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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Research Article

Study on the Interaction between Silibinin and Neuraminidase

Author(s): Haowen Fang, Yanting Ding, Yi Lu, Bing Niu*, Han Lu* and Qin Chen*

Volume 29, Issue 16, 2023

Published on: 31 May, 2023

Page: [1266 - 1273] Pages: 8

DOI: 10.2174/1381612829666230515165041

Price: $65

Abstract

Background: Neuraminidase is a pathogenic protein of the avian influenza virus. Previous studies have shown that silibinin has the potential to inhibit neuraminidase activity.

Objective: This study aims to explore the interaction between silibinin and neuraminidase and the effect of silibinin on the structure and activity of neuraminidase.

Methods: In this study, two-dimensional fluorescence spectrum, three-dimensional fluorescence spectrometry, Uv-vis spectroscopy, and circular dichroism analysis were used.

Results: Silibinin alters the secondary structure of neuraminidase and inhibits the activity of neuraminidase.

Conclusion: Silibinin can interact with neuraminidase and inhibit its activity.

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