Combinatorial Library Synthesis of Antioxidant Compounds

Stifun      Mittoo

doi:10.2174/138620706777698490

Abstract

Since oxidative cellular damage contributes to the development of cancers, heart disease and ageing, the synthesis of antioxidative agents which are able to either prevent or mitigate oxidative stress to cells is an important area of investigation. Combinatorial chemistry has had a profound impact on the discovery and optimisation of potential lead compounds, especially in the medicinal field. This review details recent examples of combinatorial chemistry dealing with the synthesis of novel antioxidants with an emphasis on solid phase compound synthesis and parallel library synthesis.

Keywords: Leu-Leu-Pro-His-His (LLPHH), propanediol library, trisubstituted indazoles, naphthoquinone, quinone libraries

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