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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

An Overview of Biosynthetic Pathway and Therapeutic Potential of Rutin

Author(s): Jugnu Goyal and Prabhakar Kumar Verma*

Volume 23, Issue 14, 2023

Published on: 14 February, 2023

Page: [1451 - 1460] Pages: 10

DOI: 10.2174/1389557523666230125104101

Price: $65

Abstract

Flavonoids are compounds abundantly found in nature and known as a polyphenolic group of compounds having flavancore and show the utmost abundant collection of complexes and are found in fiber-rich root vegetables, fruits, and their eatable items. Due to the presence of hydroxyl groups, flavonoids show various therapeutic activities like antioxidant, antibacterial, antiviral, and antiinflammatory. Substituent groups are responsible for the onset of biochemical actions of flavonoids, which affect the metabolism. The major example of flavonol is rutin, which is constituted of rutinose and quercetin. It is a glycosidic type of flavonoid, similarly identified as purple quercitrin and Vitamin P with over 70 plant species and plant-derived foods, exclusively grapefruit, buckwheat seeds, cherries, apricots, grapes, onions, plums, and oranges. Another name forrutin is a citrus flavonoid known as rutoside, and sophorin. Rutin is a polyphenolic compound having a low molecular weight.

Graphical Abstract

[1]
Mathesius, U. Flavonoid functions in plants and their interactions with other organisms. Plants, 2018, 7(2), 30.
[2]
Mouradov, A.; Spangenberg, G. Flavonoids: A metabolic network mediating plants adaptation to their real estate. Front. Plant Sci., 2014, 5, 620.
[http://dx.doi.org/10.3389/fpls.2014.00620] [PMID: 25426130]
[3]
Falcone Ferreyra, M.L.; Rius, S.P.; Casati, P. Flavonoids: Biosynthesis, biological functions, and biotechnological applications. Front. Plant Sci., 2012, 3, 222.
[http://dx.doi.org/10.3389/fpls.2012.00222] [PMID: 23060891]
[4]
Birjees Bukhari, S.; Memon, S.; Mahroof Tahir, M.; Bhanger, M.I. Synthesis, characterization and investigation of antioxidant activity of cobalt–quercetin complex. J. Mol. Struct., 2008, 892(1-3), 39-46.
[http://dx.doi.org/10.1016/j.molstruc.2008.04.050]
[5]
Ganeshpurkar, A.; Saluja, A.K. The Pharmacological Potential of Rutin. Saudi Pharm. J., 2017, 25(2), 149-164.
[http://dx.doi.org/10.1016/j.jsps.2016.04.025] [PMID: 28344465]
[6]
Patel, K.; Patel, D. K. The beneficial role of rutin, a naturally occurring flavonoid in health promotion and disease prevention: A systematic review and update. Bioact. Food Diet. Interv. Arthritis Relat. Inflamm. Dis., 2019, 457-479.
[http://dx.doi.org/10.1016/B978-0-12-813820-5.00026-X]
[7]
Prasad, S. A review on the chemistry and biological properties of rutin, a promising nutraceutical agent. A J P P, 2019, 5(S1), 1-20.
[http://dx.doi.org/10.31024/ajpp.2019.5.s1.1]
[8]
Panhwar, Q.K.; Memon, S. Synthesis, characterisation, and antioxidant study of Cr(III)-rutin complex. Chem. Pap., 2013, 68(5), 614-623.
[http://dx.doi.org/10.2478/s11696-013-0494-6]
[9]
Becho, J.M.; Peters, V.M.; Macedo, R.M.; Lucinda, L.M.; Guerra, M.D. Toxicological evaluation of the flavonoid rutin on the reproductive system of wistar rats. Rev. Interdiscip. Estud. Exp., 2015, 7, 7-14.
[10]
Bai, Y.; Song, F.; Chen, M.; Xing, J.; Liu, Z.; Liu, S. Characterization of the rutin-metal complex by electrospray ionization tandem mass spectrometry. Anal. Sci., 2004, 20(8), 1147-1151.
[http://dx.doi.org/10.2116/analsci.20.1147] [PMID: 15352502]
[11]
Enogieru, A.B.; Haylett, W.; Hiss, D.C.; Bardien, S.; Ekpo, O.E. Rutin as a Potent Antioxidant: Implications for Neurodegenerative Disor-ders. Oxid. Med. Cell. Longev., 2018, 2018, 1-17.
[http://dx.doi.org/10.1155/2018/6241017] [PMID: 30050657]
[12]
Jinous, Asgarpanah; Khoshkam, R. Phytochemistry and pharmacological properties of Ruta graveolens L. J. Med. Plants Res., 2012, 6(23), 3942-3949.
[http://dx.doi.org/10.5897/JMPR12.040]
[13]
Kostova, I.; Ivanova, A.; Mikhova, B.; Klaiber, I. Alkaloids and Coumarins from Ruta Graveolens. Monatshefte für Chemie/Chem. Mon., 1999, 130(5), 703-707.
[http://dx.doi.org/10.1007/PL00010251]
[14]
Habtemariam, S. Antioxidant and rutin content analysis of leaves of the common buckwheat (Fagopyrum esculentum Moench) Grown in the United Kingdom: A Case Study. Antioxidants, 2019, 8(6), 160.
[http://dx.doi.org/10.3390/antiox8060160] [PMID: 31163698]
[15]
Kreft, I.; Fabjan, N.; Yasumoto, K. Rutin content in buckwheat (Fagopyrum esculentum Moench) food materials and products. Food Chem., 2006, 98(3), 508-512.
[http://dx.doi.org/10.1016/j.foodchem.2005.05.081]
[16]
Fazio, A.; Plastina, P.; Meijerink, J.; Witkamp, R.F.; Gabriele, B. Comparative analyses of seeds of wild fruits of Rubus and Sambucus species from Southern Italy: Fatty acid composition of the oil, total phenolic content, antioxidant and anti-inflammatory properties of the methanolic extracts. Food Chem., 2013, 140(4), 817-824.
[http://dx.doi.org/10.1016/j.foodchem.2012.11.010] [PMID: 23692771]
[17]
Viapiana, A.; Wesolowski, M. The Phenolic contents and antioxidant activities of infusions of Sambucus nigra L. Plant Foods Hum. Nutr., 2017, 72(1), 82-87.
[http://dx.doi.org/10.1007/s11130-016-0594-x] [PMID: 28084608]
[18]
Li, T.; Fu, S.; Huang, X.; Zhang, X.; Cui, Y.; Zhang, Z.; Ma, Y.; Zhang, X.; Yu, Q.; Yang, S.; Li, S. Biological properties and potential application of hawthorn and its major functional components: A review. J. Funct. Foods, 2022, 90, 104988.
[http://dx.doi.org/10.1016/j.jff.2022.104988]
[19]
Keser, S.; Celik, S.; Turkoglu, S.; Yilmaz, O.; Turkoglu, I. The investigation of some bioactive compounds and antioxidant properties of hawthorn (Crataegus monogyna subsp. monogyna Jacq). J. Intercult. Ethnopharmacol., 2014, 3(2), 51-55.
[http://dx.doi.org/10.5455/jice.20140120103320] [PMID: 26401347]
[20]
Williams, F.B.; Sander, L.C.; Wise, S.A.; Girard, J. Development and evaluation of methods for determination of naphthodianthrones and flavonoids in St. John’s wort. J. Chromatogr. A, 2006, 1115(1-2), 93-102.
[http://dx.doi.org/10.1016/j.chroma.2006.02.078] [PMID: 16554056]
[21]
Ashok, P.K.; Saini, B. HPLC Analysis and Isolation of Rutin from Stem Bark of Ginkgo Biloba L. J. Pharmacogn. Phytochem., 2013, 2(4), 68-71.
[22]
Vachirapatama, N.; Chamnankid, B. Separation and Determination of Rutin in Apples by High Performance Liquid Chromatography. Thammasat Int. J. Sci. Technol., 17(3)
[23]
Hyson, D.A. A comprehensive review of apples and apple components and their relationship to human health. Adv. Nutr., 2011, 2(5), 408-420.
[http://dx.doi.org/10.3945/an.111.000513] [PMID: 22332082]
[24]
Shafi, W.; Mansoor, S.; Jan, S.; Singh, D.B.; Kazi, M.; Raish, M.; Alwadei, M.; Mir, J.I.; Ahmad, P. Variability in catechin and rutin con-tents and their antioxidant potential in diverse apple genotypes. Mol., 2019, 24(5), 943.
[http://dx.doi.org/10.3390/molecules24050943]
[25]
Kamiloglu, S.; Capanoglu, E. Polyphenol Content in Figs (Ficus Carica L.). Effect of Sun-Drying., 2014, 18(3), 521-535.
[http://dx.doi.org/10.1080/10942912.2013.833522]
[26]
Kochman, J.; Jakubczyk, K.; Antoniewicz, J.; Mruk, H.; Janda, K. health benefits and chemical composition of matcha green tea: A Re-view. Molecules, 2020, 26(1), 85.
[http://dx.doi.org/10.3390/molecules26010085] [PMID: 33375458]
[27]
Jeszka-Skowron, M.; Krawczyk, M.; Zgoła-Grześkowiak, A. Determination of antioxidant activity, rutin, quercetin, phenolic acids and trace elements in tea infusions: Influence of citric acid addition on extraction of metals. J. Food Compos. Anal., 2015, 40, 70-77.
[http://dx.doi.org/10.1016/j.jfca.2014.12.015]
[28]
Verhoeyen, M.E.; Bovy, A.; Collins, G.; Muir, S.; Robinson, S.; de Vos, C.H.R.; Colliver, S. Increasing antioxidant levels in tomatoes through modification of the flavonoid biosynthetic pathway. J. Exp. Bot., 2002, 53(377), 2099-2106.
[http://dx.doi.org/10.1093/jxb/erf044] [PMID: 12324533]
[29]
Taguchi, G. Flavonoid biosynthesis in buckwheat. Mol. Breed. Nutr. Asp. Buckwheat, 2016, 377-386.
[http://dx.doi.org/10.1016/B978-0-12-803692-1.00030-4]
[30]
Gupta, N.; Sharma, S.K.; Rana, J.C.; Chauhan, R.S. Expression of flavonoid biosynthesis genes vis-à-vis rutin content variation in different growth stages of Fagopyrum species. J. Plant Physiol., 2011, 168(17), 2117-2123.
[http://dx.doi.org/10.1016/j.jplph.2011.06.018] [PMID: 21872967]
[31]
Yang, J.; Guo, J.; Yuan, J. In vitro antioxidant properties of rutin. Lebensm. Wiss. Technol., 2008, 41(6), 1060-1066.
[http://dx.doi.org/10.1016/j.lwt.2007.06.010]
[32]
Koval’skii, I.V.; Krasnyuk, I.I.; Krasnyuk, I.I.; Nikulina, O.I.; Belyatskaya, A.V.; Kharitonov, Y.Y.; Feldman, N.B.; Lutsenko, S.V. Molecular-biological problems of drug design and mechanism of drug action: Mechanisms of rutin pharmacological action. Pharm. Chem. J., 2014, 48(2), 73-76. [Review].
[http://dx.doi.org/10.1007/s11094-014-1050-6]
[33]
Chen, X.; Yin, O.Q.P.; Zuo, Z.; Chow, M.S.S. Pharmacokinetics and modeling of quercetin and metabolites. Pharm. Res., 2005, 22(6), 892-901.
[http://dx.doi.org/10.1007/s11095-005-4584-1] [PMID: 15948033]
[34]
Pashikanti, S.; de Alba, D.R.; Boissonneault, G.A.; Cervantes-Laurean, D. Rutin metabolites: Novel inhibitors of nonoxidative advanced glycation end products. Free Radic. Biol. Med., 2010, 48(5), 656-663.
[http://dx.doi.org/10.1016/j.freeradbiomed.2009.11.019] [PMID: 19969069]
[35]
Erlund, I.; Kosonen, T.; Alfthan, G.; Mäenpää, J.; Perttunen, K.; Kenraali, J.; Parantainen, J.; Aro, A. Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers. Eur. J. Clin. Pharmacol., 2000, 56(8), 545-553.
[http://dx.doi.org/10.1007/s002280000197] [PMID: 11151743]
[36]
Sharma, S.; Rabbani, S.A.; Narang, J.K.; Hyder Pottoo, F.; Ali, J.; Kumar, S.; Baboota, S. Role of rutin nanoemulsion in ameliorating oxi-dative stress: Pharmacokinetic and pharmacodynamics studies. Chem. Phys. Lipids, 2020, 228, 104890.
[http://dx.doi.org/10.1016/j.chemphyslip.2020.104890] [PMID: 32032570]
[37]
Boyle, S.P.; Dobson, V.L.; Duthie, S.J.; Hinselwood, D.C.; Kyle, J.A.M.; Collins, A.R. Bioavailability and efficiency of rutin as an antioxi-dant: A human supplementation study. Eur. J. Clin. Nutr., 2000, 54(10), 774-782.
[http://dx.doi.org/10.1038/sj.ejcn.1601090] [PMID: 11083486]
[38]
Choi, S.J.; Lee, S.N.; Kim, K.; Joo, D.H.; Shin, S.; Lee, J.; Lee, H.K.; Kim, J.; Kwon, S.B.; Kim, M.J.; Ahn, K.J.; an, I.S.; an, S.; Cha, H.J. Biological effects of rutin on skin aging. Int. J. Mol. Med., 2016, 38(1), 357-363.
[http://dx.doi.org/10.3892/ijmm.2016.2604] [PMID: 27220601]
[39]
Anesti, M.; Stavropoulou, N.; Atsopardi, K.; Lamari, F.N.; Panagopoulos, N.T.; Margarity, M. Effect of rutin on anxiety-like behavior and activity of acetylcholinesterase isoforms in specific brain regions of pentylenetetrazol-treated mice. Epilepsy Behav., 2020, 102, 106632.
[http://dx.doi.org/10.1016/j.yebeh.2019.106632] [PMID: 31747631]
[40]
Nassiri-Asl, M.; Shariati-Rad, S.; Zamansoltani, F. Anticonvulsive effects of intracerebroventricular administration of rutin in rats. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2008, 32(4), 989-993.
[http://dx.doi.org/10.1016/j.pnpbp.2008.01.011] [PMID: 18262708]
[41]
Erkan, H.; Aliseydi, B.; Keskin, E.; Abdullah, E.; Ali, G.M.; Halis, S.; Zeynep, S. Effect of rutin on oxidative and proinflammatory dama-ge induced by cisplatin in blood serum, ureter, bladder and urethra in rats. Biotechnol. Biotechnol. Equip., 2020, 34(1), 171-181.
[http://dx.doi.org/10.1080/13102818.2020.1727362]
[42]
Pawar, A.; Deshmukh, C.; Bhanudas, B.; Ghodasara, J. Inhibitory effect of rutin and curcumin on experimentally-induced calcium oxalate urolithiasis in rats. Pharmacognosy Res., 2010, 2(6), 388-392.
[http://dx.doi.org/10.4103/0974-8490.75462] [PMID: 21713144]
[43]
Taşlı, N.G.; Uçak, T.; Karakurt, Y.; Keskin Çimen, F.; Özbek Bilgin, A.; Kurt, N.; Süleyman, H. The effects of rutin on cisplatin induced oxidative retinal and optic nerve injury: An experimental study. Cutan. Ocul. Toxicol., 2018, 37(3), 252-257.
[http://dx.doi.org/10.1080/15569527.2018.1442842] [PMID: 29455557]
[44]
Li, Y.; Qin, L.; Ying, L.; Dong, H.; Wang, D. Rutin prevents retinal ganglion cell death and exerts protective effects by regulating transforming growth factor-β2/Smad2/3Akt/PTEN signaling in experimental rat glaucoma. Trop. J. Pharm. Res., 2021, 18(5), 985-993.
[http://dx.doi.org/10.4314/tjpr.v18i5.11]
[45]
Muthenna, P.; Akileshwari, C.; Saraswat, M.; Bhanuprakash Reddy, G. Inhibition of advanced glycation end-product formation on eye lens protein by rutin. Br. J. Nutr., 2012, 107(7), 941-949.
[http://dx.doi.org/10.1017/S0007114511004077] [PMID: 21864418]
[46]
Lee, H.H.; Jang, J.W.; Lee, J.K.; Park, C.K. Rutin improves bone histomorphometric values by reduction of osteoclastic activity in osteoporosis mouse model induced by bilateral ovariectomy. J. Korean Neurosurg. Soc., 2020, 63(4), 433-443.
[http://dx.doi.org/10.3340/jkns.2019.0097] [PMID: 32172552]
[47]
Horcajada-Molteni, M.N.; Crespy, V.; Coxam, V.; Davicco, M.J.; Rémésy, C.; Barlet, J.P. Rutin inhibits ovariectomy-induced osteopenia in rats. J. Bone Miner. Res., 2000, 15(11), 2251-2258.
[http://dx.doi.org/10.1359/jbmr.2000.15.11.2251] [PMID: 11092407]
[48]
Bai, L.; Li, A.; Gong, C.; Ning, X.; Wang, Z. Protective effect of rutin against bleomycin induced lung fibrosis: Involvement of TGF ‐β1/α‐SMA/Col I and III pathway. Biofactors, 2020, 46(4), 637-644.
[http://dx.doi.org/10.1002/biof.1629] [PMID: 32233122]
[49]
Berthon, B.; Wood, L. Nutrition and respiratory health--feature review. Nutrients, 2015, 7(3), 1618-1643.
[http://dx.doi.org/10.3390/nu7031618] [PMID: 25751820]
[50]
Siti, H.N.; Jalil, J.; Asmadi, A.Y.; Kamisah, Y. Roles of rutin in cardiac remodeling. J. Funct. Foods, 2020, 64, 103606.
[http://dx.doi.org/10.1016/j.jff.2019.103606]
[51]
Lin, Q.; Chen, X.Y.; Zhang, J.; Yuan, Y.L.; Zhao, W.; Wei, B. Upregulation of SIRT1 contributes to the cardioprotective effect of Rutin against myocardial ischemia-reperfusion injury in rats. J. Funct. Foods, 2018, 46, 227-236.
[http://dx.doi.org/10.1016/j.jff.2018.05.007]
[52]
Lima Gonçalves, C.F.; de Souza dos Santos, M.C.; Ginabreda, M.G.; Soares Fortunato, R.; Pires de Carvalho, D.; Freitas Ferreira, A.C. Flavonoid rutin increases thyroid iodide uptake in rats. PLoS One, 2013, 8(9), e73908.
[http://dx.doi.org/10.1371/journal.pone.0073908] [PMID: 24023911]
[53]
Guo, X.; Diao, Q.; Wang, Y.; Tu, Y.; Deng, K.; Wang, X.; Fu, T.; Yan, G. The Effect of administration of rutin on plasma levels of estro-gen, prolactin, growth hormone and gene expression of their receptors in mammary glands in ovariectomized rats. J. Integr. Agric., 2012, 11(10), 1700-1706.
[http://dx.doi.org/10.1016/S2095-3119(12)60173-7]
[54]
de Medeiros, D.C.; Mizokami, S.S.; Sfeir, N.; Georgetti, S.R.; Urbano, A.; Casagrande, R.; Verri, W.A.; Baracat, M.M. Preclinical evaluation of rutin-loaded microparticles with an enhanced analgesic effect. ACS Omega, 2019, 4(1), 1221-1227.
[http://dx.doi.org/10.1021/acsomega.8b02868]
[55]
Carvalho, T.T.; Mizokami, S.S.; Ferraz, C.R.; Manchope, M.F.; Borghi, S.M.; Fattori, V.; Calixto-Campos, C.; Camilios-Neto, D.; Casa-grande, R.; Verri, W.A. The granulopoietic cytokine granulocyte colony-stimulating factor (G-CSF) induces pain: Analgesia by rutin. Inflammopharmacology, 2019, 27(6), 1285-1296.
[http://dx.doi.org/10.1007/s10787-019-00591-8]
[56]
Al-Roujeaie, A.S.; Abuohashish, H.M.; Ahmed, M.M.; Alkhamees, O.A. Effect of rutin on diabetic-induced erectile dysfunction: Possible involvement of testicular biomarkers in male rats. Andrologia, 2017, 49(8), e12737.
[http://dx.doi.org/10.1111/and.12737] [PMID: 27785836]
[57]
Hadigol, T.; Sobhani, A.; Hemadi, M.; Nekoonam, S.; Shams, A.; Eslami Farsani, B.; Dastoorpoor, M.; Saki, G. The Effect of rutin on progesterone and estrogen receptor expression in uterine endometrial tissue in the heterotopic transplantation of newborn mouse ovary. Iran. Red Crescent Med. J., 2019, 21(4)
[http://dx.doi.org/10.5812/ircmj.86289]
[58]
Fideles, L.S.; de Miranda, J.A.L.; Martins, C.S.; Barbosa, M.L.L.; Pimenta, H.B.; Pimentel, P.V.S.; Teixeira, C.S.; Scafuri, M.A.S.; Façanha, S.O.; Barreto, J.E.F.; Carvalho, P.M.M.; Scafuri, A.G.; Araújo, J.L.; Rocha, J.A.; Vieira, I.G.P.; Ricardo, N.M.P.S.; da Silva Campelo, M.; Ribeiro, M.E.N.P.; de Castro Brito, G.A.; Cerqueira, G.S. Role of rutin in 5-Fluorouracil-induced intestinal mucositis: Prevention of histo-logical damage and reduction of inflammation and oxidative stress. Molecules, 2020, 25(12), 2786.
[http://dx.doi.org/10.3390/molecules25122786]
[59]
Abdel-Raheem, I.T. Gastroprotective effect of rutin against indomethacin-induced ulcers in rats. Basic Clin. Pharmacol. Toxicol., 2010, 107(3), 742-750.
[http://dx.doi.org/10.1111/j.1742-7843.2010.00568.x] [PMID: 20374237]
[60]
Rabišková, M.; Bautzová, T.; Gajdziok, J.; Dvořáčková, K.; Lamprecht, A.; Pellequer, Y.; Spilková, J. Coated chitosan pellets containing rutin intended for the treatment of inflammatory bowel disease: In vitro characteristics and in vivo evaluation. Int. J. Pharm., 2012, 422(1-2), 151-159.
[http://dx.doi.org/10.1016/j.ijpharm.2011.10.045] [PMID: 22079717]
[61]
Chen, H.; Miao, Q.; Geng, M.; Liu, J.; Hu, Y.; Tian, L.; Pan, J.; Yang, Y. Anti-tumor effect of rutin on human neuroblastoma cell lines through inducing G2/M cell cycle arrest and promoting apoptosis. Sci. World J., 2013, 2013, 1-8.
[http://dx.doi.org/10.1155/2013/269165] [PMID: 24459422]
[62]
Imani, A.; Maleki, N.; Bohlouli, S.; Kouhsoltani, M.; Sharifi, S.; Maleki Dizaj, S. Molecular mechanisms of anticancer effect of rutin. Phytother. Res., 2021, 35(5), 2500-2513.
[http://dx.doi.org/10.1002/ptr.6977] [PMID: 33295678]
[63]
Caparica, R.; Júlio, A.; Araújo, M.E.M.; Baby, A.R.; Fonte, P.; Costa, J.G.; Santos de Almeida, T. Anticancer activity of rutin and its com-bination with ionic liquids on renal cells. Biomolecules, 2020, 10(2), 233.
[http://dx.doi.org/10.3390/biom10020233] [PMID: 32033222]
[64]
Arima, H.; Ashida, H.; Danno, G. Rutin-enhanced antibacterial activities of flavonoids against Bacillus cereus and Salmonella enteritidis. Biosci. Biotechnol. Biochem., 2002, 66(5), 1009-1014.
[http://dx.doi.org/10.1271/bbb.66.1009] [PMID: 12092809]
[65]
Amin, M.U.; Khurram, M.; Khattak, B.; Khan, J. Antibiotic additive and synergistic action of rutin, morin and quercetin against methicillin resistant Staphylococcus aureus. BMC Complement. Altern. Med., 2015, 15(1), 59.
[http://dx.doi.org/10.1186/s12906-015-0580-0] [PMID: 25879586]
[66]
Gutiérrez-Venegas, G.; Gómez-Mora, J.A.; Meraz-Rodríguez, M.A.; Flores-Sánchez, M.A.; Ortiz-Miranda, L.F. Effect of flavonoids on antimicrobial activity of microorganisms present in dental plaque. Heliyon, 2019, 5(12), e03013.
[http://dx.doi.org/10.1016/j.heliyon.2019.e03013] [PMID: 31886429]
[67]
Kumar, K.K.; Priyanka, L.; Gnananath, K.; Babu, P.R.; Sujatha, S. Pharmacokinetic Drug Interactions between Apigenin, Rutin and Paclitaxel Mediated by P-Glycoprotein in Rats. Eur. J. Drug Metab. Pharmacokinet., 2014, 40(3), 267-276.
[http://dx.doi.org/10.1007/s13318-014-0203-z]
[68]
Kourounakis, P.; Rekka, E. Effect of benzopyrone derivatives on drug activity and metabolism. Eur. J. Drug Metab. Pharmacokinet., 1986, 11(4), 269-273.
[http://dx.doi.org/10.1007/BF03189111]
[69]
Wilson, R.H.; Mortarotti, T.G.; Doxtader, E.K. Toxicity studies on rutin. Exp. Biol. Med. (Maywood), 1947, 64(3), 324-327.
[http://dx.doi.org/10.3181/00379727-64-15781] [PMID: 20293223]
[70]
Morino, K.; Matsukura, N.; Kawachi, T.; Ohgaki, H.; Sugimura, T.; Hirono, I. Carcinogenicity test of quercetin and rutin in golden hamsters by oral administration. Carcinogenesis, 1982, 3(1), 93-97.
[http://dx.doi.org/10.1093/carcin/3.1.93] [PMID: 7067042]
[71]
Ou-yang, Z.; Cao, X.; Wei, Y.; Zhang, W.W.Q.; Zhao, M.; Duan, J. Pharmacokinetic study of rutin and quercetin in rats after oral administration of total flavones of mulberry leaf extract. Rev. Bras. Farmacogn., 2013, 23(5), 776-782.
[http://dx.doi.org/10.1590/S0102-695X2013000500009]

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