Liposomes and Micro/Nanoparticles as Colloidal Carriers for Nasal Drug Delivery

Title: Liposomes and Micro/Nanoparticles as Colloidal Carriers for Nasal Drug Delivery

Volume: 3 Issue: 3

Author(s): Rubiana Mara Mainardes, Maria Cristina Cocenza Urban, Priscila Oliveira Cinto, Marco Vinicius Chaud, Raul Cesar Evangelista and Maria Palmira Daflon Gremiao

Affiliation:

Keywords: Nasal delivery, nasal bioavailability, colloidal drug delivery systems

Abstract: The use of the nasal route for drug delivery has attracted much interest in recent years in the pharmaceutical field. Local and principally systemic drug delivery can be achieved by this route of administration. But the nasal route of delivery is not applicable to all drugs. Polar drugs and some macromolecules are not absorbed in sufficient concentration due to poor membrane permeability, rapid clearance and enzymatic degradation into the nasal cavity. Thus, alternative means that help overcome these nasal barriers are currently in development. Absorption enhancers such as phospholipids and surfactants are constantly used, but care must be taken in relation to their concentration. Drug delivery systems including liposomes, cyclodextrins, micro- and nanoparticles are being investigated to increase the bioavailability of drugs delivered intranasally. This review article discusses recent progress and specific development issues relating to colloidal drug delivery systems in nasal drug delivery.

Cite this article as:

Mara Mainardes Rubiana, Cristina Cocenza Urban Maria, Oliveira Cinto Priscila, Vinicius Chaud Marco, Cesar Evangelista Raul and Palmira Daflon Gremiao Maria, Liposomes and Micro/Nanoparticles as Colloidal Carriers for Nasal Drug Delivery, Current Drug Delivery 2006; 3 (3) . https://dx.doi.org/10.2174/156720106777731019