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Endocrine, Metabolic & Immune Disorders - Drug Targets

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Review Article

Mentha Pulegium: A Plant with Several Medicinal Properties

Author(s): Smail Amtaghri, Miloudia Slaoui and Mohamed Eddouks*

Volume 24, Issue 3, 2024

Published on: 09 October, 2023

Page: [302 - 320] Pages: 19

DOI: 10.2174/1871530323666230914103731

Price: $65

Abstract

The species Mentha Pulegium L. (M. pulegium L.) belongs to the family Lamiaceae, native to Europe, North Africa, and the Middle East, and the genus Mentha. It has been traditionally used in food, cosmetics, and medicines. It is a perennial, fragrant, well-liked, herbaceous plant that can grow up to half a meter tall. It is extensively used as a food flavoring, particularly for Moroccan traditional drinks. Chewing mint and M. pulegium, a relaxing and refreshing plant, can be used to treat hiccups and act as an anticonvulsant and nerve relaxant. Pennyroyal leaves that have been crushed have a pungent, spearmint-like scent. Pennyroyal is used to make herbal teas, which, while not proven to be harmful to healthy adults in small doses, are not recommended due to their liver toxicity. Infants and children can die if they consume it. Pennyroyal leaves, both fresh and dried, are particularly effective at repelling insects. Pennyroyal essential oil should never be taken internally because it is highly toxic, even in small doses, it can be fatal. This plant is used in traditional Moroccan medicine to treat a wide range of conditions, including influenza, rheumatism, migraine, infertility, ulcer, pain, gastrointestinal problems, fever, diabetes, obesity, mental and cardiac disorders, constipation, respiratory ailments, and cough. M. pulegium is a great candidate for contemporary therapeutic usage since it contains a wide variety of biologically active compounds, including terpenoids, flavonoids, alkaloids, tannins, and saponins in all its parts. Among the different parts used are the whole plant, the aerial part, the stem, and the leaves. More interestingly, the entire plant contains a variety of compounds including Pulegone, Isomenthone, Carvone, Menthofuran, Menthol, 1,8-Cineole, Piperitone, Piperitenone, Neomenthol, -humulene, and 3-octanol. Eriocitrin, Hesperidin, Narirutin, Luteolin, Isorhoifolin, Galic acid, and Rosmarinic acid are found in the leaves. p-hydroxybenzoic acid, Ferulic acid, Caffeic acid, Vanillic acid, Syringic acid, Protocatechuic acid, Cinnamic acid, Phloretic acid, o-coumaric acid, p-coumaric acid, Catechin, Epicatechin, Chrysin, Quercetin, Naringenin, Carvacrol are all found in the areal part. Alterporriol G, Atropisomer, Alterporriol H, Altersolanol K, Altersolanol L, Stemphypyrone, 6-O-methylalaternin, Macrosporin, Altersolanol A, Alterporriol E, Alterporriol D, Alterporriol A, Alterporriol B, and Altersolanol J are also found in the stem of fungus. Pulegone, Piperitone, p-Menthane-1,2,3- triol, β-elemenene, guanine (cis-), Carvacrol acetate, and Phenyl ethyl alcohol are all components of this plant's essential oils. Moreover, the study also sought to investigate and document all currently available evidence and information on the nutritional composition and therapeutic uses of this plant ornamental. Its pharmacological applications include antimicrobial, antioxidant, antihypertensive, antidiabetic, anti-inflammatory, antiproliferative, antifungal, anticancer, burn wound healing, antispasmodic, and hepatotoxicity. Finally, toxicological studies have revealed that while low doses of extracts of the plant M. pulegium are not toxic, however, its essential oils of it are extremely toxic. In order to evaluate future research needs and investigate its pharmacological applications through clinical trials, the current assessment focuses on the distribution, chemical composition, biological activities, and primary uses of the plant.

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[1]
Abdellatif, F.; Akram, M.; Begaa, S.; Messaoudi, M.; Benarfa, A.; Egbuna, C.; Ouakouak, H.; Hassani, A.; Sawicka, B.; Elbossaty, W.F.M.; Simal-Gandara, J. Minerals, essential oils, and biological properties of Melissa officinalis L. Plants, 2021, 10(6), 1066.
[http://dx.doi.org/10.3390/plants10061066] [PMID: 34073337]
[2]
Begaa, S.; Messaoudi, M.; Benarfa, A. Statistical approach and neutron activation analysis for determining essential and toxic elements in two kinds of Algerian Artemisia plant. Biol. Trace Elem. Res., 2021, 199(6), 2399-2405.
[http://dx.doi.org/10.1007/s12011-020-02358-7] [PMID: 32862398]
[3]
Rezzoug, M.; Bakchiche, B.; Gherib, A.; Roberta, A. FlaminiGuido; Kilinçarslan, Ö.; Mammadov, R.; Bardaweel, S.K. Chemical composition and bioactivity of essential oils and Ethanolic extracts of Ocimum basilicum L. and Thymus algeriensis Boiss. & Reut. from the Algerian Saharan Atlas. BMC Complement. Altern. Med., 2019, 19(1), 146.
[http://dx.doi.org/10.1186/s12906-019-2556-y] [PMID: 31227024]
[4]
Elmastas, M.; Celik, S.M.; Genc, N.; Aksit, H.; Erenler, R.; Gulcin, İ. Antioxidant activity of an anatolian herbal tea —Origanum minutiflo-rum: isolation and characterization of its secondary metabolites. Int. J. Food Prop., 2018, 21(1), 374-384.
[http://dx.doi.org/10.1080/10942912.2017.1416399]
[5]
Rodrigues, M.J.; Pereira, C.A.; Oliveira, M.; Neng, N.R.; Nogueira, J.M.F.; Zengin, G.; Mahomoodally, M.F.; Custódio, L. Sea rose (Armeria pungens (Link) Hoffmanns. & Link) as a potential source of innovative industrial products for anti-ageing applications. Ind. Crops Prod., 2018, 121, 250-257.
[http://dx.doi.org/10.1016/j.indcrop.2018.05.018]
[6]
Dalar, A.; Mukemre, M.; Unal, M.; Ozgokce, F. Traditional medicinal plants of Ağrı Province, Turkey. J. Ethnopharmacol., 2018, 226, 56-72.
[http://dx.doi.org/10.1016/j.jep.2018.08.004] [PMID: 30099095]
[7]
Marzouk, B.; Fredj, M.B.H.; Chraief, I.; Mastouri, M.; Boukef, K.; Marzouk, Z. Chemical composition and antimicrobial activity of essential oils from Tunisian Mentha Pulegium L. J. Food Agric. Environ., 2008, 6(1), 78.
[8]
Das, B.K.; Das, B.; Arpita, F.K.; Morshed, M.A.; Uddin, A.; Bhattacherjee, R.; Hannan, J.M.A. Phytochemical screening and antioxidant activity of Leucas aspera. Int. J. Pharm. Sci. Res., 2011, 2(7), 1746.
[9]
El-Hilaly, J.; Hmammouchi, M.; Lyoussi, B. Ethnobotanical studies and economic evaluation of medicinal plants in Taounate province (Northern Morocco). J. Ethnopharmacol., 2003, 86(2-3), 149-158.
[http://dx.doi.org/10.1016/S0378-8741(03)00012-6] [PMID: 12738079]
[10]
Udo, I.J.; Ben, M.G.; Etuk, C.U.; Tiomthy, A.I. Phytochemical, proximate and antibacterial properties of Hibiscus rosa-sinensis L. Leaf. J. Med. Plant Stud., 2016, 4(5), 193-195.
[11]
Barkaoui, M.; Katiri, A.; Boubaker, H.; Msanda, F. Ethnobotanical survey of medicinal plants used in the traditional treatment of diabetes in Chtouka Ait Baha and Tiznit (Western Anti-Atlas), Morocco. J. Ethnopharmacol., 2017, 198, 338-350.
[http://dx.doi.org/10.1016/j.jep.2017.01.023] [PMID: 28109915]
[12]
Ullah, M.; Khan, M.U.; Mahmood, A.; Malik, R.N.; Hussain, M.; Wazir, S.M.; Daud, M.; Shinwari, Z.K. An ethnobotanical survey of indigenous medicinal plants in Wana district south Waziristan agency, Pakistan. J. Ethnopharmacol., 2013, 150(3), 918-924.
[http://dx.doi.org/10.1016/j.jep.2013.09.032] [PMID: 24120747]
[13]
Zengin, G.; Aumeeruddy-Elalfi, Z.; Mollica, A.; Yilmaz, M.A.; Mahomoodally, M.F. In vitro and in silico perspectives on biological and phytochemical profile of three halophyte species—A source of innovative phytopharmaceuticals from nature. Phytomedicine, 2018, 38, 35-44.
[http://dx.doi.org/10.1016/j.phymed.2017.10.017] [PMID: 29425653]
[14]
Jamila, F.; Mostafa, E. Ethnobotanical survey of medicinal plants used by people in Oriental Morocco to manage various ailments. J. Ethnopharmacol., 2014, 154(1), 76-87.
[http://dx.doi.org/10.1016/j.jep.2014.03.016] [PMID: 24685583]
[15]
Holaly, G.E.; Simplice, K.D.; Charlemagne, G.; Kodjovi, A.; Kokou, A.; Tchadjobo, T.; Amegnona, A.; Komlan, B.; Jacques, S. Étude eth-nobotanique des plantes utilisées dans le traitement du diabète dans la médecine traditionnelle de la région Maritime du Togo. Pan Afr. Med. J., 2015, 20, 20.
[http://dx.doi.org/10.11604/pamj.2015.20.437.5660]
[16]
Mrabti, H.N.; Jaradat, N.; Kachmar, M.R.; Ed-Dra, A.; Ouahbi, A.; Cherrah, Y.; Faouzi, A.M. Integrative herbal treatments of diabetes in Beni Mellal region of Morocco. J. Integr. Med., 2019, 17(2), 93-99.
[http://dx.doi.org/10.1016/j.joim.2019.01.001] [PMID: 30670366]
[17]
Hajlaoui, H.; Trabelsi, N.; Noumi, E.; Snoussi, M.; Fallah, H.; Ksouri, R.; Bakhrouf, A. Biological activities of the essential oils and methanol extract of tow cultivated mint species (Mentha longifolia and Mentha Pulegium) used in the Tunisian folkloric medicine. World J. Microbiol. Biotechnol., 2009, 25(12), 2227-2238.
[http://dx.doi.org/10.1007/s11274-009-0130-3]
[18]
Anwar, F.; Abbas, A.; Mehmood, T.; Gilani, A.H.; Rehman, N. Mentha: A genus rich in vital nutra‐pharmaceuticals-A review. Phytother. Res., 2019, 33(10), 2548-2570.
[http://dx.doi.org/10.1002/ptr.6423] [PMID: 31286590]
[19]
Gunby, P. Plant known for centuries still causes problems today. JAMA, 1979, 241(21), 2246-2247.
[http://dx.doi.org/10.1001/jama.1979.03290470006003] [PMID: 439284]
[20]
Ash, M.; Ash, I. Industrial chemical thesaurus; VCH Publishers, 1992.
[21]
Chalchat, J.C.; Gorunovic, M.S.; Maksimovic, Z.A.; Petrovic, S.D. Essential oil of wild growing Mentha Pulegium L. from Yugoslavia. J. Essent. Oil Res., 2000, 12(5), 598-600.
[http://dx.doi.org/10.1080/10412905.2000.9712166]
[22]
Mikaili, P.; Mojaverrostami, S.; Moloudizargari, M.; Aghajanshakeri, S. Pharmacological and therapeutic effects of Mentha Longifolia L. and its main constituent, menthol. Anc. Sci. Life, 2013, 33(2), 131-138.
[PMID: 25284948]
[23]
Harley, R.M.; Atkins, S.; Budantsev, A.L.; Cantino, P.D.; Conn, B.J.; Grayer, R.; Upson, T. Labiatae. In: Flowering Plants• Dicotyledons; Springer: Berlin, Heidelberg, 2004; pp. 167-275.
[http://dx.doi.org/10.1007/978-3-642-18617-2_11]
[24]
Hadi, M.Y.; Hameed, I.H.; Ibraheam, I.A. Mentha Pulegium: medicinal uses, anti-hepatic, antibacterial, antioxidant effect and analysis of bioactive natural compounds: A review. Res. J. Pharm. Techno., 2017, 10(10), 3580-3584.
[http://dx.doi.org/10.5958/0974-360X.2017.00648.5]
[25]
Müller-Riebau, F.J.; Berger, B.M.; Yegen, O.; Cakir, C. Seasonal variations in the chemical compositions of essential oils of selected aro-matic plants growing wild in Turkey. J. Agric. Food Chem., 1997, 45(12), 4821-4825.
[http://dx.doi.org/10.1021/jf970110y]
[26]
Teixeira, B.; Marques, A.; Ramos, C.; Batista, I.; Serrano, C.; Matos, O.; Neng, N.R.; Nogueira, J.M.F.; Saraiva, J.A.; Nunes, M.L. European pennyroyal (Mentha Pulegium) from Portugal: Chemical composition of essential oil and antioxidant and antimicrobial properties of extracts and essential oil. Ind. Crops Prod., 2012, 36(1), 81-87.
[http://dx.doi.org/10.1016/j.indcrop.2011.08.011]
[27]
Rocha, J.; Direito, R.; Lima, A.; Mota, J.; Gonçalves, M.; Duarte, M.P.; Solas, J.; Peniche, B.F.; Fernandes, A.; Pinto, R.; Ferreira, R.B.; Sepodes, B.; Figueira, M.E. Reduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in mice. Biomed. Pharmacother., 2019, 118, 109351.
[http://dx.doi.org/10.1016/j.biopha.2019.109351] [PMID: 31545244]
[28]
Brokl, M.; Flores, G.; Blanch, G.P.; del Castillo, M.L.R. Changes in the enantiomeric distribution of selected volatile constituents of Mentha Pulegium L. powders caused by hot water treatment. J. Agric. Food Chem., 2006, 54(23), 8836-8841.
[http://dx.doi.org/10.1021/jf060787y] [PMID: 17090131]
[29]
French, L.G. Isolation of (R)-(+)-pulegone from the european pennyroyal mint. Mentha Pulegium. Chem. Educ., 2002, 7(5), 270-277.
[http://dx.doi.org/10.1007/s00897020599a]
[30]
Kemille, K. Herbs: An Illustrated Encyclopedia; Friedman: New York, New York, 1994.
[31]
Bakerink, J.A.; Gospe, S.M., Jr; Dimand, R.J.; Eldridge, M.W. Multiple organ failure after ingestion of pennyroyal oil from herbal tea in two infants. Pediatrics, 1996, 98(5), 944-947.
[http://dx.doi.org/10.1542/peds.98.5.944] [PMID: 8909490]
[32]
Anderson, I.B.; Mullen, W.H.; Meeker, J.E. Khojasteh-BakhtSC; Oishi, S.; Nelson, S.D.; Blanc, P.D. Pennyroyal toxicity: measurement of toxic metabolite levels in two cases and review of the literature. Ann. Intern. Med., 1996, 124(8), 726-734.
[http://dx.doi.org/10.7326/0003-4819-124-8-199604150-00004] [PMID: 8633832]
[33]
Carmichael, P.G. Pennyroyal metabolites in human poisoning. Ann. Intern. Med., 1997, 126(3), 250-251.
[http://dx.doi.org/10.7326/0003-4819-126-3-199702010-00016] [PMID: 9027280]
[34]
Caputo, L.; Cornara, L.; Raimondo, F.M.; De Feo, V.; Vanin, S.; Denaro, M.; Trombetta, D.; Smeriglio, A. Mentha Pulegium l.: A plant underestimated for its toxicity to be recovered from the perspective of the circular economy. Molecules, 2021, 26(8), 2154.
[http://dx.doi.org/10.3390/molecules26082154] [PMID: 33918091]
[35]
Messaoudi, M.; Rebiai, A.; Sawicka, B.; Atanassova, M.; Ouakouak, H.; Larkem, I.; Egbuna, C.; Awuchi, C.G.; Boubekeur, S.; Ferhat, M.A.; Begaa, S.; Benchikha, N. Effect of extraction methods on polyphenols, flavonoids, mineral elements, and biological activities of essential oil and extracts of Mentha Pulegium L. Molecules, 2021, 27(1), 11.
[http://dx.doi.org/10.3390/molecules27010011] [PMID: 35011242]
[36]
Messaoudi, M.; Begaa, S. Dietary intake and content of some micronutrients and toxic elements in two algerian spices (Coriandrum sativum L. and Cuminum cyminum L.). Biol. Trace Elem. Res., 2019, 188(2), 508-513.
[http://dx.doi.org/10.1007/s12011-018-1417-8] [PMID: 29911262]
[37]
Soetan, K.O.; Olaiya, C.O.; Oyewole, O.E. he importance of mineral elements for humans, domestic animals and plants-A review. Afr. J. Food Sci., 2010, 4(5), 200-222.
[38]
Joint, F.A.O. odex alimentarius: General requirements (food hygiene). In: Codex alimentarius: general requirements (food hygiene); , 2001; p. 247.
[39]
Azhar, A.S.; Suhaila, H.B.; Imad, H.H. Analysis of bioactive chemical compounds of Euphorbia lathyrus using gas chromatography-mass spectrometry and Fourier-transform infrared spectroscopy. J. Pharmacogn. Phytother., 2016, 8(5), 109-126.
[http://dx.doi.org/10.5897/JPP2015.0371]
[40]
Huda, J.A.T.; Mohammed, Y.H.; Imad, H.H. Phytochemical analysis of Urtica dioica leaves by fourier-transform infrared spectroscopy and gas chromatography-mass spectrometry. J. Pharmacogn. Phytother., 2015, 7(10), 238-252.
[http://dx.doi.org/10.5897/JPP2015.0361]
[41]
Mohammed, G.J.; Omran, A.M.; Hussein, H.M. Antibacterial and phytochemical analysis of Piper nigrum using gas chromatography-mass Spectrum and Fourier-transform infrared spectroscopy. International. J. Pharmacog. Phytochem. Res., 2016, 8(6), 977-996.
[42]
Lena, F.H.; Sabreen, A.K.; Imad, H.H. Determination of metabolites products by Penicillium expansum and evaluating antimicobial activity. J. Pharmacogn. Phytother., 2015, 7(9), 194-220.
[http://dx.doi.org/10.5897/JPP2015.0360]
[43]
Jasim, H.; Hussein, A.O.; Hameed, I.H.; Kareem, M.A. Characterization of alkaloid constitution and evaluation of antimicrobial activity of Solanum nigrum using gas chromatography mass spectrometry (GC-MS). J. Pharmacogn. Phytother., 2015, 7(4), 56-72.
[44]
Mohammed, Y.H.; Ghaidaa, J.M.; Imad, H.H. Analysis of bioactive chemical compounds of Nigella sativa using gas chromatography-mass spectrometry. J. Pharmacogn. Phytother., 2016, 8(2), 8-24.
[http://dx.doi.org/10.5897/JPP2015.0364]
[45]
Riddle, J.M. Eve’s herbs: a history of contraception and abortion in the West; Harvard University Press, 1997.
[46]
Shahouzehi, B.; Sepehri, G.; Sadeghiyan, S.; Masoomi-Ardakani, Y. Effect of Pistacia atlantica resin oil on anti-oxidant, hydroxyprolin and VEGF changes in experimentally-induced skin burn in rat. World J. Plast. Surg., 2018, 7(3), 357-363.
[http://dx.doi.org/10.29252/wjps.7.3.357] [PMID: 30560077]
[47]
Asgarirad, H.; Chabra, A.; Rahimnejad, M.; Zaghi Hosseinzadeh, A.; Davoodi, A.; Azadbakht, M. Comparison of Albizia julibressin and silver sulfadiazine in healing of second and third degree burns. World J. Plast. Surg., 2018, 7(1), 34-44.
[PMID: 29651390]
[48]
Vaghardoost, R.; Ghavami, Y.; Sobouti, B. The effect of Mentha Pulegium on healing of burn wound injuries in rat. World J. Plast. Surg., 2019, 8(1), 43-50.
[http://dx.doi.org/10.29252/wjps.8.1.43] [PMID: 30873361]
[49]
Kachkoul, R.; Touimi, B.G.; Bennani, B.; El Habbani, R.; El Mouhri, G.; Mohim, M.; Lahrichi, A. The synergistic effect of three essential oils against bacteria responsible for the development of lithiasis infection: An optimization by the mixture design. Evid. Based Complement. Alternt. Med., 2021, 2021, 1305264.
[50]
Soares, P.M.G.; de Freitas Pires, A.; de Souza, E.P.; Assreuy, A.M.S.; Criddle, D.N. Relaxant effects of the essential oil of Mentha Pulegium L. in rat isolated trachea and urinary bladder. J. Pharm. Pharmacol., 2012, 64(12), 1777-1784.
[http://dx.doi.org/10.1111/j.2042-7158.2012.01558.x] [PMID: 23146041]
[51]
Chevallier, A. The encyclopedia of medicinal plants, 1996.
[52]
Gülçin, İ.; Gören, A.C.; Taslimi, P.; Alwasel, S.H.; Kılıc, O.; Bursal, E. Anticholinergic, antidiabetic and antioxidant activities of Anatolian pennyroyal (Mentha Pulegium)-analysis of its polyphenol contents by LC-MS/MS. Biocatal. Agric. Biotechnol., 2020, 23, 101441.
[http://dx.doi.org/10.1016/j.bcab.2019.101441]
[53]
Estrada-Soto, S.; González-Maldonado, D.; Castillo-España, P.; Aguirre-Crespo, F.; Sánchez-Salgado, J.C. Spasmolytic effect of Mentha Pulegium L. involves ionic flux regulation in rat ileum strips. J. Smooth Muscle Res., 2010, 46(2), 107-117.
[http://dx.doi.org/10.1540/jsmr.46.107] [PMID: 20551591]
[54]
Luís, Â.; Domingues, F. Screening of the potential bioactivities of pennyroyal (Mentha Pulegium L.) essential oil. Antibiotics, 2021, 10(10), 1266.
[http://dx.doi.org/10.3390/antibiotics10101266] [PMID: 34680848]
[55]
Mahboubi, M.; Haghi, G. Antimicrobial activity and chemical composition of Mentha Pulegium L. essential oil. J. Ethnopharmacol., 2008, 119(2), 325-327.
[http://dx.doi.org/10.1016/j.jep.2008.07.023] [PMID: 18703127]
[56]
Eddouks, M.; Ajebli, M.; Hebi, M. Ethnopharmacological survey of medicinal plants used in Daraa-Tafilalet region (Province of Errachidia), Morocco. J. Ethnopharmacol., 2017, 198, 516-530.
[http://dx.doi.org/10.1016/j.jep.2016.12.017] [PMID: 28003130]
[57]
Ajebli, M.; Eddouks, M. Vasorelaxant and antihypertensive effects of Mentha Pulegium L. in rats: An in vitro and in vivo approach. Endocr. Metab. Immune Disord. Drug Targets, 2021, 21(7), 1289-1299.
[58]
Maia, M.F.; Moore, S.J. Plant-based insect repellents: a review of their efficacy, development and testing. Malar. J., 2011, 10(S1), S11.
[http://dx.doi.org/10.1186/1475-2875-10-S1-S11] [PMID: 21411012]
[59]
Alamgir, A.N.M. Therapeutic use of medicinal plants and their extracts; Springer International Publishing AG, 2017, Vol. 1, .
[http://dx.doi.org/10.1007/978-3-319-63862-1]
[60]
Fahad, F.I.; Barua, N.; Islam, M.S.; Sayem, S.A.J.; Barua, K.; Uddin, M.J.; Chy, M.N.U.; Adnan, M.; Islam, M.N.; Sayeed, M.A.; Emran, T.B.; Simal-Gandara, J.; Pagano, E.; Capasso, R. Investigation of the pharmacological properties of lepidagathis hyalina nees through experimental approaches. Life, 2021, 11(3), 180.
[http://dx.doi.org/10.3390/life11030180] [PMID: 33668978]
[61]
Macêdo, N.S.; Silveira, Z.S.; Bezerra, A.H.; Costa, J.G.M.; Coutinho, H.D.M.; Romano, B.; Capasso, R.; Cunha, F.A.B.; da Silva, M.V. Caesalpinia ferrea C. Mart.(Fabaceae) phytochemistry, ethnobotany, and bioactivities: A review. Molecules, 2020, 25(17), 3831.
[http://dx.doi.org/10.3390/molecules25173831] [PMID: 32842529]
[62]
Marzouk, M.M.; Hussein, S.R.; Elkhateeb, A.; El-shabrawy, M.; Abdel-Hameed, E.S.S.; Kawashty, S.A. Comparative study of Mentha species growing wild in Egypt: LC-ESI-MS analysis and chemosystematic significance. J. Appl. Pharm. Sci., 2018, 8(8), 116-122.
[63]
Taamalli, A.; Arráez-Román, D.; Abaza, L.; Iswaldi, I.; Fernández-Gutiérrez, A.; Zarrouk, M.; Segura-Carretero, A. LC-MS-based metabolite profiling of methanolic extracts from the medicinal and aromatic species Mentha Pulegium and Origanum majorana. Phytochem. Anal., 2015, 26(5), 320-330.
[http://dx.doi.org/10.1002/pca.2566] [PMID: 25982347]
[64]
Ahmad, N.; Fazal, H.; Ahmad, I.; Abbasi, B.H. Free radical scavenging (DPPH) potential in nine Mentha species. Toxicol. Ind. Health, 2012, 28(1), 83-89.
[http://dx.doi.org/10.1177/0748233711407238] [PMID: 21646282]
[65]
Kogiannou, D.A.A.; Kalogeropoulos, N.; Kefalas, P.; Polissiou, M.G.; Kaliora, A.C. Herbal infusions; their phenolic profile, antioxidant and anti-inflammatory effects in HT29 and PC3 cells. Food Chem. Toxicol., 2013, 61, 152-159.
[http://dx.doi.org/10.1016/j.fct.2013.05.027] [PMID: 23712099]
[66]
Bouyahya, A.; Et-Touys, A.; Bakri, Y.; Talbaui, A.; Fellah, H.; Abrini, J.; Dakka, N. Chemical composition of Mentha Pulegium and Rosma-rinus officinalis essential oils and their antileishmanial, antibacterial and antioxidant activities. Microb. Pathog., 2017, 111, 41-49.
[http://dx.doi.org/10.1016/j.micpath.2017.08.015] [PMID: 28821401]
[67]
Mkaddem, M.; Boussaid, M.; Fadhel, N.B. Variability of volatiles in Tunisian Mentha Pulegium L.(Lamiaceae). J. Essent. Oil Res., 2007, 19(3), 211-214.
[http://dx.doi.org/10.1080/10412905.2007.9699263]
[68]
Karray-Bouraoui, N.; Rabhi, M.; Neffati, M.; Baldan, B.; Ranieri, A.; Marzouk, B.; Lachaâl, M.; Smaoui, A. Salt effect on yield and composition of shoot essential oil and trichome morphology and density on leaves of Mentha Pulegium. Ind. Crops Prod., 2009, 30(3), 338-343.
[http://dx.doi.org/10.1016/j.indcrop.2009.06.003]
[69]
Jebali, J.; Ghazghazi, H.; Aouadhi, C. ELBini-Dhouib, I.; Ben Salem, R.; Srairi-Abid, N.; Marrakchi, N.; Rigane, G. Tunisian native Mentha Pulegium L. extracts: phytochemical composition and biological activities. Molecules, 2022, 27(1), 314.
[http://dx.doi.org/10.3390/molecules27010314] [PMID: 35011545]
[70]
El-Ghorab, A.H. The chemical composition of the Mentha Pulegium L. essential oil from Egypt and its antioxidant activity. J. Essent. Oil-Bear. Plants, 2006, 9(2), 183-195.
[http://dx.doi.org/10.1080/0972060X.2006.10643491]
[71]
Hossan, M.S.; Rahman, S.; Bashar, A.B.M.A.; Jahan, R.; Al-Nahain, A.; Rahmatullah, M. Rosmarinic acid: A review of its anticancer action. World J. Pharm. Pharm. Sci., 2014, 3(9), 57-70.
[72]
Aires, A.; Marrinhas, E.; Carvalho, R.; Dias, C.; Saavedra, M.J. Phytochemical composition and antibacterial activity of hydroalcoholic extracts of Pterospartum tridentatum and Mentha Pulegium against Staphylococcus aureus isolates. Biomed Res. Int., 2016, 2016, 5201879.
[73]
Ibrahim, A.K. New terpenoids from Mentha Pulegium L. and their antimicrobial activity. Nat. Prod. Res., 2013, 27(8), 691-696.
[http://dx.doi.org/10.1080/14786419.2012.691488] [PMID: 22621322]
[74]
Sebai, E.; Serairi, R.; Saratsi, K.; Abidi, A.; Sendi, N.; Darghouth, M.A.; Wilson, M.S.; Sotiraki, S.; Akkari, H. Hydro-ethanolic extract of Mentha Pulegium exhibit anthelmintic and antioxidant proprieties in vitro and in vivo. Acta Parasitol., 2020, 65(2), 375-387.
[http://dx.doi.org/10.2478/s11686-020-00169-3] [PMID: 32002775]
[75]
Ceyhan-Güvensen, N.; Keskin, D. Chemical content and antimicrobial properties of three different extracts of Mentha Pulegium leaves from Mugla. Turkey. J. Environ. Biol., 2016, 37(6), 1341-1346.
[76]
Aimad, A.; Sanae, R.; Anas, F.; Abdelfattah, E.M.; Bourhia, M.; Salamatullah, M.A.; Noureddine, E. Chemical characterization and antioxidant, antimicrobial, and insecticidal properties of essential oil from Mentha Pulegium L. Evid. Based Complemen. Altern. Med., 2021, 2021, 1108133.
[77]
Debbab, A.; Aly, A.H.; Edrada-Ebel, R.; Wray, V.; Müller, W.E.G.; Totzke, F.; Zirrgiebel, U.; Schächtele, C.; Kubbutat, M.H.G.; Lin, W.H.; Mosaddak, M.; Hakiki, A.; Proksch, P.; Ebel, R. Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha Pulegium. J. Nat. Prod., 2009, 72(4), 626-631.
[http://dx.doi.org/10.1021/np8004997] [PMID: 19271717]
[78]
Teiten, M.H.; Mack, F.; Debbab, A.; Aly, A.H.; Dicato, M.; Proksch, P.; Diederich, M. Anticancer effect of altersolanol A, a metabolite produced by the endophytic fungus Stemphylium globuliferum, mediated by its pro-apoptotic and anti-invasive potential via the inhibition of NF-κB activity. Bioorg. Med. Chem., 2013, 21(13), 3850-3858.
[http://dx.doi.org/10.1016/j.bmc.2013.04.024] [PMID: 23664494]
[79]
Ekrami, M.; Emam-Djomeh, Z.; Ghoreishy, S.A.; Najari, Z.; Shakoury, N. Characterization of a high-performance edible film based on Salep mucilage functionalized with pennyroyal (Mentha Pulegium). Int. J. Biol. Macromol., 2019, 133, 529-537.
[http://dx.doi.org/10.1016/j.ijbiomac.2019.04.136] [PMID: 31005687]
[80]
Ahmed, A.; Ayoub, K.; Chaima, A.J.; Hanaa, L.; Abdelaziz, C. Effect of drying methods on yield, chemical composition and bioactivities of essential oil obtained from Moroccan Mentha Pulegium L. Biocatal. Agric. Biotechnol., 2018, 16, 638-643.
[http://dx.doi.org/10.1016/j.bcab.2018.10.016]
[81]
Domingues, P.M.; Santos, L. Essential oil of pennyroyal (Mentha Pulegium): Composition and applications as alternatives to pesticides-New tendencies. Ind. Crops Prod., 2019, 139, 111534.
[http://dx.doi.org/10.1016/j.indcrop.2019.111534]
[82]
El Arch, M.; Satrani, B.; Farah, A.; Bennani, L.; Boriky, D.; Fechtal, M.; Blaghen, M.; Talbi, M. Composition chimique et activités antimi-crobienne et insecticide de l’huile essentielle de Mentha rotundifolia du Maroc. Acta Bot. Gallica, 2003, 150(3), 267-274.
[http://dx.doi.org/10.1080/12538078.2003.10515996]
[83]
Regnault-Roger, C.; Vincent, C.; Arnason, J.T. Essential oils in insect control: low-risk products in a high-stakes world. Annu. Rev. Entomol., 2012, 57(1), 405-424.
[http://dx.doi.org/10.1146/annurev-ento-120710-100554] [PMID: 21942843]
[84]
Topuz, E.; Madanlar, N.; Erler, F. Chemical composition, toxic and development- and reproduction-inhibiting effects of some essential oils against Tetranychus urticae Koch (Acarina: Tetranychidae) as fumigants. J. Plant Dis. Prot., 2018, 125(4), 377-387.
[http://dx.doi.org/10.1007/s41348-018-0161-9]
[85]
El Asbahani, A.; Jilale, A.; Voisin, S.N.; Aït Addi, E.; Casabianca, H.; El Mousadik, A.; Hartmann, D.J.; Renaud, F.N.R. Chemical composition and antimicrobial activity of nine essential oils obtained by steam distillation of plants from the Souss-Massa Region (Morocco). J. Essent. Oil Res., 2015, 27(1), 34-44.
[http://dx.doi.org/10.1080/10412905.2014.964426]
[86]
Díaz-Maroto, M.C.; Castillo, N.; Castro-Vázquez, L.; Ángel González-Viñas, M.; Pérez-Coello, M.S. Volatile composition and olfactory profile of pennyroyal (Mentha Pulegium L.) plants. Flavour Fragrance J., 2007, 22(2), 114-118.
[http://dx.doi.org/10.1002/ffj.1766]
[87]
Petrakis, E.A.; Kimbaris, A.C.; Perdikis, D.C.; Lykouressis, D.P.; Tarantilis, P.A.; Polissiou, M.G. Responses of Myzus persicae (Sulzer) to three Lamiaceae essential oils obtained by microwave-assisted and conventional hydrodistillation. Ind. Crops Prod., 2014, 62, 272-279.
[http://dx.doi.org/10.1016/j.indcrop.2014.08.041]
[88]
Baali, F.; Boumerfeg, S.; Napoli, E.; Boudjelal, A.; Righi, N.; Deghima, A.; Baghiani, A.; Ruberto, G. Chemical composition and biological activities of essential oils from two wild Algerian medicinal plants: Mentha Pulegium L. and Lavandula stoechas L. J. Essent. Oil-Bear. Plants, 2019, 22(3), 821-837.
[http://dx.doi.org/10.1080/0972060X.2019.1642800]
[89]
Ouakouak, H.; Chohra, M.; Denane, M. Chemical composition, antioxidant activities of the essential oil of Mentha Pulegium L. South East of Algeria. Int. Lett. Nat. Sci., 2015, (39), 49-55.
[90]
Shahmohama, R.; Sariri, R.; Rasa, M.; Aghamali, M. Antioxidant activity of gilan Mentha Pulegium during growth. Pak. J. Biol. Sci., 2014, 17(3), 380-387.
[http://dx.doi.org/10.3923/pjbs.2014.380.387] [PMID: 24897792]
[91]
Kamkar, A.; Javan, A.J.; Asadi, F.; Kamalinejad, M. The antioxidative effect of Iranian Mentha Pulegium extracts and essential oil in sunflower oil. Food Chem. Toxicol., 2010, 48(7), 1796-1800.
[http://dx.doi.org/10.1016/j.fct.2010.04.003] [PMID: 20385193]
[92]
Lahlou, M. Essential oils and fragrance compounds: bioactivity and mechanisms of action. Flavour Fragrance J., 2004, 19(2), 159-165.
[http://dx.doi.org/10.1002/ffj.1288]
[93]
Osman, I.H.; Tantawy, A.A.; Ibrahim, H.M. El MoustafaAbd, G.A. Antioxidant properties of Mentha Pulegium and histopathological evaluation of its ameliorating effect on experimental acute hepatic injury. Histol. Cytol. Embryol., 2017, 1(1), 1-5.
[http://dx.doi.org/10.15761/HCE.1000101]
[94]
Piras, A.; Porcedda, S.; Falconieri, D.; Maxia, A.; Gonçalves, M.; Cavaleiro, C.; Salgueiro, L. Antifungal activity of essential oil from Mentha spicata L. and Mentha Pulegium L. growing wild in Sardinia island (Italy). Nat. Prod. Res., 2021, 35(6), 993-999.
[http://dx.doi.org/10.1080/14786419.2019.1610755] [PMID: 31321997]
[95]
Zerroug, A.; Sadrati, N.; Demirel, R.; Bakli, S.; Harzallah, D. Antibacterial activity of endophytic fungus, Penicillium griseofulvum MPR1 isolated from medicinal plant. Mentha Pulegium L. Afr. J. Microbiol. Res., 2018, 12(48), 1056-1066.
[http://dx.doi.org/10.5897/AJMR2018.8887]
[96]
Sebai, E.; Abidi, A.; Serairi, R.; Marzouki, M.; Saratsi, K.; Darghouth, M.A.; Sotiraki, S.; Akkari, H. Essential oil of Mentha Pulegium induces anthelmintic effects and reduces parasite-associated oxidative stress in rodent model. Exp. Parasitol., 2021, 225, 108105.
[http://dx.doi.org/10.1016/j.exppara.2021.108105] [PMID: 33812980]
[97]
Behi, F.; Bachrouch, O.; Boukhris-Bouhachem, S. Insecticidal activities of Mentha Pulegium L., and Pistacia lentiscus L., essential oils against two citrus aphids Aphis spiraecola Patch and Aphis gossypii Glover. J. Essent. Oil-Bear. Plants, 2019, 22(2), 516-525.
[http://dx.doi.org/10.1080/0972060X.2019.1611483]
[98]
Kim, S.I.; Yi, J.H.; Tak, J.; Ahn, Y.J. Acaricidal activity of plant essential oils against Dermanyssus gallinae (Acari: Dermanyssidae). Vet. Parasitol., 2004, 120(4), 297-304.
[http://dx.doi.org/10.1016/j.vetpar.2003.12.016] [PMID: 15063940]
[99]
Cárdenas-Ortega, N.C.; Zavala-Sánchez, M.A.; Aguirre-Rivera, J.R.; Pérez-González, C.; Pérez-Gutiérrez, S. Chemical composition and anti-fungal activity of essential oil of Chrysactinia mexicana gray. J. Agric. Food Chem., 2005, 53(11), 4347-4349.
[http://dx.doi.org/10.1021/jf040372h] [PMID: 15913293]
[100]
Maggiore, M.A.; Albanese, A.A.; Gende, L.B.; Eguaras, M.J.; Denegri, G.M.; Elissondo, M.C. Anthelmintic effect of Mentha spp. essential oils on Echinococcus granulosus protoscoleces and metacestodes. Parasitol. Res., 2012, 110(3), 1103-1112.
[http://dx.doi.org/10.1007/s00436-011-2595-x] [PMID: 21845411]
[101]
Zhang, Y.M.; White, S.W.; Rock, C.O. Inhibiting bacterial fatty acid synthesis. J. Biol. Chem., 2006, 281(26), 17541-17544.
[http://dx.doi.org/10.1074/jbc.R600004200] [PMID: 16648134]
[102]
Kelmanson, J.E.; Jäger, A.K.; van Staden, J. Zulu medicinal plants with antibacterial activity. J. Ethnopharmacol., 2000, 69(3), 241-246.
[http://dx.doi.org/10.1016/S0378-8741(99)00147-6] [PMID: 10722206]
[103]
Masika, P.J.; Afolayan, A.J. Antimicrobial activity of some plants used for the treatment of livestock disease in the Eastern Cape, South Africa. J. Ethnopharmacol., 2002, 83(1-2), 129-134.
[http://dx.doi.org/10.1016/S0378-8741(02)00242-8] [PMID: 12413718]
[104]
Vaara, M. Agents that increase the permeability of the outer membrane. Microbiol. Rev., 1992, 56(3), 395-411.
[http://dx.doi.org/10.1128/mr.56.3.395-411.1992] [PMID: 1406489]
[105]
Nikaido, H.; Vaara, M. Molecular basis of bacterial outer membrane permeability. Microbiol. Rev., 1985, 49(1), 1-32.
[http://dx.doi.org/10.1128/mr.49.1.1-32.1985] [PMID: 2580220]
[106]
Vieira, M.; Bessa, L.J.; Martins, M.R.; Arantes, S.; Teixeira, A.P.S.; Mendes, Â.; Martins da Costa, P.; Belo, A.D.F. Chemical composition, antibacterial, antibiofilm and synergistic properties of essential oils from Eucalyptus globulus Labill. and seven Mediterranean aromatic plants. Chem. Biodivers., 2017, 14(6), e1700006.
[http://dx.doi.org/10.1002/cbdv.201700006] [PMID: 28281322]
[107]
Ahmadi, F.; Sadeghi, S.; Modarresi, M.; Abiri, R.; Mikaeli, A. Chemical composition, in vitro anti-microbial, antifungal and antioxidant activities of the essential oil and methanolic extract of Hymenocrater longiflorus Benth., of Iran. Food Chem. Toxicol., 2010, 48(5), 1137-1144.
[http://dx.doi.org/10.1016/j.fct.2010.01.028] [PMID: 20132856]
[108]
Luís, Â.; Sousa, S.; Wackerlig, J.; Dobusch, D.; Duarte, A.P.; Pereira, L.; Domingues, F. Star anise (Illicium verum Hook. f.) essential oil: Antioxidant properties and antibacterial activity against Acinetobacter baumannii. Fla. Frag. J., 2019, 34(4), 260-270.
[http://dx.doi.org/10.1002/ffj.3498]
[109]
Benabdallah, A.; Rahmoune, C.; Boumendjel, M.; Aissi, O.; Messaoud, C. Total phenolic content and antioxidant activity of six wild Mentha species (Lamiaceae) from northeast of Algeria. Asian Pac. J. Trop. Biomed., 2016, 6(9), 760-766.
[http://dx.doi.org/10.1016/j.apjtb.2016.06.016]
[110]
Alpsoy, L.; Şahin, H.; Karaman, Ş. Anti-oxidative and anti-genotoxic effects of methanolic extract of Mentha Pulegium on human lympo-cyte culture. Toxicol. Ind. Health, 2011, 27(7), 647-654.
[http://dx.doi.org/10.1177/0748233710393402] [PMID: 21511894]
[111]
Fuhrman, B.; Volkova, N.; Rosenblat, M.; Aviram, M. Lycopene synergistically inhibits LDL oxidation in combination with vitamin E, glabridin, rosmarinic acid, carnosic acid, or garlic. Antioxid. Redox Signal., 2000, 2(3), 491-506.
[http://dx.doi.org/10.1089/15230860050192279] [PMID: 11229363]
[112]
Nakamura, Y.; Ohto, Y.; Murakami, A.; Ohigashi, H. Superoxide scavenging activity of rosmarinic acid from Perilla frutescens Britton var. acuta f. viridis. J. Agric. Food Chem., 1998, 46(11), 4545-4550.
[http://dx.doi.org/10.1021/jf980557m]
[113]
Ghazghazi, H.; Chedia, A.; Weslati, M.; Trakhna, F.; Houssine, S.; Abderrazak, M.; Brahim, H. Chemical composition and in vitro antimicrobial activities of Mentha Pulegium leaves extracts against foodborne pathogens. J. Food Saf., 2013, 33(3), 239-246.
[http://dx.doi.org/10.1111/jfs.12045]
[114]
Cheraif, K.; Bakchiche, B.; Gherib, A.; Bardaweel, S.K.; Çol Ayvaz, M.; Flamini, G.; Ascrizzi, R.; Ghareeb, M.A. Chemical composition, antioxidant, anti-tyrosinase, anti-cholinesterase and cytotoxic activities of essential oils of six Algerian plants. Molecules, 2020, 25(7), 1710.
[http://dx.doi.org/10.3390/molecules25071710] [PMID: 32276465]
[115]
Jain, S.; Jain, D.K.; Balekar, N. In-vivo antioxidant activity of ethanolic extract of Mentha Pulegium leaf against CCl4 induced toxicity in rats. Asian Pac. J. Trop. Biomed., 2012, 2(2), S737-S740.
[http://dx.doi.org/10.1016/S2221-1691(12)60306-2]
[116]
Amtaghri, S.; Eddouks, M. Study of the antihypertensive and vasorelaxant activities of haloxylon scoparium in rats. Cardiovasc. Hematol. Agents Med. Chem., 2023, 21(2), 139-153.
[117]
Amtaghri, S.; Amssayef, A.; Slaoui, M.; Eddouks, M. Antihypertensive and vasorelaxant effects of Hibiscus rosa-sinensis through Angio-tensin-Converting Enzyme-2 (ACE-2), and Ca2+ channels pathways. Cardiovasc. Hematol. Disord. Drug Targets, 2022, 22(1), 27-37.
[118]
Solati, K.; Karimi, M.; Rafieian-Kopaei, M.; Abbasi, N.; Abbaszadeh, S.; Bahmani, M. Phytotherapy for wound healing: The most important herbal plants in wound healing based on iranian ethnobotanical documents. Mini Rev. Med. Chem., 2021, 21(4), 500-519.
[http://dx.doi.org/10.2174/18755607MTEx0NjUrz] [PMID: 33213344]
[119]
Baali, F.; Boumerfeg, S.; Boudjelal, A.; Denaro, M.; Ginestra, G.; Baghiani, A.; Trombetta, D. Wound-healing activity of Algerian Lavandula stoechas and Mentha Pulegium extracts: From traditional use to scientific validation. Plant Biosyst., 2022, 156(2), 427-439.
[120]
Takzaree, A.; Goodarzi, M.; Rastegar, T.; Shahbabae, S.; Takzaree, N. Investigating histopathologic the synergistic effect of topical use of Mentha Pulegium essential oil and honey in healing of cutaneous ulcers. Faslnamah-i Giyahan-i Daruyi, 2019, 18(72), 274-287.
[121]
Mosmann, T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods, 1983, 65(1-2), 55-63.
[http://dx.doi.org/10.1016/0022-1759(83)90303-4] [PMID: 6606682]
[122]
Bouyahya, A.; Dakka, N.; Lagrouh, F.; Abrini, J.; Bakri, Y. In vitro antiproliferative and antidermatophyte activities of essential oils from three moroccan medicinal plants. J. Biol. Act. Prod. Nat., 2018, 8(3), 144-153.
[http://dx.doi.org/10.1080/22311866.2018.1496032]
[123]
Nikounezhad, N.; Shirazi, F.H.; Kamalinejad, M. Relative cytotoxicity of fractionated extract of arial parts of Mentha Pulegium on three cancer cell lines. Am. J. PharmTech Res, 2014, 4(6), 215-223.
[124]
Kelkawi, A.H.A.; Kajani, A.; Bordbar, A.K. Green synthesis of silver nanoparticles using Mentha Pulegium and investigation of their anti-bacterial, antifungal and anticancer activity. IET Nanobiotechnol., 2017, 11(4), 370-376.
[http://dx.doi.org/10.1049/iet-nbt.2016.0103] [PMID: 28530184]
[125]
Farid, O.; Zeggwagh, N.A.; Ouadi, F.E.; Eddouks, M. Mentha Pulegium aqueous extract exhibits antidiabetic and hepatoprotective effects in streptozotocin-induced diabetic rats. Endocr. Metab. Immune Disord. Drug Targets, 2019, 19(3), 292-301.
[126]
Abbou, F.; Azzi, R.; Ouffai, K.; El Haci, I.A.; Belyagoubi-Benhammou, N.; Bensouici, C.; Benamar, H. Phenolic profile, antioxidant and enzyme inhibitory properties of phenolic-rich fractions from the aerial parts of Mentha Pulegium L. S. Afr. J. Bot., 2022, 146, 196-204.
[http://dx.doi.org/10.1016/j.sajb.2021.10.024]
[127]
Ouattara, G.S.; Soro, D.; Gonnety, T.J.; Koffi, K.E. In vitro inhibition of alpha amylase and glucosidase of digestive snail juice by crude extracts of cashew cakes. Asian Food Sci. J., 2019, 11(4), 1-10.
[http://dx.doi.org/10.9734/afsj/2019/v11i430068]
[128]
Rauf, A.; Akram, M.; Semwal, P.; Mujawah, A.A.; Muhammad, N.; Riaz, Z.; Khan, H. Antispasmodic potential of medicinal plants: a comprehensive review. Oxid. Med. Cell. Longev., 2021, 2021, 4889719.
[http://dx.doi.org/10.1155/2021/4889719]
[129]
Yang, Q.; Liu, Q.; Lv, H.; Wang, F.; Liu, R.; Zeng, N. Effect of pulegone on the NLPR3 inflammasome during inflammatory activation of THP-1 cells. Exp. Ther. Med., 2020, 19(2), 1304-1312.
[PMID: 32010303]
[130]
Al-Rajhi, A.M.H.; Qanash, H.; Almuhayawi, M.S.; Al Jaouni, S.K.; Bakri, M.M.; Ganash, M.; Salama, H.M.; Selim, S.; Abdelghany, T.M. Molecular interaction studies and phytochemical characterization of Mentha Pulegium L. constituents with multiple biological utilities as antioxidant, antimicrobial, anticancer and anti-hemolytic agents. Molecules, 2022, 27(15), 4824.
[http://dx.doi.org/10.3390/molecules27154824] [PMID: 35956775]
[131]
Gordon, P.; Khojasteh, S.C. A decades-long investigation of acute metabolism-based hepatotoxicity by herbal constituents: a case study of pennyroyal oil. Drug Metab. Rev., 2015, 47(1), 12-20.
[http://dx.doi.org/10.3109/03602532.2014.990032] [PMID: 25512112]
[132]
Al-Rubaye, A.F.; Hameed, I.H.; Kadhim, M.J. A review: uses of gas chromatography-mass spectrometry (GC-MS) technique for analysis of bioactive natural compounds of some plants. Inter. J. Toxicol. Pharmacolo. Res., 2017, 9(1), 81-85.
[http://dx.doi.org/10.25258/ijtpr.v9i01.9042]
[133]
Kotsiou, A.; Christine, T. Hepatotoxicity of herbal medicinal products. J. Med. Plants Stud, 2017, 5(3), 80-88.
[134]
Shariati, M.; Khodaparast, L.; Mokhtari, M. Assessment of the effects of the hydro-alcoholic extract of Mentha Pulegium leaves on liver function test in male rat. J. Sabze. Uni.Med. Sci., 1970, 15(2), 73-81.
[135]
Montenegro, I.; Said, B.; Godoy, P.; Besoain, X.; Parra, C.; Díaz, K.; Madrid, A. Antifungal activity of essential oil and main components from Mentha Pulegium growing wild on the Chilean central coast. Agronomy, 2020, 10(2), 254.
[http://dx.doi.org/10.3390/agronomy10020254]
[136]
Ismaili, R.; Lamiri, A.; Moustaid, K. Study of the antifungal activity of essential oils of three Moroccan aromatic plants. Int. J. Innov. Sci. Res., 2014, 12(2), 499-505.
[137]
Ait-Ouazzou, A.; Lorán, S.; Arakrak, A.; Laglaoui, A.; Rota, C.; Herrera, A.; Pagán, R.; Conchello, P. Evaluation of the chemical composi-tion and antimicrobial activity of Mentha Pulegium, Juniperus phoenicea, and Cyperus longus essential oils from Morocco. Food Res. Int., 2012, 45(1), 313-319.
[http://dx.doi.org/10.1016/j.foodres.2011.09.004]
[138]
Alharbi, N.K.; Naghmouchi, S.; Al-Zaban, M. Evaluation of antimicrobial potential and comparison of HPLC composition, secondary metabolites count, and antioxidant activity of Mentha rotundifolia and Mentha Pulegium extracts. Evid. Based Complement. Altern. Med., 2021, 2021, 9081536.
[http://dx.doi.org/10.1155/2021/9081536]
[139]
Bakkali, F.; Averbeck, S.; Averbeck, D.; Idaomar, M. Biological effects of essential oils - A review. Food Chem. Toxicol., 2008, 46(2), 446-475.
[http://dx.doi.org/10.1016/j.fct.2007.09.106] [PMID: 17996351]
[140]
Isman, M.B. Botanical insecticides, deterrents, and repellents in modern agriculture and an increasingly regulated world. Annu. Rev. Entomol., 2006, 51(1), 45-66.
[http://dx.doi.org/10.1146/annurev.ento.51.110104.151146] [PMID: 16332203]
[141]
Asbahani, A.E.; Miladi, K.; Badri, W.; Sala, M.; Addi, E.H.A.; Casabianca, H.; Mousadik, A.E.; Hartmann, D.; Jilale, A.; Renaud, F.N.R.; Elaissari, A. Essential oils: From extraction to encapsulation. Int. J. Pharm., 2015, 483(1-2), 220-243.
[http://dx.doi.org/10.1016/j.ijpharm.2014.12.069] [PMID: 25683145]
[142]
Isman, M.B.; Miresmailli, S.; Machial, C. Commercial opportunities for pesticides based on plant essential oils in agriculture, industry and consumer products. Phytochem. Rev., 2011, 10(2), 197-204.
[http://dx.doi.org/10.1007/s11101-010-9170-4]
[143]
Isman, M.B.; Grieneisen, M.L. Botanical insecticide research: many publications, limited useful data. Trends Plant Sci., 2014, 19(3), 140-145.
[http://dx.doi.org/10.1016/j.tplants.2013.11.005] [PMID: 24332226]
[144]
Hameed, I.; Altameme, H.; Mohammed, G. Evaluation of antifungal and antibacterial activity and analysis of bioactive phytochemical compounds of Cinnamomum zeylanicum (Cinnamon bark) using gas chromatography-mass spectrometry. Orient. J. Chem., 2016, 32(4), 1769-1788.
[http://dx.doi.org/10.13005/ojc/320406]
[145]
Jaddoa, H.; Hameed, I.; Mohammed, G. Analysis of volatile metabolites released by Staphylococcus aureus using gas chromatography-Mass spectrometry and determination of its antifungal activity. Orient. J. Chem., 2016, 32(4), 2107-2116.
[http://dx.doi.org/10.13005/ojc/320439]
[146]
Kareem, M.A.; Abdulzahra, A.I.; Hameed, I.H.; Jebor, M.A. A new polymorphic positions discovered in mitochondrial DNA hypervariable region HVIII from central and north-central of Iraq. Mitochondrial DNA A. DNA Mapp. Seq. Anal., 2016, 27(5), 3250-3254.
[http://dx.doi.org/10.3109/19401736.2015.1007369] [PMID: 25703852]
[147]
Hussein, H.M. Analysis of trace heavy metals and volatile chemical compounds of Lepidium sativum using atomic absorption spectroscopy, gas chromatography-mass spectrometric and fourier-transform infrared spectroscopy. Res. J. Pharm. Biol. Chem. Sci., 2016, 7(4), 2529-2555.
[148]
Da Rocha, M.S.; Dodmane, P.R.; Arnold, L.L.; Pennington, K.L.; Anwar, M.M.; Adams, B.R.; Taylor, S.V.; Wermes, C.; Adams, T.B.; Cohen, S.M. Mode of action of pulegone on the urinary bladder of F344 rats. Toxicol. Sci., 2012, 128(1), 1-8.
[http://dx.doi.org/10.1093/toxsci/kfs135] [PMID: 22499580]
[149]
National Toxicology Program. Toxicology and carcinogenesis studies of pulegone (CAS No. 89-82-7) in F344/N rats and B6C3F1 mice (gavage studies). Natl. Toxicol. Program Tech. Rep. Ser., 2011, (563), 1-201.
[PMID: 21921962]
[150]
Eddouks, M.; Amtaghri, S.; Akdad, M.; Slaoui, M. Traditional uses, pharmacological, and phytochemical studies of euphorbia: A Review. Curr. Top. Med. Chem., 2022, 22(19), 1553-1570.
[http://dx.doi.org/10.2174/1568026622666220713143436] [PMID: 35838213]
[151]
Fadwa, E.O.; Amtaghri, S.; Akdad, M.; El-Haidani, A.; Eddouks, M. Effect of Pelargonium graveolens on glucose metabolism in Strepto-zotocin-induced diabetic rats. Cardiovasc. Hematol. Disord. Drug Targets, 2022, 22(1), 18-26.
[152]
Rubio, C.; Lucas, J.R.D.; Gutiérrez, A.J.; Glez-Weller, D.; Pérez Marrero, B.; Caballero, J.M.; Revert, C.; Hardisson, A. evaluation of metal concentrations in Mentha herbal teas (Mentha piperita, Mentha Pulegium and Mentha species) by inductively coupled plasma spectrometry. J. Pharm. Biomed. Anal., 2012, 71, 11-17.
[http://dx.doi.org/10.1016/j.jpba.2012.07.015] [PMID: 22906691]
[153]
Ainane, A.; Khammour, F.; M’hammed, E.L. TALBI, M.; Oussaid, A.; Lemhidi, A.; Ainane, T. Evaluation of the toxicity of the essential oils of certain mints grown in the region of Settat (Morocco): Mentha piperita, Mentha Pulegium and Mentha spicata against, Sitophilus Granarius. Sitophilus Oryzae and Sitophilus Zeamais. J. Analy. Sci. Appl. Biotech., 2019, 1(1), 1-1.
[154]
Gerenutti, M.; Modesto, L.; Carrara, V.A.; Magalhães, S.A.; de Freitas, N.P.; Silva, M.G. Maternal exposure to aqueous extract of Mentha Pulegium L. inducing toxicity to embryo development in rats. Afr. J. Pharm. Pharmacol., 2014, 8(22), 609-614.

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