Abstract
Background: Several studies have shown that the intake of N. sativa has a beneficial effect on metabolic syndrome and related disorders. In this meta-analysis, our primary objective was to assess the impact of Nigella sativa consumption on inflammation and oxidative stress biomarkers among individuals diagnosed with metabolic syndrome and its associated conditions.
Methods: Our search was conducted on prominent online databases such as Web of Science, Scopus, PubMed, and EMBASE, utilizing relevant keywords until August 2023.
Results: This meta-analysis was performed on 16 RCTs comprising 1033 participants. Our results showed that intake of Nigella sativa significantly decreased CRP (SMD: -0.60; (95% CI: from -0.96 to -0.23); P = 0.00), TNF-α (SMD: -0.53; (95% CI: from -0.74 to -0.53); P = 0.00); IL-6 (SMD: -0.54 ; (95% CI: from -1.01 to -0.07); P = 0.02), and MDA: (SMD: -1.28; (95% CI: from -2.11 to -0.46); P = 0.00) levels. In addition, SOD: (SMD: 1.35; (95% CI, from 0.77 to 1.93); P = 0.00) and TAC (SMD: 2.82; (95% CI, from 0.55 to 5.084); P = 0.01) levels significantly increased in the intervention group compared to the placebo group.
Conclusion: Our results showed that THE consumption of N. sativa could be associated with improved oxidative stress and inflammation in patients with metabolic syndrome and related disorders.
Graphical Abstract
[http://dx.doi.org/10.1172/JCI21625] [PMID: 15599400]
[http://dx.doi.org/10.1186/s12986-018-0274-y] [PMID: 29930690]
[http://dx.doi.org/10.3390/biom10121702] [PMID: 33371482]
[http://dx.doi.org/10.5114/aoms/152921] [PMID: 36160355]
[http://dx.doi.org/10.1016/j.jep.2016.06.061] [PMID: 27364039]
[PMID: 27247920]
[http://dx.doi.org/10.3109/07853890009011772] [PMID: 10852144]
[http://dx.doi.org/10.1074/jbc.271.16.9503] [PMID: 8621622]
[http://dx.doi.org/10.1016/j.amjcard.2005.11.010] [PMID: 16442931]
[http://dx.doi.org/10.1016/j.jacl.2015.11.019] [PMID: 27678438]
[http://dx.doi.org/10.1017/S0007114517003439] [PMID: 29307310]
[http://dx.doi.org/10.2174/0929867327666200427092114] [PMID: 32338202]
[http://dx.doi.org/10.1007/s10787-021-00902-y] [PMID: 34997431]
[http://dx.doi.org/10.1016/j.phrs.2017.03.023]
[http://dx.doi.org/10.1017/S0954422420000049] [PMID: 32172721]
[http://dx.doi.org/10.1002/ptr.7763] [PMID: 36756995]
[http://dx.doi.org/10.1016/j.biopha.2021.112242] [PMID: 34953630]
[http://dx.doi.org/10.2174/0929867328666210614113116] [PMID: 34126879]
[http://dx.doi.org/10.1002/ptr.7892] [PMID: 37246835]
[http://dx.doi.org/10.1016/j.phrs.2023.106679] [PMID: 36764041]
[http://dx.doi.org/10.1002/ptr.6991] [PMID: 33464676]
[http://dx.doi.org/10.1016/j.phymed.2018.04.018] [PMID: 30097124]
[http://dx.doi.org/10.1007/s12602-017-9299-1] [PMID: 28677046]
[http://dx.doi.org/10.3390/nu13061784] [PMID: 34073784]
[http://dx.doi.org/10.1016/S2221-1691(13)60075-1] [PMID: 23646296]
[http://dx.doi.org/10.1002/ptr.5417] [PMID: 26179113]
[http://dx.doi.org/10.1002/ptr.1309] [PMID: 12722128]
[PMID: 28195061]
[http://dx.doi.org/10.1016/j.hermed.2020.100404] [PMID: 32983848]
[http://dx.doi.org/10.2174/1871527317666180702101455] [PMID: 29962349]
[PMID: 25859298]
[http://dx.doi.org/10.1155/2019/1528635] [PMID: 31214267]
[http://dx.doi.org/10.1007/s40618-014-0150-1] [PMID: 25125023]
[http://dx.doi.org/10.1002/ptr.7891] [PMID: 37341696]
[http://dx.doi.org/10.1016/j.jff.2023.105565]
[http://dx.doi.org/10.3390/antiox12071340] [PMID: 37507880]
[http://dx.doi.org/10.7762/cnr.2016.5.2.89] [PMID: 27152298]
[PMID: 24409406]
[http://dx.doi.org/10.1002/ptr.6944] [PMID: 33315269]
[http://dx.doi.org/10.1016/j.bbalip.2022.159155] [PMID: 35483558]
[http://dx.doi.org/10.1016/j.ctim.2015.01.013] [PMID: 25847566]
[http://dx.doi.org/10.7326/0003-4819-151-4-200908180-00135] [PMID: 19622511]
[http://dx.doi.org/10.1002/14651858.ED000142]
[http://dx.doi.org/10.1136/bmj.327.7414.557] [PMID: 12958120]
[http://dx.doi.org/10.1016/0197-2456(86)90046-2] [PMID: 3802833]
[http://dx.doi.org/10.1136/bmj.315.7109.629] [PMID: 9310563]
[http://dx.doi.org/10.1093/jnci/81.2.107] [PMID: 2642556]
[http://dx.doi.org/10.1002/ptr.6707] [PMID: 32510754]
[http://dx.doi.org/10.1016/j.jdiacomp.2021.107947] [PMID: 34006388]
[http://dx.doi.org/10.1007/s12020-019-01963-4] [PMID: 31152309]
[http://dx.doi.org/10.1155/2022/2753294]
[http://dx.doi.org/10.1007/s40200-019-00439-6] [PMID: 31890671]
[http://dx.doi.org/10.1016/j.ctim.2015.01.008] [PMID: 25847554]
[http://dx.doi.org/10.1371/journal.pone.0113486] [PMID: 25706772]
[http://dx.doi.org/10.1016/j.ctim.2019.04.014] [PMID: 31126557]
[http://dx.doi.org/10.1002/ptr.7140] [PMID: 33957004]
[http://dx.doi.org/10.1002/ptr.7568] [PMID: 35871718]
[http://dx.doi.org/10.1007/s40200-021-00954-5] [PMID: 35673509]
[PMID: 26366755]
[http://dx.doi.org/10.1055/a-1263-0898] [PMID: 33075830]
[http://dx.doi.org/10.1016/j.sleep.2018.07.022] [PMID: 30278295]
[http://dx.doi.org/10.3390/antiox9030236] [PMID: 32178436]
[http://dx.doi.org/10.2174/15701611113116660175] [PMID: 24168441]
[http://dx.doi.org/10.1089/met.2004.2.82] [PMID: 18370640]
[http://dx.doi.org/10.1111/jfbc.13625] [PMID: 33559935]
[http://dx.doi.org/10.1515/jcim-2019-0198] [PMID: 34187123]
[http://dx.doi.org/10.1007/s10787-023-01213-0] [PMID: 37036558]
[http://dx.doi.org/10.1016/j.biopha.2021.111540] [PMID: 33831837]
[http://dx.doi.org/10.1016/j.molimm.2021.03.015] [PMID: 33857815]
[http://dx.doi.org/10.1155/2020/2390706] [PMID: 32454800]
[PMID: 32257890]
[PMID: 20724766]
[http://dx.doi.org/10.3389/fnut.2023.1107750] [PMID: 37057067]