Biocatalytic Reduction of Carbonyl Groups

Kaoru      Nakamura; Tomoko      Matsuda

doi:10.2174/138527206777698020

Abstract

Recent developments of biocatalytic reduction of carbonyl groups are reviewed. Methods to find, prepare and modify the biocatalysts and to improve productivity and enantioselectivity of the reactions are explained. Then, practical applications for the asymmetric reduction of carbonyl compounds with various functionalities are given, including the synthesis of pharmaceutically important compounds.

Keywords: glutathione S-transferase (GST), Redox Reaction, overexpression, Cofactor-Regenerating Enzymes, Molecular hydrogen, Geotrichum candidum

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Current Organic Chemistry

Title: Biocatalytic Reduction of Carbonyl Groups

Volume: 10 Issue: 11

Author(s): Kaoru Nakamura and Tomoko Matsuda

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Keywords: glutathione S-transferase (GST), Redox Reaction, overexpression, Cofactor-Regenerating Enzymes, Molecular hydrogen, Geotrichum candidum

Abstract: Recent developments of biocatalytic reduction of carbonyl groups are reviewed. Methods to find, prepare and modify the biocatalysts and to improve productivity and enantioselectivity of the reactions are explained. Then, practical applications for the asymmetric reduction of carbonyl compounds with various functionalities are given, including the synthesis of pharmaceutically important compounds.

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Nakamura Kaoru and Matsuda Tomoko, Biocatalytic Reduction of Carbonyl Groups, Current Organic Chemistry 2006; 10 (11) . https://dx.doi.org/10.2174/138527206777698020