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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Letter Article

[bmim]BF4-accelarated One-pot Synthesis of 2-amino Thiazole Derivatives

Author(s): Dau Xuan Duc* and Nguyen Thi Chung

Volume 20, Issue 8, 2023

Published on: 01 March, 2023

Page: [689 - 695] Pages: 7

DOI: 10.2174/1570178620666230207093953

Price: $65

Abstract

An efficient and environmentally-friendly protocol for the synthesis of 2- (arylamino) thiazoles has been investigated. The two-step, three-component reaction of aryl ketones, Nbromosuccinimide, and thiourea derivatives was performed using [bmim][BF4] ionic liquid as a solvent in one pot and gave products in good to excellent yields. Furthermore, the ionic liquid could be reused up to the 5th time without a considerable decrease in the reaction yield. Thirteen thiazoles were obtained in high yields (78-89%) under mild conditions (ambient temperature and relatively short reaction time) and their structures were confirmed by NMR data.

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