Login Register Cart 0
Generic placeholder image

Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Editorial

Repositioning of Antipsychotic Phenothiazines for Cancer Therapy: Nanotechnological Opportunities to Overcome Obstacles

Author(s): Tiago Rodrigues*

Volume 29, Issue 25, 2023

Published on: 24 August, 2023

Page: [1959 - 1960] Pages: 2

DOI: 10.2174/1381612829666230821092254

Price: $65

Next »
[1]
Ban TA. Fifty years chlorpromazine: A historical perspective. Neuropsychiatr Dis Treat 2007; 3(4): 495-500.
[PMID: 19300578]
[2]
Rodrigues T, Santos AC, Pigoso AA, Mingatto FE, Uyemura SA, Curti C. Thioridazine interacts with the membrane of mitochondria acquiring antioxidant activity toward apoptosis - potentially implicated mechanisms. Br J Pharmacol 2002; 136(1): 136-42.
[http://dx.doi.org/10.1038/sj.bjp.0704672] [PMID: 11976278]
[3]
Ordway D, Viveiros M, Leandro C, et al. Clinical concentrations of thioridazine kill intracellular multidrug-resistant Mycobacterium tuberculosis. Antimicrob Agents Chemother 2003; 47(3): 917-22.
[http://dx.doi.org/10.1128/AAC.47.3.917-922.2003] [PMID: 12604522]
[4]
Jabes DL, de Freitas Oliveira AC, Alencar VC, et al. Thioridazine inhibits gene expression control of the cell wall signaling pathway (CWI) in the human pathogenic fungus Paracoccidioides brasiliensis. Mol Genet Genomics 2016; 291(3): 1347-62.
[http://dx.doi.org/10.1007/s00438-016-1184-1] [PMID: 26956010]
[5]
Gralla RJ, Itri LM, Pisko SE, et al. Antiemetic efficacy of high-dose metoclopramide: Randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced nausea and vomiting. N Engl J Med 1981; 305(16): 905-9.
[http://dx.doi.org/10.1056/NEJM198110153051601] [PMID: 7024807]
[6]
Navari RM, Qin R, Ruddy KJ, et al. Olanzapine for the prevention of chemotherapy-induced nausea and vomiting. N Engl J Med 2016; 375(2): 134-42.
[http://dx.doi.org/10.1056/NEJMoa1515725] [PMID: 27410922]
[7]
Mortensen PB. The incidence of cancer in schizophrenic patients. J Epidemiol Community Health 1989; 43(1): 43-7.
[http://dx.doi.org/10.1136/jech.43.1.43] [PMID: 2592890]
[8]
Belkin M, Hardy WG. Effect of reserpine and chlorpromazine on sarcoma 37. Science 1957; 125(3241): 233-4.
[http://dx.doi.org/10.1126/science.125.3241.233] [PMID: 13401229]
[9]
de Faria PA, Bettanin F, Cunha RLOR, et al. Cytotoxicity of phenothiazine derivatives associated with mitochondrial dysfunction: A structure-activity investigation. Toxicology 2015; 330: 44-54.
[http://dx.doi.org/10.1016/j.tox.2015.02.004] [PMID: 25686698]
[10]
Moraes VWR, Santos VM, Suarez ER, et al. Targeting Ca2+ and mitochondrial homeostasis by antipsychotic thioridazine in leukemia cells. Life (Basel) 2022; 12(10): 1477.
[http://dx.doi.org/10.3390/life12101477] [PMID: 36294912]
[11]
Chu CW, Ko HJ, Chou CH, et al. Thioridazine enhances p62-mediated autophagy and apoptosis through Wnt/β-catenin signaling pathway in glioma cells. Int J Mol Sci 2019; 20(3): 473.
[http://dx.doi.org/10.3390/ijms20030473] [PMID: 30678307]
[12]
Spengler G, Molnar J, Viveiros M, Amaral L. Thioridazine induces apoptosis of multidrug-resistant mouse lymphoma cells transfected with the human ABCB1 and inhibits the expression of P-glycoprotein. Anticancer Res 2011; 31(12): 4201-5.
[PMID: 22199281]
[13]
Cibotaru S, Nastasa V, Sandu AI, Bostanaru AC, Mares M, Marin L. Pegylation of phenothiazine - A synthetic route towards potent anticancer drugs. J Adv Res 2022; 37: 279-90.
[http://dx.doi.org/10.1016/j.jare.2021.07.003] [PMID: 35499049]
[14]
Mello JC, Moraes VWR, Watashi CM, et al. Enhancement of chlorpromazine antitumor activity by Pluronics F127/L81 nanostructured system against human multidrug resistant leukemia. Pharmacol Res 2016; 111: 102-12.
[http://dx.doi.org/10.1016/j.phrs.2016.05.032] [PMID: 27265114]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy