Login Register Cart 0
Generic placeholder image

Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Meta-Analysis

The Effects of Lycopene and Tomato Consumption on Cardiovascular Risk Factors in Adults: A Grade Assessment Systematic Review and Meta-analysis

Author(s): Mohammad Zamani, Farimah Behmanesh Nia, Kimia Ghaedi, Saba Mohammadpour, Niusha Amirani, Kian Goudarzi, Kosar Sadat Hosseini Kolbadi, Matin Ghanavati* and Damoon Ashtary-larky

Volume 29, Issue 21, 2023

Published on: 01 August, 2023

Page: [1671 - 1700] Pages: 30

DOI: 10.2174/1381612829666230726112510

Price: $65

Abstract

Background: In recent times, modifying dietary habits to control cardiovascular risk factors has gained significant attention. However, previous studies have yielded inconsistent results regarding the effects of lycopene and tomato consumption on cardiovascular risk factors.

Objective: The objective of this study was to assess the impact of consuming lycopene and tomatoes on various cardiovascular risks factors such as lipid profile, glycemic control markers, blood pressure, inflammation, oxidative stress, and body weight.

Methods: A systematic literature search was carried out using electronic databases, including PubMed, Web of Science, and Scopus, up to November 2022 to identify eligible Randomized Control Trials (RCTs) evaluating the effect of lycopene and tomato consumption on cardiovascular risk factors. Heterogeneity tests of the selected trials were performed using the I2 statistic. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as the weighted mean difference (WMD) with a 95% confidence interval (CI).

Results: Out of 27,438 records initially identified, a total of 34 studies met the eligibility criteria and were included in this meta-analysis. The results showed that lycopene consumption was associated with a significant reduction in malondialdehyde (MDA) levels, indicating a potential benefit in reducing oxidative stress. However, lycopene and tomato consumption did not have significant effects on other cardiovascular risk factors such as triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), systolic blood pressure (SBP), diastolic blood pressure (DBP), Intercellular Adhesion Molecule 1 (ICAM-1), c-reactive protein (CRP), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), body weight, and body mass index (BMI).

Conclusion: Overall, the findings showed that lycopene and tomato consumption did not affect cardiovascular risk factors. However, lycopene supplementation may result in a significant improvement in MDA levels. With the view to confirming these results, further studies with long-term duration and different doses are needed.

« Previous Next »
[1]
Gaziano TA, Bitton A, Anand S, Abrahams-Gessel S, Murphy A. Growing epidemic of coronary heart disease in low- and middle-income countries. Curr Probl Cardiol 2010; 35(2): 72-115.
[http://dx.doi.org/10.1016/j.cpcardiol.2009.10.002] [PMID: 20109979]
[2]
Mittal BV, Singh AK. Hypertension in the developing world: Challenges and opportunities. Am J Kidney Dis 2010; 55(3): 590-8.
[http://dx.doi.org/10.1053/j.ajkd.2009.06.044] [PMID: 19962803]
[3]
Naghavi M, Abajobir AA, Abbafati C, et al. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet 2017; 390(10100): 1151-210.
[http://dx.doi.org/10.1016/S0140-6736(17)32152-9] [PMID: 28919116]
[4]
Mensah GA, Wei GS, Sorlie PD, et al. Decline in cardiovascular mortality. Circ Res 2017; 120(2): 366-80.
[http://dx.doi.org/10.1161/CIRCRESAHA.116.309115] [PMID: 28104770]
[5]
Rosiek A, Leksowski K. The risk factors and prevention of cardiovascular disease: the importance of electrocardiogram in the diagnosis and treatment of acute coronary syndrome. Ther Clin Risk Manag 2016; 12: 1223-9.
[http://dx.doi.org/10.2147/TCRM.S107849] [PMID: 27540297]
[6]
Birger M, Kaldjian AS, Roth GA, Moran AE, Dieleman JL, Bellows BK. Spending on cardiovascular disease and cardiovascular risk factors in the United States: 1996 to 2016. Circulation 2021; 144(4): 271-82.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.120.053216] [PMID: 33926203]
[7]
De Backer G, Ambrosioni E, Borch-Johnsen K, et al. European guidelines on cardiovascular disease prevention in clinical practice. Third Joint Task Force of European and other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of eight societies and by invited experts). Eur Heart J 2003; 24(17): 1601-10.
[http://dx.doi.org/10.1016/S0195-668X(03)00347-6] [PMID: 12964575]
[8]
Chareonrungrueangchai K, Wongkawinwoot K, Anothaisintawee T, Reutrakul S. Dietary factors and risks of cardiovascular diseases: An umbrella review. Nutrients 2020; 12(4): 1088.
[http://dx.doi.org/10.3390/nu12041088] [PMID: 32326404]
[9]
Shoaibinobarian N, Eslamian G, Noormohammadi M, Malek S, Rouhani S, Mirmohammadali SN. Dietary total antioxidant capacity and risk of polycystic ovary syndrome: A case-control study. Int J Fertil Steril 2022; 16(3): 200-5.
[PMID: 36029057]
[10]
Bechthold A, Boeing H, Schwedhelm C, et al. Food groups and risk of coronary heart disease, stroke and heart failure: A systematic review and dose-response meta-analysis of prospective studies. Crit Rev Food Sci Nutr 2019; 59(7): 1071-90.
[http://dx.doi.org/10.1080/10408398.2017.1392288] [PMID: 29039970]
[11]
Noormohammadi M, Eslamian G, Malek S, Shoaibinobarian N, Mirmohammadali SN. The association between fertility diet score and polycystic ovary syndrome: A case-control study. Health Care Women Int 2022; 43(1-3): 70-84.
[http://dx.doi.org/10.1080/07399332.2021.1886298] [PMID: 33797335]
[12]
Gan ZH, Cheong HC, Tu YK, Kuo PH. Association between plant-based dietary patterns and risk of cardiovascular disease: A systematic review and meta-analysis of prospective cohort studies. Nutrients 2021; 13(11): 3952.
[http://dx.doi.org/10.3390/nu13113952] [PMID: 34836208]
[13]
Kim H, Caulfield LE, Garcia-Larsen V, Steffen LM, Coresh J, Rebholz CM. Plant‐based diets are associated with a lower risk of incident cardiovascular disease, cardiovascular disease mortality, and all‐cause mortality in a general population of middle‐aged adults. J Am Heart Assoc 2019; 8(16): e012865.
[http://dx.doi.org/10.1161/JAHA.119.012865] [PMID: 31387433]
[14]
Jafari N. The effects of purslane consumption on glycemic control and oxidative stress: A systematic review and dose-response meta-analysis. Food Sci Nutr 2023; 1.
[http://dx.doi.org/10.1002/fsn3.3311]
[15]
Aune D, Giovannucci E, Boffetta P, et al. Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality-a systematic review and dose-response meta-analysis of prospective studies. Int J Epidemiol 2017; 46(3): 1029-56.
[http://dx.doi.org/10.1093/ije/dyw319] [PMID: 28338764]
[16]
Ignarro L, Balestrieri M, Napoli C. Nutrition, physical activity, and cardiovascular disease: An update. Cardiovasc Res 2007; 73(2): 326-40.
[http://dx.doi.org/10.1016/j.cardiores.2006.06.030] [PMID: 16945357]
[17]
Burton-Freeman B, Reimers K. Tomato consumption and health: Emerging benefits. Am J Lifestyle Med 2011; 5(2): 182-91.
[http://dx.doi.org/10.1177/1559827610387488]
[18]
Collins EJ, Bowyer C, Tsouza A, Chopra M. Tomatoes: An extensive review of the associated health impacts of tomatoes and factors that can affect their cultivation. Biology 2022; 11(2): 239.
[http://dx.doi.org/10.3390/biology11020239] [PMID: 35205105]
[19]
Perveen R, Suleria HAR, Anjum FM, Butt MS, Pasha I, Ahmad S. Tomato (Solanum lycopersicum) carotenoids and lycopenes chemistry; metabolism, absorption, nutrition, and allied health claims-a comprehensive review. Crit Rev Food Sci Nutr 2015; 55(7): 919-29.
[http://dx.doi.org/10.1080/10408398.2012.657809] [PMID: 24915375]
[20]
Ried K, Fakler P. Protective effect of lycopene on serum cholesterol and blood pressure: Meta-analyses of intervention trials. Maturitas 2011; 68(4): 299-310.
[http://dx.doi.org/10.1016/j.maturitas.2010.11.018] [PMID: 21163596]
[21]
Palozza P, Catalano A, Simone RE, Mele MC, Cittadini A. Effect of lycopene and tomato products on cholesterol metabolism. Ann Nutr Metab 2012; 61(2): 126-34.
[http://dx.doi.org/10.1159/000342077] [PMID: 22965217]
[22]
Cheng HM, Koutsidis G, Lodge JK, Ashor A, Siervo M, Lara J. Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis. Atherosclerosis 2017; 257: 100-8.
[http://dx.doi.org/10.1016/j.atherosclerosis.2017.01.009] [PMID: 28129549]
[23]
Wang Y, Juanjuan L, Can Z. The effect of tomato on weight, body mass index, blood pressure and inflammatory factors: A systematic review and dose-response meta-analysis of randomized controlled trials. J King Saud Univ Sci 2019; 32: 2-1627.: 1619-27.
[24]
Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med 2009; 6(7): e1000097.
[http://dx.doi.org/10.1371/journal.pmed.1000097] [PMID: 19621072]
[25]
Higgins JPT, Altman DG, Gøtzsche PC, et al. The cochrane collaboration’s tool for assessing risk of bias in randomised trials. BMJ 2011; 343(oct18 2): d5928.
[http://dx.doi.org/10.1136/bmj.d5928] [PMID: 22008217]
[26]
DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986; 7(3): 177-88.
[http://dx.doi.org/10.1016/0197-2456(86)90046-2] [PMID: 3802833]
[27]
Borenstein M, Larry VH, Julian PTH, Hannah RR. Introduction to meta-analysis. John Wiley & Sons 2011.
[28]
Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 2005; 5(1): 13.
[http://dx.doi.org/10.1186/1471-2288-5-13] [PMID: 15840177]
[29]
Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003; 327(7414): 557-60.
[http://dx.doi.org/10.1136/bmj.327.7414.557] [PMID: 12958120]
[30]
Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002; 21(11): 1539-58.
[http://dx.doi.org/10.1002/sim.1186] [PMID: 12111919]
[31]
Mitchell MN. Interpreting and visualizing regression models using Stata. TX: Stata Press College Station 2012; p. 558.
[32]
Tobias A. Assessing the influence of a single study in the meta-anyalysis estimate. Stata Tech Bull 1999; 8(47)
[33]
Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315(7109): 629-34.
[http://dx.doi.org/10.1136/bmj.315.7109.629] [PMID: 9310563]
[34]
Guyatt GH, Oxman AD, Vist GE, et al. GRADE: An emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008; 336(7650): 924-6.
[http://dx.doi.org/10.1136/bmj.39489.470347.AD] [PMID: 18436948]
[35]
Gholami F, Antonio J, Evans C, Cheraghi K, Rahmani L, Amirnezhad F. Tomato powder is more effective than lycopene to alleviate exercise-induced lipid peroxidation in well-trained male athletes: Randomized, double-blinded cross-over study. J Int Soc Sports Nutr 2021; 18(1): 17.
[http://dx.doi.org/10.1186/s12970-021-00415-7] [PMID: 33639967]
[36]
Schwarz S, Obermüller-Jevic UC, Hellmis E, Koch W, Jacobi G, Biesalski HK. Lycopene inhibits disease progression in patients with benign prostate hyperplasia. J Nutr 2008; 138(1): 49-53.
[http://dx.doi.org/10.1093/jn/138.1.49] [PMID: 18156403]
[37]
Misra R, Mangi S, Joshi S, Mittal S, Gupta SK, Pandey RM. LycoRed as an alternative to hormone replacement therapy in lowering serum lipids and oxidative stress markers: A randomized controlled clinical trial. J Obstet Gynaecol Res 2006; 32(3): 299-304.
[http://dx.doi.org/10.1111/j.1447-0756.2006.00410.x] [PMID: 16764620]
[38]
Wiese M, Bashmakov Y, Chalyk N, et al. Prebiotic effect of lycopene and dark chocolate on gut microbiome with systemic changes in liver metabolism, skeletal muscles and skin in moderately obese persons. BioMed Res Int 2019; 2019: 1-15.
[http://dx.doi.org/10.1155/2019/4625279] [PMID: 31317029]
[39]
Thies F, Masson LF, Rudd A, et al. Effect of a tomato-rich diet on markers of cardiovascular disease risk in moderately overweight, disease-free, middle-aged adults: A randomized controlled trial. Am J Clin Nutr 2012; 95(5): 1013-22.
[http://dx.doi.org/10.3945/ajcn.111.026286] [PMID: 22492370]
[40]
Tian Z, Fan D, Li K, et al. Four-week supplementation of water-soluble tomato extract attenuates platelet function in chinese healthy middle-aged and older individuals: A randomized, double-blinded, and crossover clinical trial. Front Nutr 2022; 9: 891241.
[http://dx.doi.org/10.3389/fnut.2022.891241] [PMID: 35719156]
[41]
Chernyshova MP, Pristenskiy DV, Lozbiakova MV, Chalyk NE, Bandaletova TY, Petyaev IM. Systemic and skin-targeting beneficial effects of lycopene-enriched ice cream: A pilot study. J Dairy Sci 2019; 102(1): 14-25.
[http://dx.doi.org/10.3168/jds.2018-15282] [PMID: 30447975]
[42]
Xaplanteris P, Vlachopoulos C, Pietri P, et al. Tomato paste supplementation improves endothelial dynamics and reduces plasma total oxidative status in healthy subjects. Nutr Res 2012; 32(5): 390-4.
[http://dx.doi.org/10.1016/j.nutres.2012.03.011] [PMID: 22652379]
[43]
Markovits N, Ben Amotz A, Levy Y. The effect of tomato-derived lycopene on low carotenoids and enhanced systemic inflammation and oxidation in severe obesity. Isr Med Assoc J 2009; 11(10): 598-601.
[PMID: 20077945]
[44]
Ried K, Frank OR, Stocks NP. Dark chocolate or tomato extract for prehypertension: A randomised controlled trial. BMC Complement Altern Med 2009; 9(1): 22.
[http://dx.doi.org/10.1186/1472-6882-9-22] [PMID: 19583878]
[45]
Engelhard YN, Gazer B, Paran E. Natural antioxidants from tomato extract reduce blood pressure in patients with grade-1 hypertension: A double-blind, placebo-controlled pilot study. Am Heart J 2006; 151(1): 100.e6-1.
[http://dx.doi.org/10.1016/j.ahj.2005.05.008] [PMID: 16368299]
[46]
Collins JK, Arjmandi BH, Claypool PL, Perkins-Veazie P, Baker RA, Clevidence BA. Lycopene from two food sources does not affect antioxidant or cholesterol status of middle-aged adults. Nutr J 2004; 3(1): 15.
[http://dx.doi.org/10.1186/1475-2891-3-15] [PMID: 15369594]
[47]
Upritchard JE, Sutherland WH, Mann JI. Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes. Diabetes Care 2000; 23(6): 733-8.
[http://dx.doi.org/10.2337/diacare.23.6.733] [PMID: 10840987]
[48]
Neyestani TR, Shariat-Zadeh N, Gharavi A, Kalayi A, Khalaji N. The opposite associations of lycopene and body fat mass with humoral immunity in type 2 diabetes mellitus: a possible role in atherogenesis. Iran J Allergy Asthma Immunol 2007; 6(2): 79-87.
[PMID: 17563408]
[49]
Yang TH, Chen YC, Ou TH, Chien YW. Dietary supplement of tomato can accelerate urinary aMT6s level and improve sleep quality in obese postmenopausal women. Clin Nutr 2020; 39(1): 291-7.
[http://dx.doi.org/10.1016/j.clnu.2019.02.009] [PMID: 30792141]
[50]
Hughes DA, Wright AJA, Finglas PM, et al. Effects of lycopene and lutein supplementation on the expression of functionally associated surface molecules on blood monocytes from healthy male nonsmokers. J Infect Dis 2000; 182(S1): S11-5.
[http://dx.doi.org/10.1086/315910] [PMID: 10944479]
[51]
Maruyama C, Imamura K, Oshima S, et al. Effects of tomato juice consumption on plasma and lipoprotein carotenoid concentrations and the susceptibility of low density lipoprotein to oxidative modification. J Nutr Sci Vitaminol 2001; 47(3): 213-21.
[http://dx.doi.org/10.3177/jnsv.47.213] [PMID: 11575576]
[52]
Briviba K, Kulling SE, Möseneder J, Watzl B, Rechkemmer G, Bub A. Effects of supplementing a low-carotenoid diet with a tomato extract for 2 weeks on endogenous levels of DNA single strand breaks and immune functions in healthy non-smokers and smokers. Carcinogenesis 2004; 25(12): 2373-8.
[http://dx.doi.org/10.1093/carcin/bgh249] [PMID: 15308586]
[53]
Riso P, Visioli F, Grande S, et al. Effect of a tomato-based drink on markers of inflammation, immunomodulation, and oxidative stress. J Agric Food Chem 2006; 54(7): 2563-6.
[http://dx.doi.org/10.1021/jf053033c] [PMID: 16569044]
[54]
Blum A, Monir M, Khazim K, Peleg A, Blum N. Tomato-rich (Mediterranean) diet does not modify inflammatory markers. Clin Invest Med 2007; 30(2): 70.
[http://dx.doi.org/10.25011/cim.v30i2.982] [PMID: 17716544]
[55]
Devaraj S, Mathur S, Basu A, et al. A dose-response study on the effects of purified lycopene supplementation on biomarkers of oxidative stress. J Am Coll Nutr 2008; 27(2): 267-73.
[http://dx.doi.org/10.1080/07315724.2008.10719699] [PMID: 18689558]
[56]
Nishimura M, Tominaga N, Ishikawa-Takano Y, Maeda-Yamamoto M, Nishihira J. Effect of 12-week daily intake of the high-lycopene tomato (Solanum lycopersicum), a variety named “PR-7”, on lipid metabolism: A randomized, double-blind, placebo-controlled, parallel-group study. Nutrients 2019; 11(5): 1177.
[http://dx.doi.org/10.3390/nu11051177] [PMID: 31130668]
[57]
Gajendragadkar PR, Hubsch A, Mäki-Petäjä KM, Serg M, Wilkinson IB, Cheriyan J. Effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers: A randomised controlled trial. PLoS One 2014; 9(6): e99070.
[http://dx.doi.org/10.1371/journal.pone.0099070] [PMID: 24911964]
[58]
Petyaev IM, Dovgalevsky PY, Chalyk NE, Klochkov V, Kyle NH. Reduction in blood pressure and serum lipids by lycosome formulation of dark chocolate and lycopene in prehypertension. Food Sci Nutr 2014; 2(6): 744-50.
[http://dx.doi.org/10.1002/fsn3.169] [PMID: 25493193]
[59]
Kim JY, Paik JK, Kim OY, et al. Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men. Atherosclerosis 2011; 215(1): 189-95.
[http://dx.doi.org/10.1016/j.atherosclerosis.2010.11.036] [PMID: 21194693]
[60]
Gamze Kırkıl, MD Muz MH. Enver Sancaktar MD Dilara Kaman MD, Şahin K, Küçük Ö. The effect of lycopene supplementation on chronic obstructive lung disease. Nobel Med 2012; 8: 98-104.
[61]
Cuevas-Ramos D, Almeda-Valdés P, Chávez-Manzanera E. Effect of tomato consumption on high-density lipoprotein cholesterol level: A randomized, single-blinded, controlled clinical trial. Diabetes Metab Syndr Obes 2013; 6: 263-73.
[http://dx.doi.org/10.2147/DMSO.S48858] [PMID: 23935376]
[62]
Ghavipour M, Saedisomeolia A, Djalali M, et al. Tomato juice consumption reduces systemic inflammation in overweight and obese females. Br J Nutr 2013; 109(11): 2031-5.
[http://dx.doi.org/10.1017/S0007114512004278] [PMID: 23069270]
[63]
Ghavipour M, Sotoudeh G, Ghorbani M. Tomato juice consumption improves blood antioxidative biomarkers in overweight and obese females. Clin Nutr 2015; 34(5): 805-9.
[http://dx.doi.org/10.1016/j.clnu.2014.10.012] [PMID: 25466953]
[64]
Pourahmadi Z, Mahboob S, Saedisomeolia A, Reykandeh MT. The effect of tomato juice consumption on antioxidant status in overweight and obese females. Women Health 2015; 55(7): 795-804.
[http://dx.doi.org/10.1080/03630242.2015.1050546] [PMID: 26086066]
[65]
Park E, Stacewicz-Sapuntzakis M, Sharifi R, Wu Z, Freeman VL, Bowen PE. Diet adherence dynamics and physiological responses to a tomato product whole-food intervention in African–American men. Br J Nutr 2013; 109(12): 2219-30.
[http://dx.doi.org/10.1017/S0007114512004436] [PMID: 23200261]
[66]
Samaras A, Tsarouhas K, Paschalidis E, et al. Effect of a special carbohydrate-protein bar and tomato juice supplementation on oxidative stress markers and vascular endothelial dynamics in ultra-marathon runners. Food Chem Toxicol 2014; 69: 231-6.
[http://dx.doi.org/10.1016/j.fct.2014.03.029] [PMID: 24705018]
[67]
Biddle MJ, Lennie TA, Bricker GV, Kopec RE, Schwartz SJ, Moser DK. Lycopene dietary intervention: A pilot study in patients with heart failure. J Cardiovasc Nurs 2015; 30(3): 205-12.
[http://dx.doi.org/10.1097/JCN.0000000000000108] [PMID: 24651682]
[68]
Xu Xy. Lycopene supplementation decreases oxidative stress in hemodialysis patients receiving intravenous iron therapy: An open-label, randomized controlled clinical trial. Eur J Inflamm 2019; 17.
[69]
Mazidi M. Tomato and lycopene consumption is inversely associated with total and cause-specific mortality: A population-based cohort study, on behalf of the International Lipid Expert Panel (ILEP). Br J Nutr 2020; 124(12): 1303-10.
[70]
Ito Y, Mio K, Koji S, et al. Cardiovascular disease mortality and serum carotenoid levels: A Japanese population-based follow-up study. J Epidemiol 2006; 16(4): 154-60.
[http://dx.doi.org/10.2188/jea.16.154]
[71]
Zurbau A, Fei A, Sonia BM, et al. Relation of different fruit and vegetable sources with incident cardiovascular outcomes: a systematic review and meta‐analysis of prospective cohort studies. J Am Heart Assoc 2020; 9(19): e017728.
[http://dx.doi.org/10.1161/JAHA.120.017728]
[72]
Bergin P, Leggett A, Cardwell CR, et al. The effects of vitamin E supplementation on malondialdehyde as a biomarker of oxidative stress in haemodialysis patients: a systematic review and meta-analysis. BMC Nephrol 2021; 22(1): 126.
[http://dx.doi.org/10.1186/s12882-021-02328-8] [PMID: 33832458]
[73]
Gaweł S, Wardas M, Niedworok E, Wardas P. Malondialdehyde (MDA) as a lipid peroxidation marker. Wiad Lek 2004; 57(9-10): 453-5.
[PMID: 15765761]
[74]
Asbaghi O, Naeini F, Ashtary-Larky D, et al. Effects of chromium supplementation on blood pressure, body mass index, liver function enzymes and malondialdehyde in patients with type 2 diabetes: A systematic review and dose-response meta-analysis of randomized controlled trials. Complement Ther Med 2021; 60: 102755.
[http://dx.doi.org/10.1016/j.ctim.2021.102755] [PMID: 34237387]
[75]
Haghighat N, Shimi G, Shiraseb F, et al. The effects of conjugated linoleic acid supplementation on liver function enzymes and malondialdehyde in adults: A GRADE-assessed systematic review and dose-response meta-analysis. Pharmacol Res 2022; 186: 106518.
[http://dx.doi.org/10.1016/j.phrs.2022.106518] [PMID: 36270407]
[76]
Romuk E, Wojciechowska C. Jacheć W, et al Malondialdehyde and uric acid as predictors of adverse outcome in patients with chronic heart failure. Oxid Med Cell Longev 2019; 2019: 1-15.
[http://dx.doi.org/10.1155/2019/9246138] [PMID: 31687090]
[77]
Kaefer M, De Carvalho JA, Piva SJ, et al. Plasma malondialdehyde levels and risk factors for the development of chronic complications in type 2 diabetic patients on insulin therapy. Clin Lab 2012; 58(9-10): 973-8.
[PMID: 23163113]
[78]
Naseri K, Saadati S, Ghaemi F, et al. The effects of probiotic and synbiotic supplementation on inflammation, oxidative stress, and circulating adiponectin and leptin concentration in subjects with prediabetes and type 2 diabetes mellitus: A GRADE-assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials. Eur J Nutr 2023; 62(2): 543-61.
[PMID: 36239789]
[79]
Asbaghi O, Ghanavati M, Ashtary-Larky D, et al. Effects of folic acid supplementation on oxidative stress markers: A systematic review and meta-analysis of randomized controlled trials. Antioxidants 2021; 10(6): 871.
[http://dx.doi.org/10.3390/antiox10060871] [PMID: 34071500]
[80]
Heber D. Lu Q-YJEb. Overview of mechanisms of action of lycopene. Exp Biol Med 2002; 227(10): 920-3.
[81]
Mirahmadi M, Shayan A, Ehsan S, et al. Potential inhibitory effect of lycopene on prostate cancer. Biomed Pharmacother 2020; 129: 110459.
[http://dx.doi.org/10.1016/j.biopha.2020.110459]
[82]
Xu F, Kaiyuan Y, Hongyan Y, et al. Lycopene relieves AFB1-induced liver injury through enhancing hepatic antioxidation and detoxification potential with Nrf2 activation. J Funct Foods 2017; 39: 215-24.
[83]
Karaca A, Yilmaz S, Kaya E, Altun S. The effect of lycopene on hepatotoxicity of aflatoxin B1 in rats. Arch Physiol Biochem 2021; 127(5): 429-36.
[http://dx.doi.org/10.1080/13813455.2019.1648516] [PMID: 31378089]
[84]
Agca CA, Tuzcu M, Gencoglu H, et al. Lycopene counteracts the hepatic response to 7,12-dimethylbenz[ a]anthracene by altering the expression of Bax, Bcl-2, caspases, and oxidative stress biomarkers. Pharm Biol 2012; 50(12): 1513-8.
[http://dx.doi.org/10.3109/13880209.2012.688057] [PMID: 22978712]
[85]
Sesso HD, Simin L, Michael JL, et al. Dietary lycopene, tomato-based food products and cardiovascular disease in women. J Nutr 2003; 133(7): 2336-41.
[http://dx.doi.org/10.1093/jn/133.7.2336]
[86]
Chen J, John S, Sophia JX, et al. Comparison of lycopene stability in water-and oil-based food model systems under thermal-and light-irradiation treatments. Lwt-food Sci T 2009; 42(3): 740-7.
[http://dx.doi.org/10.1016/j.lwt.2008.10.002]
[87]
Gutiérrez Galán DK, Dayne K, Pacheco-Moisés FP, et al. Hydrophilic lycopene-coated layered double hydroxide nanoparticles to enhance the antioxidant activity and the oxidative stress evaluation. Appl Nanosci 2021; 11(11): 2747-58.
[http://dx.doi.org/10.1007/s13204-021-02205-8]
[88]
Chen J, Song Y. Zhang LJJomf. Effect of lycopene supplementation on oxidative stress: An exploratory systematic review and meta-analysis of randomized controlled trials. J Med Food 2013; 16(5): 361-74.
[http://dx.doi.org/10.1089/jmf.2012.2682]
[89]
Caseiro M, Andreia A, Ana C, et al. Lycopene in human health. LWT 2020; 127: 109323.
[http://dx.doi.org/10.1016/j.lwt.2020.109323]
[90]
Asbaghi O, Omid A, Behzad N, et al. Lycopene supplementation and blood pressure: Systematic review and meta-analyses of randomized trials. J Herb Med 2022; 31: 100521.
[91]
Jacques PF, Asya L, Joseph MM, et al. Relationship of lycopene intake and consumption of tomato products to incident CVD. Br J Nutr 2013; 110(3): 545-51.
[http://dx.doi.org/10.1017/S0007114512005417]
[92]
Karppi J, Jari AL, Juhani S, et al. Serum lycopene decreases the risk of stroke in men: A population-based follow-up study. Neurology 2012; 79(15): 1540-7.
[http://dx.doi.org/10.1212/WNL.0b013e31826e26a6]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy