Anti Oxidant Property of New Cephalosporin-Aminoglycoside Fixed Dose Combination

Title: Anti Oxidant Property of New Cephalosporin-Aminoglycoside Fixed Dose Combination

Volume: 4 Issue: 1

Author(s): Manu Chaudhary, Arvind Soni, Vivek Kumar Dwivedi and Rajesh Sehgal

Affiliation:

Keywords: Cephalosporin, aminoglycoside, free radicals, catalase, superoxide dismutase, malonaldialdehyde

Abstract: Aminoglycosides are known to cause oxidative stress related toxicities and tissue injuries. Present study was planned to evaluate the effect of aminoglycosides on blood oxidative stress parameters in mice and free radical scavenging potential of cephalosporins, when combined as a single injection with aminoglycosides using chemical vector mediated technology. Mus musculus mice were divided into five groups: Control group animals (treated with normal saline), amikacin treated group, tobramycin treated group, cefepime + amikacin treated group and ceftazidime + tobramycin treated group. A significant improvement in superoxide dismutase (SOD), catalase activities, along with malonaldialdehyde (MDA) levels and creatinine levels were observed in fixed dose combination of cephalosporins and aminoglycosides treated groups as compared to aminoglycosides alone (amikacin and tobramycin) treated groups. These findings indicate that on combining cephalosporins with aminoglycosides using chemical vector mediated technology prevents oxidative stress related tissues injury induced by aminoglycosides.

Cite this article as:

Chaudhary Manu, Soni Arvind, Dwivedi Kumar Vivek and Sehgal Rajesh, Anti Oxidant Property of New Cephalosporin-Aminoglycoside Fixed Dose Combination, Current Drug Therapy 2009; 4 (1) . https://dx.doi.org/10.2174/157488509787081877