Abstract
Multiparticulate dosage forms are receiving a great deal of attention as alternative system for oral drug delivery. The present review outlines the recent findings on the manufacturing and evaluation of spherical pellets published over the past decade. The techniques namely extrusion-spheronization, hot melt extrusion, freeze pelletization, cryopelletization have been discussed along with parameters affecting pelletization. Evaluation of quality of the pellets is discussed with reference to the size distribution, shape, surface morphology, specific surface area, friability, tensile strength, density, porosity, disintegration time and in vitro dissolution studies of pellets. The use of multiparticulate dosage forms as a promising system for the oral delivery of many therapeutic agents has also been examined in the current review.
Keywords: Pelletization, extrusion spheronization, freeze pelletization, cryopelletization, hot melt extrusion
Current Drug Delivery
Title: Recent Advances in Pelletization Technique for Oral Drug Delivery: A Review
Volume: 6 Issue: 1
Author(s): Md. Akhlaquer Rahman, Alka Ahuja, S. Baboota, Bhavna, Vikas Bali, Nitin Saigal and Javed Ali
Affiliation:
Keywords: Pelletization, extrusion spheronization, freeze pelletization, cryopelletization, hot melt extrusion
Abstract: Multiparticulate dosage forms are receiving a great deal of attention as alternative system for oral drug delivery. The present review outlines the recent findings on the manufacturing and evaluation of spherical pellets published over the past decade. The techniques namely extrusion-spheronization, hot melt extrusion, freeze pelletization, cryopelletization have been discussed along with parameters affecting pelletization. Evaluation of quality of the pellets is discussed with reference to the size distribution, shape, surface morphology, specific surface area, friability, tensile strength, density, porosity, disintegration time and in vitro dissolution studies of pellets. The use of multiparticulate dosage forms as a promising system for the oral delivery of many therapeutic agents has also been examined in the current review.
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Cite this article as:
Rahman Akhlaquer Md., Ahuja Alka, Baboota S., Bhavna , Bali Vikas, Saigal Nitin and Ali Javed, Recent Advances in Pelletization Technique for Oral Drug Delivery: A Review, Current Drug Delivery 2009; 6 (1) . https://dx.doi.org/10.2174/156720109787048339
DOI https://dx.doi.org/10.2174/156720109787048339 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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