Pleiotropic Effects of Fenofibrate

Title: Pleiotropic Effects of Fenofibrate

Volume: 15 Issue: 5

Author(s): V. Tsimihodimos, E. Liberopoulos and M. Elisaf

Affiliation:

Keywords: Fenofibrate, pleiotropic effects, inflammation, endothelial function, oxidative stress, lipoprotein-associated enzymes, cardiac remodeling, angiogenesis

Abstract: Fenofibrate represents the most commonly used fibric acid derivative. The drug exerts its metabolic effects by modulating the expression of several genes involved in lipoprotein metabolism. In addition, numerous studies suggest that fenofibrate may also affect the progression of the atherosclerotic process by several lipid-independent mechanisms. This review considers the clinical pharmacology of fenofibrate and the current evidence on the pleiotropic effects of this fibric acid derivative.

Cite this article as:

Tsimihodimos V., Liberopoulos E. and Elisaf M., Pleiotropic Effects of Fenofibrate, Current Pharmaceutical Design 2009; 15 (5) . https://dx.doi.org/10.2174/138161209787315675