Login Register Cart 0
Generic placeholder image

Pharmaceutical Nanotechnology

Editor-in-Chief

ISSN (Print): 2211-7385
ISSN (Online): 2211-7393

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Synthesis and Characterization of Epigallocatechin Gallate-mediated Hydroxyapatite

Author(s): Hanish Dinesh, Sandhya Sundar, Saranya Kannan*, Ramya Ramadoss, Suganya Panneer Selvam and Pratibha Ramani

Volume 12, Issue 2, 2024

Published on: 13 July, 2023

Page: [165 - 170] Pages: 6

DOI: 10.2174/2211738511666230607113610

Price: $65

Abstract

Introduction: Hydroxyapatite is a significant material that finds its application in the field of dental and bone tissue engineering.

Methods: The formulation of nanohydroxyapatite with the aid of bioactive compounds has gained importance in recent years due to the beneficial activity contributed by them. The present work focuses on the formulation of nanohydroxyapatite synthesis using epigallocatechin gallate, an active biochemical component of green tea.

Results: The prepared epigallocatechin gallate-mediated nanohydroxyapatite (epi-HAp) was nanoglobular in shape and composed of calcium, phosphorous, carbon and oxygen, which was confirmed by Scanning electron microscope- energy dispersive X-ray analysis (SEM-EDX). The Attenuated Total Reflection- Infra red spectroscopy (ATR-IR) and X-ray photoelectron spectroscopy (XPS) assured that the reduction and stabilisation of nanohydroxyapatite were mediated by epigallocatechin gallate.

Conclusion: The epi-HAp exhibited anti-inflammatory behaviour along with nil effect on cytotoxicity. To be precise, the epi-HAp can be an effective biomaterial in bone and dental applications.

« Previous Next »
Graphical Abstract

[1]
Alorku K, Manoj M, Yuan A. A plant-mediated synthesis of nanostructured hydroxyapatite for biomedical applications: A review. RSC Advances 2020; 10(67): 40923-39.
[http://dx.doi.org/10.1039/D0RA08529D] [PMID: 35519223]
[2]
Abdul Halim NA, Hussein MZ, Kandar MK. Nanomaterials-upconverted hydroxyapatite for bone tissue engineering and a platform for drug delivery. Int J Nanomedicine 2021; 16: 6477-96.
[http://dx.doi.org/10.2147/IJN.S298936] [PMID: 34584412]
[3]
Legeay S, Rodier M, Fillon L, Faure S, Clere N. Epigallocatechin gallate: A review of its beneficial properties to prevent metabolic syndrome. Nutrients 2015; 7(7): 5443-68.
[http://dx.doi.org/10.3390/nu7075230] [PMID: 26198245]
[4]
Aggarwal V, Tuli HS, Tania M, et al. Molecular mechanisms of action of epigallocatechin gallate in cancer: Recent trends and advancement. Semin Cancer Biol 2022; 22: 256-75.
[5]
K S, S B, Chatterjee S, N R. Titanate incorporated anodized coating on magnesium alloy for corrosion protection, antibacterial responses and osteogenic enhancement. Journal of Magnesium and Alloys 2022; 10(4): 1109-23.
[http://dx.doi.org/10.1016/j.jma.2020.11.011]
[6]
AlSalem HS, Keshk AA, Ghareeb RY, et al. Physico-chemical and biological responses for hydroxyapatite/ZnO/graphene oxide nanocomposite for biomedical utilization. Mater Chem Phys 2022; 283: 125988.
[http://dx.doi.org/10.1016/j.matchemphys.2022.125988]
[7]
Zhao Y, Zhang Y, Ning F, Guo D, Xu Z. Synthesis and cellular biocompatibility of two kinds of HAP with different nanocrystal morphology. J Biomed Mater Res B Appl Biomater 2007; 83B(1): 121-6.
[http://dx.doi.org/10.1002/jbm.b.30774] [PMID: 17330894]
[8]
Saranya K, Kalaiyarasan M, Chatterjee S, Rajendran N. Dynamic electrochemical impedance study of fluoride conversion coating on AZ31 magnesium alloy to improve bio‐adaptability for orthopedic application. Mater Corros 2019; 70(4): 698-710.
[http://dx.doi.org/10.1002/maco.201810360]
[9]
Wang D, Kim D, Shin CH, Zhao Y, Park JS, Ryu M. Evaluation of epigallocatechin gallate (EGCG) to remove Pb(II) using spectroscopic and quantum chemical calculation method. Environ Earth Sci 2019; 78(5): 138.
[http://dx.doi.org/10.1007/s12665-019-8127-1]
[10]
Titorenkova R, Dyulgerova E, Petkova V, Ilieva R. Carbonation and dehydroxylation of apatite during high energy milling of biphasic Ca-phosphate ceramics. Ceram Int 2019; 45(6): 7025-33.
[http://dx.doi.org/10.1016/j.ceramint.2018.12.204]
[11]
Agilan P, Saranya K, Rajendran N. Bio-inspired polydopamine incorporated titania nanotube arrays for biomedical applications. Colloids Surf A Physicochem Eng Asp 2021; 629: 127489.
[http://dx.doi.org/10.1016/j.colsurfa.2021.127489]
[12]
Dahiya S, Rani R, Dhingra D, Kumar S, Dilbaghi N. Conjugation of epigallocatechin gallate and piperine into a zein nanocarrier: Implication on antioxidant and anticancer potential. Adv Nat Sci Nanosci Nanotech 2018; 9(3): 035011.
[http://dx.doi.org/10.1088/2043-6254/aad5c1]
[13]
Chocholata P, Kulda V, Dvorakova J, Supova M, Zaloudkova M, Babuska V. In situ hydroxyapatite synthesis enhances biocompatibility of PVA/HA hydrogels. Int J Mol Sci 2021; 22(17): 9335.
[http://dx.doi.org/10.3390/ijms22179335] [PMID: 34502243]
[14]
Foroutan R, Peighambardoust SJ, Hemmati S, et al. Zn 2+ removal from the aqueous environment using a polydopamine/hydroxyapatite/Fe3O4 magnetic composite under ultrasonic waves. RSC Advances 2021; 11(44): 27309-21.
[http://dx.doi.org/10.1039/D1RA04583K] [PMID: 35480667]
[15]
Wei W, Li J, Han X, et al. Insights into the adsorption mechanism of tannic acid by a green synthesized nano-hydroxyapatite and its effect on aqueous Cu(II) removal. Sci Total Environ 2021; 778: 146189.
[http://dx.doi.org/10.1016/j.scitotenv.2021.146189] [PMID: 33714103]
[16]
Katić J, Metikoš-Huković M, Babić R. Nitinol modified by calcium phosphate coatings prepared by sol-gel and electrodeposition methods. ECS Trans 2013; 53(19): 83-93.
[http://dx.doi.org/10.1149/05319.0083ecst]
[17]
Singh N, Chakraborty R, Gupta RK. Mutton bone derived hydroxyapatite supported TiO2 nanoparticles for sustainable photocatalytic applications. J Environ Chem Eng 2018; 6(1): 459-67.
[http://dx.doi.org/10.1016/j.jece.2017.12.027]
[18]
Qiao LP, Lou J, Zhang SF, Qu B, Chang WH, Zhang RF. The entrance mechanism of calcium and phosphorus elements into micro arc oxidation coatings developed on Ti6Al4V alloy. Surf Coat Tech 2016; 285: 187-96.
[http://dx.doi.org/10.1016/j.surfcoat.2015.11.041]
[19]
Benziger J, Madix R. Reactions and reaction intermediates on iron surfaces III. Reactions of aldehydes and ketones on Fe(100). J Catal 1982; 74(1): 55-66.
[http://dx.doi.org/10.1016/0021-9517(82)90008-2]
[20]
Zhao J, Garza EG, Lam K, Jones CM. Comparison study of physical vapor-deposited and chemical vapor-deposited titanium nitride thin films using X-ray photoelectron spectroscopy. Appl Surf Sci 2000; 158(3-4): 246-51.
[http://dx.doi.org/10.1016/S0169-4332(00)00024-6]
[21]
Kaya Z, Yayla M, Cinar I, et al. Epigallocatechin-3-gallate (EGCG) exert therapeutic effect on acute inflammatory otitis media in rats. Int J Pediatr Otorhinolaryngol 2019; 124: 106-10.
[http://dx.doi.org/10.1016/j.ijporl.2019.05.012] [PMID: 31176023]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy