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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Review Article

Rice Nutraceuticals and Bioactive Compounds: Extraction, Characterization and Antioxidant Activity: A Review

Author(s): Muhammad Zubair*, Farooq Anwar, Insha Arshad, Shanza Malik and Muhammad Nadeem Zafar*

Volume 26, Issue 15, 2023

Published on: 15 June, 2023

Page: [2625 - 2643] Pages: 19

DOI: 10.2174/1386207326666230512144834

Price: $65

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Abstract

Rice (Oryza sativa L.), a cereal grass, belongs to the genus Oryza from the family Poaceae, which encompasses twenty-five species cultured in many countries of Asia, and partly in the rest of the world. From these species, two viz. Oryza sativa (O. sativa) Asian rice and Oryza glaberrima (O. glaberrima) African rice are commonly found and the most widely consumed staple food by a large part of the human population in the world, especially in Asia due to their nutritional and nutraceutical prospects. Rice, a popular source of carbohydrates, also contains a good amount of dietary fiber, minerals (Ca, Zn, Se, P, K, Mg, Fe, and Mn), protein and vitamin B along with several other medicinally important bioactives such as tocols (α-tocopherols and α-tocotrienols) (ßsitosterol) phenolic acids, flavonoids (apiginine), and oryzanol (24-Methylenecylcoartanyl transferulate). Rice bran is a byproduct of the rice polishing industry and is valuable in terms of containing 15-20% high-value oil. Because of the natural antioxidants present in rice, several medicinal benefits and biological properties can be attributed to rice consumption. The nutrient profile of rice varies based on several factors, such as grains (white, brown, red, and black/purple), the extent of polishing, and the preparation method. Considering the importance of rice as a traditional diet rich in high-value bioactives, together with the existing gap of related information, it is worthwhile to assemble a comprehensive review that focuses on the detailed profile of valuable nutrients and high-value phytochemicals and biological activities of rice to explore its functional food and nutraceutical applications. This review attempts to provide collective information on the essential rice cereal for its nutritional and antioxidant potential.

Graphical Abstract

[1]
Saikia, D.; Deka, S.C. Cereals: From staple food to nutraceuticals. Int. Food Res. J., 2011, 18(0), 21-30.
[2]
Aziz, U.R. SYED, M.A.S.; Hidayat-Ur-Rahman, Genetic variability for morphological parameters in f2 segregating populations of rice. Pak. J. Bot., 2015, 47(5), 1759-1764.
[3]
Lawson, M.P.; Bergquist, P.R.; Cambie, R.C. The cellular localization of long chain fatty acids in sponges. Tissue Cell, 1986, 18(1), 19-26.
[http://dx.doi.org/10.1016/0040-8166(86)90004-2] [PMID: 18620155]
[4]
Chen, M.H.; Bergman, C.J. A rapid procedure for analysing rice bran tocopherol, tocotrienol and γ-oryzanol contents. J. Food Compos. Anal., 2005, 18(4), 319-331.
[http://dx.doi.org/10.1016/j.jfca.2003.09.016]
[5]
Mir, S.A.; Shah, M.A.; Bosco, S.J.D.; Sunooj, K.V.; Farooq, S. A review on nutritional properties, shelf life, health aspects, and consumption of brown rice in comparison with white rice. Cereal Chem., 2020, 97(5), 895-903.
[http://dx.doi.org/10.1002/cche.10322]
[6]
Pasha, I.; Bugti, M.A. Mineral composition of different rice varieties and their milling fractions. Pak. J. Agric. Sci., 2007, 44(2), 332-336.
[7]
Amissah, J.G.N.; Ellis, W.O.; Oduro, I.; Manful, J.T. Nutrient composition of bran from new rice varieties under study in Ghana. Food Control, 2003, 14(1), 21-24.
[http://dx.doi.org/10.1016/S0956-7135(02)00047-6]
[8]
David, E.; Eleazu, C.; Igweibor, N.; Ugwu, C.; Enwefa, G.; Nwigboji, N. Comparative study on the nutrients, heavy metals and pesticide composition of some locally produced and marketed rice varieties in Nigeria. Food Chem., 2019, 278, 617-624.
[http://dx.doi.org/10.1016/j.foodchem.2018.11.100] [PMID: 30583420]
[9]
Balakrishnan, S.; Yogeshini, R.; Hasanah, M.G.; Kharidah, M. Tocopherol and tocotrienol contents of different varieties of rice in Malaysia. J. Sci. Food Agric., 2015, 95(4), 672-678.
[http://dx.doi.org/10.1002/jsfa.6742] [PMID: 24841131]
[10]
Oberdoerfer, R.B.; Shillito, R.D.; de Beuckeleer, M.; Mitten, D.H. Rice (Oryza sativa L.) containing the bar gene is compositionally equivalent to the nontransgenic counterpart. J. Agric. Food Chem., 2005, 53(5), 1457-1465.
[http://dx.doi.org/10.1021/jf0486500] [PMID: 15740024]
[11]
Zubair, M.; Anwar, F.; Shahid, S.A. Effect of extraction solvents on phenolics and antioxidant activity of selected varieties of pakistani rice (Oryza sativa). Int. J. Agric. Biol., 2012, 14(6)
[12]
Petroni, K.; Landoni, M.; Tomay, F.; Calvenzani, V.; Simonelli, C.; Cormegna, M. Proximate composition, polyphenol content and anti-inflammatory properties of white and pigmented Italian rice varieties. Univers. J. Agric. Res., 2017, 5(5), 312-321.
[http://dx.doi.org/10.13189/ujar.2017.050509]
[13]
Kariyawasam, T.I.; Godakumbura, P.I.; Prashantha, M.A.B.; Premakumara, G.A.S. Proximate composition, calorie content and heavy metals (As, Cd, Pb) of Selected Sri Lankan traditional rice (Oryza Sativa L.) varieties. Procedia Food Sci., 2016, 6, 253-256.
[http://dx.doi.org/10.1016/j.profoo.2016.02.036]
[14]
Goufo, P.; Trindade, H. Rice antioxidants: Phenolic acids, flavonoids, anthocyanins, proanthocyanidins, tocopherols, tocotrienols, γ-oryzanol, and phytic acid. Food Sci. Nutr., 2014, 2(2), 75-104.
[http://dx.doi.org/10.1002/fsn3.86] [PMID: 24804068]
[15]
Rohrer, C.A.; Siebenmorgen, T.J. Nutraceutical concentrations within the bran of various rice kernel thickness fractions. Biosyst. Eng., 2004, 88(4), 453-460.
[http://dx.doi.org/10.1016/j.biosystemseng.2004.04.009]
[16]
Nayik, G.A. Rice bran oil, the Future edible oil of India: A mini Review. Rice Research, 2015, 4(3), 1-5.
[17]
Cicero, A.F.G.; Gaddi, A. Rice bran oil and gamma-oryzanol in the treatment of hyperlipoproteinaemias and other conditions. Phytother. Res., 2001, 15(4), 277-289.
[http://dx.doi.org/10.1002/ptr.907] [PMID: 11406848]
[18]
Lerma-García, M.J.; Herrero-Martínez, J.M.; Simó-Alfonso, E.F.; Mendonça, C.R.B.; Ramis-Ramos, G. Composition, industrial processing and applications of rice bran γ-oryzanol. Food Chem., 2009, 115(2), 389-404.
[http://dx.doi.org/10.1016/j.foodchem.2009.01.063]
[19]
Iqbal, S.; Bhanger, M.I.; Anwar, F. Antioxidant properties and components of some commercially available varieties of rice bran in Pakistan. Food Chem., 2005, 93(2), 265-272.
[http://dx.doi.org/10.1016/j.foodchem.2004.09.024]
[20]
Finocchiaro, F.; Ferrari, B.; Gianinetti, A.; Dall’Asta, C.; Galaverna, G.; Scazzina, F.; Pellegrini, N. Characterization of antioxidant compounds of red and white rice and changes in total antioxidant capacity during processing. Mol. Nutr. Food Res., 2007, 51(8), 1006-1019.
[http://dx.doi.org/10.1002/mnfr.200700011] [PMID: 17639995]
[21]
Butsat, S.; Siriamornpun, S. Antioxidant capacities and phenolic compounds of the husk, bran and endosperm of Thai rice. Food Chem., 2010, 119(2), 606-613.
[http://dx.doi.org/10.1016/j.foodchem.2009.07.001]
[22]
Esa, N.M.; Tan, B.L.; Loh, S.P. By-products of rice processing: An overview of health benefits and applications. J. Rice Res., 2013, 1, 107.
[23]
Sutharut, J.; Sudarat, J. Total anthocyanin content and antioxidant activity of germinated colored rice. Int. Food Res. J., 2012, 19(1), 215-221.
[24]
Van Hung, P. Phenolic compounds of cereals and their antioxidant capacity. Crit. Rev. Food Sci. Nutr., 2016, 56(1), 25-35.
[http://dx.doi.org/10.1080/10408398.2012.708909] [PMID: 25075608]
[25]
Mohapatra, P.K.; Sahu, B.B. Botany of Rice Plant. In: Panicle Architecture of Rice and its Relationship with Grain Filling; Springer, 2022; pp. 27-48.
[http://dx.doi.org/10.1007/978-3-030-67897-5_2]
[26]
Liakat Ali, M.; McClung, A.M.; Jia, M.H.; Kimball, J.A.; McCouch, S.R.; Eizenga, G.C. A rice diversity panel evaluated for genetic and agro-morphological diversity between subpopulations and its geographic distribution. Crop Sci., 2011, 51(5), 2021-2035.
[http://dx.doi.org/10.2135/cropsci2010.11.0641]
[27]
Kumar, A.; Dash, P.K. Transcriptome analysis for abiotic stresses in rice (Oryza sativa L.). In: Transcriptome Analysis; intechopen, 2019.
[http://dx.doi.org/10.5772/intechopen.84955]
[28]
Aaheim, A.; Amundsen, H.; Dokken, T.; Wei, T. Impacts and adaptation to climate change in European economies. Glob. Environ. Change, 2012, 22(4), 959-968.
[http://dx.doi.org/10.1016/j.gloenvcha.2012.06.005]
[29]
Stalikas, C.D. Extraction, separation, and detection methods for phenolic acids and flavonoids. J. Sep. Sci., 2007, 30(18), 3268-3295.
[http://dx.doi.org/10.1002/jssc.200700261] [PMID: 18069740]
[30]
Proteggente, A.R.; Pannala, A.S.; Paganga, G.; Buren, L.; Wagner, E.; Wiseman, S.; Put, F.; Dacombe, C.; Rice-Evans, C.A. The antioxidant activity of regularly consumed fruit and vegetables reflects their phenolic and vitamin C composition. Free Radic. Res., 2002, 36(2), 217-233.
[http://dx.doi.org/10.1080/10715760290006484] [PMID: 11999391]
[31]
Derakhshan-Honarparvar, M.; Hamedi, M.M.; Pirouzifard, M.K. Rice bran phytosterols of three widespread iranian cultivars. J. Agric. Sci. Technol., 2010, 12, 167-172.
[32]
Ghasemzadeh, A.; Jaafar, H.Z.; Rahmat, A. Effects of solvent type on phenolics and flavonoids content and antioxidant activities in two varieties of young ginger (Zingiber officinale Roscoe) extracts. J. Med. Plants Res., 2011, 5(7), 1147-1154.
[33]
Kris-Etherton, P.M.; Hecker, K.D.; Bonanome, A.; Coval, S.M.; Binkoski, A.E.; Hilpert, K.F.; Griel, A.E.; Etherton, T.D. Bioactive compounds in foods: Their role in the prevention of cardiovascular disease and cancer. Am. J. Med., 2002, 113(9), 71-88.
[http://dx.doi.org/10.1016/S0002-9343(01)00995-0] [PMID: 12566142]
[34]
Hodgson, J.M.; Croft, K.D. Dietary flavonoids: Effects on endothelial function and blood pressure. J. Sci. Food Agric., 2006, 86(15), 2492-2498.
[http://dx.doi.org/10.1002/jsfa.2675]
[35]
Yawadio, R.; Tanimori, S.; Morita, N. Identification of phenolic compounds isolated from pigmented rices and their aldose reductase inhibitory activities. Food Chem., 2007, 101(4), 1616-1625.
[http://dx.doi.org/10.1016/j.foodchem.2006.04.016]
[36]
Lai, P.; Li, K.Y.; Lu, S.; Chen, H.H. Phytochemicals and antioxidant properties of solvent extracts from Japonica rice bran. Food Chem., 2009, 117(3), 538-544.
[http://dx.doi.org/10.1016/j.foodchem.2009.04.031]
[37]
Shen, Y.; Jin, L.; Xiao, P.; Lu, Y.; Bao, J. Total phenolics, flavonoids, antioxidant capacity in rice grain and their relations to grain color, size and weight. J. Cereal Sci., 2009, 49(1), 106-111.
[http://dx.doi.org/10.1016/j.jcs.2008.07.010]
[38]
Kong, S.; Lee, J. Antioxidants in milling fractions of black rice cultivars. Food Chem., 2010, 120(1), 278-281.
[http://dx.doi.org/10.1016/j.foodchem.2009.09.089]
[39]
Zhang, H.; Jiang, L.; Ye, S.; Ye, Y.; Ren, F. Systematic evaluation of antioxidant capacities of the ethanolic extract of different tissues of jujube (Ziziphus jujuba Mill.) from China. Food Chem. Toxicol., 2010, 48(6), 1461-1465.
[http://dx.doi.org/10.1016/j.fct.2010.03.011] [PMID: 20230870]
[40]
Goffman, F.D.; Bergman, C.J. Rice kernel phenolic content and its relationship with antiradical efficiency. J. Sci. Food Agric., 2004, 84(10), 1235-1240.
[http://dx.doi.org/10.1002/jsfa.1780]
[41]
Yen, G.; Duh, P-D.; Chuang, D-Y. Antioxidant activity of anthraquinones and anthrone. Food Chem., 2000, 70(4), 437-441.
[http://dx.doi.org/10.1016/S0308-8146(00)00108-4]
[42]
Bekaert, S.; Storozhenko, S.; Mehrshahi, P.; Bennett, M.J.; Lambert, W.; Gregory, J.F., III; Schubert, K.; Hugenholtz, J.; Van Der Straeten, D.; Hanson, A.D. Folate biofortification in food plants. Trends Plant Sci., 2008, 13(1), 28-35.
[http://dx.doi.org/10.1016/j.tplants.2007.11.001] [PMID: 18083061]
[43]
Zaupa, M.; Calani, L.; Del Rio, D.; Brighenti, F.; Pellegrini, N. Characterization of total antioxidant capacity and (poly)phenolic compounds of differently pigmented rice varieties and their changes during domestic cooking. Food Chem., 2015, 187, 338-347.
[http://dx.doi.org/10.1016/j.foodchem.2015.04.055] [PMID: 25977035]
[44]
Ciulu, M.; Cádiz-Gurrea, M.; Segura-Carretero, A. Extraction and analysis of phenolic compounds in rice: A review. Molecules, 2018, 23(11), 2890.
[http://dx.doi.org/10.3390/molecules23112890] [PMID: 30404149]
[45]
Bopitiya, D.; Madhujith, T. Antioxidant potential of rice bran oil prepared from red and white rice. J. Trop. Agric., 2015, 26(1), 1-11.
[http://dx.doi.org/10.4038/tar.v26i1.8067]
[46]
Graf, E. Antioxidant potential of ferulic acid. Free Radic. Biol. Med., 1992, 13(4), 435-448.
[http://dx.doi.org/10.1016/0891-5849(92)90184-I] [PMID: 1398220]
[47]
Peterson, D.M.; Emmons, C.L.; Hibbs, A.H. henolic antioxidants and antioxidant activity in pearling fractions of oat groats. J. Cereal Sci., 2001, 33(1), 97-103.
[http://dx.doi.org/10.1006/jcrs.2000.0347]
[48]
Karimi, E.; Mehrabanjoubani, P.; Keshavarzian, M.; Oskoueian, E.; Jaafar, H.Z.E.; Abdolzadeh, A. Identification and quantification of phenolic and flavonoid components in straw and seed husk of some rice varieties (Oryza sativa L.) and their antioxidant properties. J. Sci. Food Agric., 2014, 94(11), 2324-2330.
[http://dx.doi.org/10.1002/jsfa.6567] [PMID: 24415452]
[49]
Isbilir, S.S.; Tuncay, D. A study on bioactive content, antioxidant activity, and α-amylase inhibition of black rice grown in Turkey. Eur. J. Lipid Sci. Technol., 2014, 3(7), 51-60.
[50]
Dong, X.; Chen, W.; Wang, W.; Zhang, H.; Liu, X.; Luo, J. Comprehensive profiling and natural variation of flavonoids in rice. J. Integr. Plant Biol., 2014, 56(9), 876-886.
[http://dx.doi.org/10.1111/jipb.12204] [PMID: 24730595]
[51]
Ghasemzadeh, A.; Jaafar, H.; Juraimi, A.; Tayebi-Meigooni, A. Comparative evaluation of different extraction techniques and solvents for the assay of phytochemicals and antioxidant activity of hashemi rice bran. Molecules, 2015, 20(6), 10822-10838.
[http://dx.doi.org/10.3390/molecules200610822] [PMID: 26111171]
[52]
Tai-Sun, S.; Godber, J.S. Isolation of four tocopherols and four tocotrienols from a variety of natural sources by semi-preparative high-performance liquid chromatography. J. Chromatogr. A, 1994, 678(1), 49-58.
[http://dx.doi.org/10.1016/0021-9673(94)87073-X]
[53]
Dörmann, P. Functional diversity of tocochromanols in plants. Planta, 2006, 225(2), 269-276.
[http://dx.doi.org/10.1007/s00425-006-0438-2] [PMID: 17115182]
[54]
Saikia, D.; Deka, S.C. Tocotrienols, the vitamin E of the 21st century: Its potential against cancer and other chronic diseases. Biochem. Pharmacol., 2010, 80(11), 1613-1631.
[http://dx.doi.org/10.1016/j.bcp.2010.07.043] [PMID: 20696139]
[55]
Colombo, M.L. An update on vitamin E, tocopherol and tocotrienol-perspectives. Molecules, 2010, 15(4), 2103-2113.
[http://dx.doi.org/10.3390/molecules15042103] [PMID: 20428030]
[56]
Hensley, K.; Benaksas, E.J.; Bolli, R.; Comp, P.; Grammas, P.; Hamdheydari, L.; Mou, S.; Pye, Q.N.; Stoddard, M.F.; Wallis, G.; Williamson, K.S.; West, M.; Wechter, W.J.; Floyd, R.A. New perspectives on vitamin E: γ-tocopherol and carboxyethylhydroxychroman metabolites in biology and medicine. Free Radic. Biol. Med., 2004, 36(1), 1-15.
[http://dx.doi.org/10.1016/j.freeradbiomed.2003.10.009] [PMID: 14732286]
[57]
Dietrich, M.; Traber, M.G.; Jacques, P.F.; Cross, C.E.; Hu, Y.; Block, G. Does γ-tocopherol play a role in the primary prevention of heart disease and cancer? A review. J. Am. Coll. Nutr., 2006, 25(4), 292-299.
[http://dx.doi.org/10.1080/07315724.2006.10719538] [PMID: 16943450]
[58]
Anwar, F.; Anwer, T.; Mahmood, Z. Methodical characterization of rice (Oryza sativa) bran oil from Pakistan. Grasas Aceites, 2005, 56(2), 125-134.
[http://dx.doi.org/10.3989/gya.2005.v56.i2.120]
[59]
Rupérez, F.J.; Martín, D.; Herrera, E.; Barbas, C. Chromatographic analysis of α-tocopherol and related compounds in various matrices. J. Chromatogr. A, 2001, 935(1-2), 45-69.
[http://dx.doi.org/10.1016/S0021-9673(01)01101-3] [PMID: 11762785]
[60]
Bandarra, N.M.; Campos, R.M.; Batista, I.; Nunes, M.L.; Empis, J.M. Antioxidant synergy of α-tocopherol and phospholipids. J. Am. Oil Chem. Soc., 1999, 76(8), 905-913.
[http://dx.doi.org/10.1007/s11746-999-0105-4]
[61]
Qureshi, A.A.; Sami, S.A.; Salser, W.A.; Khan, F.A. Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans. Atherosclerosis, 2002, 161(1), 199-207.
[http://dx.doi.org/10.1016/S0021-9150(01)00619-0] [PMID: 11882333]
[62]
Hu, W.; Wells, J.H.; Shin, T-S.; Godber, J.S. Comparison of isopropanol and hexane for extraction of vitamin E and oryzanols from stabilized rice bran. J. Am. Oil Chem. Soc., 1996, 73(12), 1653-1656.
[http://dx.doi.org/10.1007/BF02517967]
[63]
Lloyd, B.J.; Siebenmorgen, T.J.; Beers, K.W. Effects of commercial processing on antioxidants in rice bran. Cereal Chem., 2000, 77(5), 551-555.
[http://dx.doi.org/10.1094/CCHEM.2000.77.5.551]
[64]
Goncalves, C.B.; Batista, E. Deacidification of vegetable oils by solvent extraction. Recent Pat. Eng., 2007, 1(1), 95-102.
[http://dx.doi.org/10.2174/187221207779814699]
[65]
Duvernay, W. Microwave extraction of antioxidant components from rice bran. Pharm. Eng., 2005, 25(4), 126.
[66]
Ondruschka, B.; Asghari, J. Microwave-assisted extraction – a state-of-the-art overview of varieties. Chimia, 2006, 60(6), 321-325.
[http://dx.doi.org/10.2533/000942906777836327]
[67]
Mu, L.; Feng, S.S. A novel controlled release formulation for the anticancer drug paclitaxel (Taxol®): PLGA nanoparticles containing vitamin E TPGS. J. Control. Release, 2003, 86(1), 33-48.
[http://dx.doi.org/10.1016/S0168-3659(02)00320-6] [PMID: 12490371]
[68]
Mainardes, R.M.; Evangelista, R.C. PLGA nanoparticles containing praziquantel: Effect of formulation variables on size distribution. Int. J. Pharm., 2005, 290(1-2), 137-144.
[http://dx.doi.org/10.1016/j.ijpharm.2004.11.027] [PMID: 15664139]
[69]
Skinner, W.A.; Parkhurst, R.M. Antioxidant properties of α-tocopherol derivatives and relationship of antioxidant activity to biological activity. Lipids, 1970, 5(2), 184-186.
[http://dx.doi.org/10.1007/BF02532466] [PMID: 5436253]
[70]
Li, C.Y.; Park, D-S.; Won, S-R.; Hong, S-K.; Ham, J-K.; Choi, J-K.; Rhee, H-I. Food chemical properties of low-phytate rice cultivar, Sang-gol. J. Cereal Sci., 2008, 47(2), 262-265.
[http://dx.doi.org/10.1016/j.jcs.2007.04.012]
[71]
Tai-sun, S.; Samuel, J.G.; Daniel, E.M.; John, H.W. Hydrolytic stability and changes in E vitamers and oryzanol of extruded rice bran during storage. J. Food Sci., 1997, 62(4), 704-728.
[72]
Aguilar-Garcia, C.; Gavino, G.; Baragaño-Mosqueda, M.; Hevia, P.; Gavino, V.C. Correlation of tocopherol, tocotrienol, γ-oryzanol and total polyphenol content in rice bran with different antioxidant capacity assays. Food Chem., 2007, 102(4), 1228-1232.
[http://dx.doi.org/10.1016/j.foodchem.2006.07.012]
[73]
Sarmento, C.M.P.; Ferreira, S.R.S.; Hense, H. Supercritical fluid extraction (SFE) of rice bran oil to obtain fractions enriched with tocopherols and tocotrienols. J. Supercrit. Fluids, 2006, 23(2), 243-249.
[74]
Katsanidis, E.; Addis, P.B. Novel HPLC analysis of tocopherols, tocotrienols, and cholesterol in tissue. Free Radic. Biol. Med., 1999, 27(11-12), 1137-1140.
[http://dx.doi.org/10.1016/S0891-5849(99)00205-1] [PMID: 10641704]
[75]
Akihisa, T.; Yasukawa, K.; Yamaura, M.; Ukiya, M.; Kimura, Y.; Shimizu, N.; Arai, K. Triterpene alcohol and sterol ferulates from rice bran and their anti-inflammatory effects. J. Agric. Food Chem., 2000, 48(6), 2313-2319.
[http://dx.doi.org/10.1021/jf000135o] [PMID: 10888543]
[76]
Ha, T.Y.; Ko, S-N.; Lee, S-M.; Kim, H-R.; Chung, S-H.; Kim, S-R.; Yoon, H-H.; Kim, I-H. Changes in nutraceutical lipid components of rice at different degrees of milling. Eur. J. Lipid Sci. Technol., 2006, 108(3), 175-181.
[http://dx.doi.org/10.1002/ejlt.200500250]
[77]
Schramm, R.; Abadie, A.; Hua, N.; Xu, Z.; Lima, M. Fractionation of the rice bran layer and quantification of vitamin E, oryzanol, protein, and rice bran saccharide. J. Biol. Eng., 2007, 1(1), 9.
[http://dx.doi.org/10.1186/1754-1611-1-9] [PMID: 18271946]
[78]
Chotimarkorn, C.; Benjakul, S.; Silalai, N. Antioxidant components and properties of five long-grained rice bran extracts from commercial available cultivars in Thailand. Food Chem., 2008, 111(3), 636-641.
[http://dx.doi.org/10.1016/j.foodchem.2008.04.031]
[79]
Lin, T.C.; Huang, S.H.; Ng, L.T. Soaking conditions affect the contents of tocopherols, tocotrienols, and γ-oryzanol in pigmented and non-pigmented brown rice. J. Am. Oil Chem. Soc., 2015, 92(11-12), 1681-1688.
[http://dx.doi.org/10.1007/s11746-015-2721-5]
[80]
Ahsan, H.; Ahad, A.; Iqbal, J.; Siddiqui, W.A. Pharmacological potential of tocotrienols: A review. Nutr. Metab., 2014, 11(1), 52.
[http://dx.doi.org/10.1186/1743-7075-11-52] [PMID: 25435896]
[81]
Shahidi, F. Natural antioxidants: chemistry, health effects, and applications; The American Oil Chemists Society, 1997.
[82]
Huang, S.H.; Ng, L.T. An improved high-performance liquid chromatographic method for simultaneous determination of tocopherols, tocotrienols and γ-oryzanol in rice. J. Chromatogr. A, 2011, 1218(29), 4709-4713.
[http://dx.doi.org/10.1016/j.chroma.2011.05.056] [PMID: 21676402]
[83]
Minatel, I.O.; Han, S.I.; Aldini, G.; Colzani, M.; Matthan, N.R.; Correa, C.R.; Fecchio, D.; Yeum, K.J. Fat-soluble bioactive components in colored rice varieties. J. Med. Food, 2014, 17(10), 1134-1141.
[http://dx.doi.org/10.1089/jmf.2014.3146] [PMID: 25162990]
[84]
Forster, G.M.; Raina, K.; Kumar, A.; Kumar, S.; Agarwal, R.; Chen, M.H.; Bauer, J.E.; McClung, A.M.; Ryan, E.P. Rice varietal differences in bioactive bran components for inhibition of colorectal cancer cell growth. Food Chem., 2013, 141(2), 1545-1552.
[http://dx.doi.org/10.1016/j.foodchem.2013.04.020] [PMID: 23790950]
[85]
Singh, P.K.; Krishnan, S. Vitamin E analogs as radiation response modifiers. Evid. Based Complement. Alternat. Med., 2015, 2015, 741301.
[http://dx.doi.org/10.1155/2015/741301]
[86]
Nakashima, K.; Virgona, N.; Miyazawa, M.; Watanabe, T.; Yano, T. The tocotrienol-rich fraction from rice bran enhances cisplatin-induced cytotoxicity in human mesothelioma H28 cells. Phytother. Res., 2010, 24(9), 1317-1321.
[http://dx.doi.org/10.1002/ptr.3107] [PMID: 20127663]
[87]
Kordsmeier, M.; Howard, L.R.; Brownmiller, C.; Proctor, A.; Hauer-Jensen, M. Isolation of gamma and delta tocotrienols from rice bran oil deodorizer distillate using flash chromatography. J. Am. Oil Chem. Soc., 2015, 92(9), 1243-1252.
[http://dx.doi.org/10.1007/s11746-015-2696-2]
[88]
Raff, M. Molecular Biology of the Cell, 4th ed; Garland Science: New York, 2002.
[89]
Yankah, V.V.; Jones, P.J. Phytosterols and health implications-efficacy and nutritional aspects. INFORM-CHAMPAIGN, 2001, 12(9), 899-934.
[90]
Hallikainen, M.A.; Sarkkinen, E.S.; Gylling, H.; Erkkilä, A.T.; Uusitupa, M.I.J. Comparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet. Eur. J. Clin. Nutr., 2000, 54(9), 715-725.
[http://dx.doi.org/10.1038/sj.ejcn.1601083] [PMID: 11002384]
[91]
Carr, T.P.; Ash, M.; Brown, A. Cholesterol-lowering phytosterols: Factors affecting their use and efficacy. Nutr. Diet. Suppl., 2010, 2, 59-72.
[http://dx.doi.org/10.2147/NDS.S10974]
[92]
Nyström, L.; Achrenius, T.; Lampi, A-M.; Moreau, R.A.; Piironen, V. A comparison of the antioxidant properties of steryl ferulates with tocopherol at high temperatures. Food Chem., 2007, 101(3), 947-954.
[http://dx.doi.org/10.1016/j.foodchem.2006.02.046]
[93]
Sugano, M.; Tanaka, K.; Ide, T. Secretion of cholesterol, triglyceride and apolipoprotein A-I by isolated perfused liver from rats fed soybean protein and casein or their amino acid mixtures. J. Nutr., 1982, 112(5), 855-862.
[http://dx.doi.org/10.1093/jn/112.5.855] [PMID: 7200512]
[94]
Miettinen, T.A.; Vuoristo, M.; Nissinen, M.; Järvinen, H.J.; Gylling, H. Serum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine. Am. J. Clin. Nutr., 2000, 71(5), 1095-1102.
[http://dx.doi.org/10.1093/ajcn/71.5.1095] [PMID: 10799370]
[95]
Valsta, L.M.; Lemström, A.; Ovaskainen, M.L.; Lampi, A.M.; Toivo, J.; Korhonen, T.; Piironen, V. Estimation of plant sterol and cholesterol intake in Finland: Quality of new values and their effect on intake. Br. J. Nutr., 2004, 92(4), 671-678.
[http://dx.doi.org/10.1079/BJN20041234] [PMID: 15522137]
[96]
Wong, A. Phytosterols in selected grain processing residues. Electr. J. Enviro. Agricult. Food Chem., 2008, 7(6), 2984-2992.
[97]
J.W. Tester, H.J. Herzog, Z. Chen, R.M. Potter, M.G. Frank Prospects for universal geothermal energy from heat mining. Science Global Security, 1994, 5(1), 99-121.
[http://dx.doi.org/10.1080/08929889408426418]
[98]
Vissers, M.N.; Zock, P.L.; Meijer, G.W.; Katan, M.B. Effect of plant sterols from rice bran oil and triterpene alcohols from sheanut oil on serum lipoprotein concentrations in humans. Am. J. Clin. Nutr., 2000, 72(6), 1510-1515.
[http://dx.doi.org/10.1093/ajcn/72.6.1510] [PMID: 11101479]
[99]
Piironen, V.; Lampi, A.M.; Dutta, P. Occurrence and levels of phytosterols in foods; Marcel Dekker: New York, NY, USA, 2004.
[100]
Chen, Q.; Steinhauer, L.; Hammerlindl, J.; Keller, W.; Zou, J. Biosynthesis of phytosterol esters: Identification of a sterol o-acyltransferase in Arabidopsis. Plant Physiol., 2007, 145(3), 974-984.
[http://dx.doi.org/10.1104/pp.107.106278] [PMID: 17885082]
[101]
Gaydou, E.M.; Raonizafinimanana, R.; Bianchini, J.P. Quantitative analysis of fatty acids and sterols in Malagasy rice bran oils. J. Am. Oil Chem. Soc., 1980, 57(4), 141-142.
[http://dx.doi.org/10.1007/BF02672237]
[102]
Toivo, J.; Lampi, A.M.; Aalto, S.; Piironen, V. Factors affecting sample preparation in the gas chromatographic determination of plant sterols in whole wheat flour. Food Chem., 2000, 68(2), 239-245.
[http://dx.doi.org/10.1016/S0308-8146(99)00201-0]
[103]
Toivo, J.; Piironen, V.; Kalo, P.; Varo, P. Gas chromatographic determination of major sterols in edible oils and fats using solid-phase extraction in sample preparation. Chromatographia, 1998, 48(11-12), 745-750.
[http://dx.doi.org/10.1007/BF02467642]
[104]
Fenton, M. Chromatographic separation of cholesterol in foods. J. Chromatogr. A, 1992, 624(1-2), 369-388.
[http://dx.doi.org/10.1016/0021-9673(92)85689-Q] [PMID: 1494014]
[105]
Smith, L.L. Review of progress in sterol oxidations: 1987–1995. Lipids, 1996, 31(5), 453-487.
[http://dx.doi.org/10.1007/BF02522641] [PMID: 8727640]
[106]
Phillips, K.M.; Ruggio, D.M.; Bailey, J.A. Precise quantitative determination of phytosterols, stanols, and cholesterol metabolites in human serum by capillary gas–liquid chromatography. J. Chromatogr., Biomed. Appl., 1999, 732(1), 17-29.
[http://dx.doi.org/10.1016/S0378-4347(99)00257-1] [PMID: 10517218]
[107]
Tvrzická, E.; Mareš, P. Písaříková, A.; Novaković, J.; Hrabák, P. Simplified gas chromatographic method for the simultaneous determination of phytosterols and cholesterol. J. Chromatogr., Biomed. Appl., 1991, 563(1), 188-192.
[http://dx.doi.org/10.1016/0378-4347(91)80294-M] [PMID: 2061387]
[108]
Suttiarporn, P.; Chumpolsri, W.; Mahatheeranont, S.; Luangkamin, S.; Teepsawang, S.; Leardkamolkarn, V. Structures of phytosterols and triterpenoids with potential anti-cancer activity in bran of black non-glutinous rice. Nutrients, 2015, 7(3), 1672-1687.
[http://dx.doi.org/10.3390/nu7031672] [PMID: 25756784]
[109]
Zubair, M.; Anwar, F.; Ashraf, M.; Uddin, M.K. Characterization of high-value bioactives in some selected varieties of Pakistani Rice (Oryza sativa L.). Int. J. Mol. Sci., 2012, 13(4), 4608-4622.
[http://dx.doi.org/10.3390/ijms13044608] [PMID: 22605998]
[110]
Massarolo, K.C.; Denardi de Souza, T.; Collazzo, C.C.; Badiale Furlong, E.; Souza Soares, L.A. The impact of Rhizopus oryzae cultivation on rice bran: Gamma-oryzanol recovery and its antioxidant properties. Food Chem., 2017, 228, 43-49.
[http://dx.doi.org/10.1016/j.foodchem.2017.01.127] [PMID: 28317745]
[111]
Itoh, T.; Tamura, T.; Matsumoto, T. Effect of blending different vegetable oils on serum. J. Am. Oil Chem. Soc., 1973, 50, 122-125.
[http://dx.doi.org/10.1007/BF02633564]
[112]
Xu, Z.; Godber, J.S. Purification and identification of components of γ-oryzanol in rice bran Oil. J. Agric. Food Chem., 1999, 47(7), 2724-2728.
[http://dx.doi.org/10.1021/jf981175j] [PMID: 10552553]
[113]
Seetharamaiah, G.; Prabhakar, J. Oryzanol content of Indian rice bran oil and its extraction from soap stock. J. Food Sci. Technol., 1986, 23(5), 270-273.
[114]
Norton, R.A. Quantitation of steryl ferulate andp-coumarate esters from corn and rice. Lipids, 1995, 30(3), 269-274.
[http://dx.doi.org/10.1007/BF02537832] [PMID: 7791537]
[115]
Xu, Z.; Godber, J.S. Comparison of supercritical fluid and solvent extraction methods in extracting γ-oryzanol from rice bran. J. Am. Oil Chem. Soc., 2000, 77(5), 547-551.
[http://dx.doi.org/10.1007/s11746-000-0087-4]
[116]
Rogers, E.J.; Rice, S.M.; Nicolosi, R.J.; Carpenter, D.R.; McClelland, C.A.; Romanczyk, L.J. Jr Identification and quantitation of γ-oryzanol components and simultaneous assessment of tocols in rice bran oil. J. Am. Oil Chem. Soc., 1993, 70(3), 301-307.
[http://dx.doi.org/10.1007/BF02545312]
[117]
Azlan, A.; Ismail, M.; Abdul, H.A. Extraction and determination of oryzanol in rice bran of mixed herbarium UKMB: AZ 6807: MR 185, AZ 6808: MR 211, AZ6809: MR 29. ASEAN Food J., 2008, 15(1), 89-96.
[118]
Barber, S.; De Barber, C.B. Rice Bran: Chemistry and Technology. In: Luh, B.S. (eds) Rice. Springer, Boston, MA, pp. 313.
[119]
Nicolosi, R.J. Rice bran oil and its health benefits. Rice Sci., 1994, 59, 421-437.
[120]
Zhao, W. Fractional extraction of rice bran oil with supercritical carbon dioxide. Agric. Biol. Chem., 1987, 51(7), 1773-1777.
[121]
Qureshi, A.A.; Mo, H.; Packer, L.; Peterson, D.M. Isolation and identification of novel tocotrienols from rice bran with hypocholesterolemic, antioxidant, and antitumor properties. J. Agric. Food Chem., 2000, 48(8), 3130-3140.
[http://dx.doi.org/10.1021/jf000099t] [PMID: 10956081]
[122]
Diack, M.; Saska, M. Separation of vitamin E and γ-oryzanols from rice bran by normal-phase chromatography. J. Am. Oil Chem. Soc., 1994, 71(11), 1211-1217.
[http://dx.doi.org/10.1007/BF02540539]
[123]
Juliano, C.; Cossu, M.; Alamanni, M.C.; Piu, L. Antioxidant activity of gamma-oryzanol: Mechanism of action and its effect on oxidative stability of pharmaceutical oils. Int. J. Pharm., 2005, 299(1-2), 146-154.
[http://dx.doi.org/10.1016/j.ijpharm.2005.05.018] [PMID: 16005170]
[124]
Masao, N.; Yoshizane, S. Oryzanol from alkaline cake of rice oil. JP 68(12,725), , 1968.
[125]
Takeshi, Y. Gamma-oryzanol. German patent, 1969. 1: p. 301-302. 1969.
[126]
Indira, Process for the production of oryzanol enriched fraction from rice bran oil soapstock. U.S Patent, US6896911B2, 2005.
[127]
Tsuchiya, T.; Kaneko, R.; Tanaka, A. Tanaka, Separation of oryzanol from rice bran oil or rice embryo oil. Japanese Patent, 1957, 4895.
[128]
Mingzhi, L.; Yanyan, L. Method for extracting oryzanol from rice bran oil soapstock Chinese Patent, CN101456891A, 1997.
[129]
Narayan, A.V.; Barhate, R.S.; Raghavarao, K.S.M.S. Extraction and purification of oryzanol from rice bran oil and rice bran oil soapstock. J. Am. Oil Chem. Soc., 2006, 83(8), 663-670.
[http://dx.doi.org/10.1007/s11746-006-5021-2]
[130]
Pengkumsri, N.; Chaiyasut, C.; Sivamaruthi, B.S.; Saenjum, C.; Sirilun, S.; Peerajan, S.; Suwannalert, P.; Sirisattha, S.; Chaiyasut, K.; Kesika, P. The Influence of Extraction Methods on Composition and Antioxidant Properties of Rice Bran Oil. Food Sci. Technol. 2015, 35 3), 493–501.
[http://dx.doi.org/10.1590/1678-457x.6730]
[131]
Saenjum, C. Antioxidant and anti-inflammatory activities of gamma-oryzanol rich extracts from Thai purple rice bran. J. Med. Plants Res., 2012, 6(6), 1070-1077.
[132]
Tuncel, N.B. Yılmaz, N. Gamma-oryzanol content, phenolic acid profiles and antioxidant activity of rice milling fractions. Eur. Food Res. Technol., 2011, 233(4), 577-585.
[http://dx.doi.org/10.1007/s00217-011-1551-4]
[133]
Chakuton, K.; Puangpronp, D.; Nakornriab, M. Phytochemical content and antioxidant activity of colored and non-colored Thai rice cultivars. Asian J. Plant Sci., 2012, 11(6), 285-293.
[http://dx.doi.org/10.3923/ajps.2012.285.293]
[134]
Vorarat, S. Examination of antioxidant activity and development of rice bran oil and gamma-oryzanol microemulsion. J. Heal. Res., 2010, 24(2), 67-72.
[135]
Mäkynen, K.; Chitchumroonchokchai, C.; Adisakwattana, S.; Failla, M.; Ariyapitipun, T. Effect of gamma-oryzanol on the bioaccessibility and synthesis of cholesterol. Eur. Rev. Med. Pharmacol. Sci., 2012, 16(1), 49-56.
[PMID: 22338548]
[136]
Heidtmann-Bemvenut, R.; Nora, S.N.; Badiale-Furlong, E. Extraction of γ-oryzanol from rice bran. Ciênc Agrotec Lavras, 2012, 36(6), 665-673.
[http://dx.doi.org/10.1590/S1413-70542012000600008]
[137]
McBride, H.D.; Evans, D.H. Rapid voltammetric method for the estimation of tocopherols and antioxidants in oils and fats. Anal. Chem., 1973, 45(3), 446-449.
[http://dx.doi.org/10.1021/ac60325a003] [PMID: 4762357]
[138]
Miller, A.; Frenzel, T.; Schmarr, H.G.; Engel, K.H. Coupled liquid chromatography–gas chromatography for the rapid analysis of γ-oryzanol in rice lipids. J. Chromatogr. A, 2003, 985(1-2), 403-410.
[http://dx.doi.org/10.1016/S0021-9673(02)01238-4] [PMID: 12580509]
[139]
Kumar, R.R.; Tiku, P.K.; Prakash, V. Preferential extractability of γ-oryzanol from dried soapstock using different solvents. J. Sci. Food Agric., 2009, 89(2), 195-200.
[http://dx.doi.org/10.1002/jsfa.3448]
[140]
Zigoneanu, I.G.; Williams, L.; Xu, Z.; Sabliov, C.M. Determination of antioxidant components in rice bran oil extracted by microwave-assisted method. Bioresour. Technol., 2008, 99(11), 4910-4918.
[http://dx.doi.org/10.1016/j.biortech.2007.09.067] [PMID: 17996444]
[141]
Kumar, S.; Pandey, A.K. Chemistry and biological activities of flavonoids: An overview. Scientif. World J., 2013, 2013, 1-16.
[http://dx.doi.org/10.1155/2013/162750] [PMID: 24470791]
[142]
Mohd Esa, N.; Abdul Kadir, K.K.; Amom, Z.; Azlan, A. Antioxidant activity of white rice, brown rice and germinated brown rice (in vivo and in vitro) and the effects on lipid peroxidation and liver enzymes in hyperlipidaemic rabbits. Food Chem., 2013, 141(2), 1306-1312.
[http://dx.doi.org/10.1016/j.foodchem.2013.03.086] [PMID: 23790918]
[143]
Miller, G. 1 Whole Grain, Fiber, and Antioxidants. In:CRC Handbook of Dietary Fiber in Human Nutrition; CRC Press, 2001, pp. 475-482.
[144]
Becker, E.M.; Nissen, L.R.; Skibsted, L.H. Antioxidant evaluation protocols: Food quality or health effects. Eur. Food Res. Technol., 2004, 219(6), 561-571.
[http://dx.doi.org/10.1007/s00217-004-1012-4]
[145]
Kroon, P.A.; Faulds, C.B.; Ryden, P.; Robertson, J.A.; Williamson, G. Release of covalently bound ferulic acid from fiber in the human colon. J. Agric. Food Chem., 1997, 45(3), 661-667.
[http://dx.doi.org/10.1021/jf9604403]
[146]
Moure, A.; Cruz, J.M.; Franco, D.; Domínguez, J.M.; Sineiro, J.; Domínguez, H.; José Núñez, M.; Parajó, J.C. Natural antioxidants from residual sources. Food Chem., 2001, 72(2), 145-171.
[http://dx.doi.org/10.1016/S0308-8146(00)00223-5]
[147]
Wiseman, S.A.; Balentine, D.A.; Frei, B. Antioxidants in tea. Crit. Rev. Food Sci. Nutr., 1997, 37(8), 705-718.
[http://dx.doi.org/10.1080/10408399709527798] [PMID: 9447271]

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