The Critical Function of microRNAs in Developing Resistance against 5-
Fluorouracil in Cancer Cells

Farhad      Sheikhnia; Hossein      Maghsoudi; Maryam      Majidinia
doi:10.2174/1389557523666230825144150
Abstract

Although there have been significant advancements in cancer treatment, resistance and recurrence in patients make it one of the leading causes of death worldwide. 5-fluorouracil (5-FU), an antimetabolite agent, is widely used in treating a broad range of human malignancies. The cytotoxic effects of 5-FU are mediated by the inhibition of thymidylate synthase (TYMS/TS), resulting in the suppression of essential biosynthetic activity, as well as the misincorporation of its metabolites into RNA and DNA. Despite its huge benefits in cancer therapy, the application of 5-FU in the clinic is restricted due to the occurrence of drug resistance. MicroRNAs (miRNAs) are small, non-coding RNAs that act as negative regulators in many gene expression processes. Research has shown that changes in miRNA play a role in cancer progression and drug resistance. This review examines the role of miRNAs in 5-FU drug resistance in cancers.
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DOI https://dx.doi.org/10.2174/1389557523666230825144150	Print ISSN 1389-5575
Publisher Name Bentham Science Publisher	Online ISSN 1875-5607
Mini-Reviews in Medicinal Chemistry

The Critical Function of microRNAs in Developing Resistance against 5- Fluorouracil in Cancer Cells

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