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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Review Article

Coenzyme Q10 for Enhancing Physical Activity and Extending the Human Life Cycle

Author(s): Geir Bjørklund*, Yuliya Semenova, Amin Gasmi, Neluwa-Liyanage Ruwan Indika, Ihor Hrynovets, Roman Lysiuk, Larysa Lenchyk, Taras Uryr, Hanna Yeromina and Massimiliano Peana

Volume 31, Issue 14, 2024

Published on: 26 May, 2023

Page: [1804 - 1817] Pages: 14

DOI: 10.2174/0929867330666230228103913

Price: $65

Abstract

Background: Coenzyme Q (CoQ) is an enzyme family that plays a crucial role in maintaining the electron transport chain and antioxidant defense. CoQ10 is the most common form of CoQ in humans. A deficiency of CoQ10 occurs naturally with aging and may contribute to the development or progression of many diseases. Besides, certain drugs, in particular, statins and bisphosphonates, interfere with the enzymes responsible for CoQ10 biosynthesis and, thus, lead to CoQ10 deficiency.

Objectives: This article aims to evaluate the cumulative studies and insights on the topic of CoQ10 functions in human health, focusing on a potential role in maintaining physical activity and extending the life cycle.

Results: Although supplementation with CoQ10 offers many benefits to patients with cardiovascular disease, it appears to add little value to patients suffering from statin-associated muscular symptoms. This may be attributed to substantial heterogeneity in doses and treatment regimens used.

Conclusion: Therefore, there is a need for further studies involving a greater number of patients to clarify the benefits of adjuvant therapy with CoQ10 in a range of health conditions and diseases.

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[1]
Crane, F.L. Biochemical functions of coenzyme Q10. J. Am. Coll. Nutr., 2001, 20(6), 591-598.
[http://dx.doi.org/10.1080/07315724.2001.10719063] [PMID: 11771674]
[2]
Gutierrez-Mariscal, F.M.; Yubero-Serrano, E.M.; Villalba, J.M.; Lopez-Miranda, J.; Coenzyme, Q. Coenzyme Q10: From bench to clinic in aging diseases, a translational review. Crit. Rev. Food Sci. Nutr., 2019, 59(14), 2240-2257.
[http://dx.doi.org/10.1080/10408398.2018.1442316] [PMID: 29451807]
[3]
Barcelos, I.P.; Haas, R.H. CoQ10 and aging. Biology, 2019, 8(2), 28.
[http://dx.doi.org/10.3390/biology8020028] [PMID: 31083534]
[4]
Schmelzer, C.; Lindner, I.; Rimbach, G.; Niklowitz, P.; Menke, T.; Döring, F. Functions of coenzyme Q10 in inflammation and gene expression. Biofactors, 2008, 32(1-4), 179-183.
[http://dx.doi.org/10.1002/biof.5520320121] [PMID: 19096114]
[5]
Zhang, Y.; Liu, J.; Chen, X.; Oliver Chen, C.Y. Ubiquinol is superior to ubiquinone to enhance coenzyme Q10 status in older men. Food Funct., 2018, 9(11), 5653-5659.
[http://dx.doi.org/10.1039/C8FO00971F] [PMID: 30302465]
[6]
Palamakula, A.; Soliman, M.; Khan, M.M. Regional permeability of coenzyme Q10 in isolated rat gastrointestinal tracts. Pharmazie, 2005, 60(3), 212-214.
[PMID: 15801676]
[7]
Raizner, A.E.; Coenzyme, Q. Coenzyme Q(10). Methodist DeBakey Cardiovasc. J., 2019, 15(3), 185-191.
[http://dx.doi.org/10.14797/mdcj-15-3-185] [PMID: 31687097]
[8]
Tippairote, T.; Bjørklund, G.; Gasmi, A.; Semenova, Y.; Peana, M.; Chirumbolo, S.; Hangan, T. Combined supplementation of coenzyme Q10 and other nutrients in specific medical conditions. Nutrients, 2022, 14(20), 4383.
[http://dx.doi.org/10.3390/nu14204383] [PMID: 36297067]
[9]
Hargreaves, I.; Heaton, R.A.; Mantle, D. Disorders of human coenzyme Q10 metabolism: An overview. Int. J. Mol. Sci., 2020, 21(18), 6695.
[http://dx.doi.org/10.3390/ijms21186695] [PMID: 32933108]
[10]
Testai, L.; Martelli, A.; Flori, L.; Cicero, A.F.G. Colletti A. Coenzyme Q10: Clinical applications beyond cardiovascular diseases. Nutrients, 2021, 13(5), 1697.
[http://dx.doi.org/10.3390/nu13051697] [PMID: 34067632]
[11]
Saini, R. Coenzyme Q10: The essential nutrient. J. Pharm. Bioallied Sci., 2011, 3(3), 466-467.
[http://dx.doi.org/10.4103/0975-7406.84471] [PMID: 21966175]
[12]
Clement, A.M. The Antioxidant Defense Network: Synergistic Combinations to Prevent Oxidative Damage; Brigham Young University: Provo, Utah, 2008.
[13]
Rabanal-Ruiz, Y.; Llanos-González, E.; Alcain, F.J. The use of coenzyme Q10 in cardiovascular diseases. Antioxidants, 2021, 10(5), 755.
[http://dx.doi.org/10.3390/antiox10050755] [PMID: 34068578]
[14]
Åberg, F.; Appelkvist, E.L.; Dallner, G.; Ernster, L. Distribution and redox state of ubiquinones in rat and human tissues. Arch. Biochem. Biophys., 1992, 295(2), 230-234.
[http://dx.doi.org/10.1016/0003-9861(92)90511-T] [PMID: 1586151]
[15]
Crane, F.L.; Hatefi, Y.; Lester, R.L.; Widmer, C. Isolation of a quinone from beef heart mitochondria. Biochim. Biophys. Acta, 1957, 25(1), 220-221.
[http://dx.doi.org/10.1016/0006-3002(57)90457-2] [PMID: 13445756]
[16]
Glancy, B.; Kane, D.A.; Kavazis, A.N.; Goodwin, M.L.; Willis, W.T.; Gladden, L.B. Mitochondrial lactate metabolism: History and implications for exercise and disease. J. Physiol., 2021, 599(3), 863-888.
[http://dx.doi.org/10.1113/JP278930] [PMID: 32358865]
[17]
Sazanov, L.A. The mechanism of coupling between electron transfer and proton translocation in respiratory complex I. J. Bioenerg. Biomembr., 2014, 46(4), 247-253.
[http://dx.doi.org/10.1007/s10863-014-9554-z] [PMID: 24943718]
[18]
Zickermann, V.; Wirth, C.; Nasiri, H.; Siegmund, K.; Schwalbe, H.; Hunte, C.; Brandt, U. Mechanistic insight from the crystal structure of mitochondrial complex I. Science, 2015, 347(6217), 44-49.
[http://dx.doi.org/10.1126/science.1259859] [PMID: 25554780]
[19]
Alcázar-Fabra, M.; Navas, P.; Brea-Calvo, G. Coenzyme Q biosynthesis and its role in the respiratory chain structure. Biochim. Biophys. Acta Bioenerg., 2016, 1857(8), 1073-1078.
[http://dx.doi.org/10.1016/j.bbabio.2016.03.010] [PMID: 26970214]
[20]
Turunen, M.; Olsson, J.; Dallner, G. Metabolism and function of coenzyme Q. Biochim. Biophys. Acta Biomembr., 2004, 1660(1-2), 171-199.
[http://dx.doi.org/10.1016/j.bbamem.2003.11.012] [PMID: 14757233]
[21]
Xu, Z.; Huo, J.; Ding, X.; Yang, M.; Li, L.; Dai, J.; Hosoe, K.; Kubo, H.; Mori, M.; Higuchi, K.; Sawashita, J. Coenzyme Q10 improves lipid metabolism and ameliorates obesity by regulating CaMKII-mediated PDE4 inhibition. Sci. Rep., 2017, 7(1), 8253.
[http://dx.doi.org/10.1038/s41598-017-08899-7] [PMID: 28811612]
[22]
Hajiluian, G.; Heshmati, J.; Jafari Karegar, S.; Sepidarkish, M.; Shokri, A.; Shidfar, F. Diabetes, age, and duration of supplementation subgroup analysis for the effect of coenzyme Q10 on oxidative stress: A systematic review and meta-analysis. Complement. Med. Res., 2021, 28(6), 557-570.
[http://dx.doi.org/10.1159/000515249] [PMID: 33866314]
[23]
Tomasetti, M.; Littarru, G.P.; Stocker, R.; Alleva, R. Coenzyme Q10 enrichment decreases oxidative DNA damage in human lymphocytes. Free Radic. Biol. Med., 1999, 27(9-10), 1027-1032.
[http://dx.doi.org/10.1016/S0891-5849(99)00132-X] [PMID: 10569635]
[24]
Tomasetti, M.; Alleva, R.; Collins, A.R.; Collins, A.R. In vivo supplementation with coenzyme Q10 enhances the recovery of human lymphocytes from oxidative DNA damage. FASEB J., 2001, 15(8), 1425-1427.
[http://dx.doi.org/10.1096/fj.00-0694fje] [PMID: 11387245]
[25]
Pala, R.; Orhan, C.; Tuzcu, M.; Sahin, N.; Ali, S.; Cinar, V.; Atalay, M.; Sahin, K. Coenzyme Q10 supplementation modulates NFκB and Nrf2 pathways in exercise training. J. Sports Sci. Med., 2016, 15(1), 196-203.
[PMID: 26957943]
[26]
Xia, L.; Nordman, T.; Olsson, J.M.; Damdimopoulos, A.; Björkhem-Bergman, L.; Nalvarte, I.; Eriksson, L.C.; Arnér, E.S.J.; Spyrou, G.; Björnstedt, M. The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress. J. Biol. Chem., 2003, 278(4), 2141-2146.
[http://dx.doi.org/10.1074/jbc.M210456200] [PMID: 12435734]
[27]
Nordman, T.; Xia, L.; Björkhem-Bergman, L.; Damdimopoulos, A.; Nalvarte, I.; Arnér, E.S.J.; Spyrou, G.; Eriksson, L.C.; Björnstedt, M.; Olsson, J.M. Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase. Biofactors, 2003, 18(1-4), 45-50.
[http://dx.doi.org/10.1002/biof.5520180206] [PMID: 14695919]
[28]
Bjørklund, G.; Zou, L.; Wang, J.; Chasapis, C.T.; Peana, M. Thioredoxin reductase as a pharmacological target. Pharmacol. Res., 2021, 174, 105854.
[http://dx.doi.org/10.1016/j.phrs.2021.105854] [PMID: 34455077]
[29]
Aaseth, J.; Alexander, J.; Alehagen, U.; Coenzyme, Q. Coenzyme Q10 supplementation – In ageing and disease. Mech. Ageing Dev., 2021, 197, 111521.
[http://dx.doi.org/10.1016/j.mad.2021.111521] [PMID: 34129891]
[30]
Reig, M.; Aristoy, M.C.; Toldrá, F. Sources of variability in the analysis of meat nutrient coenzyme Q10 for food composition databases. Food Control, 2015, 48, 151-154.
[http://dx.doi.org/10.1016/j.foodcont.2014.02.009]
[31]
Pravst, I.; Žmitek, K.; Žmitek, J. Coenzyme Q10 contents in foods and fortification strategies. Crit. Rev. Food Sci. Nutr., 2010, 50(4), 269-280.
[http://dx.doi.org/10.1080/10408390902773037] [PMID: 20301015]
[32]
Kamei, M.; Fujita, T.; Kanbe, T.; Sasaki, K.; Oshiba, K.; Otani, S.; Matsui-Yuasa, I.; Morisawa, S. The distribution and content of ubiquinone in foods. Int. J. Vitam. Nutr. Res., 1986, 56(1), 57-63.
[PMID: 3710719]
[33]
Strazisar, M.; Fir, M.; Golc-Wondra, A.; Milivojevic, L.; Prosek, M.; Abram, V. Quantitative determination of coenyzme Q10 by liquid chromatography and liquid chromatography/mass spectrometry in dairy products. J. AOAC Int., 2005, 88(4), 1020-1027.
[http://dx.doi.org/10.1093/jaoac/88.4.1020] [PMID: 16152917]
[34]
Grażyna, C.; Hanna, C.; Adam, A.; Magdalena, B.M. Natural antioxidants in milk and dairy products. Int. J. Dairy Technol., 2017, 70(2), 165-178.
[http://dx.doi.org/10.1111/1471-0307.12359]
[35]
Campisi, L.; La Motta, C. The use of the coenzyme Q10 as a food supplement in the management of fibromyalgia: A critical review. Antioxidants, 2022, 11(10), 1969.
[http://dx.doi.org/10.3390/antiox11101969] [PMID: 36290691]
[36]
Mantle, D.; Dybring, A. Bioavailability of coenzyme Q10: An overview of the absorption process and subsequent metabolism. Antioxidants, 2020, 9(5), 386.
[http://dx.doi.org/10.3390/antiox9050386] [PMID: 32380795]
[37]
Bhagavan, H.N.; Chopra, R.K. Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic. Res., 2006, 40(5), 445-453.
[http://dx.doi.org/10.1080/10715760600617843] [PMID: 16551570]
[38]
Kwong, L.K.; Kamzalov, S.; Rebrin, I.; Bayne, A.C.V.; Jana, C.K.; Morris, P.; Forster, M.J.; Sohal, R.S. Effects of coenzyme Q10 administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat. Free Radic. Biol. Med., 2002, 33(5), 627-638.
[http://dx.doi.org/10.1016/S0891-5849(02)00916-4] [PMID: 12208349]
[39]
Rodick, T.C.; Seibels, D.R.; Babu, J.R.; Huggins, K.W.; Ren, G.; Mathews, S.T. Potential role of coenzyme Q10 in health and disease conditions. Nutr. Diet. Suppl., 2018, 10, 1-11.
[http://dx.doi.org/10.2147/NDS.S112119]
[40]
Banach, M.; Serban, C.; Ursoniu, S.; Rysz, J.; Muntner, P.; Toth, P.P.; Jones, S.R.; Rizzo, M.; Glasser, S.P.; Watts, G.F.; Blumenthal, R.S.; Lip, G.Y.H.; Mikhailidis, D.P.; Sahebkar, A. Statin therapy and plasma coenzyme Q10 concentrations-A systematic review and meta-analysis of placebo- controlled trials. Pharmacol. Res., 2015, 99, 329-336.
[http://dx.doi.org/10.1016/j.phrs.2015.07.008] [PMID: 26192349]
[41]
Gasmi, A.; Bjørklund, G.; Mujawdiya, P.K.; Semenova, Y.; Piscopo, S.; Peana, M.; Coenzyme, Q. Coenzyme Q10 in aging and disease. Crit. Rev. Food Sci. Nutr., 2022, 1-13.
[http://dx.doi.org/10.1080/10408398.2022.2137724] [PMID: 36300654]
[42]
Taylor, F.; Huffman, M.D.; Macedo, A.F.; Moore, T.H.M.; Burke, M.; Davey Smith, G.; Ward, K.; Ebrahim, S.; Gay, H.C. Statins for the primary prevention of cardiovascular disease. Cochrane Libr., 2013, 2021(9), CD004816.
[http://dx.doi.org/10.1002/14651858.CD004816.pub5] [PMID: 23440795]
[43]
Borowy-Borowski, H.; Sodja, C.; Docherty, J.; Roy Walker, P.; Sikorska, M. Unique technology for solubilization and delivery of highly lipophilic bioactive molecules. J. Drug Target., 2004, 12(7), 415-424.
[http://dx.doi.org/10.1080/10611860412331285233] [PMID: 15621666]
[44]
Masterson, R.V. Coenzyme Q10 compositions for organ protection during perfusion. EP Patent 1082005A1, 2000.
[45]
Zappia, V.; De Rosa, M. Lipophilic salts of S-adenosyl-L-methionine (SAM) with acylated taurine derivatives. US Patent 5073546A, 1989.
[46]
Ohashi, H.; Takami, T.; Koyama, N.; Kogure, Y.; Ida, K. Aqueous solution containing ubidecarenone. EP Patent 0083108B1, 1984.
[47]
Prošek, M.; Šmidovnik, A.; Milivojevič, M.F.; Golc-Wondra, A.; Žmitek, J.; Kostanjevec, B.; Donša, B.; Vindiš-Zelenko, B. Use of coenzyme Q10 for improved effectiveness of animal husbandry and production of animal tissues with an increased content of the said coenzyme. WIPO-World Intellectual Property Organization, 2008.
[48]
Kamisoyama, H.; Honda, K.; Kitaguchi, K.; Hasegawa, S. Transfer of dietary coenzyme Q10 into the egg yolk of laying hens. J. Poult. Sci., 2010, 47(1), 28-33.
[http://dx.doi.org/10.2141/jpsa.009037]
[49]
Pravst, I.; Prošek, M.; Wondra, A.G.; Žmitek, K.; Žmitek, J. The stability of coenzyme Q 10 in fortified foods. Acta Chim. Slov., 2009, 56, 953-958.
[50]
Pravst, I.; Žmitek, K. The coenzyme Q10 content of food supplements. J. Verbraucherschutz Lebensmsicherh., 2011, 6(4), 457-463.
[http://dx.doi.org/10.1007/s00003-011-0704-5]
[51]
Kettawan, A.; Kunthida, C.; Takahashi, T.; Kishi, T.; Chikazawa, J.; Sakata, Y.; Yano, E.; Watabe, K.; Yamamoto, Y.; Okamoto, T. The quality control assessment of commercially available coenzyme Q(10)-containing dietary and health supplements in Japan. J. Clin. Biochem. Nutr., 2007, 41(2), 124-131.
[http://dx.doi.org/10.3164/jcbn.2007017] [PMID: 18193106]
[52]
Hrynovets, I.; Hrynovets, V.; Renka, M.; Ripetska, O.; Buchkovska, A.; Renka, D-J.; Chaban, T.; Harkov, S.; Demchuk, I.; Ogurtsov, V. Development and construction of devices to perfect the process of production of biodental films by the solvent casting method. Farmatsija, 2018, 65(2), 47-53.
[53]
Hidaka, T.; Fujii, K.; Funahashi, I.; Fukutomi, N.; Hosoe, K. Safety assessment of coenzyme Q10 (CoQ10). Biofactors, 2008, 32(1-4), 199-208.
[http://dx.doi.org/10.1002/biof.5520320124] [PMID: 19096117]
[54]
Shults, C.W.; Flint Beal, M.; Song, D.; Fontaine, D. Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson’s disease. Exp. Neurol., 2004, 188(2), 491-494.
[http://dx.doi.org/10.1016/j.expneurol.2004.05.003] [PMID: 15246848]
[55]
Arenas-Jal, M.; Suñé-Negre, J.M.; García-Montoya, E. Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges. Compr. Rev. Food Sci. Food Saf., 2020, 19(2), 574-594.
[http://dx.doi.org/10.1111/1541-4337.12539] [PMID: 33325173]
[56]
Mantle, D.; Hargreaves, I. Coenzyme Q10 and degenerative disorders affecting longevity: An overview. Antioxidants, 2019, 8(2), 44.
[http://dx.doi.org/10.3390/antiox8020044] [PMID: 30781472]
[57]
Wear, D.; Vegh, C.; Sandhu, J.K.; Sikorska, M.; Cohen, J.; Pandey, S. Ubisol-Q10, a nanomicellar and water-dispersible formulation of coenzyme-Q10 as a potential treatment for Alzheimer’s and Parkinson’s disease. Antioxidants, 2021, 10(5), 764.
[http://dx.doi.org/10.3390/antiox10050764] [PMID: 34064983]
[58]
Dahri, M.; Tarighat-Esfanjani, A.; Asghari-Jafarabadi, M.; Hashemilar, M. Oral coenzyme Q10 supplementation in patients with migraine: Effects on clinical features and inflammatory markers. Nutr. Neurosci., 2019, 22(9), 607-615.
[http://dx.doi.org/10.1080/1028415X.2017.1421039] [PMID: 29298622]
[59]
Gvozdjáková, A.; Kucharská, J.; Ostatníková, D.; Babinská, K.; Nakládal, D.; Crane, F.L. Ubiquinol improves symptoms in children with autism. Oxid. Med. Cell. Longev., 2014, 2014, 1-6.
[http://dx.doi.org/10.1155/2014/798957] [PMID: 24707344]
[60]
Qu, H.; Guo, M.; Chai, H.; Wang, W.; Gao, Z.; Shi, D. Effects of coenzyme Q10 on statin-induced myopathy: An updated meta-analysis of randomized controlled trials. J. Am. Heart Assoc., 2018, 7(19), e009835.
[http://dx.doi.org/10.1161/JAHA.118.009835] [PMID: 30371340]
[61]
Kennedy, C.; Köller, Y.; Surkova, E. Effect of coenzyme Q10 on statin-associated myalgia and adherence to statin therapy: A systematic review and meta-analysis. Atherosclerosis, 2020, 299, 1-8.
[http://dx.doi.org/10.1016/j.atherosclerosis.2020.03.006] [PMID: 32179207]
[62]
Wei, H.; Xin, X.; Zhang, J.; Xie, Q.; Naveed, M.; Kaiyan, C.; Xiao, P. Effects of coenzyme Q10 supplementation on statin-induced myopathy: A meta-analysis of randomized controlled trials. Ir. J. Med. Sci., 2022, 191(2), 719-725.
[http://dx.doi.org/10.1007/s11845-021-02651-x] [PMID: 33999383]
[63]
Orlando, P.; Silvestri, S.; Galeazzi, R.; Antonicelli, R.; Marcheggiani, F.; Cirilli, I.; Bacchetti, T.; Tiano, L. Effect of ubiquinol supplementation on biochemical and oxidative stress indexes after intense exercise in young athletes. Redox Rep., 2018, 23(1), 136-145.
[http://dx.doi.org/10.1080/13510002.2018.1472924] [PMID: 29734881]
[64]
García Verazaluce, J.J.; Vargas Corzo, Mdel.C.; Aguilar Cordero, M.J.; Ocaña Peinado, F.; Sarmiento Ramírez, Á.; Guisado Barrilao, R. Effect of phlebodium decumanum and coenzyme Q10 on sports performance in professional volleyball players. Nutr. Hosp., 2014, 31(1), 401-414.
[http://dx.doi.org/10.3305/nh.2015.31.1.8177] [PMID: 25561135]
[65]
Sarmiento, A.; Diaz-Castro, J.; Pulido-Moran, M.; Kajarabille, N.; Guisado, R.; Ochoa, J.J. Coenzyme Q10 supplementation and exercise in healthy humans: A systematic review. Curr. Drug Metab., 2016, 17(4), 345-358.
[http://dx.doi.org/10.2174/1389200216666151103115654] [PMID: 26526835]
[66]
Emami, A.; Tofighi, A.; Asri-Rezaei, S.; Bazargani-Gilani, B. The effect of short-term coenzyme Q10 supplementation and pre-cooling strategy on cardiac damage markers in elite swimmers. Br. J. Nutr., 2018, 119(4), 381-390.
[http://dx.doi.org/10.1017/S0007114517003774] [PMID: 29498347]
[67]
Drobnic, F.; Lizarraga, M.A.; Caballero-García, A.; Cordova, A.; Coenzyme, Q. Coenzyme Q10 supplementation and its impact on exercise and sport performance in humans: A recovery or a performance-enhancing molecule? Nutrients, 2022, 14(9), 1811.
[http://dx.doi.org/10.3390/nu14091811] [PMID: 35565783]
[68]
Zheng, A.; Moritani, T. Influence of CoQ10 on autonomic nervous activity and energy metabolism during exercise in healthy subjects. J. Nutr. Sci. Vitaminol., 2008, 54(4), 286-290.
[http://dx.doi.org/10.3177/jnsv.54.286] [PMID: 18797149]
[69]
Yang, Y.K.; Wang, L.P.; Chen, L.; Yao, X.P.; Yang, K.Q.; Gao, L.G.; Zhou, X.L. Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction. Clin. Chim. Acta, 2015, 450, 83-89.
[http://dx.doi.org/10.1016/j.cca.2015.08.002] [PMID: 26254995]
[70]
Castro-Marrero, J.; Cordero, M.D.; Segundo, M.J.; Sáez-Francàs, N.; Calvo, N.; Román-Malo, L.; Aliste, L.; Fernández de Sevilla, T.; Alegre, J. Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome? Antioxid. Redox Signal., 2015, 22(8), 679-685.
[http://dx.doi.org/10.1089/ars.2014.6181] [PMID: 25386668]
[71]
Castro-Marrero, J.; Sáez-Francàs, N.; Segundo, M.J.; Calvo, N.; Faro, M.; Aliste, L.; Fernández de Sevilla, T.; Alegre, J. Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome – A randomized, controlled, double-blind trial. Clin. Nutr., 2016, 35(4), 826-834.
[http://dx.doi.org/10.1016/j.clnu.2015.07.010] [PMID: 26212172]
[72]
McHugh, D.; Gil, J. Senescence and aging: Causes, consequences, and therapeutic avenues. J. Cell Biol., 2018, 217(1), 65-77.
[http://dx.doi.org/10.1083/jcb.201708092] [PMID: 29114066]
[73]
Mylonas, A.; O’Loghlen, A. Cellular senescence and ageing: Mechanisms and interventions. Front. Aging, 2022, 3, 866718.
[http://dx.doi.org/10.3389/fragi.2022.866718] [PMID: 35821824]
[74]
Braakhuis, A.J.; Nagulan, R.; Somerville, V. The effect of MitoQ on aging-related biomarkers: A systematic review and meta-analysis. Oxid. Med. Cell. Longev., 2018, 2018, 1-12.
[http://dx.doi.org/10.1155/2018/8575263] [PMID: 30116495]
[75]
Sangsefidi, Z.S.; Yaghoubi, F.; Hajiahmadi, S.; Hosseinzadeh, M. The effect of coenzyme Q10 supplementation on oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials. Food Sci. Nutr., 2020, 8(4), 1766-1776.
[http://dx.doi.org/10.1002/fsn3.1492] [PMID: 32328242]
[76]
Dai, S.; Tian, Z.; Zhao, D.; Liang, Y.; Liu, M.; Liu, Z.; Hou, S.; Yang, Y. Effects of coenzyme Q10 supplementation on biomarkers of oxidative stress in adults: A GRADE-assessed systematic review and updated meta-analysis of randomized controlled trials. Antioxidants, 2022, 11(7), 1360.
[http://dx.doi.org/10.3390/antiox11071360] [PMID: 35883851]
[77]
Alehagen, U.; Aaseth, J.; Alexander, J.; Brismar, K.; Larsson, A. Selenium and coenzyme Q10 supplementation improves renal function in elderly deficient in selenium: Observational results and results from a subgroup analysis of a prospective randomised double-blind placebo-controlled trial. Nutrients, 2020, 12(12), 3780.
[http://dx.doi.org/10.3390/nu12123780] [PMID: 33317156]
[78]
Alehagen, U.; Johansson, P.; Aaseth, J.; Alexander, J.; Surowiec, I.; Lundstedt-Enkel, K.; Lundstedt, T. Significant changes in metabolic profiles after intervention with selenium and coenzyme Q10 in an elderly population. Biomolecules, 2019, 9(10), 553.
[http://dx.doi.org/10.3390/biom9100553] [PMID: 31575091]
[79]
Linnane, A.W.; Kopsidas, G.; Zhang, C.; Yarovaya, N.; Kovalenko, S.; Papakostopoulos, P.; Eastwood, H.; Graves, S.; Richardson, M. Cellular redox activity of coenzyme Q10: Effect of CoQ10 supplementation on human skeletal muscle. Free Radic. Res., 2002, 36(4), 445-453.
[http://dx.doi.org/10.1080/10715760290021306] [PMID: 12069109]
[80]
Feher, J.; Kovacs, B.; Kovacs, I.; Schveoller, M.; Papale, A.; Balacco Gabrieli, C. Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10. Ophthalmologica, 2005, 219(3), 154-166.
[http://dx.doi.org/10.1159/000085248] [PMID: 15947501]
[81]
Alehagen, U.; Aaseth, J.; Alexander, J.; Johansson, P. Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly. PLoS One, 2018, 13(4), e0193120.
[http://dx.doi.org/10.1371/journal.pone.0193120] [PMID: 29641571]
[82]
Alehagen, U.; Alexander, J.; Aaseth, J. Supplementation with selenium and coenzyme Q10 reduces cardiovascular mortality in elderly with low selenium status. A secondary analysis of a randomised clinical trial. PLoS One, 2016, 11(7), e0157541.
[http://dx.doi.org/10.1371/journal.pone.0157541] [PMID: 27367855]
[83]
Almahmoud, M.F.; Soliman, E.Z.; Bertoni, A.G.; Kestenbaum, B.; Katz, R.; Lima, J.A.C.; Ouyang, P.; Miller, P.E.; Michos, E.D.; Herrington, D.M. Fibroblast growth factor-23 and heart failure with reduced versus preserved ejection fraction: MESA. J. Am. Heart Assoc., 2018, 7(18), e008334.
[http://dx.doi.org/10.1161/JAHA.117.008334] [PMID: 30371180]
[84]
Alehagen, U.; Aaseth, J.; Larsson, A.; Alexander, J. Decreased concentration of fibroblast growth factor 23 (FGF-23) as a result of supplementation with selenium and coenzyme Q10 in an elderly swedish population: A sub-analysis. Cells, 2022, 11(3), 509.
[http://dx.doi.org/10.3390/cells11030509] [PMID: 35159318]
[85]
Rudolf, H.; Mügge, A.; Trampisch, H.J.; Scharnagl, H.; März, W.; Kara, K. NT-proBNP for risk prediction of cardiovascular events and all-cause mortality: The getABI-study. Int. J. Cardiol. Heart Vasc., 2020, 29, 100553.
[http://dx.doi.org/10.1016/j.ijcha.2020.100553] [PMID: 32529024]
[86]
Alehagen, U.; Johansson, P.; Björnstedt, M.; Rosén, A.; Dahlström, U. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int. J. Cardiol., 2013, 167(5), 1860-1866.
[http://dx.doi.org/10.1016/j.ijcard.2012.04.156] [PMID: 22626835]
[87]
Alehagen, U.; Aaseth, J.; Lindahl, T.L.; Larsson, A.; Alexander, J. Dietary supplementation with selenium and coenzyme Q10 prevents increase in plasma D-dimer while lowering cardiovascular mortality in an elderly swedish population. Nutrients, 2021, 13(4), 1344.
[http://dx.doi.org/10.3390/nu13041344] [PMID: 33920725]
[88]
Alehagen, U.; Aaseth, J.; Johansson, P. Less increase of copeptin and MR-proADM due to intervention with selenium and coenzyme Q10 combined: Results from a 4-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Biofactors, 2015, 41(6), 443-452.
[http://dx.doi.org/10.1002/biof.1245] [PMID: 26662217]
[89]
Hargreaves, I.P.; Mantle, D. Coenzyme Q10 supplementation in fibrosis and aging. Adv. Exp. Med. Biol., 2019, 1178, 103-112.
[http://dx.doi.org/10.1007/978-3-030-25650-0_6] [PMID: 31493224]
[90]
Alehagen, U.; Aaseth, J.; Alexander, J.; Svensson, E.; Johansson, P.; Larsson, A. Less fibrosis in elderly subjects supplemented with selenium and coenzyme Q10-A mechanism behind reduced cardiovascular mortality? Biofactors, 2018, 44(2), 137-147.
[http://dx.doi.org/10.1002/biof.1404] [PMID: 29220105]
[91]
Alehagen, U.; Aaseth, J.; Johansson, P. Reduced cardiovascular mortality 10 years after supplementation with selenium and coenzyme Q10 for four years: Follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly citizens. PLoS One, 2015, 10(12), e0141641.
[http://dx.doi.org/10.1371/journal.pone.0141641] [PMID: 26624886]
[92]
Jafari, M.; Mousavi, S.M.; Asgharzadeh, A.; Yazdani, N. Coenzyme Q10 in the treatment of heart failure: A systematic review of systematic reviews. Indian Heart J., 2018, 70 Suppl 1(Suppl 1), S111-S117.
[http://dx.doi.org/10.1016/j.ihj.2018.01.031]
[93]
Soja, A.M.; Mortensen, S.A. Treatment of congestive heart failure with coenzyme Q10 Illuminated by meta-analyses of clinical trials. Mol. Aspects Med., 1997, 18(Suppl.), 159-168.
[http://dx.doi.org/10.1016/S0098-2997(97)00042-3] [PMID: 9266518]
[94]
Sander, S.; Coleman, C.I.; Patel, A.A.; Kluger, J.; Michael White, C. The impact of coenzyme Q10 on systolic function in patients with chronic heart failure. J. Card. Fail., 2006, 12(6), 464-472.
[http://dx.doi.org/10.1016/j.cardfail.2006.03.007] [PMID: 16911914]
[95]
Rosenfeldt, F.; Hilton, D.; Pepe, S.; Krum, H. Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure. Biofactors, 2003, 18(1-4), 91-100.
[http://dx.doi.org/10.1002/biof.5520180211] [PMID: 14695924]
[96]
Fotino, A.D.; Thompson-Paul, A.M.; Bazzano, L.A. Effect of coenzyme Q10 supplementation on heart failure: A meta- analysis. Am. J. Clin. Nutr., 2013, 97(2), 268-275.
[http://dx.doi.org/10.3945/ajcn.112.040741] [PMID: 23221577]
[97]
Madmani, M.E.; Yusuf Solaiman, A.; Tamr Agha, K.; Madmani, Y.; Shahrour, Y.; Essali, A.; Kadro, W. Coenzyme Q10 for heart failure. Cochrane Libr., 2014, (6), CD008684.
[http://dx.doi.org/10.1002/14651858.CD008684.pub2] [PMID: 24049047]
[98]
Lei, L.; Liu, Y. Efficacy of coenzyme Q10 in patients with cardiac failure: A meta-analysis of clinical trials. BMC Cardiovasc. Disord., 2017, 17(1), 196.
[http://dx.doi.org/10.1186/s12872-017-0628-9] [PMID: 28738783]
[99]
Trongtorsak, A.; Kongnatthasate, K.; Susantitaphong, P.; Kittipibul, V.; Ariyachaipanich, A. Effect of coenzyme Q10 on left ventricular remodeling and mortality in patients with heart failure: A meta-analysis. J. Am. Coll. Cardiol., 2017, 69(Suppl. 11), 707-707.
[http://dx.doi.org/10.1016/S0735-1097(17)34096-2]
[100]
Al Saadi, T.; Assaf, Y.; Farwati, M.; Turkmani, K.; Al- Mouakeh, A.; Shebli, B.; Khoja, M.; Essali, A.; Madmani, M.E. Coenzyme Q10 for heart failure. Cochrane Database Syst. Rev., 2021, 2(2), CD008684.
[http://dx.doi.org/10.1002/14651858.CD008684.pub3]

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