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Current Drug Research Reviews

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ISSN (Print): 2589-9775
ISSN (Online): 2589-9783

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Systematic Review Article

The Effect of Fenugreek on the Severity of Dysmenorrhea: A Systematic Review and Meta-analysis

Author(s): Robab Hassanzadeh, Fatemeh Shabani, Maryam Montazeri and Mojgan Mirghafourvand*

Volume 16, Issue 2, 2024

Published on: 04 September, 2023

Page: [219 - 227] Pages: 9

DOI: 10.2174/2589977515666230818092814

Price: $65

Abstract

Introduction: Dysmenorrhea is the most common periodic pain, which affects more than 50% of women with regular menstruation. Fenugreek is one of the medicinal plants with analgesic properties. This study aimed to determine the effect of fenugreek application in the severity of dysmenorrhea and its side effects in women with dysmenorrhea.

PICO: Population: women with dysmenorrhea; Intervention: fenugreek; Comparison: control groups; and Outcome: reduction in the severity of dysmenorrhea and its side effects.

Methods: English database (PubMed, Cochrane Library, Scopus, and Web of Science) and Persian database [SID (Scientific Information Database) and Magiran] were used for research until February 11, 2023, using the keywords “Dysmenorrhea [Mesh],” “Foenum [Mesh],” “fenugreek [Mesh],” and “Trigonella [Mesh].” The reference list of the selected articles was also checked. The quality assessment was conducted through the Cochrane Handbook for Systematic Reviews of Interventions version 5.2.0. The RevMan 5.3 software was used to analyze and report the data of the entered studies. Meta-analysis results were reported with the standardized mean difference (95% confidence interval). A subgroup analysis was performed based on the type of control groups. The quality of evidence was assessed using the GRADE approach.

Results: After removing duplicates and ineligible cases, four articles were included in the systematic review out of the 1526 records obtained. The results showed that the pain intensity caused by primary dysmenorrhea decreased with fenugreek compared to placebo (pooled result SMD: -2.21; 95% CI: -3.26 to -1.17; Z: 4.17; p <0.001). There was no significant difference between fenugreek with mefenamic acid (SMD: 0.05; 95% CI: -0.57 to 0.67; Z: 0.17; p = 0.86) and fenugreek with Chandrasura churna (SMD: 0.06; 95% CI: -0.56 to 0.68; Z: 0.19; p = 0.85). Bias, in terms of incomplete outcome data and selective reporting, was low risk in all studies, and the available evidence was low quality according to the GRADE approach.

Conclusion: The results showed that the effect of fenugreek on pain intensity in dysmenorrhea is highly uncertain. The true effect is likely to be substantially different from the estimate of effect. Regarding the importance of the health and quality of life of women of reproductive age and the low quality of evidence of the studies, clinical trials with stronger methodology are suggested in this field.

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[1]
Iacovides S, Avidon I, Bentley A, Baker FC. Reduced quality of life when experiencing menstrual pain in women with primary dysmen-orrhea. Acta Obstet Gynecol Scand 2014; 93(2): 213-7.
[http://dx.doi.org/10.1111/aogs.12287] [PMID: 24266425]
[2]
Bajaj M. Approach to a woman presenting with lower abdominal pain. Clin Meth Obstet Gynecol 2020; 342: 328-41.
[3]
Itani R, Soubra L, Karout S, Rahme D, Karout L, Khojah HMJ. Primary dysmenorrhea: Pathophysiology, diagnosis, and treatment up-dates. Korean J Fam Med 2022; 43(2): 101-8.
[http://dx.doi.org/10.4082/kjfm.21.0103] [PMID: 35320895]
[4]
Sharghi M, Mansurkhani SM, Ashtary-Larky D, et al. An update and systematic review on the treatment of primary dysmenorrhea. JBRA Assist Reprod 2019; 23(1): 51-7.
[http://dx.doi.org/10.5935/1518-0557.20180083] [PMID: 30521155]
[5]
Karout S, Soubra L, Rahme D, Karout L, Khojah HMJ, Itani R. Prevalence, risk factors, and management practices of primary dysmen-orrhea among young females. BMC Wom Heal 2021; 21(1): 392.
[http://dx.doi.org/10.1186/s12905-021-01532-w] [PMID: 34749716]
[6]
Ferries-Rowe E, Corey E, Archer JS. Primary dysmenorrhea. Obstet Gynecol 2020; 136(5): 1047-58.
[http://dx.doi.org/10.1097/AOG.0000000000004096] [PMID: 33030880]
[7]
Nagy H, Khan MAB. Dysmenorrhea.StatPearls. Treasure Island, FL: StatPearls Publishing 2023. Available from: https:// www.ncbi. nlm. nih. gov/ books/NBK560834/(Updated 2022 Jul 18).
[8]
Fajrin I, Alam G, Usman AN. Prostaglandin level of primary dysmenorrhea pain sufferers. Enferm Clin 2020; 30: 5-9.
[http://dx.doi.org/10.1016/j.enfcli.2019.07.016]
[9]
Almanasef M, Alqarni H. Self-care strategies for the management of primary dysmenorrhea among young women in Asir region, Saudi Arabia: A cross-sectional study. Eur Rev Med Pharmacol Sci 2023; 27(1): 172-8.
[PMID: 36647866]
[10]
Rajput V. An overview on dysmenorrhea. Int J Nurs Educ 2021; 9(3): 381-4.
[11]
McKenna KA, Fogleman CD. Dysmenorrhea. Am Fam Physician 2021; 104(2): 164-70.
[PMID: 34383437]
[12]
Suryantini NP. Effleurage Massage: Alternative non-pharmacological therapy in decreasing dysmenorrhea pain. women. Midw Midwif 2022; 2(3): 41-50.
[13]
Yoshino O, Suzukamo Y, Yoshihara K, Takahashi N. Quality of life in Japanese Patients with dysmenorrhea or endometriosis-associated pelvic pain treated with extended regimen ethinylestradiol/drospirenone in a real-world setting: A prospective observational study. Adv Ther 2022; 39(11): 5087-104.
[http://dx.doi.org/10.1007/s12325-022-02301-3] [PMID: 36053449]
[14]
Xuan Y, Zhang H, Liu D, et al. The efficacy and safety of simple-needling for the treatment of primary dysmenorrhea compared with ibuprofen. Medicine 2022; 101(7): e28919.
[http://dx.doi.org/10.1097/MD.0000000000028919] [PMID: 35363216]
[15]
Wal A, Wal P, Gupta D, Kumar A, Sharma P, Kumar N. Natural products: A rising star for treating primary dysmenorrhea? Traditional Medicine Research 2022; 7(6): 55.
[http://dx.doi.org/10.53388/TMR20220410001]
[16]
Guo Y, Liu F-Y, Shen Y, Xu J-Y, Xie L-Z, Li S-Y, et al. Complementary and alternative medicine for dysmenorrhea caused by endome-triosis: A review of utilization and mechanism. Evid Based Complement Alternat Med 2021; 2021: 6663602.
[http://dx.doi.org/10.1155/2021/6663602]
[17]
Yadav SR, Biyani DM, Umekar MJ. Trigonella foenum-graecum: A herbal plant review. World J Pharm Res 2019; 8(12): 402-19.
[18]
Shahrajabian MH, Sun W, Magadlela A, Hong S, Cheng Q. Fenugreek cultivation in the middle east and other parts of the world with emphasis on historical aspects and its uses in traditional medicine and modern pharmaceutical science. Singapore: Fenugreek. Springer 2021; pp. 13-30.
[http://dx.doi.org/10.1007/978-981-16-1197-1_2]
[19]
Nimse S, Deshkar S. Fenugreek based products in USA, Australia, Canada, and India. Fenugreek: CRC Press 2022; pp. 441-51.
[20]
Meenakshi P, Singh D, Naveen K, Asheesh K. Therapeutic significance of Fenugreek WSR to its hypolipidemic activity. Int J Ayurveda Pharma Res 2017; 5(7): 58-62.
[21]
Padmaja K, Ramesh A, Prasad T. A review on phytochemistry and pharmacological profile of fenugreek. J Curr Pha Res 2015; 5(4): 1591-9.
[http://dx.doi.org/10.33786/JCPR.2015.v05i04.002]
[22]
Pellow J, Nienhuis C. Medicinal plants for primary dysmenorrhoea: A systematic review. Complement Ther Med 2018; 37: 13-26.
[http://dx.doi.org/10.1016/j.ctim.2018.01.001] [PMID: 29609924]
[23]
Idris S, Mishra A, Khushtar M. Recent therapeutic interventions of fenugreek seed: A mechanistic approach. Drug Res 2021; 71(4): 180-92.
[http://dx.doi.org/10.1055/a-1320-0479] [PMID: 33378775]
[24]
Camilo FM, Bossini PS, Driusso P, et al. The effects of electrode placement on analgesia using transcutaneous electrical nerve stimula-tion for primary dysmenorrhea: A single-blind randomized controlled clinical trial. Cureus 2023; 15(5): e39326.
[http://dx.doi.org/10.7759/cureus.39326] [PMID: 37378135]
[25]
Dworkin RH, Turk DC, McDermott MP, et al. Interpreting the clinical importance of group differences in chronic pain clinical trials: IMMPACT recommendations. Pain 2009; 146(3): 238-44.
[http://dx.doi.org/10.1016/j.pain.2009.08.019] [PMID: 19836888]
[26]
Inanmdar W, Sultana A, Mubeen U, Rahman K. Clinical efficacy of Trigonella foenum graecum (Fenugreek) and dry cupping therapy on intensity of pain in patients with primary dysmenorrhea. Chin J Integr Med 2016 May 25; 1-8.
[http://dx.doi.org/10.1007/s11655-016-2259-x] [PMID: 27225291]
[27]
Deepa K, Pradeep H, Shashikant M. Clinical evaluation of methika (trigonella foenum-graecum linn.) and chandrasura (Lepidium sativum Linn.). On kashtarthava 2018; 7(1): 1-8.
[28]
Younesy S, Amiraliakbari S, Esmaeili S, Alavimajd H, Nouraei S. Effects of fenugreek seed on the severity and systemic symptoms of dysmenorrhea. J Reprod Infertil 2014; 15(1): 41-8.
[PMID: 24695380]
[29]
Masoumi SZ, Shayan A, Ahmadinia H, Ebrahimi R, Ahmadi Niyatabesh R, Moradkhani S, et al. Effects of fenugreek seeds on the severity and duration of pain in primary dysmenorrhea in the students at Hamadan University of Medical sciences, Iran. J Obstet Gynecol Infertil 2018; 21(4): 25-33.
[30]
Joshi T, Kural M, Agrawal D, Noor N, Patil A. Primary dysmenorrhea and its effect on quality of life in young girls. Int J Med Sci Public Health 2015; 4(3): 381.
[http://dx.doi.org/10.5455/ijmsph.2015.0711201472]
[31]
Fernández-Martínez E, Onieva-Zafra MD, Parra-Fernández ML. The impact of dysmenorrhea on quality of life among Spanish female university students. Int J Environ Res Public Health 2019; 16(5): 713.
[http://dx.doi.org/10.3390/ijerph16050713] [PMID: 30818861]
[32]
Bergsjø P. Socioeconomic implications of dysmenorrhea. Obstet Gynecol 1979; 58(S87): 67-8.
[http://dx.doi.org/10.3109/00016347909157793]
[33]
Blumenthal M, Goldberg A, Brinckmann J. Herbal medicine: Expanded commission E monographs. Integ Med Commun Newton 2000; pp. 78-83.
[34]
Akbari M, Rasouli H, Bahdor T. Physiological and pharmaceutical effect of fenugreek: A review. IOSR J Pharm 2012; 2(4): 49-53.
[35]
Pattanittum P, Kunyanone N, Brown J, et al. Dietary supplements for dysmenorrhoea. Cochrane Database Syst Rev 2016; 3(3): CD002124.
[PMID: 27000311]
[36]
Khanna A, Thomas J, John F, Maliakel B, Krishnakumar IM. Safety and influence of a novel extract of fenugreek on healthy young women: A randomized, double-blinded, placebo-controlled study. Clin Phytosci 2021; 7(1): 63.
[http://dx.doi.org/10.1186/s40816-021-00296-y]
[37]
Mandegary A, Pournamdari M, Sharififar F, Pournourmohammadi S, Fardiar R, Shooli S. Alkaloid and flavonoid rich fractions of fenu-greek seeds (Trigonella foenum-graecum L.) with antinociceptive and anti-inflammatory effects. Food Chem Toxicol 2012; 50(7): 2503-7.
[http://dx.doi.org/10.1016/j.fct.2012.04.020] [PMID: 22542922]
[38]
Fields HL. How expectations influence pain. Pain 2018; 159(1): S3-S10.
[http://dx.doi.org/10.1097/j.pain.0000000000001272] [PMID: 30113941]
[39]
Wani SA, Kumar P. Fenugreek: A review on its nutraceutical properties and utilization in various food products. J Saudi Soc Agric Sci 2018; 17(2): 97-106.
[http://dx.doi.org/10.1016/j.jssas.2016.01.007]
[40]
Khan F, Negi K, Kumar T. Effect of sprouted fenugreek seeds on various diseases: A review. J Diabetes Metab Disord Control 2018; 5(4): 119-25.
[http://dx.doi.org/10.15406/jdmdc.2018.05.00149]
[41]
Bahmani M, Shirzad H, Mirhosseini M, Mesripour A, Rafieian-Kopaei M. A review on ethnobotanical and therapeutic uses of fenugreek (Trigonella foenum-graceum L). J Evid Based Complementary Altern Med 2016; 21(1): 53-62.
[http://dx.doi.org/10.1177/2156587215583405] [PMID: 25922446]

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