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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Synthesis Memantine and Memantine Hydrochloride by Direct Amination of 1-Bromo-3,5-dimethyladamantane with Thiourea

Author(s): Thi Hong Tham Nguyen, Binh Duong Vu*, Dinh Chau Phan*, Thi Hong Thanh Nguyen, Quang Anh Luong and Thi Xuan Thu Ngo

Volume 20, Issue 7, 2023

Published on: 16 February, 2023

Page: [672 - 677] Pages: 6

DOI: 10.2174/1570178620666230123094019

Price: $65

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Abstract

Memantine hydrochloride (MH) is a first-line therapeutic drug approved by the US FDA for the management of moderate to severe Alzheimer's disease. This study involves the synthesis of memantine hydrochloride from 1-bromo-3,5-dimethyladamantane through a reaction with thiourea. The research results showed that the solvent reaction was propylene glycol (PG); the total time reaction was 5.5 hours, the temperature reaction in the first stage was 160°C and in the second stage was 80°C; the overall yield was 82.44%. The reaction intermediates were confirmed by the IR, MS,1HNMR, and 13C-NMR spectra.

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