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CNS & Neurological Disorders - Drug Targets

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ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

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Review Article

Brain-Derived Neurotrophic Factor – The Protective Agent Against Neurological Disorders

Author(s): Prathyusha Koyya, Ram Kumar Manthari* and Santhi Latha Pandrangi

Volume 23, Issue 3, 2024

Published on: 15 June, 2023

Page: [353 - 366] Pages: 14

DOI: 10.2174/1871527322666230607110617

Price: $65

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Abstract

The burden of neurological illnesses on global health is significant. Our perception of the molecular and biological mechanisms underlying intellectual processing and behavior has significantly advanced over the last few decades, laying the groundwork for potential therapies for various neurodegenerative diseases. A growing body of literature reveals that most neurodegenerative diseases could be due to the gradual failure of neurons in the brain's neocortex, hippocampus, and various subcortical areas. Research on various experimental models has uncovered several gene components to understand the pathogenesis of neurodegenerative disorders. One among them is the brain-derived neurotrophic factor (BDNF), which performs several vital functions, enhancing synaptic plasticity and assisting in the emergence of long-term thoughts. The pathophysiology of some neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Schizophrenia, and Huntington’s, has been linked to BDNF. According to numerous research, high levels of BDNF are connected to a lower risk of developing a neurodegenerative disease. As a result, we want to concentrate on BDNF in this article and outline its protective role against neurological disorders.

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