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CNS & Neurological Disorders - Drug Targets

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ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

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Review Article

Emerging Nanotechnology for the Treatment of Alzheimer’s Disease

Author(s): Aditya Singh, Vaseem Ahamad Ansari*, Tarique Mahmood, Farogh Ahsan, Rufaida Wasim, Shubhrat Maheshwari, Mohammad Shariq, Saba Parveen and Arshiya Shamim

Volume 23, Issue 6, 2024

Published on: 22 May, 2023

Page: [687 - 696] Pages: 10

DOI: 10.2174/1871527322666230501232815

Price: $65

Abstract

Nanotechnology is a great choice for medical research, and the green synthesis approach is a novel and better way to synthesize nanoparticles. Biological sources are cost-effective, environmentally friendly, and allow large-scale production of nanoparticles. Naturally obtained 3 β-hydroxy-urs- 12-en-28-oic acids reported for neuroprotective and dendritic structure are reported as solubility enhancers. Plants are free from toxic substances and act as natural capping agents. In this review, the pharmacological properties of ursolic acid (UA) and the structural properties of the dendritic structure are discussed. UA acid appears to have negligible toxicity and immunogenicity, as well as favorable biodistribution, according to the current study, and the dendritic structure improves drug solubility, prevents drug degradation, increases circulation time, and potentially targets by using different pathways with different routes of administration. Nanotechnology is a field in which materials are synthesized at the nanoscale. Nanotechnology could be the next frontier of humankind's technological advancement. Richard Feynman first used the term ‘Nanotechnology’ in his lecture, “There is Plenty of Room at the Bottom”, on 29th December, 1959, and since then, interest has increased in the research on nanoparticles. Nanotechnology is capable of helping humanity by solving major challenges, particularly in neurological disorders like Alzheimer's disease (AD), the most prevalent type, which may account for 60-70% of cases. Other significant forms of dementia include vascular dementia, dementia with Lewy bodies (abnormal protein aggregates that form inside nerve cells), and a number of illnesses that exacerbate frontotemporal dementia. Dementia is an acquired loss of cognition in several cognitive domains that are severe enough to interfere with social or professional functioning. However, dementia frequently co-occurs with other neuropathologies, typically AD with cerebrovascular dysfunction. Clinical presentations show that neurodegenerative diseases are often incurable because patients permanently lose some neurons. A growing body of research suggests that they also advance our knowledge of the processes that are probably crucial for maintaining the health and functionality of the brain. Serious neurological impairment and neuronal death are the main features of neurodegenerative illnesses, which are also extremely crippling ailments. The most prevalent neurodegenerative disorders cause cognitive impairment and dementia, and as average life expectancy rises globally, their effects become more noticeable.

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[1]
Thies W, Bleiler L. Alzheimer’s Association. 2012 Alzheimer’s disease facts and figures Alzheimer’s Association. Alzheimers Dement 2012; 8(2): 131-68.
[http://dx.doi.org/10.1016/j.jalz.2012.02.001] [PMID: 22404854]
[2]
Iadecola C. Vascular and metabolic factors in Alzheimer’s disease and related dementias: Introduction. Cell Mol Neurobiol 2016; 36(2): 151-4.
[http://dx.doi.org/10.1007/s10571-015-0319-y] [PMID: 26898551]
[3]
Anderson JM, Shive MS. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Deliv Rev 1997; 28(1): 5-24.
[http://dx.doi.org/10.1016/S0169-409X(97)00048-3] [PMID: 10837562]
[4]
Aranda-Espinoza H, Bermudez H, Bates FS, Discher DE. Electromechanical limits of polymersomes. Phys Rev Lett 2001; 87(20): 208301.
[http://dx.doi.org/10.1103/PhysRevLett.87.208301] [PMID: 11690515]
[5]
Bar H, Bhui DK, Sahoo GP, Sarkar P, De SP, Misra A. Green synthesis of silver nanoparticles using latex of Jatropha curcas. Colloids Surf A Physicochem Eng Asp 2009; 339(1-3): 134-9.
[http://dx.doi.org/10.1016/j.colsurfa.2009.02.008]
[6]
Bar H, Bhui DK, Sahoo GP, Sarkar P, Pyne S, Misra A. Green synthesis of silver nanoparticles using seed extract of Jatropha curcas. Colloids Surf A Physicochem Eng Asp 2009; 348(1-3): 212-6.
[http://dx.doi.org/10.1016/j.colsurfa.2009.07.021]
[7]
Becker RE, Greig NH. Increasing the success rate for Alzheimer’s disease drug discovery and development. Expert Opin Drug Discov 2012; 7(4): 367-70.
[http://dx.doi.org/10.1517/17460441.2012.672409] [PMID: 22439785]
[8]
Bhalgat MK, Roberts JC. Molecular modeling of polyamidoamine (PAMAM) Starburst™ dendrimers. Eur Polym J 2000; 36(3): 647-51.
[http://dx.doi.org/10.1016/S0014-3057(99)00088-9]
[9]
Castellani RJ, Perry G. Pathogenesis and disease-modifying therapy in Alzheimer’s disease: The flat line of progress. Arch Med Res 2012; 43(8): 694-8.
[http://dx.doi.org/10.1016/j.arcmed.2012.09.009] [PMID: 23085451]
[10]
Chandran SP, Chaudhary M, Pasricha R, Ahmad A, Sastry M. Synthesis of gold nanotriangles and silver nanoparticles using Aloe vera plant extract. Biotechnol Prog 2006; 22(2): 577-83.
[http://dx.doi.org/10.1021/bp0501423] [PMID: 16599579]
[11]
Chen JW, Kalback WM. Effect of ultrasound on chemical reaction rate. Ind Eng Chem Fundam 1967; 6(2): 175-8.
[http://dx.doi.org/10.1021/i160022a003]
[12]
Choi KY, Chung H, Min KH, et al. Self-assembled hyaluronic acid nanoparticles for active tumor targeting. Biomaterials 2010; 31(1): 106-14.
[http://dx.doi.org/10.1016/j.biomaterials.2009.09.030] [PMID: 19783037]
[13]
Choi SH, Joe EH, Kim SU, Jin BK. Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo. J Neurosci 2003; 23(13): 5877-86.
[http://dx.doi.org/10.1523/JNEUROSCI.23-13-05877.2003] [PMID: 12843292]
[14]
Cummings J. What can be inferred from the interruption of the semagacestat trial for treatment of Alzheimer’s disease? Biol Psychiatry 2010; 68(10): 876-8.
[http://dx.doi.org/10.1016/j.biopsych.2010.09.020] [PMID: 21035622]
[15]
Cummings JL, Morstorf T, Zhong K. Alzheimer’s disease drug-development pipeline: few candidates, frequent failures. Alzheimers Res Ther 2014; 6(4): 37.
[http://dx.doi.org/10.1186/alzrt269] [PMID: 25024750]
[16]
de Gennes PG, Hervet H. Statistics of « starburst » polymers. Journal de Physique Lettres 1983; 44(9): 351-60.
[http://dx.doi.org/10.1051/jphyslet:01983004409035100]
[17]
Singh A, Ansari VA, Mahmood T, Ahsan F, Wasim R. Dendrimers: A Neuroprotective Lead in Alzheimer Disease: A review on its synthetic approach and applications. Drug Res 2022; 72(8): 417-23.
[http://dx.doi.org/10.1055/a-1886-3208] [PMID: 35931069]
[18]
Discher DE, Ahmed F. Polymersomes. Annu Rev Biomed Eng 2006; 8: 323-41.
[http://dx.doi.org/10.1146/annurev.bioeng.8.061505.095838]
[19]
Dubey SP, Lahtinen M, Sillanpää M. Green synthesis and characterizations of silver and gold nanoparticles using leaf extract of Rosa rugosa. Colloids Surf A Physicochem Eng Asp 2010; 364(1-3): 34-41.
[http://dx.doi.org/10.1016/j.colsurfa.2010.04.023]
[20]
Dwivedi AD, Gopal K. Biosynthesis of silver and gold nanoparticles using Chenopodium album leaf extract. Colloids Surf A Physicochem Eng Asp 2010; 369(1-3): 27-33.
[http://dx.doi.org/10.1016/j.colsurfa.2010.07.020]
[21]
Dwivedi C, Sahu R, Tiwari SP, Satapathy T, Roy A. Role of liposome in novel drug delivery system. J Drug Deliv Ther 2014; 4(2): 116-29.
[http://dx.doi.org/10.22270/jddt.v4i2.768]
[22]
Elechiguerra JL, Burt JL, Morones JR, et al. Interaction of silver nanoparticles with HIV-1. J Nanobiotechnology 2005; 3(1): 6.
[http://dx.doi.org/10.1186/1477-3155-3-6] [PMID: 15987516]
[23]
Eloy JO, Saraiva J, Albuquerque S, Marchetti JM. Preparation, characterization and evaluation of the in vivo trypanocidal activity of ursolic acid-loaded solid dispersion with poloxamer 407 and sodium caprate. Braz J Pharm Sci 2015; 51(1): 101-9.
[http://dx.doi.org/10.1590/S1984-82502015000100011]
[24]
Farajnia S, Hassan M, Hallaj Nezhadi S, Mohammadnejad L, Milani M, Lotfipour F. Determination of indicator bacteria in pharmaceutical samples by multiplex PCR. J Rapid Methods Autom Microbiol 2009; 17(3): 328-38.
[http://dx.doi.org/10.1111/j.1745-4581.2009.00154.x]
[25]
Farazuddin M, Chauhan A, Khan RMM, Owais M. Amoxicillin-bearing microparticles: potential in the treatment of Listeria monocytogenes infection in Swiss albino mice. Biosci Rep 2011; 31(4): 265-72.
[http://dx.doi.org/10.1042/BSR20100027] [PMID: 20687896]
[26]
Fellahi O, Sarma RK, Das MR, et al. The antimicrobial effect of silicon nanowires decorated with silver and copper nanoparticles. Nanotechnology 2013; 24(49): 495101.
[http://dx.doi.org/10.1088/0957-4484/24/49/495101] [PMID: 24231372]
[27]
Fessi H, Puisieux F, Devissaguet JP, Ammoury N, Benita S. Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int J Pharm 1989; 55(1): R1-4.
[http://dx.doi.org/10.1016/0378-5173(89)90281-0]
[28]
García MC. Nano-and microparticles as drug carriers. In: Engineering Drug Delivery Systems. Woodhead Publishing 2020; pp. 71-110.
[http://dx.doi.org/10.1016/B978-0-08-102548-2.00004-4]
[29]
Guidelli EJ, Ramos AP, Zaniquelli MED, Baffa O. Green synthesis of colloidal silver nanoparticles using natural rubber latex extracted from Hevea brasiliensis. Spectrochim Acta A Mol Biomol Spectrosc 2011; 82(1): 140-5.
[http://dx.doi.org/10.1016/j.saa.2011.07.024] [PMID: 21803643]
[30]
Hamdi SS. Synthesis of Ag-TiO2 Thin Films by Spin Coating process. Eng Tech J 2016; pp. 2443-9.
[31]
Harkany T, O’Mahony S, Keijser J, et al. β-amyloid(1-42)-induced cholinergic lesions in rat nucleus basalis bidirectionally modulate serotonergic innervation of the basal forebrain and cerebral cortex. Neurobiol Dis 2001; 8(4): 667-78.
[http://dx.doi.org/10.1006/nbdi.2001.0398] [PMID: 11493031]
[32]
Hasani A, Sharifi Y, Ghotaslou R, et al. Molecular screening of virulence genes in high-level gentamicin-resistant Enterococcus faecalis and Enterococcus faecium isolated from clinical specimens in Northwest Iran. Indian J Med Microbiol 2012; 30(2): 175-81.
[http://dx.doi.org/10.4103/0255-0857.96687] [PMID: 22664433]
[33]
Hawker CJ, Frechet JMJ. Preparation of polymers with controlled molecular architecture. A new convergent approach to dendritic macromolecules. J Am Chem Soc 1990; 112(21): 7638-47.
[http://dx.doi.org/10.1021/ja00177a027]
[34]
He G, Luo W, Li P, et al. Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease. Nature 2010; 467(7311): 95-8.
[http://dx.doi.org/10.1038/nature09325] [PMID: 20811458]
[35]
Heneka MT, Golenbock DT, Latz E. Innate immunity in Alzheimer’s disease. Nat Immunol 2015; 16(3): 229-36.
[http://dx.doi.org/10.1038/ni.3102] [PMID: 25689443]
[36]
Jeffreys S. Beauty and misogyny: Harmful cultural practices in the West. Routledge 2014.
[37]
Jha AK, Prasad K, Prasad K, Kulkarni AR. Plant system: Nature’s nanofactory. Colloids Surf B Biointerfaces 2009; 73(2): 219-23.
[http://dx.doi.org/10.1016/j.colsurfb.2009.05.018] [PMID: 19539452]
[38]
Jinhua W. Ursolic acid: Pharmacokinetics process in vitro and in vivo, a mini review. Arch Pharm 2019; 352(3): 1800222.
[http://dx.doi.org/10.1002/ardp.201800222] [PMID: 30663087]
[39]
Johnson SM, Bangham AD, Hill MW, Korn ED. Single bilayer liposomes. Biochim Biophys Acta Biomembr 1971; 233(3): 820-6.
[http://dx.doi.org/10.1016/0005-2736(71)90184-2]
[40]
Jung JH, Cheol Oh H, Soo Noh H, Ji JH, Soo Kim S. Metal nanoparticle generation using a small ceramic heater with a local heating area. J Aerosol Sci 2006; 37(12): 1662-70.
[http://dx.doi.org/10.1016/j.jaerosci.2006.09.002]
[41]
Singh P, Arya M, Kanoujia J, Singh M, Gupta KP, Saraf SA. Design of topical nanostructured lipid carrier of silymarin and its effect on 7,12-dimethylbenz[a]anthracene (DMBA) induced cellular differentiation in mouse skin. RSC Advances 2016; 6(88): 84965-77.
[http://dx.doi.org/10.1039/C6RA20231D]
[42]
Kato H. Tracking nanoparticles inside cells. Nat Nanotechnol 2011; 6(3): 139-40.
[http://dx.doi.org/10.1038/nnano.2011.25] [PMID: 21372839]
[43]
Katz L, Baltz RH. Natural product discovery: Past, present, and future. J Ind Microbiol Biotechnol 2016; 43(2-3): 155-76.
[http://dx.doi.org/10.1007/s10295-015-1723-5] [PMID: 26739136]
[44]
Kaviya S, Santhanalakshmi J, Viswanathan B. Green synthesis of silver nanoparticles using Polyalthia longifolia leaf extract along with D-sorbitol: study of antibacterial activity. Journal of nanotechnology 2011; Vol. 2019, Article ID 1613475: 1-5.
[http://dx.doi.org/10.1155/2019/1613475]
[45]
Khwaza V, Oyedeji O, Aderibigbe B. Antiviral activities of oleanolic acid and its analogues. Molecules 2018; 23(9): 2300.
[http://dx.doi.org/10.3390/molecules23092300] [PMID: 30205592]
[46]
Kikuchi H, Yamauchi H, Hirota S. A polyol dilution method for mass production of liposomes. J Liposome Res 1994; 4(1): 71-91.
[http://dx.doi.org/10.3109/08982109409037030]
[47]
Kim G, DeCoster J, Huang CH, Parmelee P. Health disparities grants funded by National Institute on Aging: trends between 2000 and 2010. Gerontologist 2012; 52(6): 748-58.
[http://dx.doi.org/10.1093/geront/gns035] [PMID: 22454392]
[48]
Klaus T, Joerger R, Olsson E, Granqvist CG. Silver-based crystalline nanoparticles, microbially fabricated. Proc Natl Acad Sci 1999; 96(24): 13611-4.
[http://dx.doi.org/10.1073/pnas.96.24.13611] [PMID: 10570120]
[49]
Koo EH, Squazzo SL. Evidence that production and release of amyloid beta-protein involves the endocytic pathway. J Biol Chem 1994; 269(26): 17386-9.
[http://dx.doi.org/10.1016/S0021-9258(17)32449-3] [PMID: 8021238]
[50]
Kouhi M, Vahedi A, Akbarzadeh A, Hanifehpour Y, Joo SW. Investigation of quadratic electro-optic effects and electro-absorption process in GaN/AlGaN spherical quantum dot. Nanoscale Res Lett 2014; 9(1): 131.
[http://dx.doi.org/10.1186/1556-276X-9-131] [PMID: 24646318]
[51]
Kulhari H, Pooja D, Prajapati SK, Chauhan AS. Performance evaluation of PAMAM dendrimer based simvastatin formulations. Int J Pharm 2011; 405(1-2): 203-9.
[http://dx.doi.org/10.1016/j.ijpharm.2010.12.002] [PMID: 21145960]
[52]
Kumar A, Badde S, Kamble R, Pokharkar VB. Development and characterization of liposomal drug delivery system for nimesulide. Int J Pharm Pharm Sci 2010; 2(4): 87-9.
[53]
Kwon GS. Polymeric micelles for delivery of poorly water-soluble compounds. Crit Rev Therap Drug Carrier Systems 2003; 20(5): 357-403.
[http://dx.doi.org/10.1615/CritRevTherDrugCarrierSyst.v20.i5.20]
[54]
Lambertini E, Piva R, Khan M, et al. Effects of extracts from Bangladeshi medicinal plants on in vitro proliferation of human breast cancer cell lines and expression of estrogen receptor α gene. Int J Oncol 2004; 24(2): 419-23.
[http://dx.doi.org/10.3892/ijo.24.2.419] [PMID: 14719119]
[55]
Lasoń E, Ogonowski J. Stałe nanocząsteczki lipidowe-charakterystyka, zastosowanie i otrzymywanie. Chemik 2011; 65(10): 960-7.
[56]
Ledesma MD, Da Silva JS, Crassaerts K, Delacourte A, De Strooper B, Dotti CG. Brain plasmin enhances APP α‐cleavage and Aβ degradation and is reduced in Alzheimer’s disease brains. EMBO Rep 2000; 1(6): 530-5.
[http://dx.doi.org/10.1093/embo-reports/kvd107] [PMID: 11263499]
[57]
Leon WC, Canneva F, Partridge V, et al. A novel transgenic rat model with a full Alzheimer’s-like amyloid pathology displays pre-plaque intracellular amyloid-β-associated cognitive impairment. J Alzheimers Dis 2010; 20(1): 113-26.
[http://dx.doi.org/10.3233/JAD-2010-1349] [PMID: 20164597]
[58]
Li SD, Chen YC, Hackett MJ, Huang L. Tumor-targeted delivery of siRNA by self-assembled nanoparticles. Mol Ther 2008; 16(1): 163-9.
[http://dx.doi.org/10.1038/sj.mt.6300323] [PMID: 17923843]
[59]
Liu W, Li Q, Hu J, Wang H, Xu F, Bian Q. Application of natural products derivatization method in the design of targeted anticancer agents from 2000 to 2018. Bioorg Med Chem 2019; 27(23): 115150.
[http://dx.doi.org/10.1016/j.bmc.2019.115150] [PMID: 31635893]
[60]
Machado DG, Neis VB, Balen GO, et al. Antidepressant-like effect of ursolic acid isolated from Rosmarinus officinalis L. in mice: Evidence for the involvement of the dopaminergic system. Pharmacol Biochem Behav 2012; 103(2): 204-11.
[http://dx.doi.org/10.1016/j.pbb.2012.08.016] [PMID: 22940588]
[61]
Magnusson MH, Deppert K, Malm JO, Bovin JO, Samuelson L. Gold nanoparticles: production, reshaping, and thermal charging. J Nanopart Res 1999; 1(2): 243-51.
[http://dx.doi.org/10.1023/A:1010012802415]
[62]
Mansfield ML, Klushin LI. Monte Carlo studies of dendrimer macromolecules. Macromolecules 1993; 26(16): 4262-8.
[http://dx.doi.org/10.1021/ma00068a029]
[63]
McConlogue L, Castellano F, deWit C, Schenk D, Maltese WA. Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer’s β-amyloid precursor protein. J Biol Chem 1996; 271(3): 1343-8.
[http://dx.doi.org/10.1074/jbc.271.3.1343] [PMID: 8576122]
[64]
Menéndez-González M, Pérez-Pinera P, Martínez-Rivera M, Calatayud MT, Blázquez Menes B. APP processing and the APP-KPI domain involvement in the amyloid cascade. Neurodegener Dis 2005; 2(6): 277-83.
[http://dx.doi.org/10.1159/000092315] [PMID: 16909010]
[65]
Michel JP, Ivanovska IL, Gibbons MM, et al. Nanoindentation studies of full and empty viral capsids and the effects of capsid protein mutations on elasticity and strength. Proc Natl Acad Sci USA 2006; 103(16): 6184-9.
[http://dx.doi.org/10.1073/pnas.0601744103] [PMID: 16606825]
[66]
Mohammadi G, Valizadeh H, Barzegar-Jalali M, et al. Development of azithromycin–PLGA nanoparticles: Physicochemical characterization and antibacterial effect against Salmonella typhi. Colloids Surf B Biointerfaces 2010; 80(1): 34-9.
[http://dx.doi.org/10.1016/j.colsurfb.2010.05.027] [PMID: 20558048]
[67]
Mukherjee P, Ahmad A, Mandal D, et al. Fungus-mediated synthesis of silver nanoparticles and their immobilization in the mycelial matrix: a novel biological approach to nanoparticle synthesis. Nano Lett 2001; 1(10): 515-9.
[http://dx.doi.org/10.1021/nl0155274]
[68]
Mullane K, Williams M. Alzheimer’s therapeutics: Continued clinical failures question the validity of the amyloid hypothesis—but what lies beyond? Biochem Pharmacol 2013; 85(3): 289-305.
[http://dx.doi.org/10.1016/j.bcp.2012.11.014] [PMID: 23178653]
[69]
Muzzarelli R, Biagini G, Pugnaloni A, et al. Reconstruction of parodontal tissue with chitosan. Biomaterials 1989; 10(9): 598-603.
[http://dx.doi.org/10.1016/0142-9612(89)90113-0] [PMID: 2611308]
[70]
Newkome GR, Yao Z, Baker GR, Gupta VK. Micelles. Part 1. Cascade molecules: A new approach to micelles. A [27]-arborol. J Org Chem 1985; 50(11): 2003-4.
[http://dx.doi.org/10.1021/jo00211a052]
[71]
Ogunbanjo GA. Nanotechnology and Health Care: What are the opportunities and possible risks? S Afr Fam Pract 2015; 57(6): 1.
[http://dx.doi.org/10.4102/safp.v57i6.4409]
[72]
Oliveira MM, Ugarte D, Zanchet D, Zarbin AJG. Influence of synthetic parameters on the size, structure, and stability of dodecanethiol-stabilized silver nanoparticles. J Colloid Interface Sci 2005; 292(2): 429-35.
[http://dx.doi.org/10.1016/j.jcis.2005.05.068] [PMID: 16055140]
[73]
Patidar A, Thakur DS, Kumar P, Verma J. A review on novel lipid based nanocarriers. Int J Pharm Pharm Sci 2010; 2(4): 30-5.
[74]
Pourhassan-Moghaddam M, Rahmati-Yamchi M, Akbarzadeh A, et al. Protein detection through different platforms of immuno-loop-mediated isothermal amplification. Nanoscale Res Lett 2013; 8(1): 485.
[http://dx.doi.org/10.1186/1556-276X-8-485] [PMID: 24237767]
[75]
Prabhu S, Poulose EK. Silver nanoparticles: mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects. Int Nano Lett 2012; 2(1): 32.
[http://dx.doi.org/10.1186/2228-5326-2-32]
[76]
Pradeep T, Anshup . Noble metal nanoparticles for water purification: A critical review. Thin Solid Films 2009; 517(24): 6441-78.
[http://dx.doi.org/10.1016/j.tsf.2009.03.195]
[77]
Qin L, Pahud DR, Ding Y, et al. Efficient transfer of genes into murine cardiac grafts by Starburst polyamidoamine dendrimers. Hum Gene Ther 1998; 9(4): 553-60.
[http://dx.doi.org/10.1089/hum.1998.9.4-553] [PMID: 9525316]
[78]
Rai SN, Zahra W, Singh SS, et al. Anti-inflammatory activity of ursolic acid in MPTP-induced parkinsonian mouse model. Neurotox Res 2019; 36(3): 452-62.
[http://dx.doi.org/10.1007/s12640-019-00038-6] [PMID: 31016688]
[79]
Salvador JAR, Leal AS, Valdeira AS, et al. Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment. Eur J Med Chem 2017; 142: 95-130.
[http://dx.doi.org/10.1016/j.ejmech.2017.07.013] [PMID: 28754470]
[80]
Sapone A, Gustavino B, Monfrinotti M, et al. Perturbation of cytochrome P450, generation of oxidative stress and induction of DNA damage in Cyprinus carpio exposed in situ to potable surface water. Mutat Res Genet Toxicol Environ Mutagen 2007; 626(1-2): 143-54.
[http://dx.doi.org/10.1016/j.mrgentox.2006.09.010] [PMID: 17141554]
[81]
Sathali AH, Ekambaram P, Priyanka K. Solid lipid nanoparticles: a review. Sci Rev Chem Commun 2012; 2(1): 80-102.
[82]
Sathya S, Sudhagar S, Sarathkumar B, Lakshmi BS. EGFR inhibition by pentacyclic triterpenes exhibit cell cycle and growth arrest in breast cancer cells. Life Sci 2014; 95(1): 53-62.
[http://dx.doi.org/10.1016/j.lfs.2013.11.019] [PMID: 24333132]
[83]
Sharifi Y, Hasani A, Ghotaslou R, et al. Vancomycin-resistant enterococci among clinical isolates from north-west Iran: identification of therapeutic surrogates. J Med Microbiol 2012; 61(4): 600-2.
[http://dx.doi.org/10.1099/jmm.0.036780-0] [PMID: 22135024]
[84]
Sharma VK, Yngard RA, Lin Y. Silver nanoparticles: Green synthesis and their antimicrobial activities. Adv Colloid Interface Sci 2009; 145(1-2): 83-96.
[http://dx.doi.org/10.1016/j.cis.2008.09.002] [PMID: 18945421]
[85]
Singh A, Ansari VA, Ahsan F, et al. Viridescent concoction of genstein tendentious silver nanoparticles for breast cancer. Res J Pharm Technol 2021; 14(5): 2867-72.
[http://dx.doi.org/10.52711/0974-360X.2021.00504]
[86]
Singh A, Ansari VA, Haider F, Akhtar J, Ahsan F. Essential oils used in modified drug delivery and its formulation of liposomes for topical purpose. Res J Pharmacol Pharmacodyn 2020; 12(1): 34-8.
[http://dx.doi.org/10.5958/2321-5836.2020.00008.7]
[87]
Singhal G, Bhavesh R, Kasariya K, Sharma AR, Singh RP. Biosynthesis of silver nanoparticles using Ocimum sanctum (Tulsi) leaf extract and screening its antimicrobial activity. J Nanopart Res 2011; 13(7): 2981-8.
[http://dx.doi.org/10.1007/s11051-010-0193-y]
[88]
Sun RWY, Chen R, Chung NPY, Ho CM, Lin CLS, Che CM. Silver nanoparticles fabricated in Hepes buffer exhibit cytoprotective activities toward HIV-1 infected cells. Chem Commun 2005; (40): 5059-61.
[http://dx.doi.org/10.1039/b510984a] [PMID: 16220170]
[89]
Tessier PM, Velev OD, Kalambur AT, Rabolt JF, Lenhoff AM, Kaler EW. Assembly of gold nanostructured films templated by colloidal crystals and use in surface-enhanced Raman spectroscopy. J Am Chem Soc 2000; 122(39): 9554-5.
[http://dx.doi.org/10.1021/ja0022831]
[90]
Wolinsky J, Grinstaff M. Therapeutic and diagnostic applications of dendrimers for cancer treatment. Adv Drug Deliv Rev 2008; 60(9): 1037-55.
[http://dx.doi.org/10.1016/j.addr.2008.02.012] [PMID: 18448187]
[91]
Xu C, Liao Y, Fang C, et al. Simultaneous analysis of ursolic acid and oleanolic acid in guava leaves using QuEChERS-based extraction followed by high-performance liquid chromatography. J Anal Methods Chem 2017; 2017: 1-7.
[http://dx.doi.org/10.1155/2017/2984562] [PMID: 28781908]

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