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Current Pediatric Reviews

Editor-in-Chief

ISSN (Print): 1573-3963
ISSN (Online): 1875-6336

Review Article

Reactive Arthritis in Children: Case Report, Narrative Review and Proposed Therapy

Author(s): Milad Alshaya, Nouf Almutairi, Abdulrahman Alrasheed*, Ihtifal Albanaqi, Ronald M. Laxer and Abdullah Alhammad

Volume 20, Issue 4, 2024

Published on: 17 October, 2023

Page: [444 - 452] Pages: 9

DOI: 10.2174/1573396320666230913103007

Price: $65

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Abstract

Reactive arthritis is an acute inflammatory aseptic arthritis that is preceded by an infectious process in genetically predisposed individuals. It has been associated with gastrointestinal or genitourinary infection. Reactive arthritis is rare in children. In this review, we present two index cases that need biologic treatment followed by a thorough review of reactive arthritis in children and adolescents with proposed treatment algorithm.

Graphical Abstract

[1]
Junghanns O. Another case of urethritis non gonorrhoica and septic general disease: A contribution to spirochaetosis arthritica. Dtsch Med Wochenschr 1918; 44: 1304-5.
[http://dx.doi.org/10.1055/s-0028-1134810]
[2]
Flores D, Marquez J, Garza M, Espinoza LR. Reactive arthritis: Newer developments. Rheum Dis Clin North Am 2003; 29(1): 37-59.
[http://dx.doi.org/10.1016/S0889-857X(02)00081-9]
[3]
Fan P, Yu D. Reiter’s syndrome. In: Kelley WN, Harris ED, Ruddy S, Sledge C, Eds. Textbook of rheumatology. (4th ed.). Philadelphia: WB Saunders Company 1993; pp. 961-73.
[4]
Reiter H. Ueber eine bisher unerkannte spirochaetenin- fektion. Dtsch Med Wochenschr 1916; 42: 1535-6.
[http://dx.doi.org/10.1055/s-0028-1135542]
[5]
Singsen BH, Bernstein BH, Koster-King KG, Glovsky MM, Hanson V. Reiter’s syndrome in childhood. Arthritis Rheum 1977; 20(2) (Suppl.): 402-7.
[PMID: 263918]
[6]
Lockie GN, Hunder GG. Reiter’s syndrome in children. A case report and review. Arthritis Rheum 1971; 14(6): 767-72.
[http://dx.doi.org/10.1002/art.1780140614] [PMID: 5135795]
[7]
Rosenberg AM, Petty RE. Reiter’s disease in children. Am J Dis Child 1979; 133(4): 394-8.
[PMID: 373419]
[8]
Cuttica RJ, Scheines EJ, Garay SM, Romanelli MC, Maldonado Cocco JA. Juvenile onset Reiter’s syndrome. A retrospective study of 26 patients. Clin Exp Rheumatol 1992; 10(3): 285-8.
[PMID: 1582074]
[9]
Conaglen J, Grennan DM, Signal T, McArthur JE, Lucasi R, Palmer DG. Juvenile Reiter’s syndrome. Aust N Z J Med 1979; 9(2): 193-6.
[http://dx.doi.org/10.1111/j.1445-5994.1979.tb04328.x] [PMID: 287465]
[10]
Thomas DG, Roberton DM. Reiter’s syndrome in an adolescent girl. Acta Paediatr 1994; 83(3): 339-40.
[http://dx.doi.org/10.1111/j.1651-2227.1994.tb18110.x] [PMID: 8038544]
[11]
Friis J. Reiter’s disease with childhood onset having special reference to HLA B27. Report of a case and a review. Scand J Rheumatol 1980; 9(4): 250-2.
[http://dx.doi.org/10.3109/03009748009112358] [PMID: 6969934]
[12]
Bauman C, Cron RQ, Sherry DD, Francis JS. Reiter syndrome initially misdiagnosed as Kawasaki disease. J Pediatr 1996; 128(3): 366-9.
[http://dx.doi.org/10.1016/S0022-3476(96)70283-4] [PMID: 8774506]
[13]
Carter JD. Reactive arthritis: Defined etiologies, emerging pathophysiology, and unresolved treatment. Infect Dis Clin North Am 2006; 20(4): 827-47.
[http://dx.doi.org/10.1016/j.idc.2006.09.004] [PMID: 17118292]
[14]
Bentaleb I, Ben Abdelghani K, Rostom S. etal. Reactive arthritis: Update. Curr Clin Microbiol Rep 2020; 1-9.
[15]
Taurog JD. The role of bacteria in HLA-B27-associated reactive arthritis. Cliniguide Rheum 1995; 5: 1-8.
[16]
Finger DR, Neubauer JV. Reactive arthritis following Clostridium difficile colitis in a 3-year-old patient. J Clin Rheumatol 1997; 3(2): 102-4.
[http://dx.doi.org/10.1097/00124743-199704000-00007] [PMID: 19078131]
[17]
Cron RQ, Gordon PV. Reactive arthritis to clostridium difficile in a child. West J Med 1997; 166(6): 419-21.
[PMID: 9217461]
[18]
Putterman C, Rubinow A. Reactive arthritis associated with Clostridium difficile pseudomembranous colitis. Semin Arthritis Rheum 1993; 22(6): 420-6.
[http://dx.doi.org/10.1016/S0049-0172(05)80033-2] [PMID: 8342048]
[19]
Horton DB, Strom BL, Putt ME, Rose CD, Sherry DD, Sammons JS. Epidemiology of clostridium difficle infection-associated reactive arthritis in children. An underdiagnosed, potentially morbid condition. JAMA Pediatr 2016; 170(7): e160217.
[http://dx.doi.org/10.1001/jamapediatrics.2016.0217] [PMID: 27182697]
[20]
Braun J, Kingsley G, van der Heijde D, Sieper J. On the difficulties of establishing a consensus on the definition of and diagnostic investigations for reactive arthritis. Results and discussion of a questionnaire prepared for the 4th International Workshop on Reactive Arthritis, Berlin, Germany, July 3-6, 1999. J Rheumatol 2000; 27(9): 2185-92.
[PMID: 10990232]
[21]
Denardo BA, Tucker LB, Miller LC, Szer IS, Schaller JG. Demography of a regional pediatric rheumatology patient population. J Rheumatol 1994; 21(8): 1553-61.
[PMID: 7983664]
[22]
Symmons DP, Jones M, Osborne J, Sills J, Southwood TR, Woo P. Pediatric rheumatology in the United Kingdom: Data from the British pediatric rheumatology group national diagnostic register. J Rheumatol 1996; 23(11): 1975-80.
[PMID: 8923378]
[23]
Malleson PN, Fung MY, Rosenberg AM. The incidence of pediatric rheumatic diseases: Results from the Canadian Pediatric Rheumatology Association Disease Registry. J Rheumatol 1996; 23(11): 1981-7.
[PMID: 8923379]
[24]
Gupta L, Naveen R, Ahmed S, et al. Juvenile reactive arthritis and other spondyloarthritides of childhood: A 28-year experience from India. Mediterr J Rheumatol 2021; 32(4): 338-44.
[http://dx.doi.org/10.31138/mjr.32.4.338] [PMID: 35128326]
[25]
Bowness P. HLA-B27. Annu Rev Immunol 2015; 33(1): 29-48.
[http://dx.doi.org/10.1146/annurev-immunol-032414-112110] [PMID: 25861975]
[26]
Colbert RA, Navid F, Gill T. The role of HLA-B*27 in spondyloarthritis. Best Pract Res Clin Rheumatol 2017; 31(6): 797-815.
[http://dx.doi.org/10.1016/j.berh.2018.07.012] [PMID: 30509441]
[27]
Sorrentino R, Böckmann RA, Fiorillo MT. HLA-B27 and antigen presentation: At the crossroads between immune defense and autoimmunity. Mol Immunol 2014; 57(1): 22-7.
[http://dx.doi.org/10.1016/j.molimm.2013.06.017] [PMID: 23916069]
[28]
Hermann E, Meyer zum Büschenfelde K-H, Fleischer B, Yu DTY. HLA-B27-restricted CD8 T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis. Lancet 1993; 342(8872): 646-50.
[http://dx.doi.org/10.1016/0140-6736(93)91760-J] [PMID: 8103147]
[29]
Appel H, Kuon W, Kuhne M, et al. Use of HLA-B27 tetramers to identify low-frequency antigen-specific T cells in Chlamydia-triggered reactive arthritis. Arthritis Res 2004; 6(6): R521-34.
[http://dx.doi.org/10.1186/ar1221] [PMID: 15535830]
[30]
Wong-Baeza I, Ridley A, Shaw J, et al. KIR3DL2 binds to HLA-B27 dimers and free H chains more strongly than other HLA class I and promotes the expansion of T cells in ankylosing spondylitis. J Immunol 2013; 190(7): 3216-24.
[http://dx.doi.org/10.4049/jimmunol.1202926] [PMID: 23440420]
[31]
Colbert RA. HLA-B27 misfolding: A solution to the spondyloarthropathy conundrum? Mol Med Today 2000; 6(6): 224-30.
[http://dx.doi.org/10.1016/S1357-4310(00)01699-3] [PMID: 10840380]
[32]
Colbert RA, Tran TM, Layh-Schmitt G. HLA-B27 misfolding and ankylosing spondylitis. Mol Immunol 2014; 57(1): 44-51.
[http://dx.doi.org/10.1016/j.molimm.2013.07.013] [PMID: 23993278]
[33]
Colbert RA, DeLay ML, Layh-Schmitt G, Sowders DP. HLA-B27 misfolding and spondyloarthropathies. Prion 2009; 3(1): 15-26.
[http://dx.doi.org/10.4161/pri.3.1.8072] [PMID: 19363299]
[34]
Childs SG. Reactive arthritis. Orthop Nurs 2004; 23(4): 267-73.
[http://dx.doi.org/10.1097/00006416-200407000-00013] [PMID: 15379178]
[35]
Katsicas MM, Russo R. Biologic agents in juvenile spondyloarthropathies. Pediatr Rheumatol Online J 2016; 14(1): 17.
[http://dx.doi.org/10.1186/s12969-016-0076-6] [PMID: 26968522]
[36]
Manasson J, Shen N, Garcia Ferrer HR, et al. Gut microbiota perturbations in reactive arthritis and postinfectious spondyloarthritis. Arthritis Rheumatol 2018; 70(2): 242-54.
[http://dx.doi.org/10.1002/art.40359] [PMID: 29073348]
[37]
Margileth AM. Reiter’s syndrome in children: Case report and review of literature. Clin Pediatr 1962; 1(3): 148-51.
[http://dx.doi.org/10.1177/000992286200100307] [PMID: 13933010]
[38]
Zivony D, Nocton J, Wortmann D, Esterly N. Juvenile Reiter’s syndrome: A report of four cases. J Am Acad Dermatol 1998; 38(1): 32-7.
[http://dx.doi.org/10.1016/S0190-9622(98)70535-3] [PMID: 9448202]
[39]
Zewi M. Morbut rieteri. Acta Ophthalmol 1947; 25(1): 47-60.
[http://dx.doi.org/10.1111/j.1755-3768.1947.tb07544.x]
[40]
Fischel JD, Lipton J. Acute anterior uveitis in juvenile Reiter’s syndrome. Clin Rheumatol 1996; 15(1): 83-5.
[http://dx.doi.org/10.1007/BF02231693] [PMID: 8929784]
[41]
Jacobs AG. A case of Reiter’s syndrome in childhood. BMJ 1961; 2(5245): 155.
[http://dx.doi.org/10.1136/bmj.2.5245.155] [PMID: 13718550]
[42]
Willkens RF, Arnett FC, Bitter T, et al. Reiter’s syndrome. Arthritis Rheum 1981; 24(6): 844-9.
[http://dx.doi.org/10.1002/art.1780240612] [PMID: 7247978]
[43]
Manimegalai N, Rajamurugan PSA, Rajendran CP, et al. Childhood reactive arthritis. J Clin Rheumatol 2008; 14(5): 292-3.
[http://dx.doi.org/10.1097/RHU.0b013e318188be96] [PMID: 18824921]
[44]
Kanakoudi-Tsakalidou F, Pardalos G, Pratsidou-Gertsi P, Kansouzidou-Kanakoudi A, Tsangaropoulou-Stinga H. Persistent or severe course of reactive arthritis following Salmonella enteritidis infection. A prospective study of 9 cases. Scand J Rheumatol 1998; 27(6): 431-4.
[http://dx.doi.org/10.1080/030097498442253] [PMID: 9855213]
[45]
Liao CH, Huang JL, Yeh KW. Juvenile Reiter’s syndrome: A case report. J Microbiol Immunol Infect 2004; 37(6): 379-81.
[PMID: 15599472]
[46]
Wu IB, Schwartz RA. Reiter’s syndrome: The classic triad and more. J Am Acad Dermatol 2008; 59(1): 113-21.
[http://dx.doi.org/10.1016/j.jaad.2008.02.047] [PMID: 18436339]
[47]
Gladman DD. Clinical aspects of the spondyloarthropathies. Am J Med Sci 1998; 316(4): 234-8.
[http://dx.doi.org/10.1016/S0002-9629(15)40413-6] [PMID: 9766484]
[48]
Ansell BM. Reactive arthritis/Reiter’s syndrome in children. Clin Exp Rheumatol 1994; 12(6): 581-2.
[PMID: 7895389]
[49]
Reece RJ, Canete JD, Parsons WJ, Emery P, Veale DJ. Distinct vascular patterns of early synovitis in psoriatic, reactive, and rheumatoid arthritis. Arthritis Rheum 1999; 42(7): 1481-4.
[http://dx.doi.org/10.1002/1529-0131(199907)42:7<1481::AID-ANR23>3.0.CO;2-E] [PMID: 10403277]
[50]
Jones RA. Reiter’s disease after Salmonella typhimurium enteritis. BMJ 1977; 1(6073): 1391.
[http://dx.doi.org/10.1136/bmj.1.6073.1391] [PMID: 324575]
[51]
Hülsemann JL, Zeidler H. Diagnostic evaluation of classification criteria for rheumatoid arthritis and reactive arthritis in an early synovitis outpatient clinic. Ann Rheum Dis 1999; 58(5): 278-80.
[http://dx.doi.org/10.1136/ard.58.5.278] [PMID: 10225811]
[52]
Hunter T, Harding GKM, Kaprove RE, Schroeder ML. Fecal carriage of variousKlebsiellaandEnterobacter species in patients with active ankylosing spondylitis. Arthritis Rheum 1981; 24(1): 106-8.
[http://dx.doi.org/10.1002/art.1780240122] [PMID: 7470165]
[53]
Pennisi M, Perdue J, Roulston T, Nicholas J, Schmidt E, Rolfs J. An overview of reactive arthritis. JAAPA 2019; 32(7): 25-8.
[http://dx.doi.org/10.1097/01.JAA.0000558320.47868.2f] [PMID: 31169570]
[54]
Li CW, Ma JJ, Yin J, Liu L, Hu J. [Reiter’s syndrome in children: A clinical analysis of 22 cases]. Zhonghua Er Ke Za Zhi 2010; 48(3): 212-5.
[PMID: 20426959]
[55]
Clegg DO, Reda DJ, Weisman MH, et al. Comparison of sulfasalazine and placebo in the treatment of reactive arthritis (Reiter’s syndrome). A department of veterans affairs cooperative study. Arthritis Rheum 1996; 39(12): 2021-7.
[http://dx.doi.org/10.1002/art.1780391211] [PMID: 8961907]
[56]
Brinster A, Guillot X, Prati C, Wendling D. Anti-TNF treatment of reactive arthritis. A monocentric experience. Joint Bone Spine 2017; 84(2): 237-8.
[http://dx.doi.org/10.1016/j.jbspin.2016.02.022] [PMID: 27236263]
[57]
Frydén A, Bengtsson A, Foberg U, et al. Early antibiotic treatment of reactive arthritis associated with enteric infections: Clinical and serological study. BMJ 1990; 301(6764): 1299-302.
[http://dx.doi.org/10.1136/bmj.301.6764.1299] [PMID: 2271852]
[58]
Laasila K, Laasonen L, Leirisalo-Repo M. Antibiotic treatment and long term prognosis of reactive arthritis. Ann Rheum Dis 2003; 62(7): 655-8.
[http://dx.doi.org/10.1136/ard.62.7.655] [PMID: 12810429]
[59]
Amor B, Santos RS, Nahal R, Listrat V, Dougados M. Predictive factors for the longterm outcome of spondyloarthropathies. J Rheumatol 1994; 21(10): 1883-7.
[PMID: 7837155]
[60]
Yıldız M, Haşlak F, Adroviç A, Şahin S, Barut K, Kasapçopur Ö. Juvenile spondyloartropathies. Eur J Rheumatol 2022; 9(1): 42-9.
[http://dx.doi.org/10.5152/eurjrheum.2021.20235] [PMID: 34101576]

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