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Current Computer-Aided Drug Design

Editor-in-Chief

ISSN (Print): 1573-4099
ISSN (Online): 1875-6697

Research Article

Exploring the Molecular Mechanism of HongTeng Decoction against Inflammation based on Network Analysis and Experiments Validation

Author(s): Yuanyuan Yang, Chongwen Bi, Bin Li, Yun Li, Yin Song, Minghui Zhang, Longxi Peng, Dongmei Fan*, Rong Duan* and Zhengxiang Li*

Volume 20, Issue 2, 2024

Published on: 03 July, 2023

Page: [170 - 182] Pages: 13

DOI: 10.2174/1573409919666230612103201

Price: $65

Abstract

Background: HongTeng Decoction (HTD) is a traditional Chinese medicine that is widely used to treat bacterial infections and chronic inflammation. However, its pharmacological mechanism is not clear. Here, network pharmacology and experimental verification were applied to investigate the drug targets and potential mechanisms of HTD in inflammation treatment.

Methods: The active ingredients of HTD were collected from the multi-source databases and clarified by Q Exactive Orbitrap analysis in the treatment of inflammation. Then, molecular docking technology was used to explore the binding ability of key active ingredients and targets in HTD. In vitro experiments, the inflammatory factors and MAPK signaling pathways are detected to verify the anti-inflammatory effect of HTD on the RAW264.7 cells. Finally, the anti-inflammatory effect of HTD was evaluated in LPS induced mice model.

Results: A total of 236 active compounds and 492 targets of HTD were obtained through database screening, and 954 potential targets of inflammation were identified. Finally, 164 possible targets of HTD acting on inflammation were obtained. The PPI analysis and KEGG enrichment analyses showed that the targets of HTD in inflammation were mostly related to the MAPK signaling pathway, the IL-17 signaling pathway, and the TNF signaling pathway. By integrating the results of the network analysis, the core targets of HTD in inflammation mainly include MAPK3, TNF, MMP9, IL6, EGFR, and NFKBIA. The molecular docking results indicated solid binding activity between MAPK3-naringenin and MAPK3-paeonol. It has been shown that HTD could inhibit the levels of inflammatory factors, IL6 and TNF-α, as well as the splenic index in the LPS-stimulated mice. Moreover, HTD could regulate protein expression levels of p-JNK1/2, and p-ERK1/2, which reflects the inhibitory effect of HTD on the MAPKS signaling pathway.

Conclusion: Our study is expected to provide the pharmacological mechanisms by which HTD may be a promising anti-inflammatory drug for future clinical trials.

Graphical Abstract

[1]
Dona, I.; Salas, M.; Perkins, J.; Barrionuevo, E.; Gaeta, F.; Cornejo-Garcia, J.; Campo, P.; Torres, M. Hypersensitivity Reactions to Non-Steroidal Anti-Inflammatory Drugs. Curr. Pharm. Des., 2017, 22(45), 6784-6802.
[http://dx.doi.org/10.2174/1381612822666160928142814] [PMID: 27779082]
[2]
Bindu, S.; Mazumder, S.; Bandyopadhyay, U. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective. Biochem. Pharmacol., 2020, 180114147.
[http://dx.doi.org/10.1016/j.bcp.2020.114147] [PMID: 32653589]
[3]
Zhang, Q.; Li, X.; Li, J. Mechanism of anti-inflammatory and antibacterial effects of qingxiaowuwei decoction based on network pharmacology, molecular docking and in vitro experiments. Front. Pharmacol., 2021, 12, 1-19.
[4]
Furman, D.; Campisi, J.; Verdin, E.; Carrera-Bastos, P.; Targ, S.; Franceschi, C.; Ferrucci, L.; Gilroy, D.W.; Fasano, A.; Miller, G.W.; Miller, A.H.; Mantovani, A.; Weyand, C.M.; Barzilai, N.; Goronzy, J.J.; Rando, T.A.; Effros, R.B.; Lucia, A.; Kleinstreuer, N.; Slavich, G.M. Chronic inflammation in the etiology of disease across the life span. Nat. Med., 2019, 25(12), 1822-1832.
[http://dx.doi.org/10.1038/s41591-019-0675-0] [PMID: 31806905]
[5]
Stark, K.; Massberg, S. Interplay between inflammation and thrombosis in cardiovascular pathology. Nat. Rev. Cardiol., 2021, 18(9), 666-682.
[http://dx.doi.org/10.1038/s41569-021-00552-1] [PMID: 33958774]
[6]
Roth, G.A.; Abate, D.; Abate, K.H.; Abay, S.M.; Abbafati, C.; Abbasi, N.; Abbastabar, H.; Abd-Allah, F.; Abdela, J.; Abdelalim, A.; Abdollahpour, I.; Abdulkader, R.S.; Abebe, H.T.; Abebe, M.; Abebe, Z.; Abejie, A.N.; Abera, S.F.; Abil, O.Z.; Abraha, H.N.; Abrham, A.R.; Abu-Raddad, L.J.; Accrombessi, M.M.K.; Acharya, D.; Adamu, A.A.; Adebayo, O.M.; Adedoyin, R.A.; Adekanmbi, V.; Adetokunboh, O.O.; Adhena, B.M.; Adib, M.G.; Admasie, A.; Afshin, A.; Agarwal, G.; Agesa, K.M.; Agrawal, A.; Agrawal, S.; Ahmadi, A.; Ahmadi, M.; Ahmed, M.B.; Ahmed, S.; Aichour, A.N.; Aichour, I.; Aichour, M.T.E.; Akbari, M.E.; Akinyemi, R.O.; Akseer, N.; Al-Aly, Z.; Al-Eyadhy, A.; Al-Raddadi, R.M.; Alahdab, F.; Alam, K.; Alam, T.; Alebel, A.; Alene, K.A.; Alijanzadeh, M.; Alizadeh-Navaei, R.; Aljunid, S.M.; Alkerwi, A.; Alla, F.; Allebeck, P.; Alonso, J.; Altirkawi, K.; Alvis-Guzman, N.; Amare, A.T.; Aminde, L.N.; Amini, E.; Ammar, W.; Amoako, Y.A.; Anber, N.H.; Andrei, C.L.; Androudi, S.; Animut, M.D.; Anjomshoa, M.; Ansari, H.; Ansha, M.G.; Antonio, C.A.T.; Anwari, P.; Aremu, O.; Ärnlöv, J.; Arora, A.; Arora, M.; Artaman, A.; Aryal, K.K.; Asayesh, H.; Asfaw, E.T.; Ataro, Z.; Atique, S.; Atre, S.R.; Ausloos, M.; Avokpaho, E.F.G.A.; Awasthi, A.; Quintanilla, B.P.A.; Ayele, Y.; Ayer, R.; Azzopardi, P.S.; Babazadeh, A.; Bacha, U.; Badali, H.; Badawi, A.; Bali, A.G.; Ballesteros, K.E.; Banach, M.; Banerjee, K.; Bannick, M.S.; Banoub, J.A.M.; Barboza, M.A.; Barker-Collo, S.L.; Bärnighausen, T.W.; Barquera, S.; Barrero, L.H.; Bassat, Q.; Basu, S.; Baune, B.T.; Baynes, H.W.; Bazargan-Hejazi, S.; Bedi, N.; Beghi, E.; Behzadifar, M.; Behzadifar, M.; Béjot, Y.; Bekele, B.B.; Belachew, A.B.; Belay, E.; Belay, Y.A.; Bell, M.L.; Bello, A.K.; Bennett, D.A.; Bensenor, I.M.; Berman, A.E.; Bernabe, E.; Bernstein, R.S.; Bertolacci, G.J.; Beuran, M.; Beyranvand, T.; Bhalla, A.; Bhattarai, S.; Bhaumik, S.; Bhutta, Z.A.; Biadgo, B.; Biehl, M.H.; Bijani, A.; Bikbov, B.; Bilano, V.; Bililign, N.; Bin Sayeed, M.S.; Bisanzio, D.; Biswas, T.; Blacker, B.F.; Basara, B.B.; Borschmann, R.; Bosetti, C.; Bozorgmehr, K.; Brady, O.J.; Brant, L.C.; Brayne, C.; Brazinova, A.; Breitborde, N.J.K.; Brenner, H.; Briant, P.S.; Britton, G.; Brugha, T.; Busse, R.; Butt, Z.A.; Callender, C.S.K.H.; Campos-Nonato, I.R.; Campuzano Rincon, J.C.; Cano, J.; Car, M.; Cárdenas, R.; Carreras, G.; Carrero, J.J.; Carter, A.; Carvalho, F.; Castañeda-Orjuela, C.A.; Castillo Rivas, J.; Castle, C.D.; Castro, C.; Castro, F.; Catalá-López, F.; Cerin, E.; Chaiah, Y.; Chang, J-C.; Charlson, F.J.; Chaturvedi, P.; Chiang, P.P-C.; Chimed-Ochir, O.; Chisumpa, V.H.; Chitheer, A.; Chowdhury, R.; Christensen, H.; Christopher, D.J.; Chung, S-C.; Cicuttini, F.M.; Ciobanu, L.G.; Cirillo, M.; Cohen, A.J.; Cooper, L.T.; Cortesi, P.A.; Cortinovis, M.; Cousin, E.; Cowie, B.C.; Criqui, M.H.; Cromwell, E.A.; Crowe, C.S.; Crump, J.A.; Cunningham, M.; Daba, A.K.; Dadi, A.F.; Dandona, L.; Dandona, R.; Dang, A.K.; Dargan, P.I.; Daryani, A.; Das, S.K.; Gupta, R.D.; Neves, J.D.; Dasa, T.T.; Dash, A.P.; Davis, A.C.; Davis Weaver, N.; Davitoiu, D.V.; Davletov, K.; De La Hoz, F.P.; De Neve, J-W.; Degefa, M.G.; Degenhardt, L.; Degfie, T.T.; Deiparine, S.; Demoz, G.T.; Demtsu, B.B.; Denova-Gutiérrez, E.; Deribe, K.; Dervenis, N.; Des Jarlais, D.C.; Dessie, G.A.; Dey, S.; Dharmaratne, S.D.; Dicker, D.; Dinberu, M.T.; Ding, E.L.; Dirac, M.A.; Djalalinia, S.; Dokova, K.; Doku, D.T.; Donnelly, C.A.; Dorsey, E.R.; Doshi, P.P.; Douwes-Schultz, D.; Doyle, K.E.; Driscoll, T.R.; Dubey, M.; Dubljanin, E.; Duken, E.E.; Duncan, B.B.; Duraes, A.R.; Ebrahimi, H.; Ebrahimpour, S.; Edessa, D.; Edvardsson, D.; Eggen, A.E.; El Bcheraoui, C.; El Sayed Zaki, M.; El-Khatib, Z.; Elkout, H.; Ellingsen, C.L.; Endres, M.; Endries, A.Y.; Er, B.; Erskine, H.E.; Eshrati, B.; Eskandarieh, S.; Esmaeili, R.; Esteghamati, A.; Fakhar, M.; Fakhim, H.; Faramarzi, M.; Fareed, M.; Farhadi, F.; Farinha, C.S.E.; Faro, A.; Farvid, M.S.; Farzadfar, F.; Farzaei, M.H.; Feigin, V.L.; Feigl, A.B.; Fentahun, N.; Fereshtehnejad, S-M.; Fernandes, E.; Fernandes, J.C.; Ferrari, A.J.; Feyissa, G.T.; Filip, I.; Finegold, S.; Fischer, F.; Fitzmaurice, C.; Foigt, N.A.; Foreman, K.J.; Fornari, C.; Frank, T.D.; Fukumoto, T.; Fuller, J.E.; Fullman, N.; Fürst, T.; Furtado, J.M.; Futran, N.D.; Gallus, S.; Garcia-Basteiro, A.L.; Garcia-Gordillo, M.A.; Gardner, W.M.; Gebre, A.K.; Gebrehiwot, T.T.; Gebremedhin, A.T.; Gebremichael, B.; Gebremichael, T.G.; Gelano, T.F.; Geleijnse, J.M.; Genova-Maleras, R.; Geramo, Y.C.D.; Gething, P.W.; Gezae, K.E.; Ghadami, M.R.; Ghadimi, R.; Ghasemi Falavarjani, K.; Ghasemi-Kasman, M.; Ghimire, M.; Gibney, K.B.; Gill, P.S.; Gill, T.K.; Gillum, R.F.; Ginawi, I.A.; Giroud, M.; Giussani, G.; Goenka, S.; Goldberg, E.M.; Goli, S.; Gómez-Dantés, H.; Gona, P.N.; Gopalani, S.V.; Gorman, T.M.; Goto, A.; Goulart, A.C.; Gnedovskaya, E.V.; Grada, A.; Grosso, G.; Gugnani, H.C.; Guimaraes, A.L.S.; Guo, Y.; Gupta, P.C.; Gupta, R.; Gupta, R.; Gupta, T.; Gutiérrez, R.A.; Gyawali, B.; Haagsma, J.A.; Hafezi-Nejad, N.; Hagos, T.B.; Hailegiyorgis, T.T.; Hailu, G.B.; Haj-Mirzaian, A.; Haj-Mirzaian, A.; Hamadeh, R.R.; Hamidi, S.; Handal, A.J.; Hankey, G.J.; Harb, H.L.; Harikrishnan, S.; Haro, J.M.; Hasan, M.; Hassankhani, H.; Hassen, H.Y.; Havmoeller, R.; Hay, R.J.; Hay, S.I.; He, Y.; Hedayatizadeh-Omran, A.; Hegazy, M.I.; Heibati, B.; Heidari, M.; Hendrie, D.; Henok, A.; Henry, N.J.; Herteliu, C.; Heydarpour, F.; Heydarpour, P.; Heydarpour, S.; Hibstu, D.T.; Hoek, H.W.; Hole, M.K.; Homaie Rad, E.; Hoogar, P.; Hosgood, H.D.; Hosseini, S.M.; Hosseinzadeh, M.; Hostiuc, M.; Hostiuc, S.; Hotez, P.J.; Hoy, D.G.; Hsiao, T.; Hu, G.; Huang, J.J.; Husseini, A.; Hussen, M.M.; Hutfless, S.; Idrisov, B.; Ilesanmi, O.S.; Iqbal, U.; Irvani, S.S.N.; Irvine, C.M.S.; Islam, N.; Islam, S.M.S.; Islami, F.; Jacobsen, K.H.; Jahangiry, L.; Jahanmehr, N.; Jain, S.K.; Jakovljevic, M.; Jalu, M.T.; James, S.L.; Javanbakht, M.; Jayatilleke, A.U.; Jeemon, P.; Jenkins, K.J.; Jha, R.P.; Jha, V.; Johnson, C.O.; Johnson, S.C.; Jonas, J.B.; Joshi, A.; Jozwiak, J.J.; Jungari, S.B.; Jürisson, M.; Kabir, Z.; Kadel, R.; Kahsay, A.; Kalani, R.; Karami, M.; Karami Matin, B.; Karch, A.; Karema, C.; Karimi-Sari, H.; Kasaeian, A.; Kassa, D.H.; Kassa, G.M.; Kassa, T.D.; Kassebaum, N.J.; Katikireddi, S.V.; Kaul, A.; Kazemi, Z.; Karyani, A.K.; Kazi, D.S.; Kefale, A.T.; Keiyoro, P.N.; Kemp, G.R.; Kengne, A.P.; Keren, A.; Kesavachandran, C.N.; Khader, Y.S.; Khafaei, B.; Khafaie, M.A.; Khajavi, A.; Khalid, N.; Khalil, I.A.; Khan, E.A.; Khan, M.S.; Khan, M.A.; Khang, Y-H.; Khater, M.M.; Khoja, A.T.; Khosravi, A.; Khosravi, M.H.; Khubchandani, J.; Kiadaliri, A.A.; Kibret, G.D.; Kidanemariam, Z.T.; Kiirithio, D.N.; Kim, D.; Kim, Y-E.; Kim, Y.J.; Kimokoti, R.W.; Kinfu, Y.; Kisa, A.; Kissimova-Skarbek, K.; Kivimäki, M.; Knudsen, A.K.S.; Kocarnik, J.M.; Kochhar, S.; Kokubo, Y.; Kolola, T.; Kopec, J.A.; Koul, P.A.; Koyanagi, A.; Kravchenko, M.A.; Krishan, K.; Kuate Defo, B.; Kucuk Bicer, B.; Kumar, G.A.; Kumar, M.; Kumar, P.; Kutz, M.J.; Kuzin, I.; Kyu, H.H.; Lad, D.P.; Lad, S.D.; Lafranconi, A.; Lal, D.K.; Lalloo, R.; Lallukka, T.; Lam, J.O.; Lami, F.H.; Lansingh, V.C.; Lansky, S.; Larson, H.J.; Latifi, A.; Lau, K.M-M.; Lazarus, J.V.; Lebedev, G.; Lee, P.H.; Leigh, J.; Leili, M.; Leshargie, C.T.; Li, S.; Li, Y.; Liang, J.; Lim, L-L.; Lim, S.S.; Limenih, M.A.; Linn, S.; Liu, S.; Liu, Y.; Lodha, R.; Lonsdale, C.; Lopez, A.D.; Lorkowski, S.; Lotufo, P.A.; Lozano, R.; Lunevicius, R.; Ma, S.; Macarayan, E.R.K.; Mackay, M.T.; MacLachlan, J.H.; Maddison, E.R.; Madotto, F.; Magdy Abd El Razek, H.; Magdy Abd El Razek, M.; Maghavani, D.P.; Majdan, M.; Majdzadeh, R.; Majeed, A.; Malekzadeh, R.; Malta, D.C.; Manda, A-L.; Mandarano-Filho, L.G.; Manguerra, H.; Mansournia, M.A.; Mapoma, C.C.; Marami, D.; Maravilla, J.C.; Marcenes, W.; Marczak, L.; Marks, A.; Marks, G.B.; Martinez, G.; Martins-Melo, F.R.; Martopullo, I.; März, W.; Marzan, M.B.; Masci, J.R.; Massenburg, B.B.; Mathur, M.R.; Mathur, P.; Matzopoulos, R.; Maulik, P.K.; Mazidi, M.; McAlinden, C.; McGrath, J.J.; McKee, M.; McMahon, B.J.; Mehata, S.; Mehndiratta, M.M.; Mehrotra, R.; Mehta, K.M.; Mehta, V.; Mekonnen, T.C.; Melese, A.; Melku, M.; Memiah, P.T.N.; Memish, Z.A.; Mendoza, W.; Mengistu, D.T.; Mengistu, G.; Mensah, G.A.; Mereta, S.T.; Meretoja, A.; Meretoja, T.J.; Mestrovic, T.; Mezgebe, H.B.; Miazgowski, B.; Miazgowski, T.; Millear, A.I.; Miller, T.R.; Miller-Petrie, M.K.; Mini, G.K.; Mirabi, P.; Mirarefin, M.; Mirica, A.; Mirrakhimov, E.M.; Misganaw, A.T.; Mitiku, H.; Moazen, B.; Mohammad, K.A.; Mohammadi, M.; Mohammadifard, N.; Mohammed, M.A.; Mohammed, S.; Mohan, V.; Mokdad, A.H.; Molokhia, M.; Monasta, L.; Moradi, G.; Moradi-Lakeh, M.; Moradinazar, M.; Moraga, P.; Morawska, L.; Moreno Velásquez, I.; Morgado-Da-Costa, J.; Morrison, S.D.; Moschos, M.M.; Mouodi, S.; Mousavi, S.M.; Muchie, K.F.; Mueller, U.O.; Mukhopadhyay, S.; Muller, K.; Mumford, J.E.; Musa, J.; Musa, K.I.; Mustafa, G.; Muthupandian, S.; Nachega, J.B.; Nagel, G.; Naheed, A.; Nahvijou, A.; Naik, G.; Nair, S.; Najafi, F.; Naldi, L.; Nam, H.S.; Nangia, V.; Nansseu, J.R.; Nascimento, B.R.; Natarajan, G.; Neamati, N.; Negoi, I.; Negoi, R.I.; Neupane, S.; Newton, C.R.J.; Ngalesoni, F.N.; Ngunjiri, J.W.; Nguyen, A.Q.; Nguyen, G.; Nguyen, H.T.; Nguyen, H.T.; Nguyen, L.H.; Nguyen, M.; Nguyen, T.H.; Nichols, E.; Ningrum, D.N.A.; Nirayo, Y.L.; Nixon, M.R.; Nolutshungu, N.; Nomura, S.; Norheim, O.F.; Noroozi, M.; Norrving, B.; Noubiap, J.J.; Nouri, H.R.; Nourollahpour Shiadeh, M.; Nowroozi, M.R.; Nyasulu, P.S.; Odell, C.M.; Ofori-Asenso, R.; Ogbo, F.A.; Oh, I-H.; Oladimeji, O.; Olagunju, A.T.; Olivares, P.R.; Olsen, H.E.; Olusanya, B.O.; Olusanya, J.O.; Ong, K.L.; Ong, S.K.S.; Oren, E.; Orpana, H.M.; Ortiz, A.; Ortiz, J.R.; Otstavnov, S.S.; Øverland, S.; Owolabi, M.O.; Özdemir, R.; P A, M.; Pacella, R.; Pakhale, S.; Pakhare, A.P.; Pakpour, A.H.; Pana, A.; Panda-Jonas, S.; Pandian, J.D.; Parisi, A.; Park, E-K.; Parry, C.D.H.; Parsian, H.; Patel, S.; Pati, S.; Patton, G.C.; Paturi, V.R.; Paulson, K.R.; Pereira, A.; Pereira, D.M.; Perico, N.; Pesudovs, K.; Petzold, M.; Phillips, M.R.; Piel, F.B.; Pigott, D.M.; Pillay, J.D.; Pirsaheb, M.; Pishgar, F.; Polinder, S.; Postma, M.J.; Pourshams, A.; Poustchi, H.; Pujar, A.; Prakash, S.; Prasad, N.; Purcell, C.A.; Qorbani, M.; Quintana, H.; Quistberg, D.A.; Rade, K.W.; Radfar, A.; Rafay, A.; Rafiei, A.; Rahim, F.; Rahimi, K.; Rahimi-Movaghar, A.; Rahman, M.; Rahman, M.H.U.; Rahman, M.A.; Rai, R.K.; Rajsic, S.; Ram, U.; Ranabhat, C.L.; Ranjan, P.; Rao, P.C.; Rawaf, D.L.; Rawaf, S.; Razo-García, C.; Reddy, K.S.; Reiner, R.C.; Reitsma, M.B.; Remuzzi, G.; Renzaho, A.M.N.; Resnikoff, S.; Rezaei, S.; Rezaeian, S.; Rezai, M.S.; Riahi, S.M.; Ribeiro, A.L.P.; Rios-Blancas, M.J.; Roba, K.T.; Roberts, N.L.S.; Robinson, S.R.; Roever, L.; Ronfani, L.; Roshandel, G.; Rostami, A.; Rothenbacher, D.; Roy, A.; Rubagotti, E.; Sachdev, P.S.; Saddik, B.; Sadeghi, E.; Safari, H.; Safdarian, M.; Safi, S.; Safiri, S.; Sagar, R.; Sahebkar, A.; Sahraian, M.A.; Salam, N.; Salama, J.S.; Salamati, P.; Saldanha, R.D.F.; Saleem, Z.; Salimi, Y.; Salvi, S.S.; Salz, I.; Sambala, E.Z.; Samy, A.M.; Sanabria, J.; Sanchez-Niño, M.D.; Santomauro, D.F.; Santos, I.S.; Santos, J.V.; Milicevic, M.M.S.; Sao Jose, B.P.; Sarker, A.R.; Sarmiento-Suárez, R.; Sarrafzadegan, N.; Sartorius, B.; Sarvi, S.; Sathian, B.; Satpathy, M.; Sawant, A.R.; Sawhney, M.; Saxena, S.; Sayyah, M.; Schaeffner, E.; Schmidt, M.I.; Schneider, I.J.C.; Schöttker, B.; Schutte, A.E.; Schwebel, D.C.; Schwendicke, F.; Scott, J.G.; Sekerija, M.; Sepanlou, S.G.; Serván-Mori, E.; Seyedmousavi, S.; Shabaninejad, H.; Shackelford, K.A.; Shafieesabet, A.; Shahbazi, M.; Shaheen, A.A.; Shaikh, M.A.; Shams-Beyranvand, M.; Shamsi, M.; Shamsizadeh, M.; Sharafi, K.; Sharif, M.; Sharif-Alhoseini, M.; Sharma, R.; She, J.; Sheikh, A.; Shi, P.; Shiferaw, M.S.; Shigematsu, M.; Shiri, R.; Shirkoohi, R.; Shiue, I.; Shokraneh, F.; Shrime, M.G.; Si, S.; Siabani, S.; Siddiqi, T.J.; Sigfusdottir, I.D.; Sigurvinsdottir, R.; Silberberg, D.H.; Silva, D.A.S.; Silva, J.P.; Silva, N.T.D.; Silveira, D.G.A.; Singh, J.A.; Singh, N.P.; Singh, P.K.; Singh, V.; Sinha, D.N.; Sliwa, K.; Smith, M.; Sobaih, B.H.; Sobhani, S.; Sobngwi, E.; Soneji, S.S.; Soofi, M.; Sorensen, R.J.D.; Soriano, J.B.; Soyiri, I.N.; Sposato, L.A.; Sreeramareddy, C.T.; Srinivasan, V.; Stanaway, J.D.; Starodubov, V.I.; Stathopoulou, V.; Stein, D.J.; Steiner, C.; Stewart, L.G.; Stokes, M.A.; Subart, M.L.; Sudaryanto, A.; Sufiyan, M.B.; Sur, P.J.; Sutradhar, I.; Sykes, B.L.; Sylaja, P.N.; Sylte, D.O.; Szoeke, C.E.I.; Tabarés-Seisdedos, R.; Tabuchi, T.; Tadakamadla, S.K.; Takahashi, K.; Tandon, N.; Tassew, S.G.; Taveira, N.; Tehrani-Banihashemi, A.; Tekalign, T.G.; Tekle, M.G.; Temsah, M-H.; Temsah, O.; Terkawi, A.S.; Teshale, M.Y.; Tessema, B.; Tessema, G.A.; Thankappan, K.R.; Thirunavukkarasu, S.; Thomas, N.; Thrift, A.G.; Thurston, G.D.; Tilahun, B.; To, Q.G.; Tobe-Gai, R.; Tonelli, M.; Topor-Madry, R.; Torre, A.E.; Tortajada-Girbés, M.; Touvier, M.; Tovani-Palone, M.R.; Tran, B.X.; Tran, K.B.; Tripathi, S.; Troeger, C.E.; Truelsen, T.C.; Truong, N.T.; Tsadik, A.G.; Tsoi, D.; Tudor Car, L.; Tuzcu, E.M.; Tyrovolas, S.; Ukwaja, K.N.; Ullah, I.; Undurraga, E.A.; Updike, R.L.; Usman, M.S.; Uthman, O.A.; Uzun, S.B.; Vaduganathan, M.; Vaezi, A.; Vaidya, G.; Valdez, P.R.; Varavikova, E.; Vasankari, T.J.; Venketasubramanian, N.; Villafaina, S.; Violante, F.S.; Vladimirov, S.K.; Vlassov, V.; Vollset, S.E.; Vos, T.; Wagner, G.R.; Wagnew, F.S.; Waheed, Y.; Wallin, M.T.; Walson, J.L.; Wang, Y.; Wang, Y-P.; Wassie, M.M.; Weiderpass, E.; Weintraub, R.G.; Weldegebreal, F.; Weldegwergs, K.G.; Werdecker, A.; Werkneh, A.A.; West, T.E.; Westerman, R.; Whiteford, H.A.; Widecka, J.; Wilner, L.B.; Wilson, S.; Winkler, A.S.; Wiysonge, C.S.; Wolfe, C.D.A.; Wu, S.; Wu, Y-C.; Wyper, G.M.A.; Xavier, D.; Xu, G.; Yadgir, S.; Yadollahpour, A.; Yahyazadeh Jabbari, S.H.; Yakob, B.; Yan, L.L.; Yano, Y.; Yaseri, M.; Yasin, Y.J.; Yentür, G.K.; Yeshaneh, A.; Yimer, E.M.; Yip, P.; Yirsaw, B.D.; Yisma, E.; Yonemoto, N.; Yonga, G.; Yoon, S-J.; Yotebieng, M.; Younis, M.Z.; Yousefifard, M.; Yu, C.; Zadnik, V.; Zaidi, Z.; Zaman, S.B.; Zamani, M.; Zare, Z.; Zeleke, A.J.; Zenebe, Z.M.; Zhang, A.L.; Zhang, K.; Zhou, M.; Zodpey, S.; Zuhlke, L.J.; Naghavi, M.; Murray, C.J.L. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2018, 392(10159), 1736-1788.
[http://dx.doi.org/10.1016/S0140-6736(18)32203-7] [PMID: 30496103]
[7]
Cui, S.; Chen, S.; Wu, Q.; Chen, T.; Li, S. A network pharmacology approach to investigate the anti-inflammatory mechanism of effective ingredients from Salvia miltiorrhiza. Int. Immunopharmacol., 2020, 81106040.
[http://dx.doi.org/10.1016/j.intimp.2019.106040] [PMID: 31818704]
[8]
To, K-I.; Zhu, Z-X.; Wang, Y-N. Integrative network pharmacology and experimental verification to reveal the anti-inflammatory mechanism of ginsenoside Rh4. Front. Pharmacol., 2022, 13, 1-13.
[http://dx.doi.org/10.3389/fphar.2022.953871]
[9]
Zhang, W.; Sun, C.; Zhou, S.; Zhao, W.; Wang, L.; Sheng, L.; Yi, J.; Liu, T.; Yan, J.; Ma, X.; Fang, B. Recent advances in chemistry and bioactivity of Sargentodoxa cuneata. J. Ethnopharmacol., 2021, 270113840.
[http://dx.doi.org/10.1016/j.jep.2021.113840] [PMID: 33460761]
[10]
Hu, L.; Chen, Y.; Chen, T. A systematic study of mechanism of sargentodoxa cuneata and patrinia scabiosifolia against pelvic inflammatory disease with dampness-heat stasis syndrome via network pharmacology approach. Front. Pharmacol., 2020, 11, 1-13.
[http://dx.doi.org/10.3389/fphar.2020.582520]
[11]
Zhang, R.; Zhu, X.; Bai, H. Network pharmacology databases for traditional chinese medicine: review and assessment. Front. Pharmacol., 2019, 10, 123.
[12]
Sharma, R.; Singla, R.K.; Banerjee, S. Deciphering the impact and mechanism of Trikatu, a spices-based formulation on alcoholic liver disease employing network pharmacology analysis and in vivo validation. Front. Nutr., 9, 1-23.
[http://dx.doi.org/10.3389/fnut.2022.1063118]
[13]
Sharma, R.; Singla, R.K.; Banerjee, S.; Sinha, B.; Shen, B.; Sharma, R. Role of Shankhpushpi (Convolvulus pluricaulis) in neurological disorders: An umbrella review covering evidence from ethnopharmacology to clinical studies. Neurosci. Biobehav. Rev., 2022, 140104795.
[http://dx.doi.org/10.1016/j.neubiorev.2022.104795] [PMID: 35878793]
[14]
Vakser, I.A. Protein-protein docking: from interaction to interactome. Biophys J., 2014, 107(8), 1785-1793.
[15]
Xue, L.C.; Dobbs, D.; Honavar, V. Computational prediction of protein interfaces: A review of data driven methods. FEBS Lett., 2015, 58923, 3516-3526.
[16]
Liu, J.; Liu, J.; Tong, X.; Peng, W.; Wei, S.; Sun, T.; Wang, Y.; Zhang, B.; Li, W. Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Huai Hua San Against Ulcerative Colitis. Drug Des. Devel. Ther., 2021, 15, 3255-3276.
[http://dx.doi.org/10.2147/DDDT.S319786] [PMID: 34349502]
[17]
Ru, J.; Li, P.; Wang, J. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J. Cheminform., 2014, 6, 13.
[18]
Xu, H.Y.; Zhang, Y.Q.; Liu, Z.M.; Chen, T.; Lv, C.Y.; Tang, S.H.; Zhang, X.B.; Zhang, W.; Li, Z.Y.; Zhou, R.R.; Yang, H.J.; Wang, X.J.; Huang, L.Q. ETCM: an encyclopaedia of traditional Chinese medicine. Nucleic Acids Res., 2019, 47(D1), D976-D982.
[http://dx.doi.org/10.1093/nar/gky987] [PMID: 30365030]
[19]
Daina, A.; Michielin, O.; Zoete, V. SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Res., 2019, 47(W1), W357-W364.
[http://dx.doi.org/10.1093/nar/gkz382] [PMID: 31106366]
[20]
UniProt: the universal protein knowledgebase in 2021. Nucleic Acids Res., 2021, 49, D480-D489.
[21]
McNeill, A. Fond farewell to clinical utility gene cards. Eur. J. Hum. Genet., 2021, 29(10), 1473-1474.
[http://dx.doi.org/10.1038/s41431-021-00957-z] [PMID: 34497400]
[22]
Wishart, D.S.; Knox, C.; Guo, A.C.; Shrivastava, S.; Hassanali, M.; Stothard, P.; Chang, Z.; Woolsey, J. DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res., 2006, 34(90001), D668-D672.
[http://dx.doi.org/10.1093/nar/gkj067] [PMID: 16381955]
[23]
Chen, X.; Ji, Z.L.; Chen, Y.Z. TTD: Therapeutic Target Database. Nucleic Acids Res., 2002, 30(1), 412-415.
[http://dx.doi.org/10.1093/nar/30.1.412] [PMID: 11752352]
[24]
Amberger, J.S.; Bocchini, C.A.; Schiettecatte, F. OMIM.org: Online Mendelian Inheritance in Man (OMIM®), an online catalog of human genes and genetic disorders. Nucleic Acids Res., 2015, 43, D789-D798.
[25]
Dalmaijer, E.S.; Nord, C.L.; Astle, D.E. Statistical power for cluster analysis. BMC Bioinformatics, 2022, 23(1), 205.
[http://dx.doi.org/10.1186/s12859-022-04675-1] [PMID: 35641905]
[26]
Kang, J.K.; Chung, Y.C.; Hyun, C.G. Anti-Inflammatory Effects of 6-Methylcoumarin in LPS-Stimulated RAW 264.7 Macrophages via Regulation of MAPK and NF-κB Signaling Pathways. Molecules, 2021, 26(17), 5351.
[http://dx.doi.org/10.3390/molecules26175351] [PMID: 34500784]
[27]
Amatya, N.; Garg, A.V.; Gaffen, S.L. IL-17 Signaling: The Yin and the Yang. Trends Immunol., 2017, 38(5), 310-322.
[http://dx.doi.org/10.1016/j.it.2017.01.006] [PMID: 28254169]
[28]
Fan, Y.; Wang, Y.; Yu, S.; Chang, J.; Yan, Y.; Wang, Y.; Bian, Y. Natural products provide a new perspective for anti-complement treatment of severe COVID-19: a review. Chin. Med., 2021, 16(1), 67.
[http://dx.doi.org/10.1186/s13020-021-00478-3] [PMID: 34321065]
[29]
Tang, H.; Yang, D.; Zhu, L. Paeonol interferes with quorum-sensing in pseudomonas aeruginosa and modulates inflammatory responses In Vitro and In Vivo. Front. Immunol., 2022, 13, 896874.
[http://dx.doi.org/10.3389/fimmu.2022.896874]
[30]
Picos-Salas, M.A.; Cabanillas-Bojórquez, L.Á.; Elizalde-Romero, C.A.; Leyva-López, N.; Montoya-Inzunza, L.A.; Heredia, J.B.; Gutiérrez-Grijalva, E.P. Naringenin as a Natural Agent Against Oxidative Stress and Inflammation, and Its Bioavailability. Food Rev. Int., 2022, 0, 1-39.
[http://dx.doi.org/10.1080/87559129.2022.2123502]
[31]
Hu, Y.; Huang, W.; Luo, Y.; Xiang, L.; Wu, J.; Zhang, Y.; Zeng, Y.; Xu, C.; Meng, X.; Wang, P. Assessment of the anti-inflammatory effects of three rhubarb anthraquinones in LPS-Stimulated RAW264.7 macrophages using a pharmacodynamic model and evaluation of the structure-activity relationships. J. Ethnopharmacol., 2021, 273114027.
[http://dx.doi.org/10.1016/j.jep.2021.114027] [PMID: 33741438]
[32]
Shen, S.C.; Lee, W.R.; Lin, H.Y.; Huang, H.C.; Ko, C.H.; Yang, L.L.; Chen, Y.C. In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production. Eur. J. Pharmacol., 2002, 446(1-3), 187-194.
[http://dx.doi.org/10.1016/S0014-2999(02)01792-2] [PMID: 12098601]
[33]
Tang, N-Y.; Yang, J-S.; Chang, Y-H.; Lu, H.F.; Hsia, T.C.; Lin, W.C.; Chung, J.G. Effects of wogonin on the levels of cytokines and functions of leukocytes associated with NF-kappa B expression in Sprague-Dawley rats. In Vivo, 2006, 20(4), 527-532.
[PMID: 16900784]
[34]
Yao, J.; Pan, D.; Zhao, Y.; Zhao, L.; Sun, J.; Wang, Y.; You, Q.D.; Xi, T.; Guo, Q.L.; Lu, N. Wogonin prevents lipopolysaccharide-induced acute lung injury and inflammation in mice via peroxisome proliferator-activated receptor gamma-mediated attenuation of the nuclear factor-kappaB pathway. Immunology, 2014, 143(2), 241-257.
[http://dx.doi.org/10.1111/imm.12305] [PMID: 24766487]
[35]
Liu, M.; Fang, G.; Yin, S.; Zhao, X.; Zhang, C.; Li, J.; Liu, Z. Caffeic Acid Prevented LPS-Induced Injury of Primary Bovine Mammary Epithelial Cells through Inhibiting NF- κ B and MAPK Activation. Mediators Inflamm., 2019, 2019, 1-12.
[http://dx.doi.org/10.1155/2019/1897820] [PMID: 31182930]

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