Abstract
Introduction: Increasing evidence suggests that microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) have emerged as attractive targets in viral infections, including Human immunodeficiency virus (HIV).
Objective: To deepen the understanding of the molecular mechanisms that lead to HIV and provide potential targets for the future development of molecular therapies for its treatment.
Methods: Four miRNAs were selected as candidates based on a previous systematic review. A combination of bioinformatic analyses was performed to identify their target genes, lncRNAs and biological processes that regulate them.
Results: In the constructed miRNA–mRNA network, 193 gene targets are identified. These miRNAs potentially control genes from several important processes, including signal transduction and cancer. LncRNA-XIST, lncRNA-NEAT1 and lncRNA-HCG18 interact with all four miRNAs.
Conclusion: This preliminary result forms the basis for improving reliability in future studies to fully understand the role these molecules and their interactions play in HIV.
Graphical Abstract
[http://dx.doi.org/10.1097/QAD.0000000000001511] [PMID: 28574965]
[http://dx.doi.org/10.3389/fimmu.2017.00580] [PMID: 28588579]
[http://dx.doi.org/10.1186/1742-4690-10-67] [PMID: 23803414]
[http://dx.doi.org/10.1089/aid.2018.0118] [PMID: 30056745]
[http://dx.doi.org/10.1515/jib-2019-0027] [PMID: 31301674]
[http://dx.doi.org/10.1016/j.intimp.2021.108460] [PMID: 34942460]
[http://dx.doi.org/10.2147/HIV.S383347] [PMID: 36942082]
[http://dx.doi.org/10.3390/ijms19113416] [PMID: 30384456]
[http://dx.doi.org/10.1007/978-1-62703-748-8_2] [PMID: 24272429]
[http://dx.doi.org/10.1261/rna.068692.118] [PMID: 30333195]
[http://dx.doi.org/10.2217/epi-2020-0289] [PMID: 33355508]
[http://dx.doi.org/10.1080/09603123.2020.1757043] [PMID: 32393046]
[http://dx.doi.org/ 10.1080/00365513.2016.1210330] [PMID: 27542003]
[http://dx.doi.org/10.3389/fimmu.2020.02129] [PMID: 33072075]
[http://dx.doi.org/10.1128/mBio.02314-20] [PMID: 32994328]
[http://dx.doi.org/10.3390/ncrna4010003] [PMID: 29657300]
[http://dx.doi.org/10.1016/j.cell.2011.07.014] [PMID: 21802130]
[http://dx.doi.org/10.1038/cddis.2017.321] [PMID: 28703801]
[http://dx.doi.org/10.1089/aid.2017.0177] [PMID: 29620929]
[http://dx.doi.org/10.1038/ni.3771] [PMID: 28829444]
[http://dx.doi.org/10.1038/srep36111] [PMID: 27782208]
[http://dx.doi.org/10.1371/journal.pone.0224879] [PMID: 31710657]
[http://dx.doi.org/10.7717/peerj.8911] [PMID: 32341894]
[http://dx.doi.org/10.1016/j.jiph.2022.10.027] [PMID: 36395669]
[http://dx.doi.org/10.1016/j.virusres.2018.08.018] [PMID: 30165080]
[http://dx.doi.org/10.2217/epi-2021-0237] [PMID: 34693727]
[http://dx.doi.org/10.7554/eLife.05005] [PMID: 26267216]
[http://dx.doi.org/10.1093/nar/gku1104] [PMID: 25378301]
[http://dx.doi.org/10.1093/nar/gky1141] [PMID: 30423142]
[http://dx.doi.org/10.1007/978-1-0716-2815-7_14] [PMID: 36264497]
[http://dx.doi.org/10.1186/s12859-015-0611-3] [PMID: 25994840]
[http://dx.doi.org/10.1002/0471250953.bi0813s47]
[http://dx.doi.org/10.1093/nar/gkac194] [PMID: 35325185]
[http://dx.doi.org/10.1038/75556] [PMID: 10802651]
[http://dx.doi.org/10.1093/nar/28.1.27] [PMID: 10592173]
[http://dx.doi.org/10.1093/nar/gkt1248] [PMID: 24297251]
[http://dx.doi.org/10.1093/nar/gks1099] [PMID: 23175614]
[http://dx.doi.org/10.3390/v12121443] [PMID: 33334019]
[http://dx.doi.org/10.3389/fgene.2022.862642] [PMID: 35601502]
[http://dx.doi.org/10.1007/978-981-13-0484-2_7] [PMID: 30030793]
[http://dx.doi.org/10.7717/peerj.5721] [PMID: 30345171]
[http://dx.doi.org/10.3389/fmolb.2021.809085] [PMID: 35004856]
[http://dx.doi.org/10.1186/1742-4690-5-117] [PMID: 19102781]
[http://dx.doi.org/10.1016/j.molcel.2009.06.003] [PMID: 19560422]
[http://dx.doi.org/10.1097/QAD.0000000000001938] [PMID: 30005016]
[http://dx.doi.org/10.1097/MD.0000000000002116] [PMID: 26579828]
[http://dx.doi.org/10.1128/JVI.05065-11] [PMID: 22205749]
[http://dx.doi.org/10.1371/journal.pone.0095920] [PMID: 24828336]
[http://dx.doi.org/10.1038/s41598-019-44743-w] [PMID: 31311940]
[http://dx.doi.org/10.3390/v12050495] [PMID: 32365692]
[http://dx.doi.org/10.3390/v12010084] [PMID: 31936859]
[http://dx.doi.org/10.1038/s41419-018-0962-6] [PMID: 30250022]
[http://dx.doi.org/10.1016/B978-0-12-799958-6.00017-2]
[http://dx.doi.org/10.1016/j.molcel.2018.05.007] [PMID: 29883611]
[http://dx.doi.org/10.1038/ni.3156] [PMID: 25988886]
[http://dx.doi.org/10.1126/science.1176009] [PMID: 19965464]
[http://dx.doi.org/10.1038/nrm3904] [PMID: 25415508]
[http://dx.doi.org/10.1016/j.gene.2019.02.057] [PMID: 30825593]
[http://dx.doi.org/10.1002/jcb.22956] [PMID: 21328446]
[http://dx.doi.org/10.1186/1743-422X-8-477] [PMID: 22023789]
[http://dx.doi.org/10.1073/pnas.1121427109] [PMID: 22308487]
[http://dx.doi.org/10.1038/s42003-020-1103-1] [PMID: 32665623]
[http://dx.doi.org/10.3390/v5123192] [PMID: 24351799]
[http://dx.doi.org/10.1007/82_2010_58] [PMID: 20517722]
[http://dx.doi.org/10.1016/j.chom.2008.10.004] [PMID: 18976975]
[http://dx.doi.org/10.1016/j.cytogfr.2014.11.002] [PMID: 25466647]
[http://dx.doi.org/10.3390/cancers11122002] [PMID: 31842362]
[http://dx.doi.org/10.1158/2643-3230.BCD-20-0051] [PMID: 33225311]
[http://dx.doi.org/10.1016/j.bj.2022.03.012] [PMID: 35364293]
[http://dx.doi.org/10.1016/j.ijid.2020.01.006] [PMID: 31945493]
[http://dx.doi.org/10.1016/j.virol.2018.07.020] [PMID: 30036787]
[http://dx.doi.org/10.1128/mBio.00596-12] [PMID: 23362321]
[http://dx.doi.org/10.1111/hiv.12276] [PMID: 26139386]
[http://dx.doi.org/10.3389/fcell.2021.645647] [PMID: 34178980]
[http://dx.doi.org/10.1186/s12977-019-0475-0] [PMID: 31036006]
[http://dx.doi.org/10.1002/cam4.3288] [PMID: 32725768]
[http://dx.doi.org/10.1038/s41598-017-13364-6] [PMID: 29038477]
[http://dx.doi.org/10.3389/fonc.2019.00669] [PMID: 31404273]
[http://dx.doi.org/10.3390/ncrna5010017] [PMID: 30781588]
[http://dx.doi.org/10.3389/fimmu.2021.601298] [PMID: 33776993]