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Letters in Drug Design & Discovery

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ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

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Mini-Review Article

Synthesis and Biological Activity of 2-pyridone Derivatives: A Mini Review

Author(s): Krishan Kumar Verma*, Sapna Kapoor, Vivek Kumar Kushwaha, Ashish Mishra and Anshul Upadhyay

Volume 21, Issue 10, 2024

Published on: 12 May, 2023

Page: [1617 - 1631] Pages: 15

DOI: 10.2174/1570180820666230417084456

Price: $65

Abstract

The 2-pyridone nucleus is an important scaffold present in various compounds with diverse pharmacological activity. Among the reported 2-pyridone analogs, the majority of the compounds either have a substituted ring system or a fused ring system. Till now, several derivatives have been reported by different researchers for their antimicrobial activity, anticancer activity, antiviral activity, antioxidant activity, anti-hepatitis virus activity, and anti-allodynia and anti-obesity activities. In this review, we have attempted to compile synthetic methods of 2-pyridone ring by ring cyclization along with pharmacological aspects related to various synthesized derivatives of the 2-pyridone nucleus.

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