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Current Stem Cell Research & Therapy

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ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

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Mini-Review Article

Research Progress on the Effect of Autophagy and Exosomes on Liver Fibrosis

Author(s): Yikuan Du, Silin Zhu, Haojie Zeng, Zhenjie Wang, Yixing Huang, Yuqi Zhou, Weichui Zhang, Jinfeng Zhu and Chun Yang*

Volume 19, Issue 6, 2024

Published on: 11 May, 2023

Page: [785 - 797] Pages: 13

DOI: 10.2174/1574888X18666230427112930

Price: $65

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Abstract

Chronic liver disease is a known risk factor for the development of liver cancer, and the development of microRNA (miRNA) liver therapies has been hampered by the difficulty of delivering miRNA to damaged tissues. In recent years, numerous studies have shown that hepatic stellate cell (HSC) autophagy and exosomes play an important role in maintaining liver homeostasis and ameliorating liver fibrosis. In addition, the interaction between HSC autophagy and exosomes also affects the progression of liver fibrosis. In this paper, we review the research progress of mesenchymal stem cell-derived exosomes (MSC-EVs) loaded with specific miRNA and autophagy, and their related signaling pathways in liver fibrosis, which will provide a more reliable basis for the use of MSC-EVs for therapeutic delivery of miRNAs targeting the chronic liver disease.

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