Asymmetric Construction of γ-lactams Displaying All-carbon, Aza-, Thia- and Oxaquaternary
Chiral Centers

Mario      Orena; Samuele      Rinaldi
doi:10.2174/0113852728264028230919060328
Abstract

γ-lactams, bearing one or more chiral centers are important scaffolds and widely occur in many natural and synthetic products of clinical interest, but the synthetic approaches mainly focus on the preparation of rings that display trisubstituted carbons, whereas only a few examples concern the construction of chiral γ- lactams that display tetrasubstituted carbon atoms. However, in recent years, the broad potential of these latter compounds was recognized and deserved high interest, owing to their complex three-dimensional features and structural rigidity. Thus, several efforts were engaged in the pursuit of new synthetic strategies towards γ-lactam rings that contain tetrasubstituted carbons that pose a particular challenge, and the present review gathers advances reported since 2015 about the enantioselective preparation of these molecules, carried out to exploit both internal and external asymmetric induction.
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Graphical Abstract

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DOI https://dx.doi.org/10.2174/0113852728264028230919060328	Print ISSN 1385-2728
Publisher Name Bentham Science Publisher	Online ISSN 1875-5348
Current Organic Chemistry

Asymmetric Construction of γ-lactams Displaying All-carbon, Aza-, Thia- and Oxaquaternary Chiral Centers

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Catalytic C-H bond activation as a tool for functionalization of heterocycles

Chemistry and Biology of Carbohydrates

Current Organic Chemistry

Asymmetric Construction of γ-lactams Displaying All-carbon, Aza-, Thia- and Oxaquaternary Chiral Centers

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Catalytic C-H bond activation as a tool for functionalization of heterocycles

Chemistry and Biology of Carbohydrates

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