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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

The Effects of Curcumin on Astrocytes in Common Neurodegenerative Conditions

Author(s): Ameer A. Alameri, Muhammad Usman Ghanni, Arsalan Ali, Mandeep Singh, Moaed E. Al-Gazally, Abbas F. Almulla, Andrés Alexis Ramírez-Coronel, Yasser Fakri Mustafa, Reena Gupta, Rasha Fadhel Obaid, Gamal A. Gabr and Bagher Farhood*

Volume 23, Issue 22, 2023

Published on: 11 May, 2023

Page: [2117 - 2129] Pages: 13

DOI: 10.2174/1389557523666230502143131

Price: $65

Abstract

Neurodegenerative diseases are age-related, multifactorial, and complicated conditions that affect the nervous system. In most cases, these diseases may begin with an accumulation of misfolded proteins rather than decay before they develop clinical symptoms. The progression of these diseases can be influenced by a number of internal and external factors, including oxidative damage, neuro-inflammation, and the accumulation of misfolded amyloid proteins. Astrocytes, with the highest abundance among the cells of the mammalian central nervous system, perform several important activities, such as maintaining brain homeostasis and playing a role in the neurodegenerative condition onset and progress. Therefore, these cells have been considered to be potential targets for managing neurodegeneration. Curcumin, with multiple special properties, has been effectively prescribed to manage various diseases. It has hepato-protective, anti-carcinogenic, cardio-protective, thrombo-suppressive, anti-inflammatory, chemo-therapeutic, anti-arthritic, chemo-preventive, and anti-oxidant activities. In the current review, the effects of curcumin on astrocytes in common neurodegenerative conditions, such as Huntington’s disease, amyotrophic lateral sclerosis, multiple sclerosis, Alzheimer’s disease, and Parkinson’s disease, are discussed. Hence, it can be concluded that astrocytes play a critical role in neurodegenerative diseases, and curcumin is able to directly modulate astrocyte activity in neurodegenerative diseases.

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