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Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Mini-Review Article

An Insight into the Combination of Probiotics and their Implications for Human Health

Author(s): El Bethel Lalthavel Hmar, Sujata Paul and Hemanta Kumar Sharma*

Volume 24, Issue 1, 2024

Published on: 17 July, 2023

Page: [1 - 12] Pages: 12

DOI: 10.2174/1871530323666230502141717

Price: $65

Abstract

Over 100-1000 microbial species reside in the human gut, where they predominantly influence the host's internal environment and, thus, have a significant impact on host health. Probiotics are best characterized as a microbe or a group of microbes that reside in the gut and support the body's internal microbiota. Probiotics are linked to increased health advantages, including better immune function, improved nutritional absorption, and protection against cancer and heart-related illnesses. Several studies have demonstrated that combining probiotics from different strains with complementary activities may have synergistic advantages and aid in re-establishing the equilibrium of how immunological niches and microorganisms interact. Another thing to remember is that even though a product contains more probiotic strains, that doesn't always guarantee that the health benefits will be more significant. For specific combinations to be justified, there must be clinical proof. The clinical results of a probiotic strain are specifically pertinent to the participants in the relevant research, such as studies on adults or newborn infants. Clinical outcomes of a probiotic strain are mainly connected to the investigated health area (such as gut health, immune health, oral health, etc.). As a result, picking the right probiotic is essential yet tricky because of several factors, including probiotic products with the disease and strain-specific effectiveness exists; however, various probiotic strains have diverse modes of action. The current review focuses on probiotic categorization, their function in enhancing human health, and any potential health benefits of probiotic combinations.

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[1]
Lilly, D.M.; Stillwell, R.H. Probiotics: Growth-promoting factors produced by microorganisms. Science, 1965, 147(3659), 747-748.
[http://dx.doi.org/10.1126/science.147.3659.747] [PMID: 14242024]
[2]
Bielecka, M. Probiotics in food: Health and nutritional properties and guidelines for evaluation. Food and Agriculture Organization (FAO) 2006, 85, 0254-0304. Available from: https://agris.fao.org/agris-search/search.do?recordID=XF2007431319
[3]
Gibson, G.R.; Roberfroid, M.B. Dietary modulation of the human colonic microbiota: Introducing the concept of prebiotics. J. Nutr., 1995, 125(6), 1401-1412.
[http://dx.doi.org/10.1093/jn/125.6.1401] [PMID: 7782892]
[4]
Degnan, P.H.; Taga, M.E.; Goodman, A.L. Vitamin B12 as a modulator of gut microbial ecology. Cell Metab., 2014, 20(5), 769-778.
[http://dx.doi.org/10.1016/j.cmet.2014.10.002] [PMID: 25440056]
[5]
Anagnostopoulos, D.A.; Tsaltas, D. Chapter 10Fermented foods and beverages; Innovations Traditional Foods, 2019, pp. 257-291.
[6]
Kristensen, N.B.; Bryrup, T.; Allin, K.H.; Nielsen, T.; Hansen, T.H.; Pedersen, O. Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: A systematic review of randomized controlled trials. Genome Med., 2016, 8(1), 52.
[http://dx.doi.org/10.1186/s13073-016-0300-5] [PMID: 27159972]
[7]
Bermudez-Brito, M.; Plaza-Díaz, J.; Muñoz-Quezada, S.; Gómez-Llorente, C.; Gil, A. Probiotic mechanisms of action. Ann. Nutr. Metab., 2012, 61(2), 160-174.
[http://dx.doi.org/10.1159/000342079] [PMID: 23037511]
[8]
Wang, Y.; Xie, Q.; Zhang, Y.; Ma, W.; Ning, K.; Xiang, J.Y.; Cui, J.; Xiang, H. Combination of probiotics with different functions alleviate DSS-induced colitis by regulating intestinal microbiota, IL-10, and barrier function. Appl. Microbiol. Biotechnol., 2020, 104(1), 335-349.
[http://dx.doi.org/10.1007/s00253-019-10259-6] [PMID: 31758237]
[9]
Probiotics: A comprehensive review of their classification, mode of action and role in human nutrition. In: Probiotics and Prebiotics in Human Nutrition and Health In: Rijeka IntechOpen; Rao, V.; Rao, L.G., Eds.; , 2016; pp. 1-394.
[10]
Bintsis, T. Lactic acid bacteria: Their applications in foods. J. Bacteriol. Mycol. Open Access, 2018, 6(2), 89-94.
[11]
Abedi, E.; Hashemi, S.M.B. Lactic acid production-producing microorganisms and substrates sources-state of art. Heliyon, 2020, 6(10), e04974-e04974.
[http://dx.doi.org/10.1016/j.heliyon.2020.e04974] [PMID: 33088933]
[12]
Pleissner, D.; Demichelis, F.; Mariano, S.; Fiore, S.; Navarro Gutiérrez, I.M.; Schneider, R.; Venus, J. Direct production of lactic acid based on simultaneous saccharification and fermentation of mixed restaurant food waste. J. Clean. Prod., 2017, 143, 615-623.
[http://dx.doi.org/10.1016/j.jclepro.2016.12.065]
[13]
Lübeck, M.; Lübeck, P.S. Application of lactic acid bacteria in greenbiorefineries. FEMS Microbiol. Lett., 2019, 366(3), 1-8.
[14]
Åvall-Jääskeläinen, S.; Palva, A. Lactobacillus surface layers and their applications. FEMS Microbiol. Rev., 2005, 29(3), 511-529.
[15]
Vanderhoof, J.A.; Young, R.J. Current and potential uses of probiotics. Ann. Allergy Asthma Immunol., 2004, 93(5)(Suppl. 3), S33-S37.
[http://dx.doi.org/10.1016/S1081-1206(10)61730-9] [PMID: 15562872]
[16]
Weiss, N.; Busse, M.; Kandler, O. Origin of by-products in lactic acid fermentation of Lactobacillus acidophilus. Arch. Microbiol., 1968, 62(1), 85-93.
[http://dx.doi.org/10.1007/BF00407055] [PMID: 5709358]
[17]
Giori, G.S.; Hebert, E.M.; Raya, R.R. Differentiation of Lactobacilli Strains by Electrophoretic Protein Profiles BT ; In: Spencer, J.F.T., de Ragout Spencer, A.L. (eds) Food Microbiology Protocols. Methods in biotechnology,, 2001, pp. 191-196.
[18]
Goldstein, E.J.C.; Tyrrell, K.L.; Citron, D.M. Lactobacillus species: Taxonomic complexity and controversial susceptibilities. Clin. Infect. Dis., 2015, 60(Suppl. 2), S98-S107.
[http://dx.doi.org/10.1093/cid/civ072] [PMID: 25922408]
[19]
Madsen, K.L.; Doyle, J.S.; Jewell, L.D.; Tavernini, M.M.; Fedorak, R.N. Lactobacillus species prevents colitis in interleukin 10 gene–deficient mice. Gastroenterology, 1999, 116(5), 1107-1114.
[http://dx.doi.org/10.1016/S0016-5085(99)70013-2] [PMID: 10220502]
[20]
O’Callaghan, J.; O’Toole, P.W. Lactobacillus: Host-microbe relationships. Curr. Top. Microbiol. Immunol., 2011, 358, 119-154.
[http://dx.doi.org/10.1007/82_2011_187] [PMID: 22102141]
[21]
Shornikova, A.V.; Casas, I.A.; Isolauri, E.; Mykkänen, H.; Vesikari, T. Lactobacillus reuteri as a therapeutic agent in acute diarrhea in young children. J. Pediatr. Gastroenterol. Nutr., 1997, 24(4), 399-404.
[http://dx.doi.org/10.1097/00005176-199704000-00008] [PMID: 9144122]
[22]
Ljungh, A.; Wadström, T. Lactic acid bacteria as probiotics. Curr. Issues Intest. Microbiol., 2006, 7(2), 73-89.
[PMID: 16875422]
[23]
Yang, K.; Xu, M.; Zhong, F.; Zhu, J. Rapid differentiation of Lactobacillus species via metabolic profiling. J. Microbiol. Methods, 2018, 154(October), 147-155.
[http://dx.doi.org/10.1016/j.mimet.2018.10.013] [PMID: 30359661]
[24]
Turroni, F.; van Sinderen, D.; Ventura, M. Genomics and ecological overview of the genus Bifidobacterium. Int. J. Food Microbiol., 2011, 149(1), 37-44.
[http://dx.doi.org/10.1016/j.ijfoodmicro.2010.12.010] [PMID: 21276626]
[25]
Lee, J.H.; Karamychev, V.N.; Kozyavkin, S.A.; Mills, D.; Pavlov, A.R.; Pavlova, N.V.; Polouchine, N.N.; Richardson, P.M.; Shakhova, V.V.; Slesarev, A.I.; Weimer, B.; O’Sullivan, D.J. Comparative genomic analysis of the gut bacterium Bifidobacterium longum reveals loci susceptible to deletion during pure culture growth. BMC Genomics, 2008, 9(1), 247.
[http://dx.doi.org/10.1186/1471-2164-9-247] [PMID: 18505588]
[26]
Ventura, M.; Turroni, F.; Lugli, G.A.; van Sinderen, D. Bifidobacteria and humans: Our special friends, from ecological to genomics perspectives. J. Sci. Food Agric., 2014, 94(2), 163-168.
[http://dx.doi.org/10.1002/jsfa.6356] [PMID: 23963950]
[27]
Lamendella, R.; Domingo, J.W.S.; Kelty, C.; Oerther, D.B. Bifidobacteria in feces and environmental waters. Appl. Environ. Microbiol., 2008, 74(3), 575-584.
[http://dx.doi.org/10.1128/AEM.01221-07] [PMID: 17993557]
[28]
Klijn, A.; Mercenier, A.; Arigoni, F. Lessons from the genomes of bifidobacteria. FEMS Microbiol. Rev., 2005, 29(3), 491-509.
[http://dx.doi.org/10.1016/j.fmrre.2005.04.010] [PMID: 15939502]
[29]
Laureys, D.; Cnockaert, M.; De Vuyst, L.; Vandamme, P. Bifidobacterium aquikefiri sp. nov., isolated from water kefir. Int. J. Syst. Evol. Microbiol., 2016, 66(3), 1281-1286.
[http://dx.doi.org/10.1099/ijsem.0.000877] [PMID: 26739269]
[30]
Cremonini, F.; Caro, S.; Covino, M.; Armuzzi, A.; Gabrielli, M.; Santarelli, L.; Nista, E.C.; Cammarota, G.; Gasbarrini, G.; Gasbarrini, A. Effect of different probiotic preparations on anti-Helicobacter pylori therapy-related side effects: A parallel group, triple blind, placebo-controlled study. Am. J. Gastroenterol., 2002, 97(11), 2744-2749.
[http://dx.doi.org/10.1111/j.1572-0241.2002.07063.x] [PMID: 12425542]
[31]
Ghoddusi, H.B.; Tamime, A.Y. Microflora of the intestine-biology of bifidobacteria. In:Encyclopedia of Food Microbiology, 2nd; Batt, C.A.; Tortorello, M.L, Eds.; Academic Press: Oxford, 2014, pp. 639-645.
[32]
Hoyos, A.B. Reduced incidence of necrotizing enterocolitis associated with enteral administration of Lactobacillus acidophilus and Bifidobacterium infantis to neonates in an intensive care unit. Int. J. Infect. Dis., 1999, 3(4), 197-202.
[http://dx.doi.org/10.1016/S1201-9712(99)90024-3] [PMID: 10575148]
[33]
Mishra, S.; Acharya, S. A brief overview on probiotics: The health friendly microbes. Biomed. Pharmacol. J., 2021, 14(4), 1869-1880.
[http://dx.doi.org/10.13005/bpj/2285]
[34]
Kechagia, M.; Basoulis, D.; Konstantopoulou, S.; Dimitriadi, D.; Gyftopoulou, K.; Skarmoutsou, N.; Fakiri, E.M. Health benefits of probiotics: A review. ISRN Nutr., 2013, 2013, 1-7.
[http://dx.doi.org/10.5402/2013/481651] [PMID: 24959545]
[35]
Ramos, C.L.; Esteves, E.A.; de Miranda, N.M.Z.; Moreno, L.G.; Schwan, R.F. Non-lactic acid bacteria as probiotics and their functional roles. In:Probiotics, Prebiotics and Synbiotics; John Wiley & Sons, Ltd, 2022, pp. 73-102.
[http://dx.doi.org/10.1002/9781119702160.ch4]
[36]
Holzapfel, W.H.; Haberer, P.; Geisen, R.; Björkroth, J.; Schillinger, U. Taxonomy and important features of probiotic microorganisms in food and nutrition. Am. J. Clin. Nutr., 2001, 73(Suppl. 2), 365s-373s.
[http://dx.doi.org/10.1093/ajcn/73.2.365s] [PMID: 11157343]
[37]
Nagpal, R.; Kumar, A.; Kumar, M.; Behare, P.V.; Jain, S.; Yadav, H. Probiotics, their health benefits and applications for developing healthier foods: A review. FEMS Microbiol. Lett., 2012, 334(1), 1-15.
[http://dx.doi.org/10.1111/j.1574-6968.2012.02593.x] [PMID: 22568660]
[38]
Kerry, R.G.; Patra, J.K.; Gouda, S.; Park, Y.; Shin, H-S.; Das, G. Benefaction of probiotics for human health: A review. Yao Wu Shi Pin Fen Xi, 2018, 26(3), 927-939.
[PMID: 29976412]
[39]
Quijano, G. The benefits of probiotics on human health. J. Microb. Biochem. Technol., 2011, s1(1), 1-6.
[http://dx.doi.org/10.4172/1948-5948.S1-003]
[40]
Bhatt, A.; Dhyey Kothari, C.K. Probiotic: An Uprising Human Health Concept. In:Prebiotics and probiotics: From food to health; Kothari, D., Ed.; IntechOpen: Rijeka, 2021, pp. 1-22.
[41]
Amara, A.A.; Shibl, A. Role of Probiotics in health improvement, infection control and disease treatment and management. Saudi Pharm. J., 2015, 23(2), 107-114.
[http://dx.doi.org/10.1016/j.jsps.2013.07.001] [PMID: 25972729]
[42]
Gill, H.S.; Guarner, F. Probiotics and human health: A clinical perspective. Postgrad. Med. J., 2004, 80(947), 516-526.
[http://dx.doi.org/10.1136/pgmj.2003.008664] [PMID: 15356352]
[43]
Hajela, N.; Ramakrishna, B.S.; Nair, G.B.; Abraham, P.; Gopalan, S.; Ganguly, N.K. Gut microbiome, gut function, and probiotics: Implications for health. Indian J. Gastroenterol., 2015, 34(2), 93-107.
[http://dx.doi.org/10.1007/s12664-015-0547-6] [PMID: 25917520]
[44]
Chen, Y.; Zhou, J.; Role, L.W. Role and mechanism of gut microbiota in human disease. Front. Cell. Infect. Microbiol., 2021, 11, 1-12.
[45]
Tojo, R.; Suárez, A.; Clemente, M.G.; de los Reyes-Gavilán, C.G.; Margolles, A.; Gueimonde, M.; Ruas-Madiedo, P. Intestinal microbiota in health and disease: Role of Bifidobacteria in gut homeostasis. World J. Gastroenterol., 2014, 20(41), 15163-15176.
[http://dx.doi.org/10.3748/wjg.v20.i41.15163] [PMID: 25386066]
[46]
Pace, F.; Pace, M.; Quartarone, G. Probiotics in digestive diseases: Focus on Lactobacillus GG. Minerva Gastroenterol. Dietol., 2015, 61(4), 273-292.
[PMID: 26657927]
[47]
LeBlanc, A.M.; LeBlanc, J.G. Effect of probiotic administration on the intestinal microbiota, current knowledge and potential applications. World J. Gastroenterol., 2014, 20(44), 16518-16528.
[http://dx.doi.org/10.3748/wjg.v20.i44.16518] [PMID: 25469019]
[48]
Baarlen, P.V.; Troost, F.; der Meer, C.V.; Hooiveld, G.; Boekschoten, M.; M. Brummer, R.J.; Kleerebezem, M. Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways. Proc. Natl. Acad. Sci. U. S. A., 2011, 108(Suppl. 1), 4562-4569.
[49]
Elangovan, A.; Allegretti, J.R.; Fischer, M. Microbiota modulation-based therapy for luminal GI disorders: Current applications of probiotics and fecal microbiota transplantation. Expert Opin. Biol. Ther., 2019, 19(12), 1343-1355.
[http://dx.doi.org/10.1080/14712598.2019.1673725] [PMID: 31570017]
[50]
Domingo, S. Review of the role of probiotics in gastrointestinal diseases in adults. Gastroenterol. Hepatol., 2017, 40(6), 417-429.
[51]
Derrien, M.; van Hylckama Vlieg, J.E.T. Fate, activity, and impact of ingested bacteria within the human gut microbiota. Trends Microbiol., 2015, 23(6), 354-366.
[http://dx.doi.org/10.1016/j.tim.2015.03.002] [PMID: 25840765]
[52]
Smith, P.M.; Howitt, M.R.; Panikov, N.; Michaud, M.; Gallini, C.A.; Bohlooly-Y, M.; Glickman, J.N.; Garrett, W.S. The microbial metabolites, short-chain fatty acids, regulate colonic treg cell homeostasis. Science, 2013, 341(6145), 569-573.
[http://dx.doi.org/10.1126/science.1241165] [PMID: 23828891]
[53]
Girardin, M.; Seidman, E.G. Indications for the use of probiotics in gastrointestinal diseases. Dig. Dis., 2011, 29(6), 574-587.
[http://dx.doi.org/10.1159/000332980] [PMID: 22179214]
[54]
Penner, R.; Fedorak, R.; Madsen, K. Probiotics and nutraceuticals: Non-medicinal treatments of gastrointestinal diseases. Curr. Opin. Pharmacol., 2005, 5(6), 596-603.
[http://dx.doi.org/10.1016/j.coph.2005.06.009] [PMID: 16214413]
[55]
Issa, I.; Moucari, R. Probiotics for antibiotic-associated diarrhea: Do we have a verdict? World J. Gastroenterol., 2014, 20(47), 17788-17795.
[http://dx.doi.org/10.3748/wjg.v20.i47.17788] [PMID: 25548477]
[56]
Vaughan, E.E.; Schut, F.; Heilig, H.G.H.J.; Zoetendal, E.G.; de Vos, W.M.; Akkermans, A.D.L. A molecular view of the intestinal ecosystem. Curr. Issues Intest. Microbiol., 2000, 1(1), 1-12.
[PMID: 11709849]
[57]
Stevens, E.J.; Bates, K.A.; King, K.C. Host microbiota can facilitate pathogen infection. PLoS Pathog., 2021, 17(5), e1009514.
[http://dx.doi.org/10.1371/journal.ppat.1009514] [PMID: 33984069]
[58]
Azad, M.A.K.; Sarker, M.; Li, T.; Yin, J. Probiotic species in the modulation of gut microbiota: An overview. BioMed Res. Int., 2018, 2018, 1-8.
[http://dx.doi.org/10.1155/2018/9478630] [PMID: 29854813]
[59]
Hemarajata, P.; Versalovic, J. Effects of probiotics on gut microbiota: Mechanisms of intestinal immunomodulation and neuromodulation. Therap. Adv. Gastroenterol., 2013, 6(1), 39-51.
[http://dx.doi.org/10.1177/1756283X12459294] [PMID: 23320049]
[60]
Lee, B.J.; Bak, Y.T. Irritable bowel syndrome, gut microbiota and probiotics. J. Neurogastroenterol. Motil., 2011, 17(3), 252-266.
[http://dx.doi.org/10.5056/jnm.2011.17.3.252] [PMID: 21860817]
[61]
Liang, Y.; Liang, S.; Zhang, Y.; Deng, Y.; He, Y.; Chen, Y.; Liu, C.; Lin, C.; Yang, Q. Oral Administration of compound probiotics ameliorates hfd-induced gut microbe dysbiosis and chronic metabolic inflammation via the G protein-coupled receptor 43 in non-alcoholic fatty liver disease rats. Probiotics Antimicrob. Proteins, 2019, 11(1), 175-185.
[http://dx.doi.org/10.1007/s12602-017-9378-3] [PMID: 29353414]
[62]
Valdes, A.M.; Walter, J.; Segal, E.; Spector, T.D. Role of the gut microbiota in nutrition and health. BMJ, 2018, 361, k2179.
[http://dx.doi.org/10.1136/bmj.k2179] [PMID: 29899036]
[63]
Could probiotics evolve in the gut and cause harm?. Available from: https://www.medicalnewstoday.com/articles/324834#How-probiotics-change-inside-the-gut (Accessed on: 2022-06-25).
[64]
Abee, T.; Krockel, L.; Hill, C. Bacteriocins: Modes of action and potentials in food preservation and control of food poisoning. Int. J. Food Microbiol., 1995, 28(2), 169-185.
[http://dx.doi.org/10.1016/0168-1605(95)00055-0] [PMID: 8750665]
[65]
Simova, E.D.; Beshkova, D.B.; Dimitrov, Z.P. Characterization and antimicrobial spectrum of bacteriocins produced by lactic acid bacteria isolated from traditional Bulgarian dairy products. J. Appl. Microbiol., 2009, 106(2), 692-701.
[http://dx.doi.org/10.1111/j.1365-2672.2008.04052.x] [PMID: 19200334]
[66]
Chen, K.; Xin, J.; Zhang, G.; Xie, H.; Luo, L.; Yuan, S.; Bu, Y.; Yang, X.; Ge, Y.; Liu, C. A combination of three probiotic strains for treatment of acute diarrhoea in hospitalised children: An open label, randomised controlled trial. Benef. Microbes, 2020, 11(4), 339-346.
[http://dx.doi.org/10.3920/BM2020.0046] [PMID: 32720832]
[67]
Hamad, G.M.; Botros, W.A.; Hafez, E.E. Combination of probiotic filtrates as antibacterial agent against selected some pathogenic bacteria in milk and cheese. Int. J. Dairy Sci., 2017, 12(6), 368-376.
[http://dx.doi.org/10.3923/ijds.2017.368.376]
[68]
Goldin, B.R.; Gorbach, S.L. Effect of Lactobacillus acidophilus dietary supplements on 1, 2-dimethylhydrazine dihydrochloride-induced intestinal cancer in rats. J. Natl. Cancer Inst., 1980, 64(2), 263-265.
[http://dx.doi.org/10.1093/jnci/64.2.263] [PMID: 6766509]
[69]
Goldin, B.R.; Gorbach, S.L. The effect of milk and Lactobacillus feeding on human intestinal bacterial enzyme activity. Am. J. Clin. Nutr., 1984, 39(5), 756-761.
[http://dx.doi.org/10.1093/ajcn/39.5.756] [PMID: 6424430]
[70]
Kumar, M.; Verma, V.; Nagpal, R.; Kumar, A.; Gautam, S.K.; Behare, P.V.; Grover, C.R.; Aggarwal, P.K. Effect of probiotic fermented milk and chlorophyllin on gene expressions and genotoxicity during AFB1-induced hepatocellular carcinoma. Gene, 2011, 490(1-2), 54-59.
[http://dx.doi.org/10.1016/j.gene.2011.09.003] [PMID: 21963996]
[71]
Uccello, M.; Malaguarnera, G.; Basile, F.; D’agata, V.; Malaguarnera, M.; Bertino, G.; Vacante, M.; Drago, F.; Biondi, A. Potential role of probiotics on colorectal cancer prevention. BMC Surg., 2012, 12(Suppl. 1), S35.
[http://dx.doi.org/10.1186/1471-2482-12-S1-S35] [PMID: 23173670]
[72]
Hmar, E.B.L.; Paul, S.; Boruah, N.; Sarkar, P.; Borah, S.; Sharma, H.K. Apprehending ulcerative colitis management with springing up therapeutic approaches: Can nanotechnology play a nascent role? Curr. Pathobiol. Rep., 2021, 9(1), 9-32.
[http://dx.doi.org/10.1007/s40139-020-00218-6]
[73]
Baricault, L.; Denariaz, G.; Houri, J.J.; Bouley, C.; Sapin, C.; Trugnan, G. Use of HT-29, a cultured human colon cancer cell line, to study the effect of fermented milks on colon cancer cell growth and differentiation. Carcinogenesis, 1995, 16(2), 245-252.
[http://dx.doi.org/10.1093/carcin/16.2.245] [PMID: 7859355]
[74]
Grimoud, J.; Durand, H.; de Souza, S.; Monsan, P.; Ouarné, F.; Theodorou, V.; Roques, C. In vitro screening of probiotics and synbiotics according to anti-inflammatory and anti-proliferative effects. Int. J. Food Microbiol., 2010, 144(1), 42-50.
[http://dx.doi.org/10.1016/j.ijfoodmicro.2010.09.007] [PMID: 20951454]
[75]
Li, S.C.; Hsu, W.F.; Chang, J.S.; Shih, C.K. Combination of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis shows a stronger anti-inflammatory effect than individual strains in HT-29 Cells. Nutrients, 2019, 11(5), 969.
[http://dx.doi.org/10.3390/nu11050969] [PMID: 31035617]
[76]
Riera, B.J.; Viladomiu, M.; Pedragosa, M.; De Simone, C.; Hontecillas, R. Immunoregulatory mechanisms underlying prevention of colitis-associated colorectal cancer by probiotic bacteria. PLoS One, 2012, 7(4), 1-8.
[77]
Mi, H.; Dong, Y.; Zhang, B.; Wang, H.; Peter, C.C.K.; Gao, P.; Fu, H.; Gao, Y. Bifidobacterium infantis ameliorates chemotherapy-induced intestinal mucositis via regulating T cell immunity in colorectal cancer rats. Cell. Physiol. Biochem., 2017, 42(6), 2330-2341.
[http://dx.doi.org/10.1159/000480005] [PMID: 28848081]
[78]
Tuohy, K.M.; Probert, H.M.; Smejkal, C.W.; Gibson, G.R. Using probiotics and prebiotics to improve gut health. Drug Discov. Today, 2003, 8(15), 692-700.
[http://dx.doi.org/10.1016/S1359-6446(03)02746-6] [PMID: 12927512]
[79]
Cammarota, G.; Pecere, S.; Ianiro, G.; Masucci, L.; Currò, D. Principles of DNA-based gut microbiota assessment and therapeutic efficacy of fecal microbiota transplantation in gastrointestinal diseases. Dig. Dis., 2016, 34(3), 279-285.
[http://dx.doi.org/10.1159/000443362] [PMID: 27027524]
[80]
Spiller, R. Irritable bowel syndrome: New insights into symptom mechanisms and advances in treatment. F1000 Res., 2016, 5, 780.
[http://dx.doi.org/10.12688/f1000research.7992.1] [PMID: 27158477]
[81]
Verdenelli, M.C.; Silvi, S.; Cecchini, C.; Orpianesi, C.; Cresci, A. Influence of a combination of two potential probiotic strains, Lactobacillus rhamnosus IMC 501® and Lactobacillus paracasei IMC 502® on bowel habits of healthy adults. Lett. Appl. Microbiol., 2011, 52(6), 596-602.
[http://dx.doi.org/10.1111/j.1472-765X.2011.03042.x] [PMID: 21395626]
[82]
5-strain probiotic blend improves functional gastrointestinal symptoms- latest news for doctors, nurses and pharmacists-gastroenterology., 2022. Available from: https://specialty.mims.com/topic/5-strain-probiotic-blend-improves-functional-gastrointestinal-symptoms
[83]
Azad, M.A.K.; Sarker, M.; Wan, D. Immunomodulatory effects of probiotics on cytokine profiles. BioMed Res. Int., 2018, 2018, 1-10.
[http://dx.doi.org/10.1155/2018/8063647] [PMID: 30426014]
[84]
Al-Megrin, W.A.; Yehia, H.M.; Korany, S.M.; Alkhateeb, M.A.; Alahdal, H.; Sonbol, H.; Alkhuriji, A.F.; Elkhadragy, M.F. In vitro and in vivo. Evaluation of probiotic as immunomodulatory and anti-Campylobacter agent. Food Sci. Technol., 2022, 42, e20322.
[http://dx.doi.org/10.1590/fst.20322]
[85]
McGuckin, M.A.; Eri, R.; Simms, L.A.; Florin, T.H.J.; Radford-Smith, G. Intestinal barrier dysfunction in inflammatory bowel diseases. Inflamm. Bowel Dis., 2009, 15(1), 100-113.
[http://dx.doi.org/10.1002/ibd.20539] [PMID: 18623167]
[86]
Hooper, L.V.; Wong, M.H.; Thelin, A.; Hansson, L.; Falk, P.G.; Gordon, J.I. Molecular analysis of commensal host-microbial relationships in the intestine. Science, 2001, 291(5505), 881-884.
[http://dx.doi.org/10.1126/science.291.5505.881] [PMID: 11157169]
[87]
Sartor, R.B. Mechanisms of Disease: Pathogenesis of Crohn’s disease and ulcerative colitis. Nat. Clin. Pract. Gastroenterol. Hepatol., 2006, 3(7), 390-407.
[http://dx.doi.org/10.1038/ncpgasthep0528] [PMID: 16819502]
[88]
Resta-Lenert, S.; Barrett, K.E. Live probiotics protect intestinal epithelial cells from the effects of infection with Enteroinvasive Escherichia coli (EIEC). Gut, 2003, 52(7), 988-997.
[http://dx.doi.org/10.1136/gut.52.7.988] [PMID: 12801956]
[89]
Dai, C.; Zhao, D-H.; Jiang, M. VSL#3 probiotics regulate the intestinal epithelial barrier in vivo and in vitro via the p38 and ERK signaling pathways. Int. J. Mol. Med., 2012, 29(2), 202-208.
[PMID: 22089663]
[90]
Finlay, B.B.; Falkow, S. Common themes in microbial pathogenicity revisited. Microbiol. Mol. Biol. Rev., 1997, 61(2), 136-169.
[PMID: 9184008]
[91]
Juntunen, M.; Kirjavainen, P.V.; Ouwehand, A.C.; Salminen, S.J.; Isolauri, E. Adherence of probiotic bacteria to human intestinal mucus in healthy infants and during rotavirus infection. Clin. Diagn. Lab. Immunol., 2001, 8(2), 293-296.
[http://dx.doi.org/10.1128/CDLI.8.2.293-296.2001] [PMID: 11238211]
[92]
Collado, M.C.; Gueimonde, M.; Hernández, M.; Sanz, Y.; Salminen, S. Adhesion of selected Bifidobacterium strains to human intestinal mucus and the role of adhesion in enteropathogen exclusion. J. Food Prot., 2005, 68(12), 2672-2678.
[http://dx.doi.org/10.4315/0362-028X-68.12.2672] [PMID: 16355841]
[93]
González-Rodríguez, I.; Sánchez, B.; Ruiz, L.; Turroni, F.; Ventura, M.; Ruas-Madiedo, P.; Gueimonde, M.; Margolles, A. Role of extracellular transaldolase from Bifidobacterium bifidum in mucin adhesion and aggregation. Appl. Environ. Microbiol., 2012, 78(11), 3992-3998.
[http://dx.doi.org/10.1128/AEM.08024-11] [PMID: 22447584]
[94]
Ohland, C.L.; MacNaughton, W.K. Probiotic bacteria and intestinal epithelial barrier function. Am. J. Physiol. Gastrointest. Liver Physiol., 2010, 298(6), G807-G819.
[http://dx.doi.org/10.1152/ajpgi.00243.2009] [PMID: 20299599]
[95]
Schiffrin, E.J.; Blum, S. Interactions between the microbiota and the intestinal mucosa. Eur. J. Clin. Nutr., 2002, 56(Suppl. 3), S60-S64.
[http://dx.doi.org/10.1038/sj.ejcn.1601489] [PMID: 12142966]
[96]
Neeser, J.R.; Granato, D.; Rouvet, M.; Servin, A.; Teneberg, S.; Karlsson, K.A. Lactobacillus johnsonii La1 shares carbohydrate-binding specificities with several enteropathogenic bacteria. Glycobiology, 2000, 10(11), 1193-1199.
[http://dx.doi.org/10.1093/glycob/10.11.1193] [PMID: 11087711]
[97]
Fujiwara, S.; Hashiba, H.; Hirota, T.; Forstner, J.F. Inhibition of the binding of enterotoxigenic Escherichia coli Pb176 to human intestinal epithelial cell line HCT-8 by an extracellular protein fraction containing BIF of Bifidobacterium longum SBT2928: Suggestive evidence of blocking of the binding receptor gangliotetraosylceramide on the cell surface. Int. J. Food Microbiol., 2001, 67(1-2), 97-106.
[http://dx.doi.org/10.1016/S0168-1605(01)00432-9] [PMID: 11482574]
[98]
Mukai, T.; Asasaka, T.; Sato, E.; Mori, K.; Matsumoto, M.; Ohori, H. Inhibition of binding of to the glycolipid receptors by probiotic Lactobacillus reuteri. FEMS Immunol. Med. Microbiol., 2002, 32(2), 105-110.
[http://dx.doi.org/10.1111/j.1574-695X.2002.tb00541.x] [PMID: 11821231]
[99]
Coconnier, M.H.; Bernet, M.F.; Chauvière, G.; Servin, A.L. Adhering heat-killed human Lactobacillus acidophilus, strain LB, inhibits the process of pathogenicity of diarrhoeagenic bacteria in cultured human intestinal cells. J. Diarrhoeal Dis. Res., 1993, 11(4), 235-242.
[PMID: 8188996]
[100]
Alakomi, H.L.; Skyttä, E.; Saarela, M.; Mattila-Sandholm, T.; Latva-Kala, K.; Helander, I.M. Lactic acid permeabilizes gram-negative bacteria by disrupting the outer membrane. Appl. Environ. Microbiol., 2000, 66(5), 2001-2005.
[http://dx.doi.org/10.1128/AEM.66.5.2001-2005.2000] [PMID: 10788373]
[101]
Makras, L.; Triantafyllou, V.; Fayol-Messaoudi, D.; Adriany, T.; Zoumpopoulou, G.; Tsakalidou, E.; Servin, A.; De Vuyst, L. Kinetic analysis of the antibacterial activity of probiotic lactobacilli towards Salmonella enterica serovar Typhimurium reveals a role for lactic acid and other inhibitory compounds. Res. Microbiol., 2006, 157(3), 241-247.
[http://dx.doi.org/10.1016/j.resmic.2005.09.002] [PMID: 16266797]
[102]
Savadogo, A.; Ouattara, C.A.T.; Bassole, I.H.N.; Traore, A.S. Antimicrobial activities of lactic acid bacteria strains isolated from burkina faso fermented milk. Pak. J. Nutr., 2004, 3(3), 174-179.
[103]
Russell, J.B.; Diez-Gonzalez, F. The effects of fermentation acids on bacterial growth. Adv. Microb. Physiol., 1997, 39, 205-234.
[http://dx.doi.org/10.1016/S0065-2911(08)60017-X] [PMID: 9328648]
[104]
Nielsen, D.S.; Cho, G.S.; Hanak, A.; Huch, M.; Franz, C.M.A.P.; Arneborg, N. The effect of bacteriocin-producing Lactobacillus plantarum strains on the intracellular pH of sessile and planktonic Listeria monocytogenes single cells. Int. J. Food Microbiol., 2010, 141(Suppl. 1), S53-S59.
[http://dx.doi.org/10.1016/j.ijfoodmicro.2010.03.040] [PMID: 20447709]
[105]
Hassan, M.; Kjos, M.; Nes, I.F.; Diep, D.B.; Lotfipour, F. Natural antimicrobial peptides from bacteria: Characteristics and potential applications to fight against antibiotic resistance. J. Appl. Microbiol., 2012, 113(4), 723-736.
[http://dx.doi.org/10.1111/j.1365-2672.2012.05338.x] [PMID: 22583565]
[106]
Magnusson, J.; Schnürer, J. Lactobacillus coryniformis subsp. Coryniformis strain Si3 produces a broad-spectrum proteinaceous antifungal compound. Appl. Environ. Microbiol., 2001, 67(1), 1-5.
[http://dx.doi.org/10.1128/AEM.67.1.1-5.2001] [PMID: 11133421]
[107]
Rouse, S.; Harnett, D.; Vaughan, A.; Sinderen, D. Lactic acid bacteria with potential to eliminate fungal spoilage in foods. J. Appl. Microbiol., 2008, 104(3), 915-923.
[http://dx.doi.org/10.1111/j.1365-2672.2007.03619.x] [PMID: 17976175]
[108]
Oelschlaeger, T.A. Mechanisms of probiotic actions-A review. Int. J. Med. Microbiol., 2010, 300(1), 57-62.
[http://dx.doi.org/10.1016/j.ijmm.2009.08.005] [PMID: 19783474]
[109]
Wang, H.; Yan, Y.; Wang, J.; Zhang, H.; Qi, W. Production and characterization of antifungal compounds produced by Lactobacillus plantarum IMAU10014. PLoS One, 2012, 7(1), e29452.
[http://dx.doi.org/10.1371/journal.pone.0029452] [PMID: 22276116]
[110]
Niku-Paavola, M.L.; Laitila, A.; Mattila-Sandholm, T.; Haikara, A. New types of antimicrobial compounds produced by Lactobacillus plantarum. J. Appl. Microbiol., 1999, 86(1), 29-35.
[http://dx.doi.org/10.1046/j.1365-2672.1999.00632.x] [PMID: 10200070]
[111]
Sjögren, J.; Magnusson, J.; Broberg, A.; Schnürer, J.; Kenne, L. Antifungal 3-hydroxy fatty acids from Lactobacillus plantarum MiLAB 14. Appl. Environ. Microbiol., 2003, 69(12), 7554-7557.
[http://dx.doi.org/10.1128/AEM.69.12.7554-7557.2003] [PMID: 14660414]
[112]
D’Amelio, P.; Sassi, F. Gut microbiota, immune system, and bone. Calcif. Tissue Int., 2018, 102(4), 415-425.
[http://dx.doi.org/10.1007/s00223-017-0331-y] [PMID: 28965190]
[113]
Gómez-Llorente, C.; Muñoz, S.; Gil, A. Role of Toll-like receptors in the development of immunotolerance mediated by probiotics. Proc. Nutr. Soc., 2010, 69(3), 381-389.
[http://dx.doi.org/10.1017/S0029665110001527] [PMID: 20416121]
[114]
Giorgetti, G.; Brandimarte, G.; Fabiocchi, F.; Ricci, S.; Flamini, P.; Sandri, G.; Trotta, M.C.; Elisei, W.; Penna, A.; Lecca, P.G.; Picchio, M.; Tursi, A. Interactions between innate immunity, microbiota, and probiotics. J. Immunol. Res., 2015, 2015, 1-7.
[http://dx.doi.org/10.1155/2015/501361] [PMID: 26090492]
[115]
Neish, A.S.; Gewirtz, A.T.; Zeng, H.; Young, A.N.; Hobert, M.E.; Karmali, V.; Rao, A.S.; Madara, J.L. Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination. Science, 2000, 289(5484), 1560-1563.
[http://dx.doi.org/10.1126/science.289.5484.1560] [PMID: 10968793]
[116]
Yan, F.; Polk, D.B. Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells. J. Biol. Chem., 2002, 277(52), 50959-50965.
[http://dx.doi.org/10.1074/jbc.M207050200] [PMID: 12393915]
[117]
Doron, S.; Snydman, D.R. Risk and safety of probiotics. Clin. Infect. Dis., 2015, 60(Suppl. 2), S129-S134.
[http://dx.doi.org/10.1093/cid/civ085] [PMID: 25922398]
[118]
Kazamel, M.; Desnick, R.J.; Quigley, J.G. Correction to: Porphyric neuropathy: Pathophysiology, diagnosis, and updated management. Curr. Neurol. Neurosci. Rep., 2021, 21(1), 1-2488.
[http://dx.doi.org/10.1007/s11910-020-01089-5] [PMID: 33300100]
[119]
Segarra-Newnham, M. Probiotics for Clostridium difficile–associated diarrhea: Focus on Lactobacillus rhamnosus GG and Saccharomyces boulardii. Ann. Pharmacother., 2007, 41(7-8), 1212-1221.
[http://dx.doi.org/10.1345/aph.1K110] [PMID: 17595306]
[120]
Elahi, B.; Nikfar, S.; Derakhshani, S.; Vafaie, M.; Abdollahi, M. On the benefit of probiotics in the management of pouchitis in patients underwent ileal pouch anal anastomosis: A meta-analysis of controlled clinical trials. Dig. Dis. Sci., 2008, 53(5), 1278-1284.
[http://dx.doi.org/10.1007/s10620-007-0006-z] [PMID: 17940902]
[121]
Hempel, S.; Newberry, S.; Ruelaz, A.; Wang, Z.; Miles, J.N.V.; Suttorp, M.J.; Johnsen, B.; Shanman, R.; Slusser, W.; Fu, N.; Smith, A.; Roth, B.; Polak, J.; Motala, A.; Perry, T.; Shekelle, P.G. Safety of probiotics used to reduce risk and prevent or treat disease. Evid. Rep. Technol. Assess., 2011, (200), 1-645.
[PMID: 23126627]
[122]
Whelan, K.; Myers, C.E. Safety of probiotics in patients receiving nutritional support: A systematic review of case reports, randomized controlled trials, and nonrandomized trials. Am. J. Clin. Nutr., 2010, 91(3), 687-703.
[http://dx.doi.org/10.3945/ajcn.2009.28759] [PMID: 20089732]

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