Abstract
The accessibility to topical administration through inhalation, combined with its large surface area, has led to speculation that the lung might offer an ideal target for the application of oligonucleotide based therapeutics. In this review, we shall critically examine the challenges facing antisense and siRNA based approaches for target validation in vivo and as potential therapeutics. In particular, we shall discuss the antisense and siRNA based approaches in relation to factors such as delivery, distribution, stability, off-target effects, unwanted immune responses and the selection of the optimum mRNA targets.
Keywords: siRNA, antisense, airways, lung, RNA interference
Current Pharmaceutical Design
Title: Targeting the Lung Using siRNA and Antisense Based Oligonucleotides
Volume: 14 Issue: 34
Author(s): Sterghios A. Moschos, Karen Spinks, Andrew E. Williams and Mark A. Lindsay
Affiliation:
Keywords: siRNA, antisense, airways, lung, RNA interference
Abstract: The accessibility to topical administration through inhalation, combined with its large surface area, has led to speculation that the lung might offer an ideal target for the application of oligonucleotide based therapeutics. In this review, we shall critically examine the challenges facing antisense and siRNA based approaches for target validation in vivo and as potential therapeutics. In particular, we shall discuss the antisense and siRNA based approaches in relation to factors such as delivery, distribution, stability, off-target effects, unwanted immune responses and the selection of the optimum mRNA targets.
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Cite this article as:
Moschos A. Sterghios, Spinks Karen, Williams E. Andrew and Lindsay A. Mark, Targeting the Lung Using siRNA and Antisense Based Oligonucleotides, Current Pharmaceutical Design 2008; 14 (34) . https://dx.doi.org/10.2174/138161208786898851
DOI https://dx.doi.org/10.2174/138161208786898851 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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