Abstract
Background: Glaucoma is widely treated using eye drops, but around 95% of the drug is lost by the ocular barrier resulting in low bioavailability. The incorporation of polymeric nanoparticles into mucoadhesive polymer containing in situ gel is generally helpful in the retention of nanoparticles on the eye and improves the efficacy of the formulation.
Objective: The objective of the present investigation has to develop polymeric brinzolamide (BRZ) nanoparticles laden with timolol maleate (TM) in situ gel formulation.
Methods: The optimized BRZ nanoparticles were prepared using PLGA by nanoprecipitation technique
utilizing 3
Conclusion: The proposed formulation could successfully deliver therapeutic concentrations in the
eye with prolonged resident time and serve as a potential alternative for the treatment of glaucoma.
Graphical Abstract
[http://dx.doi.org/10.1007/s12325-020-01525-5] [PMID: 33108623]
[http://dx.doi.org/10.1208/s12248-010-9183-3] [PMID: 20437123]
[http://dx.doi.org/10.3109/02713683.2011.652286] [PMID: 22510004]
[http://dx.doi.org/10.3390/pharmaceutics12010022] [PMID: 31878298]
[http://dx.doi.org/10.3390/polym12071519] [PMID: 32650536]
[http://dx.doi.org/10.3390/nano10071403] [PMID: 32707641]
[http://dx.doi.org/10.1007/s40005-019-00439-x]
[http://dx.doi.org/10.3390/gels7030130] [PMID: 34563016]
[http://dx.doi.org/10.3109/10717544.2014.987333] [PMID: 25579467]
[http://dx.doi.org/10.1016/j.jsps.2016.12.008] [PMID: 28951671]
[http://dx.doi.org/10.1016/j.amepre.2014.06.021] [PMID: 25092122]
[http://dx.doi.org/10.1016/j.jconrel.2008.12.018] [PMID: 19331856]
[http://dx.doi.org/10.1007/s13346-018-0504-x] [PMID: 29508159]
[http://dx.doi.org/10.2147/IJN.S131850] [PMID: 28331311]
[http://dx.doi.org/10.5530/phm.2018.2.13]
[http://dx.doi.org/10.1088/1361-6528/aad7da] [PMID: 30074486]
[http://dx.doi.org/10.1016/j.jddst.2015.06.002]
[http://dx.doi.org/10.31686/ijier.vol2.iss5.188]
[http://dx.doi.org/10.22159/ajpcr.2020.v13i10.38848]
[PMID: 29110631]
[http://dx.doi.org/10.7508/nmrj.2016.02.006]
[http://dx.doi.org/10.2174/1574885514666190916151506]