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Current Organic Synthesis

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ISSN (Online): 1875-6271

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Review Article

An Overview of Julia-lythgoe Olefination

Author(s): Vijayan Varsha, Sankaran Radhika and Gopinathan Anilkumar*

Volume 21, Issue 2, 2024

Published on: 06 July, 2023

Page: [97 - 126] Pages: 30

DOI: 10.2174/1570179420666230510104114

Price: $65

Abstract

Julia-Lythgoe olefination (or simply Julia olefination) is an olefination process between phenyl sulfones and aldehydes (or ketones) to give alkenes after alcohol functionalization and reductive elimination using sodium amalgam or SmI2. It is mainly used to synthesize E-alkenes and is a key step in numerous total syntheses of many natural products. This review exclusively deals with the Julia-Lythgoe olefination and concentrates mainly on the applications of this reaction in natural product synthesis covering literature up to 2021.

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Graphical Abstract

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