Login Register Cart 0
Generic placeholder image

Current Pharmaceutical Biotechnology

Editor-in-Chief

ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Natural Polyphenols in Cancer Management: Promising Role, Mechanisms, and Chemistry

Author(s): Prabhat Kumar Upadhyay*, Sonia Singh and Vishal Kumar Vishwakarma

Volume 25, Issue 6, 2024

Published on: 04 September, 2023

Page: [694 - 712] Pages: 19

DOI: 10.2174/1389201024666230822090318

Price: $65

Abstract

Background: Although cancers emerge rapidly and cancer cells divide aggressively, which affects our vital organ systems. Recently, cancer treatments are targeted immune systems mediating intrinsic cellular mechanisms. Natural efficacious polyphenols have been exhibited to help prevent most cancers and reverse the progression of cancers.

Methods: Many resources have been used to know the promising role of polyphenols in preventing and treating cancers. The electronic databases include Science Direct, Google, Google Scholar, PubMed, and Scopus. The search was limited to the English language only.

Results: Polyphenols have been reported as anti-metastatic agents that explore the promising role of these compounds in cancer prevention. Such agents act through many signaling pathways, including PI3K/Akt and TNF-induced signaling pathways. The chemical modifications of polyphenols and the structure-activity relationships (SARs) between polyphenols and anticancer activities have also been discussed.

Conclusion: Many research papers were reported to explain the anti-cancer potential of Polyphenols, The SARs between polyphenols and anti-cancer activities, which correlate structures of polyphenols with significant chemotherapeutic action. The mechanism of anti-cancer potential is to be added for searching for new anti-cancer natural products.

« Previous Next »
Graphical Abstract

[1]
Johung, T.; Monje, M. Neuronal activity in the glioma microenvironment. Curr. Opin. Neurobiol., 2017, 47, 156-161.
[http://dx.doi.org/10.1016/j.conb.2017.10.009] [PMID: 29096244]
[2]
Venkatesh, H.S.; Tam, L.T.; Woo, P.J.; Lennon, J.; Nagaraja, S.; Gillespie, S.M.; Ni, J.; Duveau, D.Y.; Morris, P.J.; Zhao, J.J.; Thomas, C.J.; Monje, M. Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma. Nature, 2017, 549(7673), 533-537.
[http://dx.doi.org/10.1038/nature24014] [PMID: 28959975]
[3]
Batiha, G.E.S.; Beshbishy, A.M.; Ikram, M.; Mulla, Z.S.; El-Hack, M.E.A.; Taha, A.E.; Algammal, A.M.; Elewa, Y.H.A. The pharmacological activity, biochemical properties, and pharmacokinetics of the major natural polyphenolic flavonoid: Quercetin. Foods, 2020, 9(3), 374.
[http://dx.doi.org/10.3390/foods9030374] [PMID: 32210182]
[4]
Caselli, A.; Cirri, P.; Santi, A.; Paoli, P. Morin: A promising natural drug. Curr. Med. Chem., 2016, 23(8), 774-791.
[http://dx.doi.org/10.2174/0929867323666160106150821] [PMID: 26018232]
[5]
Scalbert, A.; Manach, C.; Morand, C.; Rémésy, C.; Jiménez, L. Dietary polyphenols and the prevention of diseases. Crit. Rev. Food Sci. Nutr., 2005, 45(4), 287-306.
[http://dx.doi.org/10.1080/1040869059096] [PMID: 16047496]
[6]
Thun, M.J.; DeLancey, J.O.; Center, M.M.; Jemal, A.; Ward, E.M. The global burden of cancer: Priorities for prevention. Carcinogenesis, 2010, 31(1), 100-110.
[http://dx.doi.org/10.1093/carcin/bgp263] [PMID: 19934210]
[7]
Averilla, J.N.; Oh, J.; Kim, H.J.; Kim, J.S.; Kim, J.S. Potential health benefits of phenolic compounds in grape processing by-products. Food Sci. Biotechnol., 2019, 28(6), 1607-1615.
[http://dx.doi.org/10.1007/s10068-019-00628-2] [PMID: 31807333]
[8]
Gupta, A.; Kagliwal, L.D.; Singhal, R.S. Biotransformation of polyphenols for improved bioavailability and processing stability. Adv. Food Nutr. Res., 2013, 69, 183-217.
[http://dx.doi.org/10.1016/B978-0-12-410540-9.00004-1] [PMID: 23522797]
[9]
Syed, D.N.; Khan, N.; Afaq, F.; Mukhtar, H. Chemoprevention of prostate cancer through dietary agents: Progress and promise. Cancer Epidemiol. Biomarkers Prev., 2007, 16(11), 2193-2203.
[http://dx.doi.org/10.1158/1055-9965.EPI-06-0942] [PMID: 18006906]
[10]
Zheng, P.P.; Li, J.; Kros, J.M. Breakthroughs in modern cancer therapy and elusive cardiotoxicity: Critical research-practice gaps, challenges, and insights. Med. Res. Rev., 2018, 38(1), 325-376.
[http://dx.doi.org/10.1002/med.21463] [PMID: 28862319]
[11]
Xiang, J.; Zhang, Y.; Liu, X.; Zhou, Q.; Piao, Y.; Shao, S.; Tang, J.; Zhou, Z.; Xie, T.; Shen, Y. Natural polyphenols-platinum nanocomplexes stimulate immune system for combination cancer therapy. Nano Lett., 2022, 22(13), 5615-5625.
[http://dx.doi.org/10.1021/acs.nanolett.2c02161] [PMID: 35749341]
[12]
Lopus, M. Nano-ayurvedic medicine and its potential in cancer treatment. J. Integr. Med., 2023, 21(2), 117-119.
[http://dx.doi.org/10.1016/j.joim.2022.12.001] [PMID: 36610811]
[13]
Chimento, A.; De Luca, A.; D’Amico, M.; De Amicis, F.; Pezzi, V. The involvement of natural polyphenols in molecular mechanisms inducing apoptosis in tumor cells: A promising adjuvant in cancer therapy. Int. J. Mol. Sci., 2023, 24(2), 1680.
[http://dx.doi.org/10.3390/ijms24021680] [PMID: 36675194]
[14]
Swallah, M.S.; Sun, H.; Affoh, R.; Fu, H.; Yu, H. Antioxidant potential overviews of secondary metabolites (polyphenols) in fruits. Int. J. Food Sci., 2020, 2020, 1-8.
[http://dx.doi.org/10.1155/2020/9081686] [PMID: 32455130]
[15]
Brglez Mojzer, E.; Knez Hrnčič, M.; Škerget, M.; Knez, Ž.; Bren, U. Polyphenols: Extraction methods, antioxidative action, bioavailability and anticarcinogenic effects. Molecules, 2016, 21(7), 901.
[http://dx.doi.org/10.3390/molecules21070901] [PMID: 27409600]
[16]
Pandey, K.B.; Rizvi, S.I. Plant polyphenols as dietary antioxidants in human health and disease. Oxid. Med. Cell. Longev., 2009, 2(5), 270-278.
[http://dx.doi.org/10.4161/oxim.2.5.9498] [PMID: 20716914]
[17]
Sorrenti, V.; Fortinguerra, S.; Caudullo, G.; Buriani, A. Deciphering the role of polyphenols in sports performance: From nutritional genomics to the gut microbiota toward phytonutritional epigenomics. Nutrients, 2020, 12(5), 1265.
[http://dx.doi.org/10.3390/nu12051265] [PMID: 32365576]
[18]
Skalicka-Woźniak, K.; Orhan, I.E.; Cordell, G.A.; Nabavi, S.M.; Budzyńska, B. Implication of coumarins towards central nervous system disorders. Pharmacol. Res., 2016, 103, 188-203.
[http://dx.doi.org/10.1016/j.phrs.2015.11.023] [PMID: 26657416]
[19]
Sansone, R.; Rodriguez-Mateos, A.; Heuel, J.; Falk, D.; Schuler, D.; Wagstaff, R.; Kuhnle, G.G.C.; Spencer, J.P.E.; Schroeter, H.; Merx, M.W.; Kelm, M.; Heiss, C. Cocoa flavanol intake improves endothelial function and framingham risk score in healthy men and women: A randomised, controlled, double-masked trial: The Flaviola Health Study. Br. J. Nutr., 2015, 114(8), 1246-1255.
[http://dx.doi.org/10.1017/S0007114515002822] [PMID: 26348767]
[20]
Amawi, H.; Ashby, C., Jr; Samuel, T.; Peraman, R.; Tiwari, A. Polyphenolic nutrients in cancer chemoprevention and metastasis: Role of the epithelial-to-mesenchymal (EMT) pathway. Nutrients, 2017, 9(8), 911.
[http://dx.doi.org/10.3390/nu9080911] [PMID: 28825675]
[21]
Mashhadi Akbar Boojar, M. An overview of the cellular mechanisms of flavonoids radioprotective effects. Adv. Pharm. Bull., 2019, 10(1), 13-19.
[http://dx.doi.org/10.15171/apb.2020.002] [PMID: 32002357]
[22]
Metsämuuronen, S.; Sirén, H. Bioactive phenolic compounds, metabolism and properties: A review on valuable chemical compounds in Scots pine and Norway spruce. Phytochem. Rev., 2019, 18(3), 623-664.
[http://dx.doi.org/10.1007/s11101-019-09630-2]
[23]
Waffo-Téguo, P.; Hawthorne, M.E.; Cuendet, M.; Mérillon, J.M.; Kinghorn, A.D.; Pezzuto, J.M.; Mehta, R.G. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr. Cancer, 2001, 40(2), 173-179.
[http://dx.doi.org/10.1207/S15327914NC402_14] [PMID: 11962253]
[24]
Vitale, M.; Masulli, M.; Rivellese, A.A.; Bonora, E.; Cappellini, F.; Nicolucci, A.; Squatrito, S.; Antenucci, D.; Barrea, A.; Bianchi, C.; Bianchini, F.; Fontana, L.; Fornengo, P.; Giorgino, F.; Gnasso, A.; Mannucci, E.; Mazzotti, A.; Nappo, R.; Palena, A.P.; Pata, P.; Perriello, G.; Potenziani, S.; Radin, R.; Ricci, L.; Romeo, F.; Santini, C.; Scarponi, M.; Serra, R.; Timi, A.; Turco, A.A.; Vedovato, M.; Zavaroni, D.; Grioni, S.; Riccardi, G.; Vaccaro, O. Dietary intake and major food sources of polyphenols in people with type 2 diabetes: The TOSCA.IT Study. Eur. J. Nutr., 2018, 57(2), 679-688.
[http://dx.doi.org/10.1007/s00394-016-1355-1] [PMID: 28004268]
[25]
Wang, L.; Sun, R.; Zhang, Q.; Luo, Q.; Zeng, S.; Li, X.; Gong, X.; Li, Y.; Lu, L.; Hu, M.; Liu, Z. An update on polyphenol disposition via coupled metabolic pathways. Expert Opin. Drug Metab. Toxicol., 2019, 15(2), 151-165.
[http://dx.doi.org/10.1080/17425255.2019.1559815] [PMID: 30583703]
[26]
Murota, K.; Hotta, A.; Ido, H.; Kawai, Y.; Moon, J.H.; Sekido, K.; Hayashi, H.; Inakuma, T.; Terao, J. Antioxidant capacity of albumin-bound quercetin metabolites after onion consumption in humans. J. Med. Invest., 2007, 54(3,4), 370-374.
[http://dx.doi.org/10.2152/jmi.54.370] [PMID: 17878690]
[27]
De Palma, M.; Hanahan, D. The biology of personalized cancer medicine: Facing individual complexities underlying hallmark capabilities. Mol. Oncol., 2012, 6(2), 111-127.
[http://dx.doi.org/10.1016/j.molonc.2012.01.011] [PMID: 22360993]
[28]
Amararathna, M.; Johnston, M.; Rupasinghe, H. Plant polyphenols as chemopreventive agents for lung cancer. Int. J. Mol. Sci., 2016, 17(8), 1352.
[http://dx.doi.org/10.3390/ijms17081352] [PMID: 27548149]
[29]
Society, A.C. Cancer facts & figures 2017. J. Consum. Health Internet, 2012, 16, 366-367.
[30]
Turrini, E.; Ferruzzi, L.; Fimognari, C. Potential effects of pomegranate polyphenols in cancer prevention and therapy. Oxid. Med. Cell. Longev., 2015, 2015, 1-19.
[http://dx.doi.org/10.1155/2015/938475] [PMID: 26180600]
[31]
Hadi, S.M.; Asad, S.F.; Singh, S.; Ahmad, A. Putative mechanism for anticancer and apoptosis-inducing properties of plant-derived polyphenolic compounds. IUBMB Life, 2000, 50(3), 167-171.
[http://dx.doi.org/10.1080/152165400300001471] [PMID: 11142343]
[32]
Yan Xu; Zhang J.; Li Xiong; Lei Zhang; Dong Sun, Hui Liu Green tea polyphenols inhibit cognitive impairment induced by chronic cerebral hypoperfusion via modulating oxidative stress. J. Nutr. Biochem., 2010, 21(8), 741-748.
[http://dx.doi.org/10.1016/j.jnutbio.2009.05.002] [PMID: 19615878]
[33]
Harper, C.E.; Patel, B.B.; Wang, J.; Eltoum, I.A.; Lamartiniere, C.A. Epigallocatechin-3-gallate suppresses early stage, but not late stage prostate cancer in TRAMP mice: Mechanisms of action. Prostate, 2007, 67(14), 1576-1589.
[http://dx.doi.org/10.1002/pros.20643] [PMID: 17705241]
[34]
Araújo, J.R.; Gonçalves, P.; Martel, F. Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines. Nutr. Res., 2011, 31(2), 77-87.
[http://dx.doi.org/10.1016/j.nutres.2011.01.006] [PMID: 21419311]
[35]
Howells, L.M.; Mitra, A.; Manson, M.M. Comparison of oxaliplatin- and curcumin-mediated antiproliferative effects in colorectal cell lines. Int. J. Cancer, 2007, 121(1), 175-183.
[http://dx.doi.org/10.1002/ijc.22645] [PMID: 17330230]
[36]
Irazabal, M.V.; Torres, V.E. Reactive oxygen species and redox signaling in chronic kidney disease. Cells, 2020, 9(6), 1342.
[http://dx.doi.org/10.3390/cells9061342] [PMID: 32481548]
[37]
Balasubramanian, S.; Zhu, L.; Eckert, R.L. Apigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311. J. Biol. Chem., 2006, 281(47), 36162-36172.
[http://dx.doi.org/10.1074/jbc.M605368200] [PMID: 16982614]
[38]
Cháirez-Ramírez, M.H.; de la Cruz-López, K.G.; García-Carrancá, A. Polyphenols as antitumor agents targeting key players in cancer-driving signaling pathways. Front. Pharmacol., 2021, 12, 710304.
[http://dx.doi.org/10.3389/fphar.2021.710304] [PMID: 34744708]
[39]
Wee, P.; Wang, Z. Epidermal growth factor receptor cell proliferation signaling pathways. Cancers, 2017, 9(5), 52.
[http://dx.doi.org/10.3390/cancers9050052] [PMID: 28513565]
[40]
Lee, S.; Heinrich, E.L.; Lu, J.; Lee, W.; Choi, A.H.; Luu, C.; Chung, V.; Fakih, M.; Kim, J. Epidermal growth factor receptor signaling to the mitogen activated protein kinase pathway bypasses ras in pancreatic cancer cells. Pancreas, 2016, 45(2), 286-292.
[http://dx.doi.org/10.1097/MPA.0000000000000379] [PMID: 26262587]
[41]
Aggarwal, V.; Tuli, H.; Varol, A.; Thakral, F.; Yerer, M.; Sak, K.; Varol, M.; Jain, A.; Khan, M.; Sethi, G. Role of reactive oxygen species in cancer progression: Molecular mechanisms and recent advancements. Biomolecules, 2019, 9(11), 735.
[http://dx.doi.org/10.3390/biom9110735] [PMID: 31766246]
[42]
Mokra, D.; Joskova, M.; Mokry, J. Therapeutic effects of green tea polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in relation to molecular pathways controlling inflammation, oxidative stress, and apoptosis. Int. J. Mol. Sci., 2022, 24(1), 340.
[http://dx.doi.org/10.3390/ijms24010340] [PMID: 36613784]
[43]
Wang, X.; Lin, Y. Tumor necrosis factor and cancer, buddies or foes? Acta Pharmacol. Sin., 2008, 29(11), 1275-1288.
[http://dx.doi.org/10.1111/j.1745-7254.2008.00889.x] [PMID: 18954521]
[44]
Long, J.; Guan, P.; Hu, X.; Yang, L.; He, L.; Lin, Q.; Luo, F.; Li, J.; He, X.; Du, Z.; Li, T. Natural polyphenols as targeted modulators in colon cancer: Molecular mechanisms and applications. Front. Immunol., 2021, 12, 635484.
[http://dx.doi.org/10.3389/fimmu.2021.635484] [PMID: 33664749]
[45]
Lousa, I.; Reis, F.; Santos-Silva, A.; Belo, L. The signaling pathway of TNF receptors: Linking animal models of renal disease to human CKD. Int. J. Mol. Sci., 2022, 23(6), 3284.
[http://dx.doi.org/10.3390/ijms23063284] [PMID: 35328704]
[46]
Peng, F.; Liao, M.; Qin, R.; Zhu, S.; Peng, C.; Fu, L.; Chen, Y.; Han, B. Regulated cell death (RCD) in cancer: Key pathways and targeted therapies. Signal Transduct. Target. Ther., 2022, 7(1), 286.
[http://dx.doi.org/10.1038/s41392-022-01110-y] [PMID: 35963853]
[47]
Porrini, M.; Riso, P.; Brusamolino, A.; Berti, C.; Guarnieri, S.; Visioli, F. Daily intake of a formulated tomato drink affects carotenoid plasma and lymphocyte concentrations and improves cellular antioxidant protection. Br. J. Nutr., 2005, 93(1), 93-99.
[http://dx.doi.org/10.1079/BJN20041315] [PMID: 15705230]
[48]
Selvendiran, K.; Koga, H.; Ueno, T.; Yoshida, T.; Maeyama, M.; Torimura, T.; Yano, H.; Kojiro, M.; Sata, M. Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: An implication for the antitumor potential of flavonoids. Cancer Res., 2006, 66(9), 4826-4834.
[http://dx.doi.org/10.1158/0008-5472.CAN-05-4062] [PMID: 16651438]
[49]
Lee, H.J.; Wang, C.J.; Kuo, H.C.; Chou, F.P.; Jean, L.F.; Tseng, T.H. Induction apoptosis of luteolin in human hepatoma HepG2 cells involving mitochondria translocation of Bax/Bak and activation of JNK. Toxicol. Appl. Pharmacol., 2005, 203(2), 124-131.
[http://dx.doi.org/10.1016/j.taap.2004.08.004] [PMID: 15710173]
[50]
Gong, L.; Li, Y.; Nedeljkovic-Kurepa, A.; Sarkar, F.H. Inactivation of NF-κB by genistein is mediated via Akt signaling pathway in breast cancer cells. Oncogene, 2003, 22(30), 4702-4709.
[http://dx.doi.org/10.1038/sj.onc.1206583] [PMID: 12879015]
[51]
Atten, M.J.; Godoy-Romero, E.; Attar, B.M.; Milson, T.; Zopel, M.; Holian, O. Resveratrol regulates cellular PKC α and δ to inhibit growth and induce apoptosis in gastric cancer cells. Invest. New Drugs, 2005, 23(2), 111-119.
[http://dx.doi.org/10.1007/s10637-005-5855-8] [PMID: 15744586]
[52]
Wenzel, E.; Somoza, V. Metabolism and bioavailability oftrans-resveratrol. Mol. Nutr. Food Res., 2005, 49(5), 472-481.
[http://dx.doi.org/10.1002/mnfr.200500010] [PMID: 15779070]
[53]
Ahmad, K.A.; Harris, N.H.; Johnson, A.D.; Lindvall, H.C.N.; Wang, G.; Ahmed, K. Protein kinase CK2 modulates apoptosis induced by resveratrol and epigallocatechin-3-gallate in prostate cancer cells. Mol. Cancer Ther., 2007, 6(3), 1006-1012.
[http://dx.doi.org/10.1158/1535-7163.MCT-06-0491] [PMID: 17363494]
[54]
Wolter, F.; Akoglu, B.; Clausnitzer, A.; Stein, J. Downregulation of the cyclin D1/Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon cancer cell lines. J. Nutr., 2001, 131(8), 2197-2203.
[http://dx.doi.org/10.1093/jn/131.8.2197] [PMID: 11481417]
[55]
Zhou, H.B.; Yan, Y.; Sun, Y.N.; Zhu, J.R. Resveratrol induces apoptosis in human esophageal carcinoma cells. World J. Gastroenterol., 2003, 9(3), 408-411.
[http://dx.doi.org/10.3748/wjg.v9.i3.408] [PMID: 12632486]
[56]
Alkhalaf, M. Resveratrol-induced apoptosis is associated with activation of p53 and inhibition of protein translation in T47D human breast cancer cells. Pharmacology, 2007, 80(2-3), 134-143.
[http://dx.doi.org/10.1159/000103253] [PMID: 17534123]
[57]
Niles, R.M.; McFarland, M.; Weimer, M.B.; Redkar, A.; Fu, Y.M.; Meadows, G.G. Resveratrol is a potent inducer of apoptosis in human melanoma cells. Cancer Lett., 2003, 190(2), 157-163.
[http://dx.doi.org/10.1016/S0304-3835(02)00676-6] [PMID: 12565170]
[58]
Mouria, M.; Gukovskaya, A.S.; Jung, Y.; Buechler, P.; Hines, O.J.; Reber, H.A.; Pandol, S.J. Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis. Int. J. Cancer, 2002, 98(5), 761-769.
[http://dx.doi.org/10.1002/ijc.10202] [PMID: 11920648]
[59]
Gao, X.; Xu, Y.X.; Divine, G.; Janakiraman, N.; Chapman, R.A.; Gautam, S.C. Disparate in vitro and in vivo antileukemic effects of resveratrol, a natural polyphenolic compound found in grapes. J. Nutr., 2002, 132(7), 2076-2081.
[http://dx.doi.org/10.1093/jn/132.7.2076] [PMID: 12097696]
[60]
Kim, Y.A.; Lee, W.H.; Choi, T.H.; Rhee, S.H.; Park, K.Y.; Choi, Y.H. Involvement of p21WAF1/CIP1, pRB, Bax and NF-kappaB in induction of growth arrest and apoptosis by resveratrol in human lung carcinoma A549 cells. Int. J. Oncol., 2003, 23(4), 1143-1149.
[PMID: 12963997]
[61]
Medrano-Padial, C.; Puerto, M.; Moreno, F.J.; Richard, T.; Cantos-Villar, E.; Pichardo, S. In vitro toxicity assessment of stilbene extract for its potential use as antioxidant in the wine industry. Antioxidants, 2019, 8(10), 467.
[http://dx.doi.org/10.3390/antiox8100467] [PMID: 31600944]
[62]
Joe, A.K.; Liu, H.; Suzui, M.; Vural, M.E.; Xiao, D.; Weinstein, I.B. Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines. Clin. Cancer Res., 2002, 8(3), 893-903.
[PMID: 11895924]
[63]
Kello, M.; Takac, P.; Kubatka, P.; Kuruc, T.; Petrova, K.; Mojzis, J. Oxidative stress-induced DNA damage and apoptosis in clove buds-treated MCF-7 cells. Biomolecules, 2020, 10(1), 139.
[http://dx.doi.org/10.3390/biom10010139] [PMID: 31947708]
[64]
Khan, H.; Ullah, H.; Castilho, P.C.M.F.; Gomila, A.S.; D’Onofrio, G.; Filosa, R.; Wang, F.; Nabavi, S.M.; Daglia, M.; Silva, A.S.; Rengasamy, K.R.R.; Ou, J.; Zou, X.; Xiao, J.; Cao, H. Targeting NF-κB signaling pathway in cancer by dietary polyphenols. Crit. Rev. Food Sci. Nutr., 2020, 60(16), 2790-2800.
[http://dx.doi.org/10.1080/10408398.2019.1661827] [PMID: 31512490]
[65]
Krishna, B.M.; Jana, S.; Singhal, J.; Horne, D.; Awasthi, S.; Salgia, R.; Singhal, S.S. Notch signaling in breast cancer: From pathway analysis to therapy. Cancer Lett., 2019, 461, 123-131.
[http://dx.doi.org/10.1016/j.canlet.2019.07.012] [PMID: 31326555]
[66]
Niedzwiecki, A.; Roomi, M.; Kalinovsky, T.; Rath, M. Anticancer efficacy of polyphenols and their combinations. Nutrients, 2016, 8(9), 552.
[http://dx.doi.org/10.3390/nu8090552] [PMID: 27618095]
[67]
Onaciu, A.; Munteanu, R.; Munteanu, V.C.; Gulei, D.; Raduly, L.; Feder, R.I.; Pirlog, R.; Atanasov, A.G.; Korban, S.S.; Irimie, A.; Berindan-Neagoe, I. Spontaneous and induced animal models for cancer research. Diagnostics, 2020, 10(9), 660.
[http://dx.doi.org/10.3390/diagnostics10090660] [PMID: 32878340]
[68]
Ullah, A.; Munir, S.; Badshah, S.L.; Khan, N.; Ghani, L.; Poulson, B.G.; Emwas, A.H.; Jaremko, M. Important flavonoids and their role as a therapeutic agent. Molecules, 2020, 25(22), 5243.
[http://dx.doi.org/10.3390/molecules25225243] [PMID: 33187049]
[69]
Martin, H.L.; Adams, M.; Higgins, J.; Bond, J.; Morrison, E.E.; Bell, S.M.; Warriner, S.; Nelson, A.; Tomlinson, D.C. High-content, high-throughput screening for the identification of cytotoxic compounds based on cell morphology and cell proliferation markers. PLoS One, 2014, 9(2), e88338.
[http://dx.doi.org/10.1371/journal.pone.0088338] [PMID: 24505478]
[70]
Chen, B.S.; Wu, C.C. Systems biology as an integrated platform for bioinformatics, systems synthetic biology, and systems metabolic engineering. Cells, 2013, 2(4), 635-688.
[http://dx.doi.org/10.3390/cells2040635] [PMID: 24709875]
[71]
George, V.C.; Dellaire, G.; Rupasinghe, H.P.V. Plant flavonoids in cancer chemoprevention: Role in genome stability. J. Nutr. Biochem., 2017, 45, 1-14.
[http://dx.doi.org/10.1016/j.jnutbio.2016.11.007] [PMID: 27951449]
[72]
Amawi, H.; Ashby, C.R., Jr; Tiwari, A.K. Cancer chemoprevention through dietary flavonoids: what’s limiting? Chin. J. Cancer, 2017, 36(1), 50.
[http://dx.doi.org/10.1186/s40880-017-0217-4] [PMID: 28061892]
[73]
Bustos, A.S.; Håkansson, A.; Linares-Pastén, J.A.; Peñarrieta, J.M.; Nilsson, L. Interaction of quercetin and epigallocatechin gallate (EGCG) aggregates with pancreatic lipase under simplified intestinal conditions. PLoS One, 2020, 15(4), e0224853.
[http://dx.doi.org/10.1371/journal.pone.0224853] [PMID: 32298262]
[74]
Nijveldt, R.J.; van Nood, E.; van Hoorn, D.E.C.; Boelens, P.G.; van Norren, K.; van Leeuwen, P.A.M. Flavonoids: A review of probable mechanisms of action and potential applications. Am. J. Clin. Nutr., 2001, 74(4), 418-425.
[http://dx.doi.org/10.1093/ajcn/74.4.418] [PMID: 11566638]
[75]
Applegate, C.; Rowles, J., III; Ranard, K.; Jeon, S.; Erdman, J., Jr Soy consumption and the risk of prostate cancer: An updated systematic review and meta-analysis. Nutrients, 2018, 10(1), 40.
[http://dx.doi.org/10.3390/nu10010040] [PMID: 29300347]
[76]
Kim, W.; Bang, M.; Kim, E.; Kang, N.; Jung, K.; Cho, H.; Park, J. Quercetin decreases the expression of ErbB2 and ErbB3 proteins in HT-29 human colon cancer cells. J. Nutr. Biochem., 2005, 16(3), 155-162.
[http://dx.doi.org/10.1016/j.jnutbio.2004.10.010] [PMID: 15741050]
[77]
van der Woude, H.; Gliszczyńska-Świgło, A.; Struijs, K.; Smeets, A.; Alink, G.M.; Rietjens, I.M.C.M. Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans. Cancer Lett., 2003, 200(1), 41-47.
[http://dx.doi.org/10.1016/S0304-3835(03)00412-9] [PMID: 14550951]
[78]
Shan, B.E.; Wang, M.X.; Li, R. Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/β-catenin signaling pathway. Cancer Invest., 2009, 27(6), 604-612.
[http://dx.doi.org/10.1080/07357900802337191] [PMID: 19440933]
[79]
Ramos, S. Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways. Mol. Nutr. Food Res., 2008, 52(5), 507-526.
[http://dx.doi.org/10.1002/mnfr.200700326] [PMID: 18435439]
[80]
Gee, J.M.; Hara, H.; Johnson, I.T. Suppression of intestinal crypt cell proliferation and aberrant crypt foci by dietary quercetin in rats. Nutr. Cancer, 2002, 43(2), 193-201.
[http://dx.doi.org/10.1207/S15327914NC432_10] [PMID: 12599752]
[81]
Park, C.H.; Chang, J.Y.; Hahm, E.R.; Park, S.; Kim, H.K.; Yang, C.H. Quercetin, a potent inhibitor against β-catenin/Tcf signaling in SW480 colon cancer cells. Biochem. Biophys. Res. Commun., 2005, 328(1), 227-234.
[http://dx.doi.org/10.1016/j.bbrc.2004.12.151] [PMID: 15670774]
[82]
Lu, L.; Ma, X.; Zheng, J.; Li, L.; Yang, W.; Kong, Y.; Wang, J. Quercetin for myocardial ischemia reperfusion injury. Medicine, 2020, 99(26), e20856.
[http://dx.doi.org/10.1097/MD.0000000000020856] [PMID: 32590785]
[83]
Li, W.; Du, B.; Wang, T.; Wang, S.; Zhang, J. Kaempferol induces apoptosis in human HCT116 colon cancer cells via the ataxia-telangiectasia mutated-p53 pathway with the involvement of p53 upregulated modulator of apoptosis. Chem. Biol. Interact., 2009, 177(2), 121-127.
[http://dx.doi.org/10.1016/j.cbi.2008.10.048] [PMID: 19028473]
[84]
Lee, J.H.; Johnson, J.V.; Talcott, S.T. Identification of ellagic acid conjugates and other polyphenolics in muscadine grapes by HPLC-ESI-MS. J. Agric. Food Chem., 2005, 53(15), 6003-6010.
[http://dx.doi.org/10.1021/jf050468r] [PMID: 16028988]
[85]
Kim, M.E.; Ha, T.K.; Yoon, J.H.; Lee, J.S. Myricetin induces cell death of human colon cancer cells via BAX/BCL2-dependent pathway. Anticancer Res., 2014, 34(2), 701-706.
[PMID: 24511002]
[86]
Adhami, V.M.; Syed, D.N.; Khan, N.; Mukhtar, H. Dietary flavonoid fisetin: A novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management. Biochem. Pharmacol., 2012, 84(10), 1277-1281.
[http://dx.doi.org/10.1016/j.bcp.2012.07.012] [PMID: 22842629]
[87]
Lu, X.; Jung, J.; Cho, H.J.; Lim, D.Y.; Lee, H.S.; Chun, H.S.; Kwon, D.Y.; Park, J.H. Fisetin inhibits the activities of cyclin-dependent kinases leading to cell cycle arrest in HT-29 human colon cancer cells. J. Nutr., 2005, 135(12), 2884-2890.
[http://dx.doi.org/10.1093/jn/135.12.2884] [PMID: 16317137]
[88]
Liu, L.H.; Shi, R.J.; Chen, Z.C. Paeonol exerts anti-tumor activity against colorectal cancer cells by inducing G0/G1 phase arrest and cell apoptosis via inhibiting the Wnt/β-catenin signaling pathway. Int. J. Mol. Med., 2020, 46(2), 675-684.
[http://dx.doi.org/10.3892/ijmm.2020.4629] [PMID: 32626954]
[89]
Ramos, A.A.; Marques, F.; Fernandes-Ferreira, M.; Pereira-Wilson, C. Water extracts of tree Hypericum sps. protect DNA from oxidative and alkylating damage and enhance DNA repair in colon cells. Food Chem. Toxicol., 2013, 51, 80-86.
[http://dx.doi.org/10.1016/j.fct.2012.09.014] [PMID: 23000446]
[90]
Alonso-Castro, A.J.; Domínguez, F.; García-Carrancá, A. Rutin exerts antitumor effects on nude mice bearing SW480 tumor. Arch. Med. Res., 2013, 44(5), 346-351.
[http://dx.doi.org/10.1016/j.arcmed.2013.06.002] [PMID: 23867787]
[91]
Li, S.; Li, H.; Xu, X.; Saw, P.E.; Zhang, L. Nanocarrier-mediated antioxidant delivery for liver diseases. Theranostics, 2020, 10(3), 1262-1280.
[http://dx.doi.org/10.7150/thno.38834] [PMID: 31938064]
[92]
Hogan, F.S.; Krishnegowda, N.K.; Mikhailova, M.; Kahlenberg, M.S. Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer. J. Surg. Res., 2007, 143(1), 58-65.
[http://dx.doi.org/10.1016/j.jss.2007.03.080] [PMID: 17950073]
[93]
Agarwal, C.; Singh, R.P.; Dhanalakshmi, S.; Tyagi, A.K.; Tecklenburg, M.; Sclafani, R.A.; Agarwal, R. Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. Oncogene, 2003, 22(51), 8271-8282.
[http://dx.doi.org/10.1038/sj.onc.1207158] [PMID: 14614451]
[94]
Singh, R.P.; Gu, M.; Agarwal, R. Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis. Cancer Res., 2008, 68(6), 2043-2050.
[http://dx.doi.org/10.1158/0008-5472.CAN-07-6247] [PMID: 18339887]
[95]
Kauntz, H.; Bousserouel, S.; Gossé, F.; Raul, F. Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells. Apoptosis, 2011, 16(10), 1042-1053.
[http://dx.doi.org/10.1007/s10495-011-0631-z] [PMID: 21779837]
[96]
Velmurugan, B.; Gangar, S.C.; Kaur, M.; Tyagi, A.; Deep, G.; Agarwal, R. Silibinin exerts sustained growth suppressive effect against human colon carcinoma SW480 xenograft by targeting multiple signaling molecules. Pharm. Res., 2010, 27(10), 2085-2097.
[http://dx.doi.org/10.1007/s11095-010-0207-6] [PMID: 20628792]
[97]
Lin, C.M.; Chen, Y.H.; Ma, H.P.; Wang, B.W.; Chiu, J.H.; Chua, S.K.; Ong, J.R.; Shyu, K.G. Silibinin inhibits the invasion of IL-6-stimulated colon cancer cells via selective JNK/AP-1/MMP-2 modulation in vitro. J. Agric. Food Chem., 2012, 60(51), 12451-12457.
[http://dx.doi.org/10.1021/jf300964f] [PMID: 23210512]
[98]
Kauntz, H.; Bousserouel, S.; Gosse, F.; Marescaux, J.; Raul, F. Silibinin, a natural flavonoid, modulates the early expression of chemoprevention biomarkers in a preclinical model of colon carcinogenesis. Int. J. Oncol., 2012, 41(3), 849-854.
[http://dx.doi.org/10.3892/ijo.2012.1526] [PMID: 22735354]
[99]
Kumar, S; Pandey, AK Chemistry and biological activities of flavonoids: An overview. Sci. World J., 2013, 2013, 162750.
[http://dx.doi.org/10.1155/2013/162750]
[100]
Attoub, S.; Hassan, A.H.; Vanhoecke, B.; Iratni, R.; Takahashi, T.; Gaben, A.M.; Bracke, M.; Awad, S.; John, A.; Kamalboor, H.A.; Al Sultan, M.A.; Arafat, K.; Gespach, C.; Petroianu, G. Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells. Eur. J. Pharmacol., 2011, 651(1-3), 18-25.
[http://dx.doi.org/10.1016/j.ejphar.2010.10.063] [PMID: 21074525]
[101]
Lim, D.Y.; Cho, H.J.; Kim, J.; Nho, C.W.; Lee, K.W.; Park, J.H.Y. Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells. BMC Gastroenterol., 2012, 12(1), 9.
[http://dx.doi.org/10.1186/1471-230X-12-9] [PMID: 22269172]
[102]
Pandurangan, A.K. Potential targets for prevention of colorectal cancer: A focus on PI3K/Akt/mTOR and Wnt pathways. Asian Pac. J. Cancer Prev., 2013, 14(4), 2201-2205.
[http://dx.doi.org/10.7314/APJCP.2013.14.4.2201] [PMID: 23725112]
[103]
Wang, L.M.; Xie, K.P.; Huo, H.N.; Shang, F.; Zou, W.; Xie, M.J. Luteolin inhibits proliferation induced by IGF-1 pathway dependent ERα in human breast cancer MCF-7 cells. Asian Pac. J. Cancer Prev., 2012, 13(4), 1431-1437.
[http://dx.doi.org/10.7314/APJCP.2012.13.4.1431] [PMID: 22799344]
[104]
Chen, D.; Wan, S.B.; Yang, H.; Yuan, J.; Chan, T.H.; Dou, Q.P. EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment. Adv. Clin. Chem., 2011, 53, 155-177.
[http://dx.doi.org/10.1016/B978-0-12-385855-9.00007-2] [PMID: 21404918]
[105]
Shimizu, M.; Deguchi, A.; Hara, Y.; Moriwaki, H.; Weinstein, I.B. EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells. Biochem. Biophys. Res. Commun., 2005, 334(3), 947-953.
[http://dx.doi.org/10.1016/j.bbrc.2005.06.182] [PMID: 16053920]
[106]
Du, G.J.; Zhang, Z.; Wen, X.D.; Yu, C.; Calway, T.; Yuan, C.S.; Wang, C.Z. Epigallocatechin gallate (EGCG) is the most effective cancer chemopreventive polyphenol in green tea. Nutrients, 2012, 4(11), 1679-1691.
[http://dx.doi.org/10.3390/nu4111679] [PMID: 23201840]
[107]
Berger, S.J.; Gupta, S.; Belfi, C.A.; Gosky, D.M.; Mukhtar, H. Green tea constituent (--)-epigallocatechin-3-gallate inhibits topoisomerase I activity in human colon carcinoma cells. Biochem. Biophys. Res. Commun., 2001, 288(1), 101-105.
[http://dx.doi.org/10.1006/bbrc.2001.5736] [PMID: 11594758]
[108]
Chen, C.; Shen, G.; Hebbar, V.; Hu, R.; Owuor, E.D.; Kong, A.N.T. Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells. Carcinogenesis, 2003, 24(8), 1369-1378.
[http://dx.doi.org/10.1093/carcin/bgg091] [PMID: 12819184]
[109]
Adachi, S.; Nagao, T.; To, S.; Joe, A.K.; Shimizu, M.; Matsushima-Nishiwaki, R.; Kozawa, O.; Moriwaki, H.; Maxfield, F.R.; Weinstein, I.B. (-)-Epigallocatechin gallate causes internalization of the epidermal growth factor receptor in human colon cancer cells. Carcinogenesis, 2008, 29(10), 1986-1993.
[http://dx.doi.org/10.1093/carcin/bgn128] [PMID: 18586691]
[110]
Howell, A.B.; Reed, J.D.; Krueger, C.G.; Winterbottom, R.; Cunningham, D.G.; Leahy, M. A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity. Phytochemistry, 2005, 66(18), 2281-2291.
[http://dx.doi.org/10.1016/j.phytochem.2005.05.022] [PMID: 16055161]
[111]
Gorlach, S.; Wagner, W.; Podsędek, A.; Szewczyk, K.; Koziołkiewicz, M.; Dastych, J. Procyanidins from Japanese quince (Chaenomeles japonica) fruit induce apoptosis in human colon cancer Caco-2 cells in a degree of polymerization-dependent manner. Nutr. Cancer, 2011, 63(8), 1348-1360.
[http://dx.doi.org/10.1080/01635581.2011.608480] [PMID: 22026386]
[112]
Lizárraga, D.; Touriño, S.; Reyes-Zurita, F.J.; de Kok, T.M.; van Delft, J.H.; Maas, L.M.; Briedé, J.J.; Centelles, J.J.; Torres, J.L.; Cascante, M. Witch hazel (Hamamelis virginiana) fractions and the importance of gallate moieties--electron transfer capacities in their antitumoral properties. J. Agric. Food Chem., 2008, 56(24), 11675-11682.
[http://dx.doi.org/10.1021/jf802345x] [PMID: 19035659]
[113]
Engelbrecht, A.M.; Mattheyse, M.; Ellis, B.; Loos, B.; Thomas, M.; Smith, R.; Peters, S.; Smith, C.; Myburgh, K. Proanthocyanidin from grape seeds inactivates the PI3-kinase/PKB pathway and induces apoptosis in a colon cancer cell line. Cancer Lett., 2007, 258(1), 144-153.
[http://dx.doi.org/10.1016/j.canlet.2007.08.020] [PMID: 17923279]
[114]
Maldonado, M.E.; Bousserouel, S.; Gossé, F.; Lobstein, A.; Raul, F. Implication of NF-κB and p53 in the expression of TRAIL-death receptors and apoptosis by apple procyanidins in human metastatic SW620 cells. Biomédica, 2010, 30(4), 577-586.
[http://dx.doi.org/10.7705/biomedica.v30i4.296] [PMID: 21713362]
[115]
García-Lafuente, A.; Guillamón, E.; Villares, A.; Rostagno, M.A.; Martínez, J.A. Flavonoids as anti-inflammatory agents: Implications in cancer and cardiovascular disease. Inflamm. Res., 2009, 58(9), 537-552.
[http://dx.doi.org/10.1007/s00011-009-0037-3] [PMID: 19381780]
[116]
Yang, C.S.; Landau, J.M.; Huang, M.T.; Newmark, H.L. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu. Rev. Nutr., 2001, 21(1), 381-406.
[http://dx.doi.org/10.1146/annurev.nutr.21.1.381] [PMID: 11375442]
[117]
Johnson, I.T.; Williamson, G.; Musk, S.R.R. Anticarcinogenic factors in plant foods: A new class of nutrients? Nutr. Res. Rev., 1994, 7(1), 175-204.
[http://dx.doi.org/10.1079/NRR19940011] [PMID: 19094297]
[118]
Kamaraj, S.; Vinodhkumar, R.; Anandakumar, P.; Jagan, S.; Ramakrishnan, G.; Devaki, T. The effects of quercetin on antioxidant status and tumor markers in the lung and serum of mice treated with benzo(a)pyrene. Biol. Pharm. Bull., 2007, 30(12), 2268-2273.
[http://dx.doi.org/10.1248/bpb.30.2268] [PMID: 18057710]
[119]
Ryyti, R.; Hämäläinen, M.; Peltola, R.; Moilanen, E. Beneficial effects of lingonberry (Vaccinium vitis-idaea L.) supplementation on metabolic and inflammatory adverse effects induced by high-fat diet in a mouse model of obesity. PLoS One, 2020, 15(5), e0232605.
[http://dx.doi.org/10.1371/journal.pone.0232605] [PMID: 32379797]
[120]
Shiomi, K.; Kuriyama, I.; Yoshida, H.; Mizushina, Y.; Mizushina, Y. Inhibitory effects of myricetin on mammalian DNA polymerase, topoisomerase and human cancer cell proliferation. Food Chem., 2013, 139(1-4), 910-918.
[http://dx.doi.org/10.1016/j.foodchem.2013.01.009] [PMID: 23561189]
[121]
Lim, D.Y.; Park, J.H.Y. Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin. Am. J. Physiol. Gastrointest. Liver Physiol., 2009, 296(5), G1060-G1068.
[http://dx.doi.org/10.1152/ajpgi.90490.2008] [PMID: 19264955]
[122]
Wargovich, M.J.; Jimenez, A.; McKee, K.; Steele, V.E.; Velasco, M.; Woods, J.; Price, R.; Gray, K.; Kelloff, G.J. Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression. Carcinogenesis, 2000, 21(6), 1149-1155.
[http://dx.doi.org/10.1093/carcin/21.6.1149] [PMID: 10837003]
[123]
Ravichandran, K.; Velmurugan, B.; Gu, M.; Singh, R.P.; Agarwal, R. Inhibitory effect of silibinin against azoxymethane-induced colon tumorigenesis in A/J mice. Clin. Cancer Res., 2010, 16(18), 4595-4606.
[http://dx.doi.org/10.1158/1078-0432.CCR-10-1213] [PMID: 20823143]
[124]
Ashokkumar, P.; Sudhandiran, G. Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis. Biomed. Pharmacother., 2008, 62(9), 590-597.
[http://dx.doi.org/10.1016/j.biopha.2008.06.031] [PMID: 18692983]
[125]
Chiou, Y.S.; Ma, N.J.L.; Sang, S.; Ho, C.T.; Wang, Y.J.; Pan, M.H. Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice. J. Agric. Food Chem., 2012, 60(13), 3441-3451.
[http://dx.doi.org/10.1021/jf300441p] [PMID: 22409325]
[126]
Gossé, F.; Guyot, S.; Roussi, S.; Lobstein, A.; Fischer, B.; Seiler, N.; Raul, F. Chemopreventive properties of apple procyanidins on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis. Carcinogenesis, 2005, 26(7), 1291-1295.
[http://dx.doi.org/10.1093/carcin/bgi074] [PMID: 15790589]
[127]
Nabors, L.B.; Suswam, E.; Huang, Y.; Yang, X.; Johnson, M.J.; King, P.H. Tumor necrosis factor α induces angiogenic factor upregulation in malignant glioma cells: A role for RNA stabilization and HuR. Cancer Res., 2003, 63(14), 4181-4187.
[PMID: 12874024]
[128]
Suzukawa, K.; Weber, T.J.; Colburn, N.H. AP-1, NF-kappa-B, and ERK activation thresholds for promotion of neoplastic transformation in the mouse epidermal JB6 model. Environ. Health Perspect., 2002, 110(9), 865-870.
[http://dx.doi.org/10.1289/ehp.02110865] [PMID: 12204819]
[129]
Balkwill, F. TNF-α in promotion and progression of cancer. Cancer Metastasis Rev., 2006, 25(3), 409-416.
[http://dx.doi.org/10.1007/s10555-006-9005-3] [PMID: 16951987]
[130]
Hassan, M; Watari, H; AbuAlmaaty, A; Ohba, Y; Sakuragi, N Apoptosis and molecular targeting therapy in cancer. Biomed. Res. Int., 2014, 2014, 150845.
[http://dx.doi.org/10.1155/2014/150845]
[131]
Zhou, Y.; Zheng, J.; Li, Y.; Xu, D.P.; Li, S.; Chen, Y.M.; Li, H.B. Natural polyphenols for prevention and treatment of cancer. Nutrients, 2016, 8(8), 515.
[http://dx.doi.org/10.3390/nu8080515] [PMID: 27556486]
[132]
Hegde, M.M.; Lakshman, K. Role of polyphenols and flavonoids as anti-cancer drug candidates: A review. Pharmacognosy Res., 2023, 15(2), 206-216.
[http://dx.doi.org/10.5530/pres.15.2.022]
[133]
Abotaleb, M.; Liskova, A.; Kubatka, P.; Büsselberg, D. Therapeutic potential of plant phenolic acids in the treatment of cancer. Biomolecules, 2020, 10(2), 221.
[http://dx.doi.org/10.3390/biom10020221] [PMID: 32028623]
[134]
Montané, X.; Kowalczyk, O.; Reig-Vano, B.; Bajek, A.; Roszkowski, K.; Tomczyk, R.; Pawliszak, W.; Giamberini, M.; Mocek-Płóciniak, A.; Tylkowski, B. Current perspectives of the applications of polyphenols and flavonoids in cancer therapy. Molecules, 2020, 25(15), 3342.
[http://dx.doi.org/10.3390/molecules25153342] [PMID: 32717865]
[135]
Bhosale, P.B.; Ha, S.E.; Vetrivel, P.; Kim, H.H.; Kim, S.M.; Kim, G.S. Functions of polyphenols and its anticancer properties in biomedical research: A narrative review. Transl. Cancer Res., 2020, 9(12), 7619-7631.
[http://dx.doi.org/10.21037/tcr-20-2359] [PMID: 35117361]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy