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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Perspectives on Iron Deficiency as a Cause of Human Disease in Global Public Health

Author(s): Geir Bjørklund*, Yuliya Semenova, Tony Hangan*, Joeri J. Pen, Jan Aaseth and Massimiliano Peana

Volume 31, Issue 12, 2024

Published on: 15 May, 2023

Page: [1428 - 1440] Pages: 13

DOI: 10.2174/0929867330666230324154606

Price: $65

Abstract

Iron (Fe) is a necessary trace element in numerous pathways of human metabolism. Therefore, Fe deficiency is capable of causing multiple health problems. Apart from the well-known microcytic anemia, lack of Fe can cause severe psychomotor disorders in children, pregnant women, and adults in general. Iron deficiency is a global health issue, mainly caused by dietary deficiency but aggravated by inflammatory conditions. The challenges related to this deficiency need to be addressed on national and international levels. This review aims to summarize briefly the disease burden caused by Fe deficiency in the context of global public health and aspires to offer some hands-on guidelines.

[1]
Anderson, G.J.; Frazer, D.M. Current understanding of iron homeostasis. Am. J. Clin. Nutr., 2017, 106(Suppl. 6), 1559S-1566S.
[http://dx.doi.org/10.3945/ajcn.117.155804] [PMID: 29070551]
[2]
Chaparro, C.M.; Suchdev, P.S. Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries. Ann. N. Y. Acad. Sci., 2019, 1450(1), nyas.14092.
[http://dx.doi.org/10.1111/nyas.14092] [PMID: 31008520]
[3]
Mattiello, V.; Schmugge, M.; Hengartner, H.; von der Weid, N.; Renella, R. Diagnosis and management of iron deficiency in children with or without anemia: consensus recommendations of the SPOG Pediatric Hematology Working Group. Eur. J. Pediatr., 2020, 179(4), 527-545.
[http://dx.doi.org/10.1007/s00431-020-03597-5] [PMID: 32020331]
[4]
Badireddy, M.; Baradhi, K.M. Chronic Anemia; In StatPearls: Treasure Island, FL, 2022.
[5]
Shah, Y.M.; Matsubara, T.; Ito, S.; Yim, S.H.; Gonzalez, F.J. Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency. Cell Metab., 2009, 9(2), 152-164.
[http://dx.doi.org/10.1016/j.cmet.2008.12.012] [PMID: 19147412]
[6]
Lewis, S.M.; Emmanuel, J.C. Iron Deficiency and Overload: From basic biology to clinical medicine; Yehuda, S.; Mostofsky, D.I., Eds.; Humana Press: Totowa, NJ, 2010, pp. 299-312.
[http://dx.doi.org/10.1007/978-1-59745-462-9_17]
[7]
Ogun, A.S.; Adeyinka, A. Biochemistry, Transferrin; In StatPearls: Treasure Island, FL, 2022.
[8]
Zoroddu, M.A.; Aaseth, J.; Crisponi, G.; Medici, S.; Peana, M.; Nurchi, V.M. The essential metals for humans: a brief overview. J. Inorg. Biochem., 2019, 195, 120-129.
[http://dx.doi.org/10.1016/j.jinorgbio.2019.03.013] [PMID: 30939379]
[9]
Gropper, S.; Smith, J.; Groff, J. Advanced nutrition and human metabolism, 6th ed.; Wardsworth Cengage Learning: Belmont, CA, 2013.
[10]
Imam, H.S.H.; Anwar, M.I.; Anwar, M.F.; Murtaza, M.; Sadiq, R. Role of iron supplements on pregnancy outcomes. Ann. Punjab Med. Coll., 2017, 11(4), 320-324.
[http://dx.doi.org/10.29054/APMC/17.442]
[11]
Domellöf, M.; Braegger, C.; Campoy, C.; Colomb, V.; Decsi, T.; Fewtrell, M.; Hojsak, I.; Mihatsch, W.; Molgaard, C.; Shamir, R.; Turck, D.; van Goudoever, J. Iron requirements of infants and toddlers. J. Pediatr. Gastroenterol. Nutr., 2014, 58(1), 119-129.
[http://dx.doi.org/10.1097/MPG.0000000000000206] [PMID: 24135983]
[12]
Naoum, F.A. Iron deficiency in cancer patients. Rev. Bras. Hematol. Hemoter., 2016, 38(4), 325-330.
[http://dx.doi.org/10.1016/j.bjhh.2016.05.009] [PMID: 27863761]
[13]
Rodgers, G.M., III; Becker, P.S.; Blinder, M.; Cella, D.; Chanan-Khan, A.; Cleeland, C.; Coccia, P.F.; Djulbegovic, B.; Gilreath, J.A.; Kraut, E.H.; Matulonis, U.A.; Millenson, M.M.; Reinke, D.; Rosenthal, J.; Schwartz, R.N.; Soff, G.; Stein, R.S.; Vlahovic, G.; Weir, A.B., III Cancer- and chemotherapy-induced anemia. J. Natl. Compr. Canc. Netw., 2012, 10(5), 628-653.
[http://dx.doi.org/10.6004/jnccn.2012.0064] [PMID: 22570293]
[14]
Gelaw, Y.; Getaneh, Z.; Melku, M. Anemia as a risk factor for tuberculosis: a systematic review and meta-analysis. Environ. Health Prev. Med., 2021, 26(1), 13.
[http://dx.doi.org/10.1186/s12199-020-00931-z] [PMID: 33485299]
[15]
Nairz, M.; Weiss, G. Iron in infection and immunity. Mol. Aspects Med., 2020, 75, 100864.
[http://dx.doi.org/10.1016/j.mam.2020.100864] [PMID: 32461004]
[16]
Cohen-Solal, A.; Damy, T.; Terbah, M.; Kerebel, S.; Baguet, J.P.; Hanon, O.; Zannad, F.; Laperche, T.; Leclercq, C.; Concas, V.; Duvillié, L.; Darné, B.; Anker, S.; Mebazaa, A. High prevalence of iron deficiency in patients with acute decompensated heart failure. Eur. J. Heart Fail., 2014, 16(9), 984-991.
[http://dx.doi.org/10.1002/ejhf.139] [PMID: 25065368]
[17]
Yancy, C.W.; Jessup, M.; Bozkurt, B.; Butler, J.; Casey, D.E., Jr; Colvin, M.M.; Drazner, M.H.; Filippatos, G.S.; Fonarow, G.C.; Givertz, M.M.; Hollenberg, S.M.; Lindenfeld, J.; Masoudi, F.A.; McBride, P.E.; Peterson, P.N.; Stevenson, L.W.; Westlake, C. 2017 ACC/AHA/HFSA focused update of the 2013 ACCF/AHA guideline for the management of heart failure. J. Am. Coll. Cardiol., 2017, 70(6), 776-803.
[http://dx.doi.org/10.1016/j.jacc.2017.04.025] [PMID: 28461007]
[18]
Batchelor, E.K.; Kapitsinou, P.; Pergola, P.E.; Kovesdy, C.P.; Jalal, D.I. Iron deficiency in chronic kidney disease: updates on pathophysiology, diagnosis, and treatment. J. Am. Soc. Nephrol., 2020, 31(3), 456-468.
[http://dx.doi.org/10.1681/ASN.2019020213] [PMID: 32041774]
[19]
Pasricha, S.R.; Tye-Din, J.; Muckenthaler, M.U.; Swinkels, D.W. Iron deficiency. Lancet, 2021, 397(10270), 233-248.
[http://dx.doi.org/10.1016/S0140-6736(20)32594-0] [PMID: 33285139]
[20]
Abboud, S.; Haile, D.J. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J. Biol. Chem., 2000, 275(26), 19906-19912.
[http://dx.doi.org/10.1074/jbc.M000713200]
[21]
Wallace, D.F. The regulation of iron absorption and homeostasis. Clin. Biochem. Rev, 2016, 37(2), 51-62.
[22]
Ems, T.; St Lucia, K.; Huecker. Dietary Iron; In StatPearls: Treasure Island, FL, 2022.
[23]
Ito, H.; Kurokawa, H.; Matsui, H. Mitochondrial reactive oxygen species and heme, non-heme iron metabolism. Arch. Biochem. Biophys., 2021, 700, 108695.
[http://dx.doi.org/10.1016/j.abb.2020.108695] [PMID: 33232715]
[24]
Feizollahi, E.; Mirmahdi, R.S.; Zoghi, A.; Zijlstra, R.T.; Roopesh, M.S.; Vasanthan, T. Review of the beneficial and anti-nutritional qualities of phytic acid, and procedures for removing it from food products. Food Res. Int., 2021, 143, 110284.
[http://dx.doi.org/10.1016/j.foodres.2021.110284] [PMID: 33992384]
[25]
Porter, J.L.; Rawla, P. Hemochromatosis; In StatPearls: Treasure Island, FL, 2022.
[26]
Lang, F.; Qadri, S.M. Mechanisms and significance of eryptosis, the suicidal death of erythrocytes. Blood Purif., 2012, 33(1-3), 125-130.
[http://dx.doi.org/10.1159/000334163] [PMID: 22269222]
[27]
Abbasi, U.; Abbina, S.; Gill, A.; Takuechi, L.E.; Kizhakkedathu, J.N. Role of iron in the molecular pathogenesis of diseases and therapeutic opportunities. ACS Chem. Biol., 2021, 16(6), 945-972.
[http://dx.doi.org/10.1021/acschembio.1c00122] [PMID: 34102834]
[28]
Liu, Q.; Wu, J.; Zhang, X.; Wu, X.; Zhao, Y.; Ren, J. Iron homeostasis and disorders revisited in the sepsis. Free Radic. Biol. Med., 2021, 165, 1-13.
[http://dx.doi.org/10.1016/j.freeradbiomed.2021.01.025] [PMID: 33486088]
[29]
Buck, E.; Finnigan, N.A. Malaria; In StatPearls: Treasure Island, FL, 2022.
[30]
Galaris, D.; Barbouti, A.; Pantopoulos, K. Iron homeostasis and oxidative stress: An intimate relationship. Biochim. Biophys. Acta Mol. Cell Res., 2019, 1866(12), 118535.
[http://dx.doi.org/10.1016/j.bbamcr.2019.118535] [PMID: 31446062]
[31]
Imam, M.; Zhang, S.; Ma, J.; Wang, H.; Wang, F. Antioxidants mediate both iron homeostasis and oxidative stress. Nutrients, 2017, 9(7), 671.
[http://dx.doi.org/10.3390/nu9070671] [PMID: 28657578]
[32]
Warner, M.J.; Kamran, M.T. Iron Deficiency Anemia; In StatPearls: Treasure Island, FL, 2022.
[33]
Institute of Medicine (US) Committee on Micronutrient Deficiencies In: Prevention of Micronutrient Deficiencies: Tools for Policymakers and Public Health Workers; Howson, C.P.; Kennedy, E.T.; Horwitz, A., Eds.; Washington (DC), 1998.
[http://dx.doi.org/10.17226/5962]
[34]
Ghodeif, A.O.; Jain, H. Hookworm; StatPearls: Treasure Island (FL), 2022.
[35]
Salam, R.A.; Das, J.K.; Bhutta, Z.A. Effect of mass deworming with antihelminthics for soil-transmitted helminths during pregnancy. Cochrane Libr., 2021, 2021(5), CD005547.
[http://dx.doi.org/10.1002/14651858.CD005547.pub4] [PMID: 33998661]
[36]
DeVos, E.; Dunn, N. Malaria Prophylaxis; In StatPearls: Treasure Island, FL, 2022.
[37]
Gahagan, S.; Delker, E.; Blanco, E.; Burrows, R.; Lozoff, B. Randomized controlled trial of iron-fortified versus low-iron infant formula: developmental outcomes at 16 years. J. Pediatr., 2019, 212, 124-130.e1.
[http://dx.doi.org/10.1016/j.jpeds.2019.05.030] [PMID: 31253407]
[38]
Rose, E. Pediatric fever. Emerg. Med. Clin. North Am., 2021, 39(3), 627-639.
[http://dx.doi.org/10.1016/j.emc.2021.04.011] [PMID: 34215406]
[39]
Turner, J.; Parsi, M.; Badireddy, M. Normochromic Normocytic Anemia; In StatPearls: Treasure Island, FL, 2022.
[40]
Petry, N.; Olofin, I.; Hurrell, R.; Boy, E.; Wirth, J.; Moursi, M.; Donahue Angel, M.; Rohner, F. The proportion of anemia associated with iron deficiency in low, medium, and high human development index countries: A systematic analysis of national surveys. Nutrients, 2016, 8(11), 693.
[http://dx.doi.org/10.3390/nu8110693] [PMID: 27827838]
[41]
Omena, J.; Curioni, C.; Cople-Rodrigues, C.S.; Citelli, M. The effect of food and nutrients on iron overload: what do we know so far? Eur. J. Clin. Nutr., 2021, 75(12), 1771-1780.
[http://dx.doi.org/10.1038/s41430-021-00887-5] [PMID: 33712721]
[42]
Ojukwu, J.U.; Okebe, J.U.; Yahav, D.; Paul, M. Oral iron supplementation for preventing or treating anaemia among children in malaria-endemic areas. Cochrane Database Syst. Rev., 2009, (3), CD006589.
[http://dx.doi.org/10.1002/14651858.CD006589.pub2] [PMID: 19588399]
[43]
Okebe, J.U.; Yahav, D.; Shbita, R.; Paul, M. Oral iron supplements for children in malaria-endemic areas. Cochrane Database Syst. Rev., 2011, (10), CD006589.
[http://dx.doi.org/10.1002/14651858.CD006589.pub3] [PMID: 21975754]
[44]
Neuberger, A.; Okebe, J.; Yahav, D.; Paul, M. Oral iron supplements for children in malaria-endemic areas. Cochrane Libr., 2016, 2016(2), CD006589.
[http://dx.doi.org/10.1002/14651858.CD006589.pub4] [PMID: 26921618]
[45]
Cantor, A.G.; Bougatsos, C.; Dana, T.; Blazina, I.; McDonagh, M. Routine iron supplementation and screening for iron deficiency anemia in pregnancy: a systematic review for the U.S. Preventive Services Task Force. Ann. Intern. Med., 2015, 162(8), 566-576.
[http://dx.doi.org/10.7326/M14-2932]
[46]
Pasricha, S.R; Drakesmith, H.; Black, J.; Hipgrave, D.; Biggs, B.A. Control of iron deficiency anemia in low- and middle-income countries. Blood, 2013, 121(14), 2607-2617.
[47]
Muthayya, S.; Rah, J.H.; Sugimoto, J.D.; Roos, F.F.; Kraemer, K.; Black, R.E. The global hidden hunger indices and maps: an advocacy tool for action. PLoS One, 2013, 8(6), e67860.
[http://dx.doi.org/10.1371/journal.pone.0067860] [PMID: 23776712]
[48]
Sachdev, H.P.S.; Gera, T. Preventing childhood anemia in India: iron supplementation and beyond. Eur. J. Clin. Nutr., 2013, 67(5), 475-480.
[http://dx.doi.org/10.1038/ejcn.2012.212] [PMID: 23388662]
[49]
Swaminathan, S.; Edward, B.S.; Kurpad, A.V. Micronutrient deficiency and cognitive and physical performance in Indian children. Eur. J. Clin. Nutr., 2013, 67(5), 467-474.
[http://dx.doi.org/10.1038/ejcn.2013.14] [PMID: 23403875]
[50]
Beard, J.L. Why iron deficiency is important in infant development. J. Nutr., 2008, 138(12), 2534-2536.
[http://dx.doi.org/10.1093/jn/138.12.2534] [PMID: 19022985]
[51]
Peirano, P.D.; Algarín, C.R.; Chamorro, R.; Reyes, S.; Garrido, M.I.; Duran, S.; Lozoff, B. Sleep and neurofunctions throughout child development: lasting effects of early iron deficiency. J. Pediatr. Gastroenterol. Nutr., 2009, 48(Suppl. 1), S8-S15.
[http://dx.doi.org/10.1097/MPG.0b013e31819773b] [PMID: 19214058]
[52]
Youdim, M.B.H. Brain iron deficiency and excess; cognitive impairment and neurodegenration with involvement of striatum and hippocampus. Neurotox. Res., 2008, 14(1), 45-56.
[http://dx.doi.org/10.1007/BF03033574] [PMID: 18790724]
[53]
Baumgartner, J.; Smuts, C.M.; Malan, L.; Kvalsvig, J.; van Stuijvenberg, M.E.; Hurrell, R.F.; Zimmermann, M.B. Effects of iron and n-3 fatty acid supplementation, alone and in combination, on cognition in school children: a randomized, double-blind, placebo-controlled intervention in South Africa. Am. J. Clin. Nutr., 2012, 96(6), 1327-1338.
[http://dx.doi.org/10.3945/ajcn.112.041004] [PMID: 23097272]
[54]
Prentice, A.M.; Mendoza, Y.A.; Pereira, D.; Cerami, C.; Wegmuller, R.; Constable, A.; Spieldenner, J. Dietary strategies for improving iron status: balancing safety and efficacy. Nutr. Rev., 2017, 75(1), 49-60.
[http://dx.doi.org/10.1093/nutrit/nuw055] [PMID: 27974599]
[55]
Zou, C.; Du, Y.; Rashid, A.; Ram, H.; Savasli, E.; Pieterse, P.J.; Ortiz-Monasterio, I.; Yazici, A.; Kaur, C.; Mahmood, K.; Singh, S.; Le Roux, M.R.; Kuang, W.; Onder, O.; Kalayci, M.; Cakmak, I. Simultaneous biofortification of wheat with zinc, iodine, selenium, and iron through foliar treatment of a micronutrient cocktail in six countries. J. Agric. Food Chem., 2019, 67(29), 8096-8106.
[http://dx.doi.org/10.1021/acs.jafc.9b01829] [PMID: 31260296]
[56]
Berglund, S.K.; Domellöf, M. Iron deficiency in infancy: Current insights. Curr. Opin. Clin. Nutr. Metab. Care, 2021, 24(3), 240-245.
[http://dx.doi.org/10.1097/MCO.0000000000000749] [PMID: 33656466]
[57]
Abuga, K.M.; Jones-Warner, W.; Hafalla, J.C.R. Immune responses to malaria pre-erythrocytic stages: Implications for vaccine development. Parasite Immunol., 2021, 43(2), e12795.
[http://dx.doi.org/10.1111/pim.12795] [PMID: 32981095]
[58]
Keats, E.C.; Charbonneau, K.D.; Das, J.K.; Bhutta, Z.A. Large-scale food fortification has great potential to improve child health and nutrition. Curr. Opin. Clin. Nutr. Metab. Care, 2021, 24(3), 271-275.
[http://dx.doi.org/10.1097/MCO.0000000000000745] [PMID: 33631771]
[59]
El-Mallah, C.A.; Beyh, Y.S.; Obeid, O.A. Iron fortification and supplementation: Fighting anemia of chronic diseases or fueling obesity? Curr. Dev. Nutr., 2021, 5(4), nzab032.
[http://dx.doi.org/10.1093/cdn/nzab032] [PMID: 33959691]
[60]
Trivedi, R.; Barve, K. Delivery systems for improving iron uptake in anemia. Int. J. Pharm., 2021, 601, 120590.
[http://dx.doi.org/10.1016/j.ijpharm.2021.120590] [PMID: 33845149]
[61]
Field, M.S.; Mithra, P.; Peña-Rosas, J.P. Wheat flour fortification with iron and other micronutrients for reducing anaemia and improving iron status in populations. Cochrane Libr., 2021, 2021(1), CD011302.
[http://dx.doi.org/10.1002/14651858.CD011302.pub3] [PMID: 33461239]
[62]
Hertrampf, E.; Olivares, M. Iron amino acid chelates. Int. J. Vitam. Nutr. Res., 2004, 74(6), 435-443.
[http://dx.doi.org/10.1024/0300-9831.74.6.435] [PMID: 15743019]
[63]
Walter, T.; Hertrampf, E.; Pizarro, F.; Olivares, M.; Llaguno, S.; Letelier, A.; Vega, V.; Stekel, A. Effect of bovine-hemoglobin-fortified cookies on iron status of schoolchildren: a nationwide program in Chile. Am. J. Clin. Nutr., 1993, 57(2), 190-194.
[http://dx.doi.org/10.1093/ajcn/57.2.190] [PMID: 8424387]
[64]
Kawakami, Y.; Bhullar, N.K. Molecular processes in iron and zinc homeostasis and their modulation for biofortification in rice. J. Integr. Plant Biol., 2018, 60(12), 1181-1198.
[http://dx.doi.org/10.1111/jipb.12751] [PMID: 30468300]
[65]
Diego Quintaes, K.; Barberá, R.; Cilla, A. Iron bioavailability in iron-fortified cereal foods: The contribution of in vitro studies. Crit. Rev. Food Sci. Nutr., 2017, 57(10), 2028-2041.
[http://dx.doi.org/10.1080/10408398.2013.866543] [PMID: 25830598]
[66]
Olivares, M.; Walter, T.; Hertrampf, E.; Pizarro, F.; Stekel, A. Prevention of iron deficiency by milk fortification. The Chilean experience. Acta Paediatr., 1989, 78, 109-113.
[http://dx.doi.org/10.1111/apa.1989.78.s361.109] [PMID: 2485578]
[67]
Martorell, R.; de Romaña, D.L. Components of successful staple food fortification programs: Lessons from Latin America. Food Nutr. Bull., 2017, 38(3), 384-404.
[http://dx.doi.org/10.1177/0379572117707890] [PMID: 28490239]
[68]
Lachowicz, J.I.; Nurchi, V.M.; Fanni, D.; Gerosa, C.; Peana, M.; Zoroddu, M.A. Nutritional iron deficiency: the role of oral iron supplementation. Curr. Med. Chem., 2014, 21(33), 3775-3784.
[http://dx.doi.org/10.2174/0929867321666140706143925] [PMID: 25005180]
[69]
Nguyen, M.; Tadi, P. Acute Stroke; In Stat Pearls: Treasure Island, FL, 2022.
[70]
Tolkien, Z.; Stecher, L.; Mander, A.P.; Pereira, D.I.; Powell, J.J. Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis. PLoS One, 2015, 10(2), e0117383.
[http://dx.doi.org/10.1371/journal.pone.0117383]
[71]
Sen, A.; Kanani, S. Intermittent iron folate supplementation: impact on hematinic status and growth of school girls. ISRN Hematol, 2012, 2012, 482153.
[http://dx.doi.org/10.5402/2012/482153]
[72]
Ahmed, F.; Khan, M.R.; Akhtaruzzaman, M.; Karim, R.; Williams, G.; Banu, C.P.; Nahar, B.; Darnton-Hill, I. Effect of long-term intermittent supplementation with multiple micronutrients compared with iron-and-folic acid supplementation on Hb and micronutrient status of non-anaemic adolescent schoolgirls in rural Bangladesh. Br J Nutr, 2012, 108(8), 1484-1493.
[http://dx.doi.org/10.1017/S0007114511006908]
[73]
Bothwell, T.H. Iron requirements in pregnancy and strategies to meet them. Am. J. Clin. Nutr., 2000, 72(1), 257S-264S.
[http://dx.doi.org/10.1093/ajcn/72.1.257S] [PMID: 10871591]
[74]
Ford, F.A.; Mouratidou, T.; Wademan, S.E.; Fraser, R.B. Effect of the introduction of 'Healthy Start' on dietary behaviour during and after pregnancy: early results from the 'before and after' Sheffield study. Br. J. Nutr., 2009, 101(12), 1828-1836.
[75]
Caspersen, I.H.; Iglesias-Vazquez, L.; Abel, M.H.; Brantsaeter, A.L.; Arija, V.; Erlund, I.; Meltzer, H.M. Iron status in mid-pregnancy and associations with interpregnancy interval, hormonal contraceptives, dietary factors and supplement use. Br. J. Nutr., 2021, 126(8), 1270-1280.
[http://dx.doi.org/10.1017/S0007114521000295]
[76]
Casgrain, A.; Collings, R.; Harvey, L.J.; Hooper, L.; Fairweather-Tait, S.J. Effect of iron intake on iron status: a systematic review and meta-analysis of randomized controlled trials. Am. J. Clin. Nutr., 2012, 96(4), 768-780.
[http://dx.doi.org/10.3945/ajcn.112.040626] [PMID: 22932280]
[77]
Gera, T.; Sachdev, H.S.; Boy, E. Effect of iron-fortified foods on hematologic and biological outcomes: systematic review of randomized controlled trials. Am. J. Clin. Nutr., 2012, 96(2), 309-324.
[http://dx.doi.org/10.3945/ajcn.111.031500] [PMID: 22760566]
[78]
Muñoz, M.; Gómez-Ramírez, S.; Bhandari, S. The safety of available treatment options for iron-deficiency anemia. Expert Opin. Drug Saf., 2018, 17(2), 149-159.
[http://dx.doi.org/10.1080/14740338.2018.1400009] [PMID: 29103332]
[79]
Powers, J.M.; Buchanan, G.R. Disorders of iron metabolism. Hematol. Oncol. Clin. North Am., 2019, 33(3), 393-408.
[http://dx.doi.org/10.1016/j.hoc.2019.01.006] [PMID: 31030809]
[80]
Avni, T.; Bieber, A.; Grossman, A.; Green, H.; Leibovici, L.; Gafter-Gvili, A. The safety of intravenous iron preparations: systematic review and meta-analysis. Mayo Clin. Proc., 2015, 90(1), 12-23.
[http://dx.doi.org/10.1016/j.mayocp.2014.10.007] [PMID: 25572192]
[81]
Clevenger, B.; Gurusamy, K.; Klein, A.A.; Murphy, G.J.; Anker, S.D.; Richards, T. Systematic review and meta-analysis of iron therapy in anaemic adults without chronic kidney disease: Updated and abridged Cochrane review. Eur. J. Heart Fail., 2016, 18(7), 774-785.
[http://dx.doi.org/10.1002/ejhf.514] [PMID: 27121474]
[82]
Shrimpton, R.; Schultink, W.; Schultink, W. Can supplements help meet the micronutrient needs of the developing world? Proc. Nutr. Soc., 2002, 61(2), 223-229.
[http://dx.doi.org/10.1079/PNS2002163] [PMID: 12133204]
[83]
Means, R.T. Iron deficiency and iron deficiency anemia: Implications and impact in pregnancy, fetal development, and early childhood parameters. Nutrients, 2020, 12(2), 447.
[http://dx.doi.org/10.3390/nu12020447] [PMID: 32053933]
[84]
Ogawa, C.; Tsuchiya, K.; Maeda, K. Reticulocyte hemoglobin content. Clin. Chim. Acta, 2020, 504, 138-145.
[http://dx.doi.org/10.1016/j.cca.2020.01.032] [PMID: 32014518]
[85]
Porter, J.B. Iron through the prism of haematology. Br. J. Haematol., 2020, 191(4), 587-592.
[http://dx.doi.org/10.1111/bjh.17164] [PMID: 33190267]
[86]
Barffour, M.A.; Hinnouho, G.M.; Kounnavong, S.; Wessells, K.R.; Ratsavong, K.; Bounheuang, B.; Chanhthavong, B.; Sitthideth, D.; Sengnam, K.; Arnold, C.D.; Brown, K.H.; Hess, S.Y. Effects of daily zinc, daily multiple micronutrient powder, or therapeutic zinc supplementation for diarrhea prevention on physical growth, anemia, and micronutrient status in rural laotian children: A randomized controlled trial. J. Pediatr., 2019, 207, 80-89.e2.
[http://dx.doi.org/10.1016/j.jpeds.2018.11.022] [PMID: 30580974]
[87]
Nguyen, P.H.; Young, M.; Gonzalez-Casanova, I.; Pham, H.Q.; Nguyen, H.; Truong, T.V.; Nguyen, S.V.; Harding, K.B.; Reinhart, G.A.; Martorell, R.; Ramakrishnan, U. Impact of preconception micronutrient supplementation on anemia and iron status during pregnancy and postpartum: A randomized controlled trial in rural Vietnam. PLoS One, 2016, 11(12), e0167416.
[http://dx.doi.org/10.1371/journal.pone.0167416] [PMID: 27918586]
[88]
Jáuregui-Lobera, I. Iron deficiency and cognitive functions. Neuropsychiatr. Dis. Treat., 2014, 10, 2087-2095.
[http://dx.doi.org/10.2147/NDT.S72491] [PMID: 25419131]
[89]
World Health Organization (WHO). Guideline:Fortification of Maize Flour and Corn Meal with Vitamins and Minerals; Geneva, 2016.

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