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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Mini-Review Article

Plants of the Genus Mahonia as a Potential Traditional Chinese Medicine for the Prevention and Treatment of Alzheimer's Disease

Author(s): Shuo Yang, Huikai Shao, Xiyu Chen, Qiwen Liu, Shengfeng Huang* and Yang Huang*

Volume 23, Issue 13, 2023

Published on: 28 April, 2023

Page: [1214 - 1220] Pages: 7

DOI: 10.2174/1568026623666230330105251

Price: $65

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Abstract

Alzheimer’s disease (AD), a prevalent multiple neurodegenerative disease, has gained attention, particularly in the aging population. However, presently available therapies merely focus on alleviating the symptoms of AD and fail to slow disease progression significantly. Traditional Chinese medicine (TCM) has been used to ameliorate symptoms or interfere with the pathogenesis of aging-associated diseases for many years based on disease-modifying in multiple pathological roles with multi-targets, multi-systems and multi-aspects. Mahonia species as a TCM present potential for anti-inflammatory activity, antioxidant activity, anti-acetylcholinesterase activity, and antiamyloid- beta activity that was briefly discussed in this review. They are regarded as promising drug candidates for AD therapy. The findings in this review support the use of Mahonia species as an alternative therapy source for treating AD.

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[1]
Yu, T.W.; Lane, H.Y.; Lin, C.H. Novel therapeutic approaches for Alzheimer’s Disease: An Updated Review. Int. J. Mol. Sci., 2021, 22(15), 8208-8237.
[http://dx.doi.org/10.3390/ijms22158208] [PMID: 34360973]
[2]
Alzheimer’s disease international. World Alzheimer Report 2018: The state of the art of dementia research: New frontiers. Alzheimer’s Dis. Int., 2018, 1-46.
[3]
Se Thoe, E.; Fauzi, A.; Tang, Y.Q.; Chamyuang, S.; Chia, A.Y.Y. A review on advances of treatment modalities for Alzheimer’s disease. Life Sci., 2021, 276, 119129-119152.
[http://dx.doi.org/10.1016/j.lfs.2021.119129] [PMID: 33515559]
[4]
Athar, T.; Al Balushi, K.; Khan, S.A. Recent advances on drug development and emerging therapeutic agents for Alzheimer’s disease. Mol. Biol. Rep., 2021, 48(7), 5629-5645.
[http://dx.doi.org/10.1007/s11033-021-06512-9] [PMID: 34181171]
[5]
Ahmed, S.; Khan, S.T.; Zargaham, M.K.; Khan, A.U.; Khan, S.; Hussain, A.; Uddin, J.; Khan, A.; Al-Harrasi, A. Potential therapeutic natural products against Alzheimer’s disease with Reference of Acetylcholinesterase. Biomed. Pharmacother., 2021, 139, 111609-111632.
[http://dx.doi.org/10.1016/j.biopha.2021.111609] [PMID: 33915501]
[6]
Lin, H.Q.; Ho, M.T.; Lau, L.S.; Wong, K.K.; Shaw, P.C.; Wan, D.C.C. Anti-acetylcholinesterase activities of traditional Chinese medicine for treating Alzheimer’s disease. Chem. Biol. Interact., 2008, 175(1-3), 352-354.
[http://dx.doi.org/10.1016/j.cbi.2008.05.030] [PMID: 18573242]
[7]
Tatulian, S.A. Challenges and hopes for Alzheimer’s disease. Drug Discov. Today, 2022, 27(4), 1027-1043.
[http://dx.doi.org/10.1016/j.drudis.2022.01.016] [PMID: 35121174]
[8]
He, J.M.; Mu, Q. The medicinal uses of the genus Mahonia in traditional Chinese medicine: An ethnopharmacological, phytochemical and pharmacological review. J. Ethnopharmacol., 2015, 175, 668-683.
[http://dx.doi.org/10.1016/j.jep.2015.09.013] [PMID: 26387740]
[9]
Jiang, Y.; Gao, H.; Turdu, G. Traditional Chinese medicinal herbs as potential AChE inhibitors for anti-Alzheimer’s disease: A review. Bioorg. Chem., 2017, 75, 50-61.
[http://dx.doi.org/10.1016/j.bioorg.2017.09.004] [PMID: 28915465]
[10]
Dey, A.; Bhattacharya, R.; Mukherjee, A.; Pandey, D.K. Natural products against Alzheimer’s disease: Pharmaco-therapeutics and biotechnological interventions. Biotechnol. Adv., 2017, 35(2), 178-216.
[http://dx.doi.org/10.1016/j.biotechadv.2016.12.005] [PMID: 28043897]
[11]
Su, Y.; Wang, Q.; Wang, C.; Chan, K.; Sun, Y.; Kuang, H. The treatment of Alzheimer’s disease using Chinese Medicinal Plants: From disease models to potential clinical applications. J. Ethnopharmacol., 2014, 152(3), 403-423.
[http://dx.doi.org/10.1016/j.jep.2013.12.053] [PMID: 24412377]
[12]
Hu, W.; Wu, L.; Qiang, Q.; Ji, L.; Wang, X.; Luo, H.; Wu, H.; Jiang, Y.; Wang, G.; Shen, T. The dichloromethane fraction from Mahonia bealei (Fort.) Carr. leaves exerts an anti-inflammatory effect both in vitro and in vivo. J. Ethnopharmacol., 2016, 188, 134-143.
[http://dx.doi.org/10.1016/j.jep.2016.05.013] [PMID: 27167461]
[13]
China Pharmcopia Committee. Chinese Pharmacopeia; China medical science press: Beijing, 2020.
[14]
Zhang, S.L.; Li, H.; He, X.; Zhang, R.Q.; Sun, Y.H.; Zhang, C.F.; Wang, C.Z.; Yuan, C.S. Alkaloids from Mahonia bealei posses anti-H+/K+-ATPase and anti-gastrin effects on pyloric ligation-induced gastric ulcer in rats. Phytomedicine, 2014, 21(11), 1356-1363.
[http://dx.doi.org/10.1016/j.phymed.2014.07.007] [PMID: 25172799]
[15]
Howes, M.J.R.; Perry, E. The role of phytochemicals in the treatment and prevention of dementia. Drugs Aging, 2011, 28(6), 439-468.
[http://dx.doi.org/10.2165/11591310-000000000-00000] [PMID: 21639405]
[16]
Yang, W.; Zheng, X.; Chen, S.; Shan, C.; Xu, Q.; Zhu, J.Z.; Bao, X.Y.; Lin, Y.; Zheng, G.; Wang, Y. Chinese herbal medicine for Alzheimer’s disease: Clinical evidence and possible mechanism of neurogenesis. Biochem. Pharmacol., 2017, 141, 143-155.
[http://dx.doi.org/10.1016/j.bcp.2017.07.002] [PMID: 28690138]
[17]
Li, J.; Du, Q.; Li, N.; Du, S.; Sun, Z. Alpiniae oxyphyllae Fructus and Alzheimer’s disease: An update and current perspective on this traditional Chinese medicine. Biomed. Pharmacother., 2021, 135, 111167-111177.
[http://dx.doi.org/10.1016/j.biopha.2020.111167] [PMID: 33383373]
[18]
Zhang, Z.; Zhang, S.; Lui, C.N.P.; Zhu, P.; Zhang, Z.; Lin, K.; Dai, Y.; Yung, K.K-L. Traditional Chinese medicine-based neurorestorative therapy for Alzheimer’s and Parkinson’s disease. J. Neurorestoratol., 2019, 7(4), 207-222.
[http://dx.doi.org/10.26599/JNR.2019.9040026]
[19]
Wu, T.Y.; Chen, C.P.; Jinn, T.R. Traditional Chinese medicines and Alzheimer’s disease. Taiwan. J. Obstet. Gynecol., 2011, 50(2), 131-135.
[http://dx.doi.org/10.1016/j.tjog.2011.04.004] [PMID: 21791295]
[20]
Fernandes, F.; Barroso, M.F.; De Simone, A.; Emriková, E.; Dias-Teixeira, M.; Pereira, J.P.; Chlebek, J.; Fernandes, V.C.; Rodrigues, F.; Andrisano, V.; Delerue-Matos, C.; Grosso, C. Multi-target neuroprotective effects of herbal medicines for Alzheimer’s disease. J. Ethnopharmacol., 2022, 290, 115107-115121.
[http://dx.doi.org/10.1016/j.jep.2022.115107] [PMID: 35176467]
[21]
Huang, Y.; Wang, T.; Jiang, Z. Fast analysis of alkaloids from different parts of Mahonia bealei (Fort.) Carr. studied for their anti‐Alzheimer’s activity using supercritical fluid chromatography. J. Sep. Sci., 2021, 44(9), 2006-2014.
[http://dx.doi.org/10.1002/jssc.202001079] [PMID: 33650266]
[22]
Čerňáková, M.; Košt’álová, D.; Kettmann, V.; Plodová, M.; Tóth, J.; Dřímal, J. Potential antimutagenic activity of berberine, a constituent of Mahonia aquifolium. BMC Complement. Altern. Med., 2002, 2(1), 2.
[http://dx.doi.org/10.1186/1472-6882-2-2] [PMID: 11943071]
[23]
Wu, L.; Wang, G.; Shen, T.; You, L.; Hu, W.; Si, C-L. Optimizing conditions for antioxidant phenolic compound extraction from Mahonia bealei (Fort.) Carr. leaves using a response surface methodology. Hortic. Environ. Biotechnol., 2017, 58(3), 282-291.
[http://dx.doi.org/10.1007/s13580-017-0106-4]
[24]
Rackova, L.; Oblozinsky, M.; Kostalova, D.; Kettmann, V.; Bezakova, L. Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids. J. Inflamm., 2007, 4(1), 15.
[http://dx.doi.org/10.1186/1476-9255-4-15] [PMID: 17634120]
[25]
Yan, D.; Jin, C.; Xiao, X.H.; Dong, X.P. Antimicrobial properties of berberines alkaloids in Coptis chinensis Franch by microcalorimetry. J. Biochem. Biophys. Methods, 2008, 70(6), 845-849.
[http://dx.doi.org/10.1016/j.jbbm.2007.07.009] [PMID: 17804078]
[26]
Slobodníková, L; Košt’álová, D.; Labudová, D. Antimicrobial activity of Mahonia aquifolium crude extract and its major isolated alkaloids. Phyther Res, 2004, 18, 674-676.
[27]
Volleková, A.; Košt’álová, D.; Kettmann, V.; Tóth, J. Antifungal activity of Mahonia aquifolium extract and its major protoberberine alkaloids. Phytother. Res., 2003, 17(7), 834-837.
[http://dx.doi.org/10.1002/ptr.1256] [PMID: 12916091]
[28]
Hajnická, V.; Košt’álová, D.; Švecová, D.; Sochorová, R.; Fuchsberger, N.; Tóth, J. Effect of Mahonia aquifolium active compounds on interleukin-8 production in the human monocytic cell line THP-1. Planta Med., 2002, 68(3), 266-268.
[http://dx.doi.org/10.1055/s-2002-23126] [PMID: 11914967]
[29]
Račková, L.; Májeková, M.; Košt’álová, D.; Štefek, M. Antiradical and antioxidant activities of alkaloids isolated from Mahonia aquifolium. Structural aspects. Bioorg. Med. Chem., 2004, 12(17), 4709-4715.
[http://dx.doi.org/10.1016/j.bmc.2004.06.035] [PMID: 15358297]
[30]
Ondua, M.; Njoya, E.M.; Abdalla, M.A.; McGaw, L.J. Anti-inflammatory and antioxidant properties of leaf extracts of eleven South African medicinal plants used traditionally to treat inflammation. J. Ethnopharmacol., 2019, 234, 27-35.
[http://dx.doi.org/10.1016/j.jep.2018.12.030] [PMID: 30572091]
[31]
Xiao, W.; Peng, Y.; Tan, Z.; Lv, Q.; Chan, C.; Yang, J.; Chen, S. Comparative evaluation of chemical profiles of Pyrrosiae Folium originating from three Pyrrosia species by HPLC-DAD combined with multivariate statistical analysis. Molecules, 2017, 22(12), 2122-2132.
[http://dx.doi.org/10.3390/molecules22122122] [PMID: 29194397]
[32]
ROss, C.; Durka, W. Isolation and characterization of microsatellite markers in the invasive shrub Mahonia aquifolium (Berberidaceae) and their applicability in related species. Mol. Ecol. Notes, 2006, 6(3), 948-950.
[http://dx.doi.org/10.1111/j.1471-8286.2006.01412.x]
[33]
Coklar, H.; Akbulut, M. Anthocyanins and phenolic compounds of Mahonia aquifolium berries and their contributions to antioxidant activity. J. Funct. Foods, 2017, 35, 166-174.
[http://dx.doi.org/10.1016/j.jff.2017.05.037]
[34]
Bai, R.; Yao, C.; Zhong, Z.; Ge, J.; Bai, Z.; Ye, X.; Xie, T.; Xie, Y. Discovery of natural anti-inflammatory alkaloids: Potential leads for the drug discovery for the treatment of inflammation. Eur. J. Med. Chem., 2021, 213, 113165-113187.
[http://dx.doi.org/10.1016/j.ejmech.2021.113165] [PMID: 33454546]
[35]
Sahebkar, A.; Zahedipour, F.; Hosseini, S.A.; Henney, N.C.; Barreto, G.E. Phytochemicals as inhibitors of tumor necrosis factor alpha and neuroinflammatory responses in neurodegenerative diseases. Neural Regen. Res., 2022, 17(8), 1675-1684.
[http://dx.doi.org/10.4103/1673-5374.332128] [PMID: 35017414]
[36]
Ge, J.; Liu, Z.; Zhong, Z.; Wang, L.; Zhuo, X.; Li, J.; Jiang, X.; Ye, X.Y.; Xie, T.; Bai, R. Natural terpenoids with anti-inflammatory activities: Potential leads for anti-inflammatory drug discovery. Bioorg. Chem., 2022, 124, 105817-105841.
[http://dx.doi.org/10.1016/j.bioorg.2022.105817] [PMID: 35490583]
[37]
Combs, C.K.; Karlo, J.C.; Kao, S.C.; Landreth, G.E. β-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J. Neurosci., 2001, 21(4), 1179-1188.
[http://dx.doi.org/10.1523/JNEUROSCI.21-04-01179.2001] [PMID: 11160388]
[38]
Zhang, L.; Ravipati, A.S.; Koyyalamudi, S.R.; Jeong, S.C.; Reddy, N.; Smith, P.T.; Bartlett, J.; Shanmugam, K.; Münch, G.; Wu, M.J. Antioxidant and anti-inflammatory activities of selected medicinal plants containing phenolic and flavonoid compounds. J. Agric. Food Chem., 2011, 59(23), 12361-12367.
[http://dx.doi.org/10.1021/jf203146e] [PMID: 22023309]
[39]
Chao, J.; Lu, T.C.; Liao, J.W.; Huang, T.H.; Lee, M.S.; Cheng, H.Y.; Ho, L.K.; Kuo, C.L.; Peng, W.H. Analgesic and anti-inflammatory activities of ethanol root extract of Mahonia oiwakensis in mice. J. Ethnopharmacol., 2009, 125(2), 297-303.
[http://dx.doi.org/10.1016/j.jep.2009.06.024] [PMID: 19576980]
[40]
Chao, J.; Liao, J.W.; Peng, W.H.; Lee, M.S.; Pao, L.H.; Cheng, H.Y. Antioxidant, Analgesic, Anti-Inflammatory, and Hepatoprotective Effects of the Ethanol Extract of Mahonia oiwakensis Stem. Int. J. Mol. Sci., 2013, 14(2), 2928-2945.
[http://dx.doi.org/10.3390/ijms14022928] [PMID: 23364614]
[41]
Andreicut, A.D.; Pârvu, A.E.; Mot, A.C.; Pârvu, M.; Fischer Fodor, E.; Cătoi, A.F.; Feldrihan, V.; Cecan, M.; Irimie, A. Phytochemical analysis of anti-inflammatory and antioxidant effects of Mahonia aquifolium flower and fruit extracts. Oxid. Med. Cell. Longev., 2018, 2018, 1-12.
[http://dx.doi.org/10.1155/2018/2879793] [PMID: 30050649]
[42]
Uno, M.; Kitazato, K.T.; Suzue, A.; Matsuzaki, K.; Harada, M.; Itabe, H.; Nagahiro, S. Inhibition of brain damage by edaravone, a free radical scavenger, can be monitored by plasma biomarkers that detect oxidative and astrocyte damage in patients with acute cerebral infarction. Free Radic. Biol. Med., 2005, 39(8), 1109-1116.
[http://dx.doi.org/10.1016/j.freeradbiomed.2005.06.001] [PMID: 16198237]
[43]
Praticò, D.; Delanty, N. Oxidative injury in diseases of the central nervous system: Focus on alzheimer’s disease. Am. J. Med., 2000, 109(7), 577-585.
[http://dx.doi.org/10.1016/S0002-9343(00)00547-7] [PMID: 11063960]
[44]
Naghizadeh, B.; Mansouri, M.T.; Ghorbanzadeh, B.; Farbood, Y.; Sarkaki, A. Protective effects of oral crocin against intracerebroventricular streptozotocin-induced spatial memory deficit and oxidative stress in rats. Phytomedicine, 2013, 20(6), 537-542.
[http://dx.doi.org/10.1016/j.phymed.2012.12.019] [PMID: 23351962]
[45]
Gao, Y.; Zhao, J.; Zu, Y.; Fu, Y.; Liang, L.; Luo, M.; Wang, W.; Efferth, T. Antioxidant properties, superoxide dismutase and glutathione reductase activities in HepG2 cells with a fungal endophyte producing apigenin from pigeon pea [Cajanus cajan (L.). Millsp. Food Res. Int., 2012, 49(1), 147-152.
[http://dx.doi.org/10.1016/j.foodres.2012.08.001]
[46]
Grundman, M.; Delaney, P.; Delaney, P. Antioxidant strategies for Alzheimer’s disease. Proc. Nutr. Soc., 2002, 61(2), 191-202.
[http://dx.doi.org/10.1079/PNS2002146] [PMID: 12133201]
[47]
Kasote, D.M.; Katyare, S.S.; Hegde, M.V.; Bae, H. Significance of antioxidant potential of plants and its relevance to therapeutic applications. Int. J. Biol. Sci., 2015, 11(8), 982-991.
[http://dx.doi.org/10.7150/ijbs.12096] [PMID: 26157352]
[48]
Hu, W.; Yu, L.; Wang, M.H. Antioxidant and antiproliferative properties of water extract from Mahonia bealei (Fort.) Carr. leaves. Food Chem. Toxicol., 2011, 49(4), 799-806.
[http://dx.doi.org/10.1016/j.fct.2010.12.001] [PMID: 21130829]
[49]
Hu, W.; Zhou, J.; Shen, T.; Wang, X. Target-Guided Isolation of Three Main Antioxidants from Mahonia bealei (Fort.) Carr. Leaves Using HSCCC. Molecules, 2019, 24(10), 1907-1918.
[http://dx.doi.org/10.3390/molecules24101907] [PMID: 31108973]
[50]
Kumar, A.; Nisha, C.M.; Silakari, C.; Sharma, I.; Anusha, K.; Gupta, N.; Nair, P.; Tripathi, T.; Kumar, A. Current and novel therapeutic molecules and targets in Alzheimer’s disease. J. Formos. Med. Assoc., 2016, 115(1), 3-10.
[http://dx.doi.org/10.1016/j.jfma.2015.04.001] [PMID: 26220908]
[51]
Kaufmann, D.; Kaur Dogra, A.; Tahrani, A.; Herrmann, F.; Wink, M. Extracts from Traditional Chinese Medicinal Plants Inhibit Acetylcholinesterase, a Known Alzheimer’s Disease Target. Molecules, 2016, 21(9), 1161-1177.
[http://dx.doi.org/10.3390/molecules21091161] [PMID: 27589716]
[52]
Song, H.P.; Zhang, H.; Hu, R.; Xiao, H.H.; Guo, H.; Yuan, W.H.; Han, X.T.; Xu, X.Y.; Zhang, X.; Ding, Z.X.; Zhao, M.Y.; Kang, T.G.; Sun, H.Y.; Chang, A.; Chen, Y.H.; Xie, M. A strategy to discover lead chemome from traditional Chinese medicines based on natural chromatogram-effect correlation (NCEC) and natural structure-effect correlation (NSEC): Mahonia bealei and Mahonia fortunei as a case study. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2021, 1181, 122922-122930.
[http://dx.doi.org/10.1016/j.jchromb.2021.122922] [PMID: 34500403]
[53]
Salloway, S.; Mintzer, J.; Cummings, J.L.; Geldmacher, D.; Sun, Y.; Yardley, J.; Mackell, J. Subgroup analysis of US and non-US patients in a global study of high-dose donepezil (23 mg) in moderate and severe Alzheimer’s disease. Am. J. Alzheimers Dis. Other Demen., 2012, 27(6), 421-432.
[http://dx.doi.org/10.1177/1533317512454708] [PMID: 22930699]
[54]
Bullock, R. Galantamine: Use in Alzheimer’s disease and related disorders. Expert Rev. Neurother., 2004, 4(2), 153-163.
[http://dx.doi.org/10.1586/14737175.4.2.153] [PMID: 15853556]
[55]
Calabrese, P.; Essner, U.; Förstl, H. Memantine (Ebixa) in clinical practice - results of an observational study. Dement. Geriatr. Cogn. Disord., 2007, 24(2), 111-117.
[http://dx.doi.org/10.1159/000104872] [PMID: 17622714]
[56]
Huang, Y.; Su, Y.; Wang, T.J. Cultivars of Mahonia bealei (Fort.) Carr. as a source of potential natural product with anti-Alzheimer’s Disease activity. Front Drug, Chem. Clin. Res., 2021, 4, 1-7.
[57]
Li, A.R.; Zhu, Y.; Li, X.N.; Tian, X.J. Antimicrobial activity of four species of Berberidaceae. Fitoterapia, 2007, 78(5), 379-381.
[http://dx.doi.org/10.1016/j.fitote.2007.03.001] [PMID: 17499939]
[58]
Čerňáková, M.; Košťálová, D. Antimicrobial activity of berberine—a constituent of Mahonia aquifolium. Folia Microbiol., 2002, 47(4), 375-378.
[http://dx.doi.org/10.1007/BF02818693] [PMID: 12422513]
[59]
Andreicuț, A.D.; Fischer-Fodor, E.; Pârvu, A.E.; Ţigu, A.B.; Cenariu, M.; Pârvu, M.; Cătoi, F.A.; Irimie, A. Antitumoral and Immunomodulatory Effect of Mahonia aquifolium Extracts. Oxid. Med. Cell. Longev., 2019, 2019, 1-13.
[http://dx.doi.org/10.1155/2019/6439021] [PMID: 31949880]
[60]
Montoliu-Gaya, L.; Villegas, S. Protein structures in Alzheimer’s disease: The basis for rationale therapeutic design. Arch. Biochem. Biophys., 2015, 588, 1-14.
[http://dx.doi.org/10.1016/j.abb.2015.10.005] [PMID: 26475676]

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