Reproductive Toxicity of Nanoparticles: A Comprehensive Review

Title:Reproductive Toxicity of Nanoparticles: A Comprehensive Review

Volume: 31

Author(s): Elaheh Mohammadi, Behzad Behnam, Ahad Mokhtarzadeh, Ramin Rezaee, Ardavan Abiri, Mohammad Ramezani*, John P. Giesy*Amirhossein Sahebkar*

Affiliation:

• Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

• Toxicology Centre, Department of Veterinary Biomedical Sciences, University of Saskatchewan, 10 Campus Drive, Saskatoon, SKS7N 5B4, Canada
• Department of Environmental Sciences, Baylor University, Waco, 76798-7266, USA
• Department of Integrated Biology, Michigan State University, East Lansing, MI, USA

• Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
• Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract: The unique characteristics of nanoparticles (NPs) have captivated scientists in various fields of research. However, their safety profile has not been fully scrutinized. In this regard, the effects of NPs on the reproductive system of animals and humankind have been a matter of concern. In this article, we will review the potential reproductive toxicity of various types of NPs, including carbon nanomaterials, dendrimers, quantum dots, silica, gold, and magnetic nanoparticles, reported in the literature. We also mention some notable cases where NPs have elicited beneficial effects on the reproductive system. This review provides extensive insight into the effects of various NPs on sperm and ovum and the outcomes of their passage through blood-testis and placental barriers and accumulation in the reproductive organs.

Cite this article as:

Mohammadi Elaheh, Behnam Behzad, Mokhtarzadeh Ahad, Rezaee Ramin, Abiri Ardavan, Ramezani Mohammad*, Giesy P. John*, Sahebkar Amirhossein*, Reproductive Toxicity of Nanoparticles: A Comprehensive Review, Current Medicinal Chemistry 2024; 31 () . https://dx.doi.org/10.2174/0929867331666230815101141