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Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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General Review Article

Differentiated Embryo-Chondrocyte Expressed Gene1 and Parkinson’s Disease: New Insights and Therapeutic Perspectives

Author(s): Chun-Yan Wang, Zheng-Jie Qiu, Ping Zhang and Xiao-Qing Tang*

Volume 21, Issue 11, 2023

Published on: 05 July, 2023

Page: [2251 - 2265] Pages: 15

DOI: 10.2174/1570159X21666230502123729

Price: $65

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Abstract

Differentiated embryo-chondrocyte expressed gene1 (DEC1), an important transcription factor with a basic helix-loop-helix domain, is ubiquitously expressed in both human embryonic and adult tissues. DEC1 is involved in neural differentiation and neural maturation in the central nervous system (CNS). Recent studies suggest that DEC1 protects against Parkinson's disease (PD) by regulating apoptosis, oxidative stress, lipid metabolism, immune system, and glucose metabolism disorders. In this review, we summarize the recent progress on the role of DEC1 in the pathogenesis of PD and provide new insights into the prevention and treatment of PD and neurodegenerative diseases.

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