptosis, neuroblastoma, TRAIL, caspase-8, Bcl-2, IAPs
Abstract: Evasion of apoptosis, the cells intrinsic death program, is a hallmark of human cancers including neuroblastoma. Also, failure to undergo apoptosis may cause treatment resistance, since the cytotoxic activity of anticancer therapies commonly used in the clinic, e.g. chemotherapy, γ-irradiation or immunotherapy, is predominantly mediated by triggering apoptosis in tumor cells. Therefore, a better understanding of the signaling pathways and molecules that govern apoptosis in neuroblastoma cells is expected to open new avenues for the design of molecular targeted therapies for neuroblastoma.
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Cite this article as:
Fulda S., Apoptosis Pathways and Neuroblastoma Therapy, Current Pharmaceutical Design 2009; 15 (4) . https://dx.doi.org/10.2174/138161209787315846
DOI https://dx.doi.org/10.2174/138161209787315846 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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