Abstract
Aim: The current study aimed to evaluate the antidiabetic potential of Illicium verum fruits.
Background: Illicium verum fruits are frequently used by the Moroccan population in the treatment of diabetes.
Methods: The antihyperglycemic effect of the aqueous extract of Illicium verum fruits (AEIVF) in rats was assessed. The effects of AEIVF (20 mg/kg) on glycemia and lipid profile as well as its phytochemical and antioxidant properties were evaluated.
Results: In normal and diabetic rats, AEIVF reduced blood glucose levels 6 hours after administration. Furthermore, after 7 days of treatment, glycemia was lowered in diabetic rats, and this extract exhibited an antioxidant activity.
Conclusion: The study shows that Illicium verum possesses a potent antidiabetic activity. In addition, the toxicity of AEIVF was evaluated and the LD50 value was found to be greater than the 2 g/kg dose.
Graphical Abstract
[http://dx.doi.org/10.1186/1472-6882-9-48] [PMID: 19943967]
[http://dx.doi.org/10.1111/pedi.12186] [PMID: 25182305]
[http://dx.doi.org/10.1016/S2221-6189(13)60126-2]
[http://dx.doi.org/10.3390/ijerph120100554] [PMID: 25584422]
[PMID: 22195359]
[http://dx.doi.org/10.1016/j.canlet.2004.05.005] [PMID: 15363542]
[http://dx.doi.org/10.1016/j.jep.2011.04.051] [PMID: 21549817]
[http://dx.doi.org/10.1002/ps.435] [PMID: 11852640]
[http://dx.doi.org/10.1002/ptr.989] [PMID: 11807977]
[PMID: 28925906]
[http://dx.doi.org/10.2174/2210315508666180327120434]
[http://dx.doi.org/10.1016/j.foodres.2012.12.043]
[http://dx.doi.org/10.1016/S0308-8146(02)00423-5]
[http://dx.doi.org/10.1002/jsfa.2740290908]
[http://dx.doi.org/10.1038/1811199a0]
[http://dx.doi.org/10.2174/1871529X18666180223100427] [PMID: 29473527]
[http://dx.doi.org/10.2174/1871525717666190611143514] [PMID: 31187714]
[http://dx.doi.org/10.1016/0378-8741(83)90037-5] [PMID: 6677820]
[PMID: 36734899]
[http://dx.doi.org/10.2174/1871529X22666220908104724] [PMID: 36089789]
[http://dx.doi.org/10.1016/j.jep.2012.07.006] [PMID: 22842651]
[http://dx.doi.org/10.1016/j.eujim.2009.12.001]
[PMID: 22330251]
[http://dx.doi.org/10.52711/0974-360X.2021.00431]
[http://dx.doi.org/10.1007/s11655-011-0810-3] [PMID: 21826590]
[http://dx.doi.org/10.1016/j.jep.2017.06.042] [PMID: 28669771]
[http://dx.doi.org/10.1016/S0021-9258(18)63353-8] [PMID: 5416672]
[http://dx.doi.org/10.3390/ijerph6102568] [PMID: 20054455]
[http://dx.doi.org/10.1016/j.redox.2020.101799] [PMID: 33248932]
[http://dx.doi.org/10.1186/s12944-018-0688-6] [PMID: 29592809]