Abstract
Aminoglycosides represent an important resource against infectious diseases. However, the prevalence of aminoglycoside resistant bacteria has limited their clinical efficacy and prompted the renewed interest in the study of resistant mechanisms as well as the development of novel aminoglycoside antibiotics. This review will focus on the latest development in the design and synthesis of novel aminoglycoside derivatives.
Keywords: Tobramycin Derivatives, O-5 Glycosylated Neomycin, methicillin resistant S. aureus (MRSA), Conformational constrained neomycin, RNA targets, Kanamycin, glycosylation
Anti-Infective Agents in Medicinal Chemistry
Title: Recent Developments in the Synthesis of Novel Aminoglycoside Antibiotics
Volume: 5 Issue: 3
Author(s): Jie Li and Cheng-Wei Tom Chang
Affiliation:
Keywords: Tobramycin Derivatives, O-5 Glycosylated Neomycin, methicillin resistant S. aureus (MRSA), Conformational constrained neomycin, RNA targets, Kanamycin, glycosylation
Abstract: Aminoglycosides represent an important resource against infectious diseases. However, the prevalence of aminoglycoside resistant bacteria has limited their clinical efficacy and prompted the renewed interest in the study of resistant mechanisms as well as the development of novel aminoglycoside antibiotics. This review will focus on the latest development in the design and synthesis of novel aminoglycoside derivatives.
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Cite this article as:
Li Jie and Tom Chang Cheng-Wei, Recent Developments in the Synthesis of Novel Aminoglycoside Antibiotics, Anti-Infective Agents in Medicinal Chemistry 2006; 5 (3) . https://dx.doi.org/10.2174/187152106777697844
DOI https://dx.doi.org/10.2174/187152106777697844 |
Print ISSN 1871-5214 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6018 |