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Cardiovascular & Hematological Disorders-Drug Targets

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ISSN (Print): 1871-529X
ISSN (Online): 2212-4063

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Clinical Trial

Prevention of Preterm Labor by Isosorbide Dinitrate and Nitroglycerin Patch

Author(s): Masoumeh Ghafarzadeh, Amir Shakarami and Fatemeh Yari*

Volume 23, Issue 2, 2023

Published on: 05 October, 2023

Page: [130 - 135] Pages: 6

DOI: 10.2174/1871529X23666230818092437

Price: $65

Abstract

Background: Preterm labor is one of the most important causes of hospitalization during pregnancy and can lead to serious complications in neonates.

Objective: This study aims to compare the effect of transdermal nitroglycerin (TNG) patches and sublingual tablets of Isosorbide dinitrate (ISD) for the prevention of preterm delivery.

Methods: A total of 110 healthy pregnant women aged 18-35 years with a healthy and alive fetus and gestational age between 24-34 weeks who had at least 8 regular uterine contractions per hour were included in this single-blinded clinical trial. After exclusion, the women were randomly divided into TNG (n = 50) and ISD (n = 49) groups. After the first dose of medication (TNG or ISD), patients who developed complications such as hypotension, headache, or both, were also excluded from the study.

Results: A total of 58 patients completed the treatment course (29 patients in each group). A significant difference in delayed preterm labor and recovery time was reported between the TNG and ISD groups.

Conclusion: Complications and the number of contractions were not statistically different in the two groups. We concluded that the TNG patch is more effective than ISD in delaying labor. Both drugs are likely to have a similar incidence of side effects.

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[1]
Akbari, S.; Shahsavar, F.; Karami, R.; Yari, F.; Anbari, K.; Ahmadi, S.A.Y. Recurrent spontaneous abortion (RSA) and maternal KIR genes: A comprehensive meta-analysis. JBRA Assist. Reprod., 2020, 24(2), 197-213.
[http://dx.doi.org/10.5935/1518-0557.20190067] [PMID: 32049474]
[2]
Rundell, K.; Panchal, B. Preterm labor: Prevention and management. Am. Fam. Physician., 2017, 95(6), 366-372.
[PMID: 28318214]
[3]
Ghafarzadeh, M.; Shakarami, A.; Yari, F.; Namdari, P. The comparison of side effects of methyldopa, amlodipine, and metoprolol in pregnant women with chronic hypotension; Hypotension in Pregnancy, 2020, pp. 1-5.
[4]
Kiatsuda, D.; Thinkhamrop, J.; Prasertcharoensuk, W. Success rate in preterm uterine contraction inhibition with tocolytic agents in a tertiary care center. Int. J. Womens. Health., 2016, 8, 663-667.
[http://dx.doi.org/10.2147/IJWH.S122781] [PMID: 27895514]
[5]
Wax, J.R.; Cartin, A.; Pinette, M.G. Biophysical and biochemical screening for the risk of preterm labor. Clin. Lab. Med., 2016, 36(2), 369-383.
[http://dx.doi.org/10.1016/j.cll.2016.01.019] [PMID: 27235918]
[6]
Yari, F.; Behboodi, M.Z.; Parvizi, S.; Dehghan, N.N.; Rezaei, E.; Saadat, M. An evaluation of the effectiveness of a reproductive health education program for nonmedical students in Iran: A quasi-experimental pre-test, post-test research. Shiraz. E. Med. J., 2016, 17(3)
[http://dx.doi.org/10.17795/semj34772]
[7]
Vogel, J.P.; Nardin, J.M.; Dowswell, T.; West, H.M.; Oladapo, O.T. Combination of tocolytic agents for inhibiting preterm labour. Cochrane. Libr., 2014, (7), CD006169.
[http://dx.doi.org/10.1002/14651858.CD006169.pub2] [PMID: 25010869]
[8]
Duckitt, K.; Thornton, S.; O’Donovan, O.P.; Dowswell, T. Nitric oxide donors for treating preterm labour. Cochrane. Libr., 2014, 2014(5), CD002860.
[http://dx.doi.org/10.1002/14651858.CD002860.pub2] [PMID: 24809331]
[9]
Conde-Agudelo, A.; Romero, R. Transdermal nitroglycerin for the treatment of preterm labor: A systematic review and metaanalysis. Am. J. Obstet. Gynecol., 2013, 209(6), 551.e1-551.e18.
[http://dx.doi.org/10.1016/j.ajog.2013.07.022]
[10]
Haghighi, L.; Akbarian, A. Isosorbide dinitrate for treatment of preterm labor. Int. J. Gynaecol. Obstet., 2005, 89(3), 274-275.
[http://dx.doi.org/10.1016/j.ijgo.2005.03.004] [PMID: 15919396]
[11]
Haas, D.; Benjamin, T.; Sawyer, R.; Quinney, S. Short-term tocolytics for preterm delivery - current perspectives. Int. J. Womens. Health., 2014, 6, 343-349.
[http://dx.doi.org/10.2147/IJWH.S44048] [PMID: 24707187]
[12]
Flenady, V.; Wojcieszek, A.M.; Papatsonis, D.N.M.; Stock, O.M.; Murray, L.; Jardine, L.A.; Carbonne, B. Calcium channel blockers for inhibiting preterm labour and birth. Cochrane. Libr., 2014, 2014(6), CD002255.
[http://dx.doi.org/10.1002/14651858.CD002255.pub2] [PMID: 24901312]
[13]
Flenady, V.; Reinebrant, H.E.; Liley, H.G.; Tambimuttu, E.G.; Papatsonis, D.N.M. Oxytocin receptor antagonists for inhibiting preterm labour. Cochrane. Libr., 2014, (6), CD004452.
[http://dx.doi.org/10.1002/14651858.CD004452.pub3] [PMID: 24903678]
[14]
Ghomian, N.; Vahedalain, S.H.; Tavassoli, F.; Pourhoseini, S.A.; Heydari, S.T. Transdermal nitroglycerin versus oral nifedipine for suppression of preterm labor. Shiraz. E. Med. J., 2015, 16(11-12), e59923.
[http://dx.doi.org/10.17795/semj31018]
[15]
Shah, K.; Gupta, B.D.; Sharma, R. “Dermal Nitroglycerin Patch” in Treatment of Preterm Labour. J. Biosci. Med., 2015, 3(11), 82-90.
[http://dx.doi.org/10.4236/jbm.2015.311011]
[16]
Sharma, N.; Rani, S.; Huria, A.; Chawla, D. Oral nifedipine versus nitroglycerine patch for tocolysis in preterm labour. Int. J. Reprod. Contracept. Obstet. Gynecol., 2018, 8(1), 174-178.

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