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Current Alzheimer Research

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

Neuroprotection of Thioredoxin1 in the Brain

Author(s): Roxana Noriega-Navarro, Ricardo J. Martínez-Tapia, Juan L. Osornio-Hernández, Lucia Landa-Navarro, Luis O. Xinastle-Castillo, Abraham Landa and Luz Navarro*

Volume 20, Issue 5, 2023

Published on: 07 September, 2023

Page: [318 - 340] Pages: 23

DOI: 10.2174/1567205020666230809145041

Price: $65

Abstract

Thioredoxin1 (Trx1) is a ubiquitous antioxidant protein that regulates the cell's redox status. Trx1's thiol redox activity protects neurons from various physiological processes that cause neuronal damage and neurodegeneration, including oxidative stress, apoptosis, and inflammation. Several studies have found that direct or indirect Trx1 regulation has neuroprotective effects in the brain, protecting against, preventing, or delaying neurodegenerative processes or brain traumas. This review focuses on the term neuroprotection, Trx1 localization, and expression in the brain, as well as its modulation concerning its neuroprotective effect in both animal and clinical models of ischemia, hypoxia, hemorrhage, traumatic brain injury, epilepsy, Alzheimer's disease, and Parkinson's disease.

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