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Pharmaceutical Nanotechnology

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ISSN (Print): 2211-7385
ISSN (Online): 2211-7393

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Review Article

Chemistry Characterization and Application of Nanocrystals-based Drug Delivery System: Present to Future Perspective

Author(s): Manami Dhibar, Santanu Chakraborty*, Abhijeet Kundu and Payel Laha

Volume 11, Issue 3, 2023

Published on: 21 February, 2023

Page: [265 - 275] Pages: 11

DOI: 10.2174/2211738511666230109151410

Price: $65

Abstract

With the development of new technologies, various drugs with higher efficacy have been found, but their therapeutic use is still limited owing to poor water solubility, which leads to poor systemic bioavailability. Currently, about 40% of newly discovered drugs have a solubility issue. It is a major challenge for formulation scientists to overcome this problem and make a robust and effective formulation. One such unique approach is to formulate the drug as nanocrystals which alter the physical characteristics of the drug, resulting in the development of a novel formulation strategy for poorly soluble drugs. Nanocrystals are produced by various techniques such as top-down, bottom-up, or combination methods. Nanocrystals improve the clinical application of problematic drug molecules by decreasing the particle size, enhancing the dissolution rate and reducing the dose requirement, etc. This approach is not only improving the bioavailability of the drug but also facilitates the drug targeting to specific sites due to its feasibility of surface modification and all administration routes. This article deals with the various aspects of nanocrystals including chemistry, production, stabilization, characterization, and application in the field of pharmacy.

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[1]
Junghanns JUAH, Müller RH. Nanocrystal technology, drug delivery and clinical applications. Int J Nanomedicine 2008; 3(3): 295-309.
[PMID: 18990939]
[2]
Joseph E, Singhvi G. Multifunctional nanocrystals for cancer therapy: A potential nanocarrier. In: Nanomaterials for Drug Delivery and Therapy. Elsevier Inc Amsterdam 2019; pp. 91-116.
[http://dx.doi.org/10.1016/B978-0-12-816505-8.00007-2]
[3]
Malamatari M, Taylor KMG, Malamataris S, Douroumis D, Kachrimanis K. Pharmaceutical nanocrystals: production by wet milling and applications. Drug Discov Today 2018; 23(3): 534-47.
[http://dx.doi.org/10.1016/j.drudis.2018.01.016] [PMID: 29326082]
[4]
Saini JK, Kumar S. Development of nanocrystal formulation with improved dissolution. J Drug Deliv Ther 2018; 8(5): 118-29.
[http://dx.doi.org/10.22270/jddt.v8i5.1946]
[5]
Savjani KT, Gajjar AK, Savjani JK. Drug Solubility: Importance and enhancement techniques. ISRN Pharm 2012; 2012: 1-10.
[6]
Gigliobianco M, Casadidio C, Censi R, Di Martino P. Nanocrystals of poorly soluble drugs: Drug bioavailability and physicochemical stability. Pharmaceutics 2018; 10(3): 134.
[http://dx.doi.org/10.3390/pharmaceutics10030134] [PMID: 30134537]
[7]
Zhou Y, Du J, Wang L, Wang Y. Nanocrystals technology for improving bioavailability of poorly soluble drugs: A mini-review. J Nanosci Nanotechnol 2017; 17(1): 18-28.
[http://dx.doi.org/10.1166/jnn.2017.13108] [PMID: 29616786]
[8]
Katteboinaa S, Chandrasekhar P. VSR, Balaji S. Drug nanocrystals: A novel formulation approach for poorly soluble drugs. Int J Pharm Tech Res 2009; 1(3): 682-94.
[9]
Müller RH, Gohla S, Keck CM. State of the art of nanocrystals-Special features, production, nanotoxicology aspects and intracellular delivery. Eur J Pharm Biopharm 2011; 78(1): 1-9.
[http://dx.doi.org/10.1016/j.ejpb.2011.01.007] [PMID: 21266197]
[10]
Chogale M, Ghodake V, Patravale V. Performance parameters and characterizations of nanocrystals: A brief review. Pharmaceutics 2016; 8(3): 26.
[http://dx.doi.org/10.3390/pharmaceutics8030026] [PMID: 27589788]
[11]
Mosharraf M, Nyström C. The effect of particle size and shape on the surface specific dissolution rate of microsized practically insoluble drugs. Int J Pharm 1995; 122(1-2): 35-47.
[http://dx.doi.org/10.1016/0378-5173(95)00033-F]
[12]
Böhm BHL, Müller RH. Lab-scale production unit design for nanosuspensions of sparingly soluble cytotoxic drugs. Pharm Sci Technol Today 1999; 2(8): 336-9.
[http://dx.doi.org/10.1016/S1461-5347(99)00177-7] [PMID: 10441278]
[13]
Duchêne D, Ponchel G. Bioadhesion of solid oral dosage forms, why and how? Eur J Pharm Biopharm 1997; 44(1): 15-23.
[http://dx.doi.org/10.1016/S0939-6411(97)00097-0]
[14]
Sawant SV, Sankpal SV, Kadam VJ, Jadhav KR. Drug nanocrystals: novel technique for delivery of poorly soluble drugs. Int J Sci Innov Discov 2011; 1(3): 1-15.
[15]
Balamarkonda C, Rao SV, Adamkhan P, Nama S, Brahmaiah B, Sasikanth K. A review on significance of nanocrystals in drug delivery. Int J Pharm 2013; 3(2): 56-61.
[16]
Patel AP, Patel JK, Patel KS, Deshmukh AB, Mishra BR. A review on drug nanocrystal a carrier-free drug delivery. Int J Res Ayurveda Pharm 2011; 2(2): 448-58.
[17]
Desu PK, Sindhuja M, Thriveni K, Nagalakshmi V, Rao PV. A review on significance of nanocrystals in drug delivery. World J Pharm Pharm Sci 2017; 6(12): 347-58.
[18]
Gülsün T, Gürsoy RN, Öner L. Nanocrystal technology for oral delivery of poorly water-soluble drugs. Fabad J Pharm Sci 2009; 34(1): 55-65.
[19]
Raghava Srivalli KM, Mishra B. Drug nanocrystals: A way toward scale-up. Saudi Pharm J 2016; 24(4): 386-404.
[http://dx.doi.org/10.1016/j.jsps.2014.04.007] [PMID: 27330370]
[20]
Tuomela A, Hirvonen J, Peltonen L. Stabilizing agents for drug nanocrystals: effect on bioavailability. Pharmaceutics 2016; 8(2): 16.http://www.mdpi.com/1999-4923/8/2/16
[http://dx.doi.org/10.3390/pharmaceutics8020016] [PMID: 27213435]
[21]
Pawar VK, Singh Y, Meher JG, Gupta S, Chourasia MK. Engineered nanocrystal technology: In vivo fate, targeting and applications in drug delivery. J Control Release 2014; 183(1): 51-66.
[http://dx.doi.org/10.1016/j.jconrel.2014.03.030] [PMID: 24667572]
[22]
Shetea G, Jaina H, Punja D, Prajapata H, Akotiyaa P, Bansala AK. Stabilizers used in nanocrystal-based drug delivery systems. J Excip Food Chem 2014; 5(4): 184-209.
[23]
Muller RH, Keck CM. Challenges and solutions for the delivery of biotech drugs – a review of drug nanocrystal technology and lipid nanoparticles. J Biotechnol 2004; 113(1-3): 151-70.
[http://dx.doi.org/10.1016/j.jbiotec.2004.06.007] [PMID: 15380654]
[24]
Van Eerdenbrugh B, Van den Mooter G, Augustijns P. Top-down production of drug nanocrystals: Nanosuspension stabilization, miniaturization and transformation into solid products. Int J Pharm 2008; 364(1): 64-75.
[http://dx.doi.org/10.1016/j.ijpharm.2008.07.023] [PMID: 18721869]
[25]
Peltonen L, Hirvonen J. Pharmaceutical nanocrystals by nanomilling: critical process parameters, particle fracturing and stabilization methods. J Pharm Pharmacol 2010; 62(11): 1569-79.
[http://dx.doi.org/10.1111/j.2042-7158.2010.01022.x] [PMID: 21039542]
[26]
Bhakay A, Rahman M, Dave R, Bilgili E. Bioavailability enhancement of poorly water-soluble drugs via nanocomposites: Formulation-Processing aspects and challenges. Pharmaceutics 2018; 10(3): 86.
[http://dx.doi.org/10.3390/pharmaceutics10030086] [PMID: 29986543]
[27]
Kumar A, Dixit CK. Methods for characterization of nanoparticles. Adv Nanomedicine Deliv Ther Nucleic Acids 2017.44-58.
[28]
Jeevana JB, Sravani R. Development of curcumin nanocrystals and evaluation of gi absorption efficiency in comparison with curcumin and turmeric powder. World J Pharm Pharm Sci 2016; 5(4): 1990-2003.
[29]
Mu S, Li M, Guo M, et al. Spironolactone nanocrystals for oral administration: Different pharmacokinetic performances induced by stabilizers. Colloids Surf B Biointerfaces 2016; 147: 73-80.
[http://dx.doi.org/10.1016/j.colsurfb.2016.07.051] [PMID: 27490456]
[30]
Brown ME. Differential thermal analysis (DTA) and differential scanning calorimetry (DSC). Introd to Therm Anal 2004.55-90.
[31]
Sharma OP, Patel V, Mehta T. Nanocrystal for ocular drug delivery: hope or hype. Drug Deliv Transl Res 2016; 6(4): 399-413.
[http://dx.doi.org/10.1007/s13346-016-0292-0] [PMID: 27165145]
[32]
Sharma R, Mishra A. A review on potential applications of nanocrystal. Indian J Pharm Sci Res 2013; 3(1): 9-13.
[33]
Kawabata Y, Wada K, Nakatani M, Yamada S, Onoue S. Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: Basic approaches and practical applications. Int J Pharm 2011; 420(1): 1-10.
[http://dx.doi.org/10.1016/j.ijpharm.2011.08.032] [PMID: 21884771]
[34]
Gauniya A, Mazumder R, Pathak K. Nanocrystals: A challenge for improved drug delivery ajbpr. 2015; (3): 282-92.
[35]
Zhao J, Liu Y, Wang L, Zhou Y, Du J, Wang Y. Functional and modified nanocrystals technology for target drug delivery. J Nanosci Nanotechnol 2018; 18(8): 5207-21.
[http://dx.doi.org/10.1166/jnn.2018.15421] [PMID: 29458570]
[36]
Gao L, Zhang D, Chen M. Drug nanocrystals for the formulation of poorly soluble drugs and its application as a potential drug delivery system. J Nanopart Res 2008; 10(5): 845-62.
[http://dx.doi.org/10.1007/s11051-008-9357-4]
[37]
Chang TL, Zhan H, Liang D, Liang JF. Nanocrystal technology for drug formulation and delivery. Front Chem Sci Eng 2015; 9(1): 1-14.
[http://dx.doi.org/10.1007/s11705-015-1509-3]

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